Phenotypic plasticity of the ovarian surface epithelium: TGF-β1 induction of Epithelial to Mesenchymal Transition (EMT) in vitro

Endocrinology

Volumn 151, Issue 11, 2010, Pages 5497-5505

  Zhu, Yihong ^a   Nilsson, Mikael ^a   Sundfeldt, Karin ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CLAUDIN 1; HOMEODOMAIN PROTEIN; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; OCCLUDIN; PROTEIN CRUMBS3; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; ZINC FINGER E BOX BINDING HOMEOBOX 1; CADHERIN; CRB3 PROTEIN, HUMAN; MEMBRANE PROTEIN;

ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; OVARY SURFACE EPITHELIUM; PHENOTYPIC PLASTICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; CELL CULTURE; CELL DIFFERENTIATION; DRUG EFFECT; METABOLISM; OVARY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

BLOTTING, WESTERN; CADHERINS; CELL DIFFERENTIATION; CELLS, CULTURED; DOWN-REGULATION; EPITHELIUM; FEMALE; HUMANS; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; OVARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 78049494838     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2010-0486     Document Type: Article

References (42)

1. Scully RE 1995 Pathology of ovarian cancer precursors. J Cell Biochem( Suppl 23):208-218
2. Blaustein A 1984 Peritoneal mesothelium and ovarian surface cells: shared characteristics. Int J Gynecol Pathol 3:361-375
3. Auersperg N, Wong AS, Choi KC, Kang SK, Leung PC 2001 Ovarian surface epithelium: biology, endocrinology, and pathology. Endocr Rev 22:255-288
4. Sundfeldt K, Piontkewitz Y, Ivarsson K, Nilsson O, Hellberg P, Brännström M, Janson PO, Enerback S, Hedin L 1997 E-cadherin expression in human epithelial ovarian cancer and normal ovary. Int J Cancer 74:275-280 (Pubitemid 27321795)
5. Dubeau L 2008 The cell of origin of ovarian epithelial tumours. Lancet Oncol 9:1191-1197
6. Anderson JM 2001 Molecular structure of tight junctions and their role in epithelial transport. News Physiol Sci 16:126-130 (Pubitemid 33570301)
7. Findley MK, Koval M 2009 Regulation and roles for claudin-family tight junction proteins. IUBMB Life 61:431-437
8. Zhu Y, Maric J, Nilsson M, Brännström M, Janson PO, Sundfeldt K 2004 Formation and barrier function of tight junctions in human ovarian surface epithelium. Biol Reprod 71:53-59
9. Zhu Y, Brännström M, Janson PO, Sundfeldt K 2006 Differences in expression patterns of the tight junction proteins, claudin 1, 3, 4 and 5, in human ovarian surface epithelium as compared to epithelia in inclusion cysts and epithelial ovarian tumours. Int J Cancer 118: 1884-1891
10. Tsukita S, Yamazaki Y, Katsuno T, Tamura A, Tsukita S 2008 Tight junction-based epithelial microenvironment and cell proliferation. Oncogene 27:6930-6938
11. Szabó I, Kiss A, Schaff Z, Sobel G 2009 Claudins as diagnostic and prognostic markers in gynecological cancer. Histol Histopathol 24: 1607-1615
12. van Roy F, Berx G 2008 The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 65:3756-3788
13. Jeanes A, Gottardi CJ, Yap AS 2008 Cadherins and cancer: how does cadherin dysfunction promote tumor progression? Oncogene 27: 6920-6929
14. Maines-Bandiera SL, Auersperg N 1997 Increased E-cadherin expression in ovarian surface epithelium: an early step in metaplasia and dysplasia? Int J Gynecol Pathol 16:250-255
15. Wong AS, Maines-Bandiera SL, Rosen B, Wheelock MJ, Johnson KR, Leung PC, Roskelley CD, Auersperg N 1999 Constitutive and conditional cadherin expression in cultured human ovarian surface epithelium: influence of family history of ovarian cancer. Int J Cancer 81:180-188
16. Baum B, Settleman J, Quinlan MP 2008 Transitions between epithelial and mesenchymal states in development and disease. Semin Cell Dev Biol 19:294-308
17. Hugo H, Ackland ML, Blick T, Lawrence MG, Clements JA, Williams ED, Thompson EW 2007 Epithelial-mesenchymal and mesenchymal-epithelial transitions in carcinoma progression. J Cell Physiol 213:374-383
18. Salamanca CM, Maines-Bandiera SL, Leung PC, Hu YL, Auersperg N 2004 Effects of epidermal growth factor/hydrocortisone on the growth and differentiation of human ovarian surface epithelium. J Soc Gynecol Investig 11:241-251
19. Ahmed N, Maines-Bandiera S, Quinn MA, Unger WG, Dedhar S, Auersperg N 2006 Molecular pathways regulating EGF-induced epithelio-mesenchymal transition in human ovarian surface epithelium. Am J Physiol Cell Physiol 290:C1532-C1542
20. Xu J, Lamouille S, Derynck R 2009 TGF-β-induced epithelial to mesenchymal transition. Cell Res 19:156-172
21. Zavadil J, Böttinger EP 2005 TGF-β and epithelial-to- mesenchymal transitions. Oncogene 24:5764-5774
22. Nilsson E, Doraiswamy V, Parrott JA, Skinner MK 2001 Expression and action of transforming growth factor β (TGFβ1, TGFβ2, TGFβ3) in normal bovine ovarian surface epithelium and implications for human ovarian cancer. Mol Cell Endocrinol 182:145-155
23. Henriksen R, Gobl A, Wilander E, Oberg K, Miyazono K, Funa K 1995 Expression and prognostic significance of TGF-β isotypes, latent TGF-β1 binding protein, TGF-β type I and type II receptors, and endoglin in normal ovary and ovarian neoplasms. Lab Invest 73:213-220
24. Choi KC, Kang SK, Tai CJ, Auersperg N, Leung PC 2001 The regulation of apoptosis by activin and transforming growth factor-β in early neoplastic and tumorigenic ovarian surface epithelium. J Clin Endocrinol Metab 86:2125-2135
25. Larsson F, Fagman H, Nilsson M 2004 TSH receptor signaling via cyclic AMP inhibits cell surface degradation and internalization of E-cadherin in pig thyroid epithelium. Cell Mol Life Sci 61:1834-1842
26. Bolós V, Peinado H, Pérez-Moreno MA, Fraga MF, Esteller M, Cano A 2003 The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 116:499-511
27. Patel IS, Madan P, Getsios S, Bertrand MA, MacCalman CD 2003 Cadherin switching in ovarian cancer progression. Int J Cancer 106: 172-177
28. Czernobilsky B, Moll R, Levy R, Franke WW 1985 Co-expression of cytokeratin and vimentin filaments in mesothelial, granulosa and rete ovarii cells of the human ovary. Eur J Cell Biol 37:175-190
29. Chegini N, Flanders KC 1992 Presence of transforming growth factor- β and their selective cellular localization in human ovarian tissue of various reproductive stages. Endocrinology 130:1707-1715
30. 125I]TGFβ- binding sites. J Clin Endocrinol Metab 79:1177-1184
31. Potts JD, Dagle JM, Walder JA, Weeks DL, Runyan RB 1991 Epithelial-mesenchymal transformation of embryonic cardiac endothelial cells is inhibited by a modified antisense oligodeoxynucleotide to transforming growth factor β3. Proc Natl Acad Sci USA 88:1516-1520
32. Toda S, Matsumura S, Fujitani N, Nishimura T, Yonemitsu N, Sugihara H 1997 Transforming growth factor-β1 induces a mesenchyme- like cell shape without epithelial polarization in thyrocytes and inhibits thyroid folliculogenesis in collagen gel culture. Endocrinology 138:5561-5575
33. Peinado H, Quintanilla M, Cano A 2003 Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 278:21113-21123
34. Grände M, Franzen A, Karlsson JO, Ericson LE, Heldin NE, Nilsson M 2002 Transforming growth factor-β and epidermal growth factor synergistically stimulate epithelial to mesenchymal transition (EMT) through a MEK-dependent mechanism in primary cultured pig thyrocytes. J Cell Sci 115:4227-4236
35. Ikenouchi J, Matsuda M, Furuse M, Tsukita S 2003 Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 116:1959-1967
36. Roh MH, Fan S, Liu CJ, Margolis B 2003 The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells. J Cell Sci 116:2895-2906
37. Fogg VC, Liu CJ, Margolis B 2005 Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells. J Cell Sci 118:2859-2869
38. Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M, Mikulits W, Brabletz T, Strand D, Obrist P, Sommergruber W, Schweifer N, Wernitznig A, Beug H, Foisner R, Eger A 2007 The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 26:6979-6988
39. Whiteman EL, Liu CJ, Fearon ER, Margolis B 2008 The transcription factor snail represses Crumbs3 expression and disrupts apicobasal polarity complexes. Oncogene 27:3875-3879
40. Wheelock MJ, Johnson KR 2003 Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol 19:207-235
41. Rangel LB, Agarwal R, D'Souza T, Pizer ES, Alò PL, Lancaster WD, Gregoire L, Schwartz DR, Cho KR, Morin PJ 2003 Tight junction proteins claudin-3 and claudin-4 are frequently overexpressed in ovarian cancer but not in ovarian cystadenomas. Clin Cancer Res 9:2567-2575
42. Okamoto S, Okamoto A, Nikaido T, Saito M, Takao M, Yanaihara N, Takakura S, Ochiai K, Tanaka T 2009 Mesenchymal to epithelial transition in the human ovarian surface epithelium focusing on inclusion cysts. Oncol Rep 21:1209-1214