메뉴 건너뛰기




Volumn 17, Issue 30, 2011, Pages 3341-3347

Effects of mesenchymal stromal cells on diabetic cardiomyopathy

Author keywords

Diabetes mellitus; Endothelial dysfunction; Fibrosis; Mesenchymal stromal cells

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ANTIFIBROTIC AGENT; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON; GELATINASE A; GELATINASE B; INTERLEUKIN 1BETA; PROTEIN BAK; PROTEIN BAX; PROTEIN KINASE B; PROTEIN P16; PROTEIN P53; PROTEIN P66; SOMATOMEDIN C; SYNAPTOPHYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 80055096552     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161211797904163     Document Type: Review
Times cited : (13)

References (124)
  • 1
    • 33846414720 scopus 로고    scopus 로고
    • Guidelines on diabetes, prediabetes, and cardiovascular diseases: Executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)
    • Ryden L, Standl E, Bartnik M, et al. Guidelines on diabetes, prediabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 2007; 28: 88-136.
    • (2007) Eur Heart J , vol.28 , pp. 88-136
    • Ryden, L.1    Standl, E.2    Bartnik, M.3
  • 2
    • 0031445908 scopus 로고    scopus 로고
    • The rising global burden of diabetes and its complications: Estimates and projections to the year 2010
    • Amos AF, McCarty DJ, Zimmet P. The rising global burden of diabetes and its complications: estimates and projections to the year 2010. Diabet Med 1997; 14 Suppl 5: S1-85.
    • (1997) Diabet Med , vol.14 , Issue.SUPPL. 5
    • Amos, A.F.1    McCarty, D.J.2    Zimmet, P.3
  • 3
    • 0018764335 scopus 로고
    • Diabetes and cardiovascular disease. The Framingham study
    • Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. Jama 1979; 241: 2035-38.
    • (1979) Jama , vol.241 , pp. 2035-2038
    • Kannel, W.B.1    McGee, D.L.2
  • 4
    • 0035810983 scopus 로고    scopus 로고
    • Glycemic control and heart failure among adult patients with diabetes
    • Iribarren C, Karter AJ, Go AS, et al. Glycemic control and heart failure among adult patients with diabetes. Circulation 2001; 103: 2668-73.
    • (2001) Circulation , vol.103 , pp. 2668-2673
    • Iribarren, C.1    Karter, A.J.2    Go, A.S.3
  • 5
    • 0034641568 scopus 로고    scopus 로고
    • Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): Prospective observational study
    • Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. Bmj 2000; 321: 405-12.
    • (2000) Bmj , vol.321 , pp. 405-412
    • Stratton, I.M.1    Adler, A.I.2    Neil, H.A.3
  • 6
    • 0036777187 scopus 로고    scopus 로고
    • Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts
    • Vetter R, Rehfeld U, Reissfelder C, et al. Transgenic overexpression of the sarcoplasmic reticulum Ca2+ATPase improves reticular Ca2+ handling in normal and diabetic rat hearts. FASEB J 2002; 16: 1657-9.
    • (2002) FASEB J , vol.16 , pp. 1657-1659
    • Vetter, R.1    Rehfeld, U.2    Reissfelder, C.3
  • 7
    • 11144357911 scopus 로고    scopus 로고
    • Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene
    • Tschope C, Walther T, Koniger J, et al. Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene. Faseb J 2004; 18: 828-35.
    • (2004) Faseb J , vol.18 , pp. 828-835
    • Tschope, C.1    Walther, T.2    Koniger, J.3
  • 8
    • 10044241544 scopus 로고    scopus 로고
    • Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene
    • Tschope C, Spillmann F, Rehfeld U, et al. Improvement of defective sarcoplasmic reticulum Ca2+ transport in diabetic heart of transgenic rats expressing the human kallikrein-1 gene. Faseb J 2004; 18: 1967-9.
    • (2004) Faseb J , vol.18 , pp. 1967-1969
    • Tschope, C.1    Spillmann, F.2    Rehfeld, U.3
  • 9
    • 28744441357 scopus 로고    scopus 로고
    • Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy
    • Tschope C, Walther T, Escher F, et al. Transgenic activation of the kallikrein-kinin system inhibits intramyocardial inflammation, endothelial dysfunction and oxidative stress in experimental diabetic cardiomyopathy. Faseb J 2005; 19: 2057-9.
    • (2005) Faseb J , vol.19 , pp. 2057-2059
    • Tschope, C.1    Walther, T.2    Escher, F.3
  • 10
    • 0031934256 scopus 로고    scopus 로고
    • Metabolic disturbances in diabetic cardiomyopathy
    • Rodrigues B, Cam MC, McNeill JH. Metabolic disturbances in diabetic cardiomyopathy. Mol Cell Biochem 1998; 180: 53-7.
    • (1998) Mol Cell Biochem , vol.180 , pp. 53-57
    • Rodrigues, B.1    Cam, M.C.2    McNeill, J.H.3
  • 11
    • 33744782901 scopus 로고    scopus 로고
    • Vascular endothelial dysfunction in diabetic cardiomyopathy: Pathogenesis and potential treatment targets
    • Farhangkhoee H, Khan ZA, Kaur H, Xin X, Chen S, Chakrabarti S. Vascular endothelial dysfunction in diabetic cardiomyopathy: pathogenesis and potential treatment targets. Pharmacol Ther 2006; 111: 384-99.
    • (2006) Pharmacol Ther , vol.111 , pp. 384-399
    • Farhangkhoee, H.1    Khan, Z.A.2    Kaur, H.3    Xin, X.4    Chen, S.5    Chakrabarti, S.6
  • 12
    • 41249100622 scopus 로고    scopus 로고
    • Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy
    • Van Linthout S, Spillmann F, Riad A, et al. Human apolipoprotein A-I gene transfer reduces the development of experimental diabetic cardiomyopathy. Circulation 2008; 117: 1563-73.
    • (2008) Circulation , vol.117 , pp. 1563-1573
    • van Linthout, S.1    Spillmann, F.2    Riad, A.3
  • 13
    • 77953364227 scopus 로고    scopus 로고
    • Endothelial cellderived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition
    • Widyantoro B, Emoto N, Nakayama K, et al. Endothelial cellderived endothelin-1 promotes cardiac fibrosis in diabetic hearts through stimulation of endothelial-to-mesenchymal transition. Circulation 121: 2407-18.
    • Circulation , vol.121 , pp. 2407-2418
    • Widyantoro, B.1    Emoto, N.2    Nakayama, K.3
  • 14
    • 33746207801 scopus 로고    scopus 로고
    • Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene
    • Rota M, LeCapitaine N, Hosoda T, et al. Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circ Res 2006; 99: 42-52.
    • (2006) Circ Res , vol.99 , pp. 42-52
    • Rota, M.1    Lecapitaine, N.2    Hosoda, T.3
  • 16
    • 0028304920 scopus 로고
    • Which left ventricular function is impaired earlier in the evolution of diabetic cardiomyopathy? An echocardiographic study of young type I diabetic patients
    • Raev DC. Which left ventricular function is impaired earlier in the evolution of diabetic cardiomyopathy? An echocardiographic study of young type I diabetic patients. Diabetes Care 1994; 17: 633-9.
    • (1994) Diabetes Care , vol.17 , pp. 633-639
    • Raev, D.C.1
  • 17
    • 0344874204 scopus 로고    scopus 로고
    • Left ventricular diastolic dysfunction: An early sign of diabetic cardiomyopathy?
    • Cosson S, Kevorkian JP. Left ventricular diastolic dysfunction: an early sign of diabetic cardiomyopathy? Diabetes Metab 2003; 29: 455-46.
    • (2003) Diabetes Metab , vol.29 , pp. 455-456
    • Cosson, S.1    Kevorkian, J.P.2
  • 18
    • 49849089716 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy: Insights into pathogenesis, diagnostic challenges, and therapeutic options
    • Aneja A, Tang WH, Bansilal S, Garcia MJ, Farkouh ME. Diabetic cardiomyopathy: insights into pathogenesis, diagnostic challenges, and therapeutic options. Am J Med 2008; 121: 748-57.
    • (2008) Am J Med , vol.121 , pp. 748-757
    • Aneja, A.1    Tang, W.H.2    Bansilal, S.3    Garcia, M.J.4    Farkouh, M.E.5
  • 20
    • 0037453647 scopus 로고    scopus 로고
    • A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes
    • Candido R, Forbes JM, Thomas MC, et al. A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes. Circ Res 2003; 92: 785-92.
    • (2003) Circ Res , vol.92 , pp. 785-792
    • Candido, R.1    Forbes, J.M.2    Thomas, M.C.3
  • 21
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005; 54: 1615-25.
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 22
    • 0037251741 scopus 로고    scopus 로고
    • Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes
    • Aronson D. Cross-linking of glycated collagen in the pathogenesis of arterial and myocardial stiffening of aging and diabetes. J Hypertens 2003; 21: 3-12.
    • (2003) J Hypertens , vol.21 , pp. 3-12
    • Aronson, D.1
  • 23
    • 77952092094 scopus 로고    scopus 로고
    • Hyperglycaemiainduced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress
    • Brouwers O, Niessen PM, Haenen G, et al. Hyperglycaemiainduced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress. Diabetologia 53: 989-1000.
    • Diabetologia , vol.53 , pp. 989-1000
    • Brouwers, O.1    Niessen, P.M.2    Haenen, G.3
  • 24
    • 20044374676 scopus 로고    scopus 로고
    • High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction
    • Tschope C, Bock CT, Kasner M, et al. High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction. Circulation 2005; 111: 879-86.
    • (2005) Circulation , vol.111 , pp. 879-886
    • Tschope, C.1    Bock, C.T.2    Kasner, M.3
  • 25
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC, et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999; 284: 143-7.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 26
    • 0030889354 scopus 로고    scopus 로고
    • Marrow stromal cells as stem cells for nonhematopoietic tissues
    • Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71-4.
    • (1997) Science , vol.276 , pp. 71-74
    • Prockop, D.J.1
  • 27
    • 0026525255 scopus 로고
    • Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies
    • Haynesworth SE, Baber MA, Caplan AI. Cell surface antigens on human marrow-derived mesenchymal cells are detected by monoclonal antibodies. Bone 1992; 13: 69-80.
    • (1992) Bone , vol.13 , pp. 69-80
    • Haynesworth, S.E.1    Baber, M.A.2    Caplan, A.I.3
  • 28
    • 50849139576 scopus 로고    scopus 로고
    • A perivascular origin for mesenchymal stem cells in multiple human organs
    • Crisan M, Yap S, Casteilla L, et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008; 3: 301-13.
    • (2008) Cell Stem Cell , vol.3 , pp. 301-313
    • Crisan, M.1    Yap, S.2    Casteilla, L.3
  • 29
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci 2006; 119: 2204-13.
    • (2006) J Cell Sci , vol.119 , pp. 2204-2213
    • da Silva Meirelles, L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 30
    • 78751533852 scopus 로고    scopus 로고
    • Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin
    • Rossini A, Frati C, Lagrasta C, et al. Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin. Cardiovasc Res 89: 650-60.
    • Cardiovasc Res , vol.89 , pp. 650-660
    • Rossini, A.1    Frati, C.2    Lagrasta, C.3
  • 31
    • 34548442823 scopus 로고    scopus 로고
    • Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation
    • Keyser KA, Beagles KE, Kiem HP. Comparison of mesenchymal stem cells from different tissues to suppress T-cell activation. Cell Transplant 2007; 16: 555-62.
    • (2007) Cell Transplant , vol.16 , pp. 555-562
    • Keyser, K.A.1    Beagles, K.E.2    Kiem, H.P.3
  • 32
    • 85038498153 scopus 로고    scopus 로고
    • The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties
    • Raicevic G, Najar M, Stamatopoulos B, et al. The source of human mesenchymal stromal cells influences their TLR profile as well as their functional properties. Cell Immunol.
    • Cell Immunol
    • Raicevic, G.1    Najar, M.2    Stamatopoulos, B.3
  • 33
    • 77949308137 scopus 로고    scopus 로고
    • Proinflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially
    • Prasanna SJ, Gopalakrishnan D, Shankar SR, Vasandan AB. Proinflammatory cytokines, IFNgamma and TNFalpha, influence immune properties of human bone marrow and Wharton jelly mesenchymal stem cells differentially. PLoS One 5: e9016.
    • PLoS One , vol.5
    • Prasanna, S.J.1    Gopalakrishnan, D.2    Shankar, S.R.3    Vasandan, A.B.4
  • 34
    • 79953689309 scopus 로고    scopus 로고
    • Human term placenta-derived mesenchymal stromal cells are less prone to osteogenic differentiation than bone marrow-derived mesenchymal stromal cells
    • Pilz GA, Ulrich C, Ruh M, et al. Human term placenta-derived mesenchymal stromal cells are less prone to osteogenic differentiation than bone marrow-derived mesenchymal stromal cells. Stem Cells Dev 20: 635-46.
    • Stem Cells Dev , vol.20 , pp. 635-646
    • Pilz, G.A.1    Ulrich, C.2    Ruh, M.3
  • 35
    • 79951828032 scopus 로고    scopus 로고
    • Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration
    • Gaebel R, Furlani D, Sorg H, et al. Cell origin of human mesenchymal stem cells determines a different healing performance in cardiac regeneration. PLoS One 6: e15652.
    • PLoS One , vol.6
    • Gaebel, R.1    Furlani, D.2    Sorg, H.3
  • 36
    • 80055098011 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: A promising cell source for the treatment of inflammatory cardiomyopathy
    • Tschöpe C, Miteva K, Schultheiss H-P, Van Linthout S. Mesenchymal stromal cells: a promising cell source for the treatment of inflammatory cardiomyopathy. Curr Pharm Design 2011.
    • (2011) Curr Pharm Design
    • Tschöpe, C.1    Miteva, K.2    Schultheiss, H.-P.3    van Linthout, S.4
  • 37
    • 68049122875 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Immunobiology and role in immunomodulation and tissue regeneration
    • Kode JA, Mukherjee S, Joglekar MV, Hardikar AA. Mesenchymal stem cells: immunobiology and role in immunomodulation and tissue regeneration. Cytotherapy 2009; 11: 377-91.
    • (2009) Cytotherapy , vol.11 , pp. 377-391
    • Kode, J.A.1    Mukherjee, S.2    Joglekar, M.V.3    Hardikar, A.A.4
  • 38
    • 13544249606 scopus 로고    scopus 로고
    • Human mesenchymal stem cells modulate allogeneic immune cell responses
    • Aggarwal S, Pittenger MF. Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 2005; 105: 1815-1822.
    • (2005) Blood , vol.105 , pp. 1815-1822
    • Aggarwal, S.1    Pittenger, M.F.2
  • 39
    • 79959483605 scopus 로고    scopus 로고
    • Mesenchymal stem cells and inflammatory cardiomyopathy: Cardiac homing and beyond
    • Van Linthout S, Stamm C, Schultheiss HP, Tschope C. Mesenchymal stem cells and inflammatory cardiomyopathy: cardiac homing and beyond. Cardiol Res Pract 2011: 757154.
    • (2011) Cardiol Res Pract , pp. 757154
    • van Linthout, S.1    Stamm, C.2    Schultheiss, H.P.3    Tschope, C.4
  • 40
    • 69549138471 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity
    • Quevedo HC, Hatzistergos KE, Oskouei BN, et al. Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity. Proc Natl Acad Sci USA 2009; 106: 14022-7.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14022-14027
    • Quevedo, H.C.1    Hatzistergos, K.E.2    Oskouei, B.N.3
  • 41
    • 47749130371 scopus 로고    scopus 로고
    • Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells
    • Nakanishi C, Yamagishi M, Yamahara K, et al. Activation of cardiac progenitor cells through paracrine effects of mesenchymal stem cells. Biochem Biophys Res Commun 2008; 374: 11-6.
    • (2008) Biochem Biophys Res Commun , vol.374 , pp. 11-16
    • Nakanishi, C.1    Yamagishi, M.2    Yamahara, K.3
  • 42
    • 77958012860 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation
    • Hatzistergos KE, Quevedo H, Oskouei BN, et al. Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res 107: 913-22.
    • Circ Res , vol.107 , pp. 913-922
    • Hatzistergos, K.E.1    Quevedo, H.2    Oskouei, B.N.3
  • 43
    • 49149120713 scopus 로고    scopus 로고
    • A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1
    • Sheng H, Wang Y, Jin Y, et al. A critical role of IFNgamma in priming MSC-mediated suppression of T cell proliferation through up-regulation of B7-H1. Cell Res 2008; 18: 846-57.
    • (2008) Cell Res , vol.18 , pp. 846-857
    • Sheng, H.1    Wang, Y.2    Jin, Y.3
  • 44
    • 77951889580 scopus 로고    scopus 로고
    • Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression
    • Ren G, Zhao X, Zhang L, et al. Inflammatory cytokine-induced intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 in mesenchymal stem cells are critical for immunosuppression. J Immunol 184: 2321-8.
    • J Immunol , vol.184 , pp. 2321-2328
    • Ren, G.1    Zhao, X.2    Zhang, L.3
  • 45
    • 0037093058 scopus 로고    scopus 로고
    • Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli
    • Di Nicola M, Carlo-Stella C, Magni M, et al. Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 2002; 99: 3838-43.
    • (2002) Blood , vol.99 , pp. 3838-3843
    • Di Nicola, M.1    Carlo-Stella, C.2    Magni, M.3
  • 46
    • 77956215701 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype
    • Ghannam S, Pene J, Torcy-Moquet G, Jorgensen C, Yssel H. Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol 185: 302-12.
    • J Immunol , vol.185 , pp. 302-312
    • Ghannam, S.1    Pene, J.2    Torcy-Moquet, G.3    Jorgensen, C.4    Yssel, H.5
  • 47
    • 34547791338 scopus 로고    scopus 로고
    • The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells
    • Xu G, Zhang Y, Zhang L, Ren G, Shi Y. The role of IL-6 in inhibition of lymphocyte apoptosis by mesenchymal stem cells. Biochem Biophys Res Commun 2007; 361: 745-50.
    • (2007) Biochem Biophys Res Commun , vol.361 , pp. 745-750
    • Xu, G.1    Zhang, Y.2    Zhang, L.3    Ren, G.4    Shi, Y.5
  • 48
    • 77956420421 scopus 로고    scopus 로고
    • A new mesenchymal stem cell (MSC) paradigm: Polarization into a proinflammatory MSC1 or an Immunosuppressive MSC2 phenotype
    • Waterman RS, Tomchuck SL, Henkle SL, Betancourt AM. A new mesenchymal stem cell (MSC) paradigm: polarization into a proinflammatory MSC1 or an Immunosuppressive MSC2 phenotype. PLoS One 5: e10088.
    • PLoS One , vol.5
    • Waterman, R.S.1    Tomchuck, S.L.2    Henkle, S.L.3    Betancourt, A.M.4
  • 49
    • 67649209791 scopus 로고    scopus 로고
    • Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype
    • Romieu-Mourez R, Francois M, Boivin MN, Bouchentouf M, Spaner DE, Galipeau J. Cytokine modulation of TLR expression and activation in mesenchymal stromal cells leads to a proinflammatory phenotype. J Immunol 2009; 182: 7963-73.
    • (2009) J Immunol , vol.182 , pp. 7963-7973
    • Romieu-Mourez, R.1    Francois, M.2    Boivin, M.N.3    Bouchentouf, M.4    Spaner, D.E.5    Galipeau, J.6
  • 50
  • 51
    • 77958026890 scopus 로고    scopus 로고
    • Advanced glycation end products induce chemokine/cytokine production via activation of p38 pathway and inhibit proliferation and migration of bone marrow mesenchymal stem cells
    • Yang K, Wang XQ, He YS, et al. Advanced glycation end products induce chemokine/cytokine production via activation of p38 pathway and inhibit proliferation and migration of bone marrow mesenchymal stem cells. Cardiovasc Diabetol 9: 66.
    • Cardiovasc Diabetol , vol.9 , pp. 66
    • Yang, K.1    Wang, X.Q.2    He, Y.S.3
  • 52
    • 78951481861 scopus 로고    scopus 로고
    • Superoxide induced by a highglucose concentration attenuates production of angiogenic growth factors in hypoxic mouse mesenchymal stem cells
    • Ishizuka T, Hinata T, Watanabe Y. Superoxide induced by a highglucose concentration attenuates production of angiogenic growth factors in hypoxic mouse mesenchymal stem cells. J Endocrinol 208: 147-59.
    • J Endocrinol , vol.208 , pp. 147-159
    • Ishizuka, T.1    Hinata, T.2    Watanabe, Y.3
  • 53
    • 24144449526 scopus 로고    scopus 로고
    • Advanced glycation end- products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone
    • Kume S, Kato S, Yamagishi S, et al. Advanced glycation end- products attenuate human mesenchymal stem cells and prevent cognate differentiation into adipose tissue, cartilage, and bone. J Bone Miner Res 2005; 20: 1647-58.
    • (2005) J Bone Miner Res , vol.20 , pp. 1647-1658
    • Kume, S.1    Kato, S.2    Yamagishi, S.3
  • 54
    • 78650973243 scopus 로고    scopus 로고
    • Growth factor preconditioning increases the function of diabetes-impaired mesenchymal stem cells
    • Khan M, Akhtar S, Mohsin S, S NK, Riazuddin S. Growth factor preconditioning increases the function of diabetes-impaired mesenchymal stem cells. Stem Cells Dev 20: 67-75.
    • Stem Cells Dev , vol.20 , pp. 67-75
    • Khan, M.1    Akhtar, S.2    Mohsin, S.3    Nk, S.4    Riazuddin, S.5
  • 55
    • 24744448458 scopus 로고    scopus 로고
    • Aging and longevity: The IGF-1 enigma
    • Anversa P. Aging and longevity: the IGF-1 enigma. Circ Res 2005; 97: 411-414.
    • (2005) Circ Res , vol.97 , pp. 411-414
    • Anversa, P.1
  • 56
    • 51849111566 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways
    • Choi SC, Kim SJ, Choi JH, Park CY, Shim WJ, Lim DS. Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways. Stem Cells Dev 2008; 17: 725-36.
    • (2008) Stem Cells Dev , vol.17 , pp. 725-736
    • Choi, S.C.1    Kim, S.J.2    Choi, J.H.3    Park, C.Y.4    Shim, W.J.5    Lim, D.S.6
  • 57
    • 34249661093 scopus 로고    scopus 로고
    • FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2
    • Ito T, Sawada R, Fujiwara Y, Seyama Y, Tsuchiya T. FGF-2 suppresses cellular senescence of human mesenchymal stem cells by down-regulation of TGF-beta2. Biochem Biophys Res Commun 2007; 359: 108-14.
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 108-114
    • Ito, T.1    Sawada, R.2    Fujiwara, Y.3    Seyama, Y.4    Tsuchiya, T.5
  • 58
    • 33751232671 scopus 로고    scopus 로고
    • Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice
    • Lee RH, Seo MJ, Reger RL, et al. Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci USA 2006; 103: 17438-43.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17438-17443
    • Lee, R.H.1    Seo, M.J.2    Reger, R.L.3
  • 59
    • 43449112935 scopus 로고    scopus 로고
    • Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice
    • Ezquer FE, Ezquer ME, Parrau DB, Carpio D, Yanez AJ, Conget PA. Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice. Biol Blood Marrow Transplant 2008; 14: 631-40.
    • (2008) Biol Blood Marrow Transplant , vol.14 , pp. 631-640
    • Ezquer, F.E.1    Ezquer, M.E.2    Parrau, D.B.3    Carpio, D.4    Yanez, A.J.5    Conget, P.A.6
  • 60
    • 70249122431 scopus 로고    scopus 로고
    • Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes
    • Fiorina P, Jurewicz M, Augello A, et al. Immunomodulatory function of bone marrow-derived mesenchymal stem cells in experimental autoimmune type 1 diabetes. J Immunol 2009; 183: 993-1004.
    • (2009) J Immunol , vol.183 , pp. 993-1004
    • Fiorina, P.1    Jurewicz, M.2    Augello, A.3
  • 61
    • 59149098948 scopus 로고    scopus 로고
    • Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia
    • Boumaza I, Srinivasan S, Witt WT, et al. Autologous bone marrow-derived rat mesenchymal stem cells promote PDX-1 and insulin expression in the islets, alter T cell cytokine pattern and preserve regulatory T cells in the periphery and induce sustained normoglycemia. J Autoimmun 2009; 32: 33-42.
    • (2009) J Autoimmun , vol.32 , pp. 33-42
    • Boumaza, I.1    Srinivasan, S.2    Witt, W.T.3
  • 62
    • 67349207398 scopus 로고    scopus 로고
    • Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro
    • Xie QP, Huang H, Xu B, et al. Human bone marrow mesenchymal stem cells differentiate into insulin-producing cells upon microenvironmental manipulation in vitro. Differentiation 2009; 77: 483-91.
    • (2009) Differentiation , vol.77 , pp. 483-491
    • Xie, Q.P.1    Huang, H.2    Xu, B.3
  • 63
    • 3042785984 scopus 로고    scopus 로고
    • In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow
    • Tang DQ, Cao LZ, Burkhardt BR, et al. In vivo and in vitro characterization of insulin-producing cells obtained from murine bone marrow. Diabetes 2004; 53: 1721-32.
    • (2004) Diabetes , vol.53 , pp. 1721-1732
    • Tang, D.Q.1    Cao, L.Z.2    Burkhardt, B.R.3
  • 64
    • 4644310257 scopus 로고    scopus 로고
    • Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells
    • Chen LB, Jiang XB, Yang L. Differentiation of rat marrow mesenchymal stem cells into pancreatic islet beta-cells. World J Gastroenterol 2004; 10: 3016-20.
    • (2004) World J Gastroenterol , vol.10 , pp. 3016-3020
    • Chen, L.B.1    Jiang, X.B.2    Yang, L.3
  • 65
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J Clin Invest 2003; 111: 843-50.
    • (2003) J Clin Invest , vol.111 , pp. 843-850
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3    Hussain, M.A.4
  • 66
    • 38349062691 scopus 로고    scopus 로고
    • Mesenchymal stem cells cooper- ate with bone marrow cells in therapy of diabetes
    • Urban VS, Kiss J, Kovacs J, et al. Mesenchymal stem cells cooper- ate with bone marrow cells in therapy of diabetes. Stem Cells 2008; 26: 244-53.
    • (2008) Stem Cells , vol.26 , pp. 244-253
    • Urban, V.S.1    Kiss, J.2    Kovacs, J.3
  • 67
    • 77949350958 scopus 로고    scopus 로고
    • Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation
    • Park KS, Kim YS, Kim JH, et al. Trophic molecules derived from human mesenchymal stem cells enhance survival, function, and angiogenesis of isolated islets after transplantation. Transplantation 89: 509-17.
    • Transplantation , vol.89 , pp. 509-517
    • Park, K.S.1    Kim, Y.S.2    Kim, J.H.3
  • 68
    • 67349224622 scopus 로고    scopus 로고
    • Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells
    • Madec AM, Mallone R, Afonso G, et al. Mesenchymal stem cells protect NOD mice from diabetes by inducing regulatory T cells. Diabetologia 2009; 52: 1391-1399.
    • (2009) Diabetologia , vol.52 , pp. 1391-1399
    • Madec, A.M.1    Mallone, R.2    Afonso, G.3
  • 69
    • 85056045610 scopus 로고    scopus 로고
    • Imbalance in Th cell polarization and its relevance in type 1 diabetes mellitus
    • Sia C. Imbalance in Th cell polarization and its relevance in type 1 diabetes mellitus. Rev Diabet Stud 2005; 2: 182-6.
    • (2005) Rev Diabet Stud , vol.2 , pp. 182-186
    • Sia, C.1
  • 70
    • 40549118860 scopus 로고    scopus 로고
    • Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy
    • Zhang N, Li J, Luo R, Jiang J, Wang JA. Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy. Exp Clin Endocrinol Diabetes 2008; 116: 104-11.
    • (2008) Exp Clin Endocrinol Diabetes , vol.116 , pp. 104-111
    • Zhang, N.1    Li, J.2    Luo, R.3    Jiang, J.4    Wang, J.A.5
  • 71
    • 42649118760 scopus 로고    scopus 로고
    • Improved anti-apoptotic and antiremodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy
    • Li JH, Zhang N, Wang JA. Improved anti-apoptotic and antiremodeling potency of bone marrow mesenchymal stem cells by anoxic pre-conditioning in diabetic cardiomyopathy. J Endocrinol Invest 2008; 31: 103-10.
    • (2008) J Endocrinol Invest , vol.31 , pp. 103-110
    • Li, J.H.1    Zhang, N.2    Wang, J.A.3
  • 72
    • 71749112840 scopus 로고    scopus 로고
    • Right ventricular effects of intracoronary delivery of mesenchymal stem cells (MSC) in an animal model of pressure overload heart failure
    • Molina EJ, Palma J, Gupta D, Gaughan JP, Houser S, Macha M. Right ventricular effects of intracoronary delivery of mesenchymal stem cells (MSC) in an animal model of pressure overload heart failure. Biomed Pharmacother 2009; 63: 767-72.
    • (2009) Biomed Pharmacother , vol.63 , pp. 767-772
    • Molina, E.J.1    Palma, J.2    Gupta, D.3    Gaughan, J.P.4    Houser, S.5    Macha, M.6
  • 73
    • 80055069305 scopus 로고    scopus 로고
    • Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis
    • Van Linthout S, Savvatis K, Miteva K, et al. Mesenchymal stem cells improve murine acute coxsackievirus B3-induced myocarditis. Eur Heart J.
    • Eur Heart J
    • van Linthout, S.1    Savvatis, K.2    Miteva, K.3
  • 74
    • 35348835422 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy
    • Westermann D, Van Linthout S, Dhayat S, et al. Tumor necrosis factor-alpha antagonism protects from myocardial inflammation and fibrosis in experimental diabetic cardiomyopathy. Basic Res Cardiol 2007; 102: 500-7.
    • (2007) Basic Res Cardiol , vol.102 , pp. 500-507
    • Westermann, D.1    van Linthout, S.2    Dhayat, S.3
  • 75
    • 34347405900 scopus 로고    scopus 로고
    • Cardioprotective and anti-inflammatory effects of interleukin converting enzyme inhibition in experimental diabetic cardiomyopathy
    • Westermann D, Van Linthout S, Dhayat S, et al. Cardioprotective and anti-inflammatory effects of interleukin converting enzyme inhibition in experimental diabetic cardiomyopathy. Diabetes 2007; 56: 1834-41.
    • (2007) Diabetes , vol.56 , pp. 1834-1841
    • Westermann, D.1    van Linthout, S.2    Dhayat, S.3
  • 76
    • 85038511907 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ Regulatory T Cells Protect the Proinflammatory Activation of Human Umbilical Vein Endothelial Cells
    • He S, Li M, Ma X, Lin J, Li D. CD4+CD25+Foxp3+ Regulatory T Cells Protect the Proinflammatory Activation of Human Umbilical Vein Endothelial Cells. Arterioscler Thromb Vasc Biol.
    • Arterioscler Thromb Vasc Biol
    • He, S.1    Li, M.2    Ma, X.3    Lin, J.4    Li, D.5
  • 77
    • 78649984380 scopus 로고    scopus 로고
    • Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
    • Rajesh M, Mukhopadhyay P, Batkai S, et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol 56: 2115-25.
    • J Am Coll Cardiol , vol.56 , pp. 2115-2125
    • Rajesh, M.1    Mukhopadhyay, P.2    Batkai, S.3
  • 78
    • 77957366312 scopus 로고    scopus 로고
    • Inflammatory cytokine induced regulation of superoxide dismutase 3 expression by human mesenchymal stem cells
    • Kemp K, Gray E, Mallam E, Scolding N, Wilkins A. Inflammatory cytokine induced regulation of superoxide dismutase 3 expression by human mesenchymal stem cells. Stem Cell Rev 6: 548-59.
    • Stem Cell Rev , vol.6 , pp. 548-559
    • Kemp, K.1    Gray, E.2    Mallam, E.3    Scolding, N.4    Wilkins, A.5
  • 79
    • 0037418276 scopus 로고    scopus 로고
    • Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species
    • Dewald O, Frangogiannis NG, Zoerlein M, et al. Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species. Proc Natl Acad Sci USA 2003; 100: 2700-5.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2700-2705
    • Dewald, O.1    Frangogiannis, N.G.2    Zoerlein, M.3
  • 80
    • 79952987665 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate ischemia-reperfusion-induced renal dysfunction by improving the antioxidant/oxidant balance in the ischemic kidney
    • Zhuo W, Liao L, Xu T, Wu W, Yang S, Tan J. Mesenchymal stem cells ameliorate ischemia-reperfusion-induced renal dysfunction by improving the antioxidant/oxidant balance in the ischemic kidney. Urol Int 86: 191-6.
    • Urol Int , vol.86 , pp. 191-196
    • Zhuo, W.1    Liao, L.2    Xu, T.3    Wu, W.4    Yang, S.5    Tan, J.6
  • 81
    • 33748515649 scopus 로고    scopus 로고
    • Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus
    • Westermann D, Rutschow S, Van Linthout S, et al. Inhibition of p38 mitogen-activated protein kinase attenuates left ventricular dysfunction by mediating pro-inflammatory cardiac cytokine levels in a mouse model of diabetes mellitus. Diabetologia 2006; 49: 2507-13.
    • (2006) Diabetologia , vol.49 , pp. 2507-2513
    • Westermann, D.1    Rutschow, S.2    van Linthout, S.3
  • 82
    • 34547688762 scopus 로고    scopus 로고
    • Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy
    • Van Linthout S, Riad A, Dhayat N, et al. Anti-inflammatory effects of atorvastatin improve left ventricular function in experimental diabetic cardiomyopathy. Diabetologia 2007; 50: 1977-86.
    • (2007) Diabetologia , vol.50 , pp. 1977-1986
    • van Linthout, S.1    Riad, A.2    Dhayat, N.3
  • 83
    • 72849145234 scopus 로고    scopus 로고
    • Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction
    • Mias C, Lairez O, Trouche E, et al. Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction. Stem Cells 2009; 27: 2734-43.
    • (2009) Stem Cells , vol.27 , pp. 2734-2743
    • Mias, C.1    Lairez, O.2    Trouche, E.3
  • 84
    • 34547685923 scopus 로고    scopus 로고
    • Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions
    • Ohnishi S, Sumiyoshi H, Kitamura S, Nagaya N. Mesenchymal stem cells attenuate cardiac fibroblast proliferation and collagen synthesis through paracrine actions. FEBS Lett 2007; 581: 3961-6.
    • (2007) FEBS Lett , vol.581 , pp. 3961-3966
    • Ohnishi, S.1    Sumiyoshi, H.2    Kitamura, S.3    Nagaya, N.4
  • 85
    • 55649108688 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation attenuates cardiac fibrosis associated with isoproterenol-induced global heart failure
    • Li L, Zhang Y, Li Y, et al. Mesenchymal stem cell transplantation attenuates cardiac fibrosis associated with isoproterenol-induced global heart failure. Transpl Int 2008; 21: 1181-9.
    • (2008) Transpl Int , vol.21 , pp. 1181-1189
    • Li, L.1    Zhang, Y.2    Li, Y.3
  • 86
    • 0032422342 scopus 로고    scopus 로고
    • Hepatocyte growth factor as a potential index of complication in diabetes mellitus
    • Nakamura S, Morishita R, Moriguchi A, et al. Hepatocyte growth factor as a potential index of complication in diabetes mellitus. J Hypertens 1998; 16: 2019-26.
    • (1998) J Hypertens , vol.16 , pp. 2019-2026
    • Nakamura, S.1    Morishita, R.2    Moriguchi, A.3
  • 87
    • 0033153131 scopus 로고    scopus 로고
    • Dilated cardiomyopathy is associated with significant changes in collagen type I/III ratio
    • Pauschinger M, Knopf D, Petschauer S, et al. Dilated cardiomyopathy is associated with significant changes in collagen type I/III ratio. Circulation 1999; 99: 2750-2756.
    • (1999) Circulation , vol.99 , pp. 2750-2756
    • Pauschinger, M.1    Knopf, D.2    Petschauer, S.3
  • 88
    • 0036487242 scopus 로고    scopus 로고
    • Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts
    • Seeland U, Kouchi I, Zolk O, Itter G, Linz W, Bohm M. Effect of ramipril and furosemide treatment on interstitial remodeling in post-infarction heart failure rat hearts. J Mol Cell Cardiol 2002; 34: 151-63.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 151-163
    • Seeland, U.1    Kouchi, I.2    Zolk, O.3    Itter, G.4    Linz, W.5    Bohm, M.6
  • 90
    • 46149083476 scopus 로고    scopus 로고
    • Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy
    • Van Linthout S, Seeland U, Riad A, et al. Reduced MMP-2 activity contributes to cardiac fibrosis in experimental diabetic cardiomyopathy. Basic Res Cardiol 2008; 103: 319-27.
    • (2008) Basic Res Cardiol , vol.103 , pp. 319-327
    • van Linthout, S.1    Seeland, U.2    Riad, A.3
  • 91
    • 44949240607 scopus 로고    scopus 로고
    • Early improvement in cardiac tissue perfusion due to mesenchymal stem cells
    • Schuleri KH, Amado LC, Boyle AJ, et al. Early improvement in cardiac tissue perfusion due to mesenchymal stem cells. Am J Physiol Heart Circ Physiol 2008; 294: H2002-11.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Schuleri, K.H.1    Amado, L.C.2    Boyle, A.J.3
  • 92
    • 33744791185 scopus 로고    scopus 로고
    • TNF-alpha-mediated cardiomyocyte apoptosis involves caspase-12 and calpain
    • Bajaj G, Sharma RK. TNF-alpha-mediated cardiomyocyte apoptosis involves caspase-12 and calpain. Biochem Biophys Res Commun 2006; 345: 1558-64.
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 1558-1564
    • Bajaj, G.1    Sharma, R.K.2
  • 93
    • 68449088796 scopus 로고    scopus 로고
    • Protective paracrine effect of mesenchymal stem cells on cardiomyocytes
    • Xiang MX, He AN, Wang JA, Gui C. Protective paracrine effect of mesenchymal stem cells on cardiomyocytes. J Zhejiang Univ Sci B 2009; 10: 619-24.
    • (2009) J Zhejiang Univ Sci B , vol.10 , pp. 619-624
    • Xiang, M.X.1    He, A.N.2    Wang, J.A.3    Gui, C.4
  • 94
    • 33845665442 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis
    • Ohnishi S, Yanagawa B, Tanaka K, et al. Transplantation of mesenchymal stem cells attenuates myocardial injury and dysfunction in a rat model of acute myocarditis. J Mol Cell Cardiol 2007; 42: 88-97.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 88-97
    • Ohnishi, S.1    Yanagawa, B.2    Tanaka, K.3
  • 95
    • 77958087304 scopus 로고    scopus 로고
    • Improved function and myocardial repair of infarcted heart by intracoronary injection of mesenchymal stem cell-derived growth factors
    • Nguyen BK, Maltais S, Perrault LP, et al. Improved function and myocardial repair of infarcted heart by intracoronary injection of mesenchymal stem cell-derived growth factors. J Cardiovasc Transl Res 3: 547-58.
    • J Cardiovasc Transl Res , vol.3 , pp. 547-558
    • Nguyen, B.K.1    Maltais, S.2    Perrault, L.P.3
  • 96
    • 33750602514 scopus 로고    scopus 로고
    • Angiotensin II signal transduction through small GTP-binding proteins: Mechanism and significance in vascular smooth muscle cells
    • Ohtsu H, Suzuki H, Nakashima H, et al. Angiotensin II signal transduction through small GTP-binding proteins: mechanism and significance in vascular smooth muscle cells. Hypertension 2006; 48: 534-40.
    • (2006) Hypertension , vol.48 , pp. 534-540
    • Ohtsu, H.1    Suzuki, H.2    Nakashima, H.3
  • 97
    • 18144387916 scopus 로고    scopus 로고
    • Modulation of apoptosis by nitric oxide: Implications in myocardial ischemia and heart failure
    • Razavi HM, Hamilton JA, Feng Q. Modulation of apoptosis by nitric oxide: implications in myocardial ischemia and heart failure. Pharmacol Ther 2005; 106: 147-62.
    • (2005) Pharmacol Ther , vol.106 , pp. 147-162
    • Razavi, H.M.1    Hamilton, J.A.2    Feng, Q.3
  • 98
    • 80055086402 scopus 로고    scopus 로고
    • Cardioselective nitric oxide synthase 3 gene transfer protects against myocardial reperfusion injury
    • Szelid Z, Pokreisz P, Liu X, et al. Cardioselective nitric oxide synthase 3 gene transfer protects against myocardial reperfusion injury. Basic Res Cardiol 2009.
    • (2009) Basic Res Cardiol
    • Szelid, Z.1    Pokreisz, P.2    Liu, X.3
  • 99
    • 68049114479 scopus 로고    scopus 로고
    • Bone marrow derived stromal cells modified by adenovirus-mediated HIF-1alpha double mutant protect cardiac myocytes against CoCl2-induced apoptosis
    • Wang Y, Sun A, Xue J, Feng C, Li J, Wu J. Bone marrow derived stromal cells modified by adenovirus-mediated HIF-1alpha double mutant protect cardiac myocytes against CoCl2-induced apoptosis. Toxicol In Vitro 2009; 23: 1069-75.
    • (2009) Toxicol In Vitro , vol.23 , pp. 1069-1075
    • Wang, Y.1    Sun, A.2    Xue, J.3    Feng, C.4    Li, J.5    Wu, J.6
  • 100
    • 39549105786 scopus 로고    scopus 로고
    • Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction
    • Hahn JY, Cho HJ, Kang HJ, et al. Pre-treatment of mesenchymal stem cells with a combination of growth factors enhances gap junction formation, cytoprotective effect on cardiomyocytes, and therapeutic efficacy for myocardial infarction. J Am Coll Cardiol 2008; 51: 933-43.
    • (2008) J Am Coll Cardiol , vol.51 , pp. 933-943
    • Hahn, J.Y.1    Cho, H.J.2    Kang, H.J.3
  • 101
    • 42249092647 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts
    • Covas DT, Panepucci RA, Fontes AM, et al. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146+ perivascular cells and fibroblasts. Exp Hematol 2008; 36: 642-54.
    • (2008) Exp Hematol , vol.36 , pp. 642-654
    • Covas, D.T.1    Panepucci, R.A.2    Fontes, A.M.3
  • 102
    • 1842486565 scopus 로고    scopus 로고
    • Local delivery of marrowderived stromal cells augments collateral perfusion through paracrine mechanisms
    • Kinnaird T, Stabile E, Burnett MS, et al. Local delivery of marrowderived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation 2004; 109: 1543-9.
    • (2004) Circulation , vol.109 , pp. 1543-1549
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3
  • 103
    • 1642373909 scopus 로고    scopus 로고
    • Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms
    • Kinnaird T, Stabile E, Burnett MS, et al. Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 2004; 94: 678-85.
    • (2004) Circ Res , vol.94 , pp. 678-685
    • Kinnaird, T.1    Stabile, E.2    Burnett, M.S.3
  • 104
    • 34547187820 scopus 로고    scopus 로고
    • Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro
    • Potapova IA, Gaudette GR, Brink PR, et al. Mesenchymal stem cells support migration, extracellular matrix invasion, proliferation, and survival of endothelial cells in vitro. Stem Cells 2007; 25: 1761-8.
    • (2007) Stem Cells , vol.25 , pp. 1761-1768
    • Potapova, I.A.1    Gaudette, G.R.2    Brink, P.R.3
  • 105
    • 67650665277 scopus 로고    scopus 로고
    • Influence of adult mesenchymal stem cells on in vitro vascular formation
    • Sorrell JM, Baber MA, Caplan AI. Influence of adult mesenchymal stem cells on in vitro vascular formation. Tissue Eng Part A 2009; 15: 1751-61.
    • (2009) Tissue Eng Part A , vol.15 , pp. 1751-1761
    • Sorrell, J.M.1    Baber, M.A.2    Caplan, A.I.3
  • 106
    • 2942523981 scopus 로고    scopus 로고
    • Mesenchymal stem cells can be differentiated into endothelial cells in vitro
    • Oswald J, Boxberger S, Jorgensen B, et al. Mesenchymal stem cells can be differentiated into endothelial cells in vitro. Stem Cells 2004; 22: 377-84.
    • (2004) Stem Cells , vol.22 , pp. 377-384
    • Oswald, J.1    Boxberger, S.2    Jorgensen, B.3
  • 107
    • 19944432052 scopus 로고    scopus 로고
    • Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model
    • Silva GV, Litovsky S, Assad JA, et al. Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation 2005; 111: 150-6.
    • (2005) Circulation , vol.111 , pp. 150-156
    • Silva, G.V.1    Litovsky, S.2    Assad, J.A.3
  • 108
    • 67549126317 scopus 로고    scopus 로고
    • The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemia
    • Prather WR, Toren A, Meiron M, Ofir R, Tschope C, Horwitz EM. The role of placental-derived adherent stromal cell (PLX-PAD) in the treatment of critical limb ischemia. Cytotherapy 2009; 11: 427-34.
    • (2009) Cytotherapy , vol.11 , pp. 427-434
    • Prather, W.R.1    Toren, A.2    Meiron, M.3    Ofir, R.4    Tschope, C.5    Horwitz, E.M.6
  • 109
    • 34547901409 scopus 로고    scopus 로고
    • Bcl-2 engineered MSCs inhibited apoptosis and improved heart function
    • Li W, Ma N, Ong LL, et al. Bcl-2 engineered MSCs inhibited apoptosis and improved heart function. Stem Cells 2007; 25: 2118-27.
    • (2007) Stem Cells , vol.25 , pp. 2118-2127
    • Li, W.1    Ma, N.2    Ong, L.L.3
  • 110
    • 9344265225 scopus 로고    scopus 로고
    • Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis
    • Nagaya N, Fujii T, Iwase T, et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 2004; 287: H2670-6.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Nagaya, N.1    Fujii, T.2    Iwase, T.3
  • 111
    • 24044535092 scopus 로고    scopus 로고
    • Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy
    • Nagaya N, Kangawa K, Itoh T, et al. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 2005; 112: 1128-35.
    • (2005) Circulation , vol.112 , pp. 1128-1135
    • Nagaya, N.1    Kangawa, K.2    Itoh, T.3
  • 112
    • 37549045010 scopus 로고    scopus 로고
    • Late-outgrowth endothelial cells attenuate intimal hyperplasia contributed by mesenchymal stem cells after vascular injury
    • Wang CH, Cherng WJ, Yang NI, et al. Late-outgrowth endothelial cells attenuate intimal hyperplasia contributed by mesenchymal stem cells after vascular injury. Arterioscler Thromb Vasc Biol 2008; 28: 54-60.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 54-60
    • Wang, C.H.1    Cherng, W.J.2    Yang, N.I.3
  • 113
    • 60849117797 scopus 로고    scopus 로고
    • Apoptotic endothelial cells demonstrate increased adhesiveness for human mesenchymal stem cells
    • Potapova IA, Cohen IS, Doronin SV. Apoptotic endothelial cells demonstrate increased adhesiveness for human mesenchymal stem cells. J Cell Physiol 2009; 219: 23-30.
    • (2009) J Cell Physiol , vol.219 , pp. 23-30
    • Potapova, I.A.1    Cohen, I.S.2    Doronin, S.V.3
  • 114
    • 77950972617 scopus 로고    scopus 로고
    • Epidermal growth factor and perlecan fragments produced by apoptotic endothelial cells coordinately activate ERK1/2-dependent antiapoptotic pathways in mesenchymal stem cells
    • Soulez M, Sirois I, Brassard N, et al. Epidermal growth factor and perlecan fragments produced by apoptotic endothelial cells coordinately activate ERK1/2-dependent antiapoptotic pathways in mesenchymal stem cells. Stem Cells 28: 810-20.
    • Stem Cells , vol.28 , pp. 810-820
    • Soulez, M.1    Sirois, I.2    Brassard, N.3
  • 115
    • 76749127910 scopus 로고    scopus 로고
    • Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms
    • Ghajar CM, Kachgal S, Kniazeva E, et al. Mesenchymal cells stimulate capillary morphogenesis via distinct proteolytic mechanisms. Exp Cell Res 316: 813-25.
    • Exp Cell Res , vol.316 , pp. 813-825
    • Ghajar, C.M.1    Kachgal, S.2    Kniazeva, E.3
  • 116
    • 34748845732 scopus 로고    scopus 로고
    • Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis
    • Hung SC, Pochampally RR, Chen SC, Hsu SC, Prockop DJ. Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis. Stem Cells 2007; 25: 2363-70.
    • (2007) Stem Cells , vol.25 , pp. 2363-2370
    • Hung, S.C.1    Pochampally, R.R.2    Chen, S.C.3    Hsu, S.C.4    Prockop, D.J.5
  • 117
    • 20244378531 scopus 로고    scopus 로고
    • Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: Restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor
    • Yoon YS, Uchida S, Masuo O, et al. Progressive attenuation of myocardial vascular endothelial growth factor expression is a seminal event in diabetic cardiomyopathy: restoration of microvascular homeostasis and recovery of cardiac function in diabetic cardiomyopathy after replenishment of local vascular endothelial growth factor. Circulation 2005; 111: 2073-85.
    • (2005) Circulation , vol.111 , pp. 2073-2085
    • Yoon, Y.S.1    Uchida, S.2    Masuo, O.3
  • 118
    • 70350528625 scopus 로고    scopus 로고
    • Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice
    • Park CW, Kim HW, Lim JH, et al. Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice. Diabetes 2009; 58: 2666-76.
    • (2009) Diabetes , vol.58 , pp. 2666-2676
    • Park, C.W.1    Kim, H.W.2    Lim, J.H.3
  • 119
    • 77952543737 scopus 로고    scopus 로고
    • Intra-myocardial delivery of mesenchymal stem cells ameliorates left ventricular and cardiomyocyte contractile dysfunction following myocardial infarction
    • Li Q, Turdi S, Thomas DP, Zhou T, Ren J. Intra-myocardial delivery of mesenchymal stem cells ameliorates left ventricular and cardiomyocyte contractile dysfunction following myocardial infarction. Toxicol Lett 195: 119-26.
    • Toxicol Lett , vol.195 , pp. 119-126
    • Li, Q.1    Turdi, S.2    Thomas, D.P.3    Zhou, T.4    Ren, J.5
  • 120
    • 12144286490 scopus 로고    scopus 로고
    • Human mesenchymal stem cells make cardiac connexins and form functional gap junctions
    • Valiunas V, Doronin S, Valiuniene L, et al. Human mesenchymal stem cells make cardiac connexins and form functional gap junctions. J Physiol 2004; 555: 617-626.
    • (2004) J Physiol , vol.555 , pp. 617-626
    • Valiunas, V.1    Doronin, S.2    Valiuniene, L.3
  • 121
    • 1942438678 scopus 로고    scopus 로고
    • Connexin 43 and ischemic preconditioning
    • Schulz R, Heusch G. Connexin 43 and ischemic preconditioning. Cardiovasc Res 2004; 62: 335-44.
    • (2004) Cardiovasc Res , vol.62 , pp. 335-344
    • Schulz, R.1    Heusch, G.2
  • 122
    • 0037207468 scopus 로고    scopus 로고
    • Cardiac endothelial-myocardial signaling: Its role in cardiac growth, contractile performance, and rhythmicity
    • Brutsaert DL. Cardiac endothelial-myocardial signaling: its role in cardiac growth, contractile performance, and rhythmicity. Physiol Rev 2003; 83: 59-115.
    • (2003) Physiol Rev , vol.83 , pp. 59-115
    • Brutsaert, D.L.1
  • 123
    • 0027319429 scopus 로고
    • Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture
    • Nishida M, Springhorn JP, Kelly RA, Smith TW. Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture. J Clin Invest 1993; 91: 1934-41.
    • (1993) J Clin Invest , vol.91 , pp. 1934-1941
    • Nishida, M.1    Springhorn, J.P.2    Kelly, R.A.3    Smith, T.W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.