ΔNp63α protein triggers epithelial-mesenchymal transition and confers stem cell properties in normal human keratinocytes

Journal of Biological Chemistry

Volumn 286, Issue 44, 2011, Pages 38757-38767

  Oh, Ju Eun ^a   Kim, Reuben H ^a,b,c   Shin, Ki Hyuk ^a,b,c   Park, No Hee ^a,b,c   Kang, Mo K ^a,b,c  

^a UCLA SCHOOL OF DENTISTRY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOGENIC; CELLULAR RESPONSE; EMPTY VECTOR; EPITHELIAL TISSUE; EPITHELIAL-MESENCHYMAL TRANSITION; GROWTH ARREST; HUMAN EPIDERMAL KERATINOCYTES; HUMAN KERATINOCYTES; IN-CONTROL; ISOFORMS; MESENCHYMAL CELLS; MESENCHYMAL STEM CELL; MORPHOLOGICAL CHANGES; N-TERMINAL TRANSACTIVATION; PHENOTYPIC CHANGES; PLURIPOTENCY; REPLICATIVE SENESCENCE; RETROVIRAL VECTORS;

MORPHOLOGY; SIGNALING; STEM CELLS; TISSUE; TRANSCRIPTION FACTORS;

CELL CULTURE;

DELTANP63ALPHA PROTEIN; ISOPROTEIN; LIN28 PROTEIN; PROTEIN P63; RETROVIRUS VECTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NANOG; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; TP63 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ADIPOSE TISSUE CELL; AMINO TERMINAL SEQUENCE; ARTICLE; CELL AGING; CELL CYCLE ARREST; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; EPITHELIAL MESENCHYMAL TRANSITION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; KERATINOCYTE; MESENCHYME CELL; ODONTOBLAST; OSTEOBLAST; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STEM CELL; CELL LINE; CHEMISTRY; CYTOLOGY; GENETICS; MESENCHYMAL STEM CELL; METABOLISM; PHYSIOLOGY; RETROVIRUS; SIGNAL TRANSDUCTION;

CELL LINE; EPITHELIAL-MESENCHYMAL TRANSITION; HUMANS; KERATINOCYTES; MESENCHYMAL STEM CELLS; PHENOTYPE; RETROVIRIDAE; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 80055068988     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.244939     Document Type: Article

References (54)

1. Yang, A., Kaghad, M., Wang, Y., Gillett, E., Fleming, M. D., Dötsch, V., Andrews, N. C., Caput, D., and McKeon, F. (1998) Mol. Cell 2, 305-316
2. Koster, M. I., Kim, S., Mills, A. A., DeMayo, F. J., and Roop, D. R. (2004) Genes Dev. 18, 126-131
3. Koster, M. I., Dai, D., Marinari, B., Sano, Y., Costanzo, A., Karin, M., and Roop, D. R. (2007) Proc. Natl. Acad. Sci. U.S.A. 104, 3255-3260
4. Mills, A. A., Zheng, B., Wang, X. J., Vogel, H., Roop, D. R., and Bradley, A. (1999) Nature 398, 708-713
5. Yang, A., Schweitzer, R., Sun, D., Kaghad, M., Walker, N., Bronson, R. T., Tabin, C., Sharpe, A., Caput, D., Crum, C., and McKeon, F. (1999) Nature 398, 714-718
6. Keyes, W. M., Wu, Y., Vogel, H., Guo, X., Lowe, S. W., and Mills, A. A. (2005) Genes Dev. 19, 1986-1999
7. Pellegrini, G., Dellambra, E., Golisano, O., Martinelli, E., Fantozzi, I., Bondanza, S., Ponzin, D., McKeon, F., and De Luca, M. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 3156-3161
8. Cavallaro, U., and Christofori, G. (2004) Nat. Rev. Cancer 4, 118-132
9. Kalluri, R., and Weinberg, R. A. (2009) J. Clin. Invest. 119, 1420-1428
10. Xu, J., Lamouille, S., and Derynck, R. (2009) Cell Res. 19, 156-172
11. Moustakas, A., Pardali, K., Gaal, A., and Heldin, C. H. (2002) Immunol. Lett. 82, 85-91
12. Shi, Y., and Massagué, J. (2003) Cell 113, 685-700
13. Jamora, C., Lee, P., Kocieniewski, P., Azhar, M., Hosokawa, R., Chai, Y., and Fuchs, E. (2005) PLoS Biol. 3, e11
14. Shirakihara, T., Saitoh, M., and Miyazono, K. (2007) Mol. Biol. Cell 18, 3533-3544
15. Davies, M., Robinson, M., Smith, E., Huntley, S., Prime, S., and Paterson, I. (2005) J. Cell Biochem. 95, 918-931
16. Mani, S. A., Guo, W., Liao, M. J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., Brooks, M., Reinhard, F., Zhang, C. C., Shipitsin, M., Campbell, L. L., Polyak, K., Brisken, C., Yang, J., and Weinberg, R. A. (2008) Cell 133, 704-715
17. Lindsay, J., McDade, S. S., Pickard, A., McCloskey, K. D., and McCance, D. J. (2011) J. Biol. Chem. 286, 3915-3924
18. Lindley, L. E., and Briegel, K. J. (2010) Biochem. Biophys. Res. Commun. 399, 659-664
19. Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., and Clarke, M. F. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 3983-3988
20. Sleeman, K. E., Kendrick, H., Ashworth, A., Isacke, C. M., and Smalley, M. J. (2006) Breast Cancer Res. 8, R7
21. Huang, G. T., Gronthos, S., and Shi, S. (2009) J. Dent. Res. 88, 792-806
22. Battula, V. L., Evans, K. W., Hollier, B. G., Shi, Y., Marini, F. C., Ayyanan, A., Wang, R. Y., Brisken, C., Guerra, R., Andreeff, M., and Mani, S. A. (2010) Stem Cells 28, 1435-1445
23. Kang, M. K., Bibb, C., Baluda, M. A., Rey, O., and Park, N. H. (2000) Exp. Cell Res. 258, 288-297
24. Kang, M. K., Guo, W., and Park, N. H. (1998) Cell Growth Differ. 9, 85-95
25. Kang, M. K., and Park, N. H. (2007) Methods Mol. Biol. 371, 151-165
26. Cawthon, R. M. (2002) Nucleic Acids Res. 30, e47
27. Liu, L., Ishihara, K., Ichimura, T., Fujita, N., Hino, S., Tomita, S., Watanabe, S., Saitoh, N., Ito, T., and Nakao, M. (2009) J. Biol. Chem. 284, 5165-5174
28. Liang, C. C., Park, A. Y., and Guan, J. L. (2007) Nat. Protoc. 2, 329-333
29. Giannelli, G., Falk-Marzillier, J., Schiraldi, O., Stetler-Stevenson, W. G., and Quaranta, V. (1997) Science 277, 225-228
30. Matsuzaki, Y., Kinjo, K., Mulligan, R. C., and Okano, H. (2004) Immunity 20, 87-93
31. Gronthos, S., Mankani, M., Brahim, J., Robey, P. G., and Shi, S. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 13625-13630
32. Peinado, H., Olmeda, D., and Cano, A. (2007) Nat. Rev. Cancer 7, 415-428
33. Vuoriluoto, K., Haugen, H., Kiviluoto, S., Mpindi, J. P., Nevo, J., Gjerdrum, C., Tiron, C., Lorens, J. B., and Ivaska, J. (2011) Oncogene 30, 1436-1448
34. Thiboutot, D., Jabara, S., McAllister J. M., Sivarajah, A., Gilliland, K., Cong, Z., and Clawson, G. (2003) J. Invest. Dermatol. 120, 905-914
35. Michalik, L., and Wahli, W. (2007) Biochim. Biophys. Acta 1771, 991-998
36. Kim, R. H., Lieberman, M. B., Lee, R., Shin, K. H., Mehrazarin, S., Oh, J. E., Park, N. H., and Kang, M. K. (2010) Exp. Cell Res. 316, 2600-2608
37. Wang, J., Wei, X., Ling, J., Huang, Y., Huo, Y., and Zhou, Y. (2010) Biochem. Biophys. Res. Commun. 400, 334-339
38. Kang, M. K., Kameta, A., Shin, K. H., Baluda, M. A., and Park, N. H. (2004) J. Cell Physiol. 199, 364-370
39. Park, N. H., Min, B. M., Li, S. L., Huang, M. Z., Cherick, H. M., and Doniger, J. (1991) Carcinogenesis 12, 1627-1631
40. Kim, R. H., Kang, M. K., Shin, K. H., Oo, Z. M., Han, T., Baluda, M. A., and Park, N. H. (2007) Exp. Cell Res. 313, 462-472
41. Miura, M., Gronthos, S., Zhao, M., Lu, B., Fisher, L. W., Robey, P. G., and Shi, S. (2003) Proc. Natl. Acad. Sci. U.S.A. 100, 5807-5812
42. Paula-Silva, F. W., Ghosh, A., Silva, L. A., and Kapila, Y. L. (2009) J. Dent. Res. 88, 339-344
43. Kang, M. K., Swee, J., Kim, R. H., Baluda, M. A., and Park, N. H. (2002) Mech. Ageing Dev. 123, 585-592
44. Noszczyk, B. H., and Majewski, S. T. (2001) Plast. Reconstr. Surg. 108, 1242-1247
45. Truong, A. B., Kretz, M., Ridky, T. W., Kimmel, R., and Khavari, P. A. (2006) Genes Dev. 20, 3185-3197
46. Hudson, L. G., Newkirk, K. M., Chandler, H. L., Choi, C., Fossey, S. L., Parent, A. E., and Kusewitt, D. F. (2009) J. Dermatol. Sci. 56, 19-26
47. Nakamura, M., and Tokura, Y. (2011) J. Dermatol. Sci. 61, 7-13
48. Keyes, W. M., Pecoraro, M., Aranda, V., Vernersson-Lindahl, E., Li, W., Vogel, H., Guo, X., Garcia, E. L., Michurina, T. V., Enikolopov, G., Muthuswamy, S. K., and Mills, A. A. (2011) Cell Stem Cell 8, 164-176
49. Arpitha, P., Prajna, N. V., Srinivasan, M., and Muthukkaruppan, V. (2005) Invest. Ophthalmol. Vis. Sci. 46, 3631-3636
50. Lo Muzio, L., Santarelli, A., Caltabiano, R., Rubini, C., Pieramici, T., Trevisiol, L., Carinci, F., Leonardi, R., De Lillo, A., Lanzafame, S., Bufo, P., and Piattelli, A. (2005) Hum. Pathol. 36, 187-194
51. Massion, P. P., Taflan, P. M., Jamshedur Rahman, S. M., Yildiz, P., Shyr, Y., Edgerton, M. E., Westfall, M. D., Roberts, J. R., Pietenpol, J. A., Carbone, D. P., and Gonzalez, A. L. (2003) Cancer Res. 63, 7113-7121
52. Zhu, Y., Nilsson, M., and Sundfeldt, K. (2010) Endocrinology 151, 5497-5505
53. Song, L. B., Li, J., Liao, W. T., Feng, Y., Yu, C. P., Hu, L. J., Kong, Q. L., Xu, L. H., Zhang, X., Liu, W. L., Li, M. Z., Zhang, L., Kang, T. B., Fu, L. W., Huang, W. L., Xia, Y. F., Tsao, S. W., Li, M., Band, V., Band, H., Shi, Q. H., Zeng, Y. X., and Zeng, M. S. (2009) J. Clin. Invest. 119, 3626-3636
54. Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., Slukvin, I. I., and Thomson, J. A. (2007) Science 318, 1917-1920