Short-term daily or weekly administration of micronutrient Sprinkles™ has high compliance and does not cause iron overload in Chinese schoolchildren: A cluster-randomised trial

Public Health Nutrition

Volumn 9, Issue 3, 2006, Pages 336-344

  Sharieff, Waseem ^a,d   Yin, Shi An ^b   Wu, Michelle ^d   Yang, Qingjun ^b   Schauer, Claudia ^d   Tomlinson, George ^a,c   Zlotkin, Stanley ^a,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b CHINESE CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

^c UNIVERSITY HEALTH NETWORK   (Canada)

^d HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

Anaemia; Children; China; Cluster randomised trial; Iron deficiency; Micronutrients; Safety; Sprinkles

Indexed keywords

ASCORBIC ACID; COLECALCIFEROL; FERRITIN; FERROUS FUMARATE; FOLIC ACID; GLUCONATE ZINC; HEMOGLOBIN; RETINOL; TRACE ELEMENT;

ARTICLE; CHINESE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FERRITIN BLOOD LEVEL; HEMOGLOBIN BLOOD LEVEL; HUMAN; IRON OVERLOAD; MALE; OUTCOME ASSESSMENT; PATIENT COMPLIANCE; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; TIME; VITAMIN SUPPLEMENTATION;

ADMINISTRATION, ORAL; ANEMIA, IRON-DEFICIENCY; CHILD; CHILD, PRESCHOOL; CHINA; CLUSTER ANALYSIS; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; FERRITINS; HEMOGLOBINS; HUMANS; IRON; LINEAR MODELS; MALE; MICRONUTRIENTS; PATIENT COMPLIANCE; SAFETY; TREATMENT OUTCOME;

EID: 33744937584     PISSN: 13689800     EISSN: None     Source Type: Journal    
DOI: 10.1079/PHN2006841     Document Type: Article

References (30)

1. Cai M, Yan W. Study on iron nutritional status in adolescence. Biomedical and Environmental Sciences 1990; 3(1): 113-9.
2. Ge K, Zhai F, Yan H. The Dietary and Nutritional Status of Chinese Population. 1992 National Nutrition Survey, Volume 1. Beijing: People's Medical Publishing House, 1996; 43-51.
3. He Y, Wang H, Hu Z, Lin Y. Study on nutritional anemia in students of 7 nationalities in Xinjiang autonomous. Xinjiang Hygiene Prevention 1994; 12: 1-6.
4. Li R, Chen X, Yan H, Deurenberg P, Garby L, Hautvast J. Functional consequences of iron supplementation in iron-deficient female cotton mill workers in Beijing, China. American Journal of Clinical Nutrition 1994; 59(4): 908-13.
5. Zhang Q. Iron nutritional status of young female workers in Shanghai First Silk Factory. Chinese Journal of Preventive Medicine 1987; 21(2): 87-9.
6. Li A, Cheng M. Anaemia and thalassaemia in healthy adolescents from southern Chinese families. Journal of Paediatrics and Child Health 1990; 26(6): 339-42.
7. Zhao X. Nutritional situation of Beijing residents. Southeast Asian Journal of Tropical Medicine and Public Health 1992; 23(Suppl. 3): 65-8.
8. Du S, Zhai F, Wang Y, Popkin B. Current methods for estimating dietary iron bioavailability do not work in China. Journal of Nutrition 2000; 130(2): 193-8.
9. Schumann K. Safety aspects of iron in food. Annals of Nutrition & Metabolism 2001; 45(3): 91-101.
10. Majumdar I, Paul P, Talib V, Ranga S. The effect of iron therapy on the growth of iron-replete and iron-deplete children. Journal of Tropical Pediatrics 2003; 49(2): 84-8.
11. Liu X, Liu P. The effectiveness of weekly iron supplementation regimen in improving the iron status of Chinese children and pregnant women. Biomedical and Environmental Sciences 1996; 9(2-3): 341-7.
12. Beaton G, McCabe G. Efficacy of Intermittent Iron Supplementation in the Control of Iron Deficiency Anaemia in Developing, Countries. An Analysis of Experience. Ottawa: The Micronutrient Initiative, 1999.
13. Supplefer Sprinkles: A Humanitarian Project to Reduce Global Childhood Anemia [online]. Available at http://www. supplefer.com. Accessed 10 December 2004
14. Zlotkin S, Arthur P, Antwi K, Yeung G. Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. American Journal of Clinical Nutrition 2001; 74(6): 791-5.
15. Lipschitz D, Cook J, Finch C. A clinical evaluation of serum ferritin as an index of iron stores. New England Journal of Medicine 1974; 290(22): 1213-6.
16. Blaustein D, Schwenk M, Chattopadhyay J, Singh H, Daoui R, Gadh R, et al. The safety and efficacy of an accelerated iron sucrose dosing regimen in patients with chronic kidney disease. Kidney International. Supplement 2003; (87): S72-7.
17. Cohen A, Galanello R, Piga A, De Sanctis V, Tricta F. Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone. Blood 2003; 102(5): 1583-7.
18. Peng C, Chow K, Chen J, Chiang Y, Lin T, Tsai C. Safety monitoring of cardiac and hepatic systems in β-thalassemia patients with chelating treatment in Taiwan. European Journal of Haematology 2003; 70(6): 392-7.
19. A SAS Program for the CDC Growth Charts [online]. Available at http://www.cdc.gov/nccdphp/dnpa/growthcharts/sas. htm. Accessed 25 May 2004.
20. Stoltzfus R. Denning iron-deficiency anemia in public health terms: a time for reflection. Journal of Nutrition 2001; 131(Suppl. 2): 565S-7S.
21. Knutson M, Walter P, Ames B, Viteri F. Both iron deficiency and daily iron supplements increase lipid peroxidation in rats. Journal of Nutrition 2000; 130(3): 621-8.
22. Ekstrom E, Hyder S, Chowdhury A, Chowdhury S, Lonnerdal B, Habicht J, et al. Efficacy and trial effectiveness of weekly and daily iron supplementation among pregnant women in rural Bangladesh: disentangling the issues. American Journal of Clinical Nutrition 2002; 76(6): 1392-400.
23. Hallberg L, Kulten L, Gramatkovski E. Iron absorption from the whole diet in men: how effective is the regulation of iron absorption? American Journal of Clinical Nutrition 1997; 66(2): 347-56.
24. Munro H, Linder M. Ferritin: structure, biosynthesis, and role in iron metabolism. Physiological Reviews 1978; 58(2): 317-96.
25. Worwood M. Serum ferritin. In: Jacobs A, Worwood M, eds. Iron in Biochemistry and Medicine II. London: Academic Press, 1980; 204-44.
26. Halliday J, Powell L. Serum ferritin and isoferritins in clinical medicine. In: Brown EB, ed. Progress in Hematology XI. New York: Grune & Stratton, 1979; 229-66.
27. Birgegard G, Hogman C, Killander A, Levander H, Simonsson B, Wide L. Serum ferritin and erythrocyte 2,3-DPG during quantitated phlebotomy and iron treatment. Scandinavian Journal of Haematology 1977; 19(4): 327-33.
28. Milman N. Serum ferritin in Danes: studies of iron status from infancy to old age, during blood donation and pregnancy. International Journal of Hematology 1996; 63(2): 103-35.
29. Siimes M, Addiego J Jr, Dallman P. Ferritin in serum: diagnosis of iron deficiency and iron overload in infants and children. Blood 1974; 43(4): 581-90.
30. Tandon BN. Nutritional interventions through primary health care: impact of the ICDS projects in India. Bulletin of the World Health Organization 1989; 67(1): 77-80.