Functional loss of Cdkal1, a novel tRNA modification enzyme, causes the development of type 2 diabetes

Endocrine Journal

Volumn 58, Issue 10, 2011, Pages 819-825

  Wei, Fan Yan ^a   Tomizawa, Kazuhito ^a  

^a KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Cdk5; Endoplasmic reticulum (ER); Insulin synthesis; SNPs; Translation

Indexed keywords

CDK5 REGULATORY ASSOCIATED PROTEIN 1 LIKE 1 PROTEIN; PROINSULIN; REGULATOR PROTEIN; TRANSFER RNA; UNCLASSIFIED DRUG;

CDK5 REGULATORY ASSOCIATED PROTEIN 1 LIKE 1 GENE; ENDOPLASMIC RETICULUM STRESS; ENZYME STRUCTURE; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE INTOLERANCE; HUMAN; LOSS OF FUNCTION MUTATION; MOLECULAR PATHOLOGY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATOR GENE; REVIEW; SEQUENCE ANALYSIS;

ANIMALS; CYCLIN-DEPENDENT KINASE 5; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM STRESS; HUMANS; INSULIN-SECRETING CELLS; MALE; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROINSULIN; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, TRANSFER;

EID: 80055085362     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.EJ11-0099     Document Type: Review

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