Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in Cambodian infants

Journal of Pediatric Gastroenterology and Nutrition

Volumn 42, Issue 3, 2006, Pages 306-312

  Giovannini, Marcello ^a   Sala, Debora ^a   Usuelli, Michele ^a   Livio, Luca ^a   Francescato, Gaia ^a   Braga, Marta ^a   Radaelli, Giovanni ^a   Riva, Enrica ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Anemia; Growth; Iron deficiency; Sprinkles

Indexed keywords

FERRITIN; FOLIC ACID; HEMOGLOBIN; IRON; PLACEBO; TRACE ELEMENT; ZINC;

AGE; ANEMIA; ANTHROPOMETRY; ARTICLE; BODY HEIGHT; CAMBODIA; CAMBODIAN; CHILD GROWTH; CLINICAL OBSERVATION; CLINICAL TRIAL; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; FECES COLOR; FEMALE; FERRITIN BLOOD LEVEL; GROWTH CURVE; HOME; HUMAN; INFANT; IRON DEFICIENCY; LOOSE FECES; MAJOR CLINICAL STUDY; MALE; POWDER; PRESCHOOL CHILD; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCORING SYSTEM; SIDE EFFECT; TIME SERIES ANALYSIS; UNDERWEIGHT; WASTING SYNDROME;

ANEMIA, IRON-DEFICIENCY; ANTHROPOMETRY; CAMBODIA; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FERRITINS; FOLIC ACID; GROWTH; HEMOGLOBINS; HUMANS; INFANT; INFANT NUTRITION PHYSIOLOGY; IRON; LONGITUDINAL STUDIES; MALE; MICRONUTRIENTS; TREATMENT OUTCOME; ZINC;

EID: 33645305428     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mpg.0000189363.07040.4b     Document Type: Article

References (19)

1. Yip R, Ramakrishnan U. Experiences and challenges in developing countries. J Nutr 2002;132(Suppl):827S-30S.
2. Iron Deficiency Anaemia: Assessment, Prevention and Control. A Guide For Programme Managers (Document WHO/NHD/01.3). Geneva: World Health Organization, 2001.
3. Cambodia Demographic and Health Survey 2000. Preliminary Report. Calverton, MA: National Institute of Statistics, Ministry of Health. Measure DHS+, ORC Macro, 2000.
4. DeMaeyer E, Dallman P, Gurney JM, et al. Preventing and Controlling Iron Deficiency Anaemia through Primary Health Care: A Guide for Health Administrators and Programme Managers. Geneva: World Health Organization, 1989.
5. Zlotkin S, Arthur P, Antwi KY, Yeung G. Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as sprinkles to complementary (weaning) foods. Am J Clin Nutr 2001;74:791-5.
6. Zlotkin S, Arthur P, Schauer C, et al. Home-fortification with iron and zinc sprinkles or iron sprinkles alone successfully treats anemia in infants and young children. J Nutr 2003;133:1075-80.
7. Zlotkin S, Antwi KY, Schauer C, Yeung G. Use of microencapsulated iron (II) fumarate sprinkles to prevent recurrence of anaemia in infants and young children at high risk. Bull World Health Organ 2003;81:108-15.
8. Lind T, Lönnerdal B, Stenlund H, et al. A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development. Am J Cl Nutr 2004;80:729-36.
9. Desai MR, Dhar R, Rosen DH, et al. Daily iron supplementation is more efficacious than twice weekly iron supplementation for the treatment of childhood anemia in Western Kenya. J Nutr 2004;134:1167-74.
10. Food and Nutrition Board, National Academy of Sciences. Recommended Dietary Allowances, Revised. Washington, DC: National Academy of Sciences, 1989.
11. Guidelines for Outreach Services from Health Centers. Cambodia: Ministry of Health, 2001.
12. Hamill PV, Drizd TA, Johnson CL, et al. Physical growth: National Center for Health Statistics percentiles. Am J Clin Nutr 1979;32:607-29.
13. Moher D, Schulz KF, Altman DG. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet 2001;357:1191-4.
14. Brown K, Dewey K, Allen L. Complementary Feeding of Young Children in Developing Countries: A Review of Current Scientific Knowledge (WHO/NUT/98.1). Geneva: World Health Organization, 1998.
15. Lind T, Lonnerdal B, Stenlund H, et al. A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: interactions between iron and zinc. Am J Clin Nutr 2003;77:883-90.
16. Walker CF, Black RE. Zinc and the risk for infectious disease. Annu Rev Nutr 2004;24:255-75.
17. Davidsson L. Approaches to improve iron bioavailability from complementary foods. J Nutr 2003;133:1560S-2.
18. Munoz EC, Rosado JL, Lopez P, Furr HC, Allen LH. Iron and zinc supplementation improves indicators of vitamin A status of Mexican preschoolers. Am J Clin Nutr 2000;71:789-94.
19. Kolsteren P, Rahman SR, Hilderbrand K, Diniz A. Treatment for iron deficiency anaemia with a combined supplementation of iron, vitamin A and zinc in women of Dinajpur, Bangladesh. Eur J Clin Nutr 1999;53:102-6.