Therapeutic potential of stem cell in liver regeneration

Frontiers of Medicine in China

Volumn 5, Issue 1, 2011, Pages 26-32

  Li, Jinzheng ^a   Li, Min ^a   Niu, Bolin ^a   Gong, Jianping ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Liver disease; Regenerative medicine; Stem cell

Indexed keywords

ADULT STEM CELL; CELL DIFFERENTIATION; DONOR; EMBRYONIC STEM CELL; END STAGE LIVER DISEASE; HUMAN; LIVER CELL; LIVER REGENERATION; METHODOLOGY; PHYSIOLOGY; REVIEW; STEM CELL TRANSPLANTATION; TRANSPLANTATION;

ADULT STEM CELLS; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; END STAGE LIVER DISEASE; HEPATOCYTES; HUMANS; LIVER REGENERATION; STEM CELL TRANSPLANTATION; TISSUE DONORS;

EID: 80055090055     PISSN: 16737342     EISSN: 16737458     Source Type: Journal    
DOI: 10.1007/s11684-011-0107-0     Document Type: Review

References (62)

1. O'Leary J G, Lepe R, Davis G L. Indications for liver transplantation. Gastroenterology, 2008, 134(6): 1764-1776
2. Kung J W, Forbes S J. Stem cells and liver repair. Curr Opin Biotechnol, 2009, 20(5): 568-574
3. Ogawa S, Miyagawa S. Potentials of regenerative medicine for liver disease. Surg Today, 2009, 39(12): 1019-1025
4. Ehnert S, Glanemann M, Schmitt A, Vogt S, Shanny N, Nussler N C, Stöckle U, Nussler A. The possible use of stem cells in regenerative medicine: dream or reality? Langenbecks Arch Surg, 2009, 394(6): 985-997
5. Alison MR, Islam S, Lim S. Stem cells in liver regeneration, fibrosis and cancer: the good, the bad and the ugly. J Pathol, 2009, 217(2): 282-298
6. Fausto N, Campbell J S, Riehle K J. Liver regeneration. Hepatology, 2006, 43(Suppl 1): S45-S53
7. Roskams T A, Theise N D, Balabaud C, Bhagat G, Bhathal P S, Bioulac-Sage P, Brunt E M, Crawford J M, Crosby H A, Desmet V, Finegold M J, Geller S A, Gouw A S, Hytiroglou P, Knisely A S, Kojiro M, Lefkowitch J H, Nakanuma Y, Olynyk J K, Park Y N, Portmann B, Saxena R, Scheuer P J, Strain A J, Thung S N, Wanless I R, West A B. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology, 2004, 39(6): 1739-1745
8. Dorrell C, Grompe M. Liver repair by intra-and extrahepatic progenitors. Stem Cell Rev, 2005, 1(1): 61-64
9. Lee J S, Heo J, Libbrecht L, Chu I S, Kaposi-Novak P, Calvisi D F, Mikaelyan A, Roberts L R, Demetris A J, Sun Z, Nevens F, Roskams T, Thorgeirsson S S. A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells. Nat Med, 2006, 12(4): 410-416
10. Tanaka M, Okabe M, Suzuki K, Kamiya Y, Tsukahara Y, Saito S, Miyajima A. Mouse hepatoblasts at distinct developmental stages are characterized by expression of EpCAM and DLK1: drastic change of EpCAM expression during liver development. Mech Dev, 2009, 126(8-9): 665-676
11. Okabe M, Tsukahara Y, Tanaka M, Suzuki K, Saito S, Kamiya Y, Tsujimura T, Nakamura K, Miyajima A. Potential hepatic stem cells reside in EpCAM + cells of normal and injured mouse liver. Development, 2009, 136(11): 1951-1960
12. Schmelzer E, Zhang L, Bruce A, Wauthier E, Ludlow J, Yao H L, Moss N, Melhem A, McClelland R, Turner W, Kulik M, Sherwood S, Tallheden T, Cheng N, Furth M E, Reid L M. Human hepatic stem cells from fetal and postnatal donors. J Exp Med, 2007, 204(8): 1973-1987
13. Sangan C B, Tosh D. Hepatic progenitor cells. Cell Tissue Res, 2010, 342(2): 131-137
14. Oertel M, Menthena A, Dabeva MD, Shafritz D A. Cell competition leads to a high level of normal liver reconstitution by transplanted fetal liver stem/progenitor cells. Gastroenterology, 2006, 130(2): 507-520
15. Oertel M, Menthena A, Chen Y Q, Teisner B, Jensen C H, Shafritz D A. Purification of fetal liver stem/progenitor cells containing all the repopulation potential for normal adult rat liver. Gastroenterology, 2008, 134(3): 823-832
16. Mahieu-Caputo D, Allain J E, Branger J, Coulomb A, Delgado J P, Andreoletti M, Mainot S, Frydman R, Leboulch P, Di Santo J P, Capron F, Weber A. Repopulation of athymic mouse liver by cryopreserved early human fetal hepatoblasts. Hum Gene Ther, 2004, 15(12): 1219-1228
17. Kallis Y N, Alison M R, Forbes S J. Bone marrow stem cells and liver disease. Gut, 2007, 56(5): 716-724
18. Petersen B E, Bowen W C, Patrene K D, Mars W M, Sullivan A K, Murase N, Boggs S S, Greenberger J S, Goff J P. Bone marrow as a potential source of hepatic oval cells. Science, 1999, 284(5417): 1168-1170
19. Gilchrist E S, Plevris J N. Bone marrow-derived stem cells in liver repair: 10 years down the line. Liver Transpl, 2010, 16(2): 118-129
20. Houlihan D D, Newsome P N. Critical review of clinical trials of bone marrow stem cells in liver disease. Gastroenterology, 2008, 135(2): 438-450
21. Levicar N, Pai M, Habib N A, Tait P, Jiao L R, Marley S B, Davis J, Dazzi F, Smadja C, Jensen S L, Nicholls J P, Apperley J F, Gordon M Y. Long-term clinical results of autologous infusion of mobilized adult bone marrow derived CD34 + cells in patients with chronic liver disease. Cell Prolif, 2008, 41(Suppl 1): 115-125
22. Tajima F, Tsuchiya H, Nishikawa K, Kataoka M, Hisatome I, Shiota G. Hepatocyte growth factor mobilizes and recruits hematopoietic progenitor cells into liver through a stem cell factor-mediated mechanism. Hepatol Res, 2010, 40(7): 711-719
23. Yamaguchi K, Itoh K, Masuda T, Umemura A, Baum C, Itoh Y, Okanoue T, Fujita J. In vivo selection of transduced hematopoietic stem cells and little evidence of their conversion into hepatocytes in vivo. J Hepatol, 2006, 45(5): 681-687
24. Friedenstein A J, Chailakhjan R K, Lalykina K S. The development of fibroblast colonies in monolayer cultures of guinea-pig bone marrow and spleen cells. Cell Tissue Kinet, 1970, 3(4): 393-403
25. Lee K D, Kuo T K, Whang-Peng J, Chung Y F, Lin C T, Chou S H, Chen J R, Chen Y P, Lee O K. In vitro hepatic differentiation of human mesenchymal stem cells. Hepatology, 2004, 40(6): 1275-1284
26. Liu Z J, Zhuge Y, Velazquez O C. Trafficking and differentiation of mesenchymal stem cells. J Cell Biochem, 2009, 106(6): 984-991
27. Aurich H, Sgodda M, Kaltwasser P, Vetter M, Weise A, Liehr T, Brulport M, Hengstler J G, Dollinger M M, Fleig W E, Christ B. Hepatocyte differentiation of mesenchymal stem cells from human adipose tissue in vitro promotes hepatic integration in vivo. Gut, 2009, 58(4): 570-581
28. Cho K A, Ju S Y, Cho S J, Jung Y J, Woo S Y, Seoh J Y, Han H S, Ryu K H. Mesenchymal stem cells showed the highest potential for the regeneration of injured liver tissue compared with other subpopulations of the bone marrow. Cell Biol Int, 2009, 33(7): 772-777
29. Kuo T K, Hung S P, Chuang C H, Chen C T, Shih Y R, Fang S C, Yang V W, Lee O K. Stem cell therapy for liver disease: parameters governing the success of using bone marrow mesenchymal stem cells. Gastroenterology, 2008; 134(7): 2111-2121, 2121. e1-3
30. Banas A, Teratani T, Yamamoto Y, Tokuhara M, Takeshita F, Quinn G, Okochi H, Ochiya T. Adipose tissue-derived mesenchymal stem cells as a source of human hepatocytes. Hepatology, 2007, 46(1): 219-228
31. Wang Z, Lu H, Wang Y C, Cong X Q. Human embryonic stem cells and liver diseases: from basic research to future clinical application. J Dig Dis, 2008, 9(1): 14-19
32. Cai J, Zhao Y, Liu Y, Ye F, Song Z, Qin H, Meng S, Chen Y, Zhou R, Song X, Guo Y, Ding M, Deng H. Directed differentiation of human embryonic stem cells into functional hepatic cells. Hepatology, 2007, 45(5): 1229-1239
33. Dan Y Y, Yeoh G C. Liver stem cells: a scientific and clinical perspective. J Gastroenterol Hepatol, 2008, 23(5): 687-698
34. Dalgetty D M, Medine C N, Iredale J P, Hay D C. Progress and future challenges in stem cell-derived liver technologies. Am J Physiol Gastrointest Liver Physiol, 2009, 297(2): G241-G248
35. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 2006, 126(4): 663-676
36. Okita K, Ichisaka T, Yamanaka S. Generation of germlinecompetent induced pluripotent stem cells. Nature, 2007, 448(7151): 313-317
37. Yu J, Vodyanik M A, Smuga-Otto K, Antosiewicz-Bourget J, Frane J L, Tian S, Nie J, Jonsdottir G A, Ruotti V, Stewart R, Slukvin I I, Thomson J A. Induced pluripotent stem cell lines derived from human somatic cells. Science, 2007, 318(5858): 1917-1920
38. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein B E, Jaenisch R. In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature, 2007, 448(7151): 318-324
39. Lowry W E, Richter L, Yachechko R, Pyle A D, Tchieu J, Sridharan R, Clark A T, Plath K. Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci USA, 2008, 105(8): 2883-2888
40. Park I H, Zhao R, West J A, Yabuuchi A, Huo H, Ince T A, Lerou P H, Lensch M W, Daley G Q. Reprogramming of human somatic cells to pluripotency with defined factors. Nature, 2008, 451(7175): 141-146
41. Kim J B, Zaehres H, Wu G, Gentile L, Ko K, Sebastiano V, Araúzo-Bravo M J, Ruau D, Han D W, Zenke M, Schöler H R. Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature, 2008, 454(7204): 646-650
42. Carey B W, Markoulaki S, Hanna J, Saha K, Gao Q, Mitalipova M, Jaenisch R. Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci USA, 2009, 106(1): 157-162
43. Li W, Wei W, Zhu S, Zhu J, Shi Y, Lin T, Hao E, Hayek A, Deng H, Ding S. Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell, 2009, 4(1): 16-19
44. Theise N D, Nimmakayalu M, Gardner R, Illei P B, Morgan G, Teperman L, Henegariu O, Krause D S. Liver from bone marrow in humans. Hepatology, 2000, 32(1): 11-16
45. Alison MR, Poulsom R, Jeffery R, Dhillon A P, Quaglia A, Jacob J, Novelli M, Prentice G, Williamson J, Wright N A. Hepatocytes from non-hepatic adult stem cells. Nature, 2000, 406(6793): 257
46. Sato Y, Araki H, Kato J, Nakamura K, Kawano Y, Kobune M, Sato T, Miyanishi K, Takayama T, Takahashi M, Takimoto R, Iyama S, Matsunaga T, Ohtani S, Matsuura A, Hamada H, Niitsu Y. Human mesenchymal stem cells xenografted directly to rat liver are differentiated into human hepatocytes without fusion. Blood, 2005, 106(2): 756-763
47. Jang Y Y, Collector M I, Baylin S B, Diehl A M, Sharkis S J. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol, 2004, 6(6): 532-539
48. Willenbring H, Bailey A S, Foster M, Akkari Y, Dorrell C, Olson S, Finegold M, Fleming W H, Grompe M. Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat Med, 2004, 10(7): 744-748
49. Quintana-Bustamante O, Alvarez-Barrientos A, Kofman A V, Fabregat I, Bueren J A, Theise N D, Segovia J C. Hematopoietic mobilization in mice increases the presence of bone marrow-derived hepatocytes via in vivo cell fusion. Hepatology, 2006, 43(1): 108-116
50. Rodić N, Rutenberg MS, Terada N. Cell fusion and reprogramming: resolving our transdifferences. Trends Mol Med, 2004, 10(3): 93-96
51. Dahlke M H, Popp F C, Larsen S, Schlitt H J, Rasko J E. Stem cell therapy of the liver-fusion or fiction? Liver Transpl, 2004, 10(4): 471-479
52. Camargo F D, Finegold M, Goodell M A. Hematopoietic myelomonocytic cells are the major source of hepatocyte fusion partners. J Clin Invest, 2004, 113(9): 1266-1270
53. Krause P, Saghatolislam F, Koenig S, Unthan-Fechner K, Probst I. Maintaining hepatocyte differentiation in vitro through co-culture with hepatic stellate cells. In Vitro Cell Dev Biol Anim, 2009, 45(5-6): 205-212
54. Woodrow K A, Wood MJ, Saucier-Sawyer J K, Solbrig C, Saltzman W M. Biodegradable meshes printed with extracellular matrix proteins support micropatterned hepatocyte cultures. Tissue Eng Part A, 2009, 15(5): 1169-1179
55. Wen F, Chang S, Toh Y C, Arooz T, Zhuo L, Teoh S H, Yu H. Development of dual-compartment perfusion bioreactor for serial coculture of hepatocytes and stellate cells in poly(lactic-co-glycolic acid)-collagen scaffolds. J Biomed Mater Res B Appl Biomater, 2008, 87(1): 154-162
56. Jindal R, Nahmias Y, Tilles A W, Berthiaume F, Yarmush M L. Amino acid-mediated heterotypic interaction governs performance of a hepatic tissue model. FASEB J, 2009, 23(7): 2288-2298
57. Xiong A, Austin T W, Lagasse E, Uchida N, Tamaki S, Bordier B B, Weissman I L, Glenn J S, Millan M T. Isolation of human fetal liver progenitors and their enhanced proliferation by three-dimensional coculture with endothelial cells. Tissue Eng Part A, 2008, 14(6): 995-1006
58. Hoshiba T, Cho C S, Murakawa A, Okahata Y, Akaike T. The effect of natural extracellular matrix deposited on synthetic polymers on cultured primary hepatocytes. Biomaterials, 2006, 27(26): 4519-4528
59. Hoshiba T, Wakejima M, Cho C S, Shiota G, Akaike T. Different regulation of hepatocyte behaviors between natural extracellular matrices and synthetic extracellular matrices by hepatocyte growth factor. J Biomed Mater Res A, 2008, 85(1): 228-235
60. Hidaka M, Su G N, Chen J K, Mukaisho K, Hattori T, Yamamoto G. Transplantation of engineered bone tissue using a rotary threedimensional culture system. In Vitro Cell Dev Biol Anim, 2007, 43(2): 49-58
61. Chen Z, Qi L Z, Zeng R, Li H Y, Dai L J. Stem cells and hepatic cirrhosis. Panminerva Med, 2010, 52(2): 149-165
62. Russo F P, Alison M R, Bigger B W, Amofah E, Florou A, Amin F, Bou-Gharios G, Jeffery R, Iredale J P, Forbes S J. The bone marrow functionally contributes to liver fibrosis. Gastroenterology, 2006, 130(6): 1807-1821