High throughput profiling of charge heterogeneity in antibodies by microchip electrophoresis

Analytical Chemistry

Volumn 83, Issue 21, 2011, Pages 8184-8191

  Han, Hongling ^a   Livingston, Eliza ^a   Chen, Xiaoyu ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

96-WELL MICROTITER PLATE; CAPILLARY ZONE ELECTROPHORESIS; CHARGE HETEROGENEITY; CHARGE PROFILES; CHARGE PROFILING; DERIVATIZATIONS; FLUORESCENCE DETECTION; FORMULATION DEVELOPMENT; HIGH THROUGHPUT; LIMIT OF DETECTION; MICROCHIP ELECTROPHORESIS; MICROFLUIDIC CHANNEL; N-HYDROXYSUCCINIMIDE; PLATE HEIGHT; PROTEIN CHARGE; PROTEIN CHARGE VARIANTS; PROTEIN MOLECULES; SAMPLE ANALYSIS; SAMPLE PREPARATION; SEPARATION EFFICIENCY; THEORETICAL PLATES;

ANTIBODIES; CAPILLARY ELECTROPHORESIS; ESTERIFICATION; ESTERS; MICROPROCESSOR CHIPS;

THROUGHPUT;

ANTIBODY; N HYDROXYSUCCINIMIDE; N-HYDROXYSUCCINIMIDE; PROTEIN; SUCCINIMIDE DERIVATIVE;

ARTICLE; CAPILLARY ELECTROPHORESIS; CHEMISTRY; HIGH THROUGHPUT SCREENING; MICROCHIP ELECTROPHORESIS; MICROFLUIDICS;

ANTIBODIES; ELECTROPHORESIS, CAPILLARY; ELECTROPHORESIS, MICROCHIP; HIGH-THROUGHPUT SCREENING ASSAYS; MICROFLUIDICS; PROTEINS; SUCCINIMIDES;

EID: 80155134174     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac201741w     Document Type: Article

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