Prevention of cardiac fibrosis and left ventricular dysfunction in diabetic cardiomyopathy in rats by transgenic expression of the human tissue kallikrein gene

FASEB Journal

Volumn 18, Issue 7, 2004, Pages 828-835

  Tschöpe, Carsten ^a   Walther, Thomas ^a   Königer, Jens ^a   Spillmann, Frank ^a   Westermann, Dirk ^a   Escher, Felicitas ^a   Pauschinger, Matthias ^a   Pesquero, Joao B ^b   Bader, Michael ^c   Schultheiss, Heinz Peter ^a   Noutsias, Michel ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Diabetes mellitus; Diabetic cardiomyopathy; Kallikrein; Pathogenesis; Therapy; Transgenic animal

Indexed keywords

APROTININ; BRADYKININ B2 RECEPTOR; COLLAGEN TYPE 1; COLLAGEN TYPE 3; COLLAGEN TYPE 6; HUMAN KALLIKREIN 1; ICATIBANT; KALLIKREIN; STREPTOZOCIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CATHETER; CONTROLLED STUDY; CORRELATION ANALYSIS; DIABETES MELLITUS; DISEASE COURSE; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE FAILURE; HEART MUSCLE FIBROSIS; HEART VENTRICLE FUNCTION; HEART VENTRICLE REMODELING; HKLK1 GENE; IMAGE ANALYSIS; INJECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TRANSGENIC ANIMAL; TRANSGENICS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APROTININ; BRADYKININ; CARDIOMYOPATHIES; COLLAGEN; DIABETES MELLITUS, EXPERIMENTAL; HUMANS; KALLIKREINS; MALE; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, BRADYKININ B2; RECOMBINANT FUSION PROTEINS; STREPTOZOCIN; VENTRICULAR DYSFUNCTION, LEFT;

ANIMALIA;

EID: 11144357911     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.03-0736com     Document Type: Article

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