Fluazinam-induced apoptosis of SH-SY5Y cells is mediated by p53 and Bcl-2 family proteins

NeuroToxicology

Volumn 32, Issue 6, 2011, Pages 702-710

  Lee, Jeong Eun ^a   Kang, Jin Sun ^a   Shin, In Chul ^a   Lee, Soo Jin ^a   Hyun, Dong Hoon ^b   Lee, Kyung Suk ^c   Koh, Hyun Chul ^a  

^a Hanyang University   (South Korea)

^b Ewha Womans University   (South Korea)

^c National Institute of Animal Science   (South Korea)

Author keywords

Apoptosis; Bcl 2 family; Fluazinam; P53; Reactive oxygen species

Indexed keywords

CASPASE 3; CYTOCHROME C; FLUAZINAM; FUNGICIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL COUNT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN SECRETION;

ACETYLCYSTEINE; AMINOPYRIDINES; ANTIOXIDANTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CELL LINE, TUMOR; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT COMPLEX I; HUMANS; MITOCHONDRIA; NEURONS; OXIDATIVE STRESS; PESTICIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

PHYTOPHTHORA INFESTANS; SOLANUM TUBEROSUM;

EID: 80055091982     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2011.08.004     Document Type: Article

References (44)

1. Adams J.M., Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998, 281:1322-1326.
2. Bonneh-Barkay D., Langston W.J., Di Monte D.A. Toxicity of redox cycling pesticides in primary mesencephalic cultures. Antioxid Redox Signal 2005, 7:649-653.
3. Cheng E.H., Wei M.C., Weiler S., Flave R.A., Mak T.W., Lindsten T., et al. Bcl-2, Bcl-xL sequester BH3 domain-only molecules preventing Bax- and Bak-mediated mitochondrial apoptosis. Mol Cell 2001, 8:705-711.
4. Choi W.S., Kruse S.E., Palmiter R.D., Xia Z. Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat. Proc Natl Acad Sci USA 2008, 105:15136-15141.
5. Cregan S.P., Dawson V.L., Slack R.S. Role of AIF in caspase-dependent and caspase-independent cell death. Oncogene 2004, 23:2785-2796.
6. Datta K., Babbar P., Srivastava T., Sinha S., Chattopadhyay P. p53 dependent apoptosis in glioma cell lines in response to hydrogen peroxide induced oxidative stress. Int J Biochem Cell Biol 2002, 34:148-157.
7. Dinis-Oliveira R.J., Remião F., Carmo H., Duarte J.A., Navarro A.S., Bastos M.L., et al. Paraquat exposure as an etiological factor of Parkinson's disease. Neurotoxicology 2006, 27:1110-1122.
8. Draper A., Cullinan P., Campbell C., Jones M., Newman Taylor A. Occupational asthma from fungicides fluazinam and chlorothalonil. Occup Environ Med 2003, 60:76-77.
9. Duan W., Zhu X., Ladenheim B., Yu Q.S., Guo Z., Oyler J., et al. p53 inhibitors preserve dopamine neurons and motor function in experimental parkinsonism. Ann Neurol 2002, 52:597-606.
10. Fannjiang Y., Kim C.H., Huganir R.L., Zou S., Lindsten T., Thompson C.B., et al. BAK alters neuronal excitability and can switch from anti- to pro-death function during postnatal development. Dev Cell 2003, 4:575-585.
11. Green D.R. Apoptosis pathways: ten minutes to dead. Cell 2005, 121:671-674.
12. Green D.R., Kroemer G. The pathophysiology of mitochondrial cell death. Science 2004, 305:626-629.
13. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281:1309-1312.
14. Gross A., Yin X.M., Wang K., Wei M.C., Jockel J., Milliman C., et al. Caspase cleaved BID targets mitochondria and is required for cytochrome C release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death. J Biol Chem 1999, 274:1156-1163.
15. Hatcher J.M., Pennell K.D., Miller G.W. Parkinson's disease and pesticides: a toxicological perspective. Trends Pharmacol Sci 2008, 29:322-329.
16. Health Canada, Regulatory Note REG2003-12. Fluazinam. Ottawa: Pest Management Regulatory Agency, Health Canada; October 27, 2003.
17. Hockenbery D.M., Oltvai Z.N., Yin X.M., Milliman C.L., Korsmeyer S.J. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993, 75:241-251.
18. Jenner P. Oxidative stress in Parkinson's disease. Ann Neurol 2003, 3:26-36.
19. Jordán J., Ceña V., Prehn J.H. Mitochondrial control of neuron death and its role in neurodegenerative disorders. J Physiol Biochem 2003, 59:129-141.
20. Kane D.J., Sarafian T.A., Anton R., Hahn H., Gralla E.B., Valentine J.S., et al. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 1993, 262:1274-1277.
21. Kang M.J., Gil S.J., Koh H.C. Paraquat induces alternation of the dopamine catabolic pathways and glutathione levels in the substantia nigra of mice. Toxicol Lett 2009, 188:148-152.
22. Kitazawa M., Anantharam V., Kanthasamy A.G. Dieldrin induces apoptosis by promoting caspase-3-dependent proteolytic cleavage of protein kinase Cdelta in dopaminergic cells: relevance to oxidative stress and dopaminergic degeneration. Neuroscience 2003, 119:945-964.
23. Klintworth H., Newhouse K., Li T., Choi W.S., Faigle R., Xia Z. Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis. Toxicol Sci 2007, 97:149-162.
24. Komarov P.G., Komarova E.A., Kondratov R.V., Christov-Tselkov K., Coon J.S., Chernov M.V., et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999, 285:1733-1737.
25. Lotharius J., Dugan L.L., O'Malley K.L. Distinct mechanisms underlie neurotoxin-mediated cell death in cultured dopaminergic neurons. J Neurosci 1999, 19:1284-1293.
26. Lotharius J., O'Malley K.L. The parkinsonism-inducing drug 1-methyl-4-phenylpyridinium triggers intracellular dopamine oxidation. A novel mechanism of toxicity. J Biol Chem 2000, 275:38581-38588.
27. Mattson M.P., Kroemer G. Mitochondria in cell death: novel targets for neuroprotection and cardioprotection. Trends Mol Med 2003, 9:196-205.
28. Manero F., Gautier F., Gallenne T., Cauquil N., Grée D., Cartron P., et al. The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death. Cancer Res 2006, 66:2757-2764.
29. Mladenović A., Perović M., Raicević N., Kanazir S., Rakić L., Ruzdijić S. 6-Hydroxydopamine increases the level of TNFalpha and bax mRNA in the striatum and induces apoptosis of dopaminergic neurons in hemiparkinsonian rats. Brain Res 2004, 996:237-245.
30. Murphy K.M., Ranganathan V., Farnsworth M.L., Kavallaris M., Lock R.B. Bcl-2 inhibits Bax translocation from cytosol to mitochondria during drug-induced apoptosis of human tumor cells. Cell Death Differ 2000, 7:102-111.
31. Perier C., Tieu K., Guégan C., Caspersen C., Jackson-Lewis V., Carelli V., et al. Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage. Proc Natl Acad Sci USA 2005, 102:19126-19131.
32. Przedborski S., Vila M. The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model: a tool to explore the pathogenesis of Parkinson's disease. Ann N Y Acad Sci 2003, 991:189-198.
33. Ramsden D.B., Parsons R.B., Ho S.L., Waring R.H. The aetiology of idiopathic Parkinson's disease. Mol Pathol 2001, 54:369-380.
34. Rao A.V., Balachandran B. Role of oxidative stress and antioxidants in neurodegenerative diseases. Nutr Nuerosci 2002, 5:291-309.
35. Richardson J.R., Quan Y., Sherer T.B., Greenamyre J.T., Miller G.W. Paraquat neurotoxicity is distinct from that of MPTP and rotenone. Toxicol Sci 2005, 88:193-201.
36. Sanz E., Quintana A., Battaglia V., Toninello A., Hidalgo J., Ambrosio S., et al. Anti-apoptotic effect of Mao-B inhibitor PF9601N [N-(2-propynyl)-2-(5-benzyloxy-indolyl) methylamine] is mediated by p53 pathway inhibition in MPP+-treated SH-SY5Y human dopaminergic cells. J Neurochem 2008, 105:2404-2417.
37. Shimizu S., Narita M., Tsujimoto Y. Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 1999, 399:483-487.
38. Steinman H.M. The Bcl-2 oncoprotein functions as a pro-oxidant. J Biol Chem 1995, 270:3487-3490.
39. van Ginkel C.J., Sabapathy N.N. Allergic contact dermatitis from the newly introduced fungicide fluazinam. Contact Dermatitis 1995, 32:160-162.
40. Vogelstein B., Lane D., Levine A.J. Surfing the p53 network. Nature 2000, 408:307-310.
41. Wang J.L., Liu D., Zhang Z.J., Shan S., Han X., Srinivasula S.M., et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc Natl Acad Sci USA 2000, 97:7124-7129.
42. Wyttenbach A., Tolkovsky A.M. The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. J Neurochem 2006, 96:1213-1226.
43. Yang J., Liu X., Bhalla K., Kim C., Ibrado A., Cai J., et al. Prevent of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 1997, 275:1129-1132.
44. Yang W., Tiffany-Castiglionic E. Paraquat-induced apoptosis in human neuroblastoma SH-SY5Y cells: involvement of p53 and mitochondria. J Toxicol Environ Health A 2008, 71:289-299.