Use of microencapsulated iron(II) fumarate sprinkles to prevent recurrence of anaemia in infants and young children at high risk

Bulletin of the World Health Organization

Volumn 81, Issue 2, 2003, Pages 108-115

  Zlotkin, Stanley ^a,b,c   Antwi, Kojo Yeboah ^d   Schauer, Claudia ^b,c   Yeung, George ^a,b,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

^d NONE

Author keywords

Anemia, Iron deficiency drug therapy prevention and control; Food, fortified utilization; Hemoglobins analysis; Iron, dietary administration and dosage therapeutic use; Vitamin A administration and dosage

Indexed keywords

FERROUS FUMARATE; FERROUS SULFATE; PLACEBO; RETINOL;

ANEMIA; CHILD HEALTH; MALNUTRITION; NUTRITIONAL STATUS;

ARTICLE; CHILD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG MEGADOSE; FERRITIN BLOOD LEVEL; HEALTH PROGRAM; HEMOGLOBIN DETERMINATION; HIGH RISK POPULATION; HUMAN; INFANT; IRON DEFICIENCY ANEMIA; IRON THERAPY; MICROENCAPSULATION; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; TREATMENT OUTCOME; VITAMIN BLOOD LEVEL;

ADMINISTRATION, ORAL; ANEMIA, IRON-DEFICIENCY; ASCORBIC ACID; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; FERROUS COMPOUNDS; GHANA; HUMANS; INFANT; PLACEBOS; PROSPECTIVE STUDIES; RECURRENCE; RISK FACTORS;

GHANA;

EID: 0344406990     PISSN: 00429686     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. World Health Organization. Malnutrition. The global picture. Geneva: World Health Organization; 2000.
2. Institute of Medicine. Dietary reference intakes. Vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, zinc. Washington (DC): National Academy of Sciences; 2001.
3. Walter T. Infancy: mental and motor development. American Journal of Clinical Nutrition 1989;50:655-66.
4. Oski FA, Honig AS, Helu B, Howanitz P. Effect of iron therapy on behavior performance in nonanemic, iron-deficient infants. Pediatrics 1983;71:877-80.
5. Watkins WE, Pollitt E. Iron deficiency and cognition among school-age children. In: Nutrition, health, and child development: research advances and policy recommendations. Washington (DC): Pan American Health Organization, The World Bank and Tropical Medicine Research Unit; 1997 p.179-97.
6. Thomas D, Frankenberg E. Health, nutrition and prosperity: a microeconomic perspective. Bulletin of the World Health Organization 2002;80:106-13.
7. Grantham-McGregor S, Ani C. A review of studies on the effect of iron deficiency on cognitive development in children. Journal of Nutrition 2001;131:649S-68S.
8. Lozoff B, Brittenham GM, Wolf AW, McClish DK, Kuhnert PM, Jimenez E et al. Iron deficiency anemia and iron therapy effects on infant developmental test performance Pediatrics 1987;79:981-95.
9. Lozoff B, Jimenez MD, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 2000;105:852. Available from: URL: http://www.pediatrics.org/cgi/content/full/105/4/e51
10. Nestel P, Alnwick D, editors. Iron/multi-micronutrient supplements for young children. Summary and conclusions of a consultation held at UNICEF Copenhagen, Denmark, 1996 August 19-20. Washington DC: International Life Sciences Institute; 1997.
11. Zlotkin S, Arthur P, Antwi KY, Yeung G. Treatment of anemia with microencapsulated ferrous fumarate plus ascorbic acid supplied as "sprinkles" added to complementary (weaning) foods. American Journal of Clinical Nutrition 2001;74:791-5.
12. Allen LH. Iron supplements: scientific issues concerning efficacy and implications for research and programs. Nutrition 2002;132(4 Suppl):813S-9S
13. Bloem MW, Wedel M, Egger RJ, Speek AJ, Schrijver J, Saowakontha S et al. Iron metabolism and vitamin A deficiency in children in Northeast Thailand. American Journal of Clinical Nutrition 1989;50:332-8.
14. Mejia LA, Chew F. Hematological effect of supplementing anemic children with vitamin A alone and in combination with iron. American Journal of Clinical Nutrition 1988;48:595-600.
15. Gibson RS, Ferguson EL, Lehrfeld J. Complementary foods for infants feeding in developing countries: their nutrient adequacy and improvement. European Journal of Clinical Nutrition 1998;52:764-70.
16. Cohen AR, Seidl-Friedman J. HemoCue system for haemoglobin measurement. Evaluation in anemic and nonanemic children. American Journal of Clinical Pathology 1988;90:302-5.
17. Miles LEM, Lipschitz DA, Bieber CP, Cook JD. Measurement of serum ferritin by a 2-site immunoradiometric assay. Analytical Biochemistry 1974;61:209-24.
18. International Vitamin A Consultative Group. Biochemical methodology for the assessment of vitamin A status. Washington (DC): Nutrition Foundation; 1982.
19. Cook JD, Layrisse M, Finch CA. The measurement of iron absorption. Blood 1969;33:421-9.
20. Eisenstein RS. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annual Review of Nutrition 2000;20:627-62.
21. Dallman PR. Changing iron needs from birth through adolescence. In: Fomon SJ, Zlotkin SH, editors. Nutritional anemias, Nestlé Nutrition Workshop Series, Volume 3. New York (NY): Lippincott/Raven Press; 1992. p.29-38.
22. Koram KA, Owusu-Agyei S, Utz G, Binka FN, Baird JK, Hoffman SL, et al. Severe anemia in young children after high and low malaria transmission seasons in the Kassena-Nankana district of northern Ghana. American Journal of Tropical Medicine and Hygiene 2000;62:670-4.
23. Hodges RE, Sauberlich HE, Canham JE, Wallace DL, Rucker RB, Mejia LA et al. Hematopoietic studies in vitamin A deficiency. American Journal of Clinical Nutrition 1978;31:876-85.
24. Smith JE, Brown ED, Smith JC Jr. The effect of zinc deficiency on the metabolism of retinol-binding protein in the rat. Journal of Laboratory and Clinical Medicine 1974;84:692-7.
25. Shingwekar B, Mohanram M, Reddy V. Effect of zinc supplementation on plasma levels of vitamin A and retinol-binding protein in malnourished children. Clinica Chimica Acta 1979;93:97-100.
26. Christian P, West KP Jr. Interactions between zinc and vitamin A. An update. American Journal of Clinical Nutrition 1998;68:435S-41S.
27. Cooper MJ, Zlotkin SH. Day-to-day variation of transferrin receptor and ferritin in healthy men and women. American Journal of Clinical Nutrition 1996;64:738-42.
28. Odunukwe NN, Salako LA, Okany C, Ibrahim MM. Serum ferritin and other haematological measurements in apparently healthy adults with malaria parasitaemia in Lagos, Nigeria. Tropical Medicine and International Health 2000;5:582-6.