메뉴 건너뛰기




Volumn 70, Issue 4, 2010, Pages 377-385

Sodium-glucose co-transport inhibitors: Progress and therapeutic potential in type 2 diabetes mellitus

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; CANAGLIFLOZIN; DAPAGLIFLOZIN; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 2; METFORMIN; PHLORIZIN; PLACEBO; REMOGLIFLOZIN; SERGLIFLOZIN; SODIUM GLUCOSE COTRANSPORTER; SODIUM GLUCOSE COTRANSPORTER 2; UNCLASSIFIED DRUG;

EID: 77949287535     PISSN: 00126667     EISSN: 11791950     Source Type: Journal    
DOI: 10.2165/11318680-000000000-00000     Document Type: Review
Times cited : (146)

References (49)
  • 1
    • 77949279451 scopus 로고    scopus 로고
    • American Diabetes Association. All about diabetes [online] [Accessed 2009 Oct 10]
    • American Diabetes Association. All about diabetes [online]. Available from URL: http://www.diabetes.org/about-diabetes. jsp [Accessed 2009 Oct 10]
  • 2
    • 77949307201 scopus 로고    scopus 로고
    • Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States 2007. Atlanta (GA): U.S. Department of Health and Human Services, Centers for Disease Control and Prevention
    • Centers for Disease Control and Prevention. National diabetes fact sheet: general information and national estimates on diabetes in the United States, 2007. Atlanta (GA): U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, 2008
    • (2008)
  • 3
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • Patel A, MacMahon S, Chalmers J, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358: 2560-2572
    • (2008) N Engl J Med , vol.358 , pp. 2560-2572
    • Patel, A.1    MacMahon, S.2    Chalmers, J.3
  • 4
    • 0027988548 scopus 로고
    • The association of glycemia and cause specific mortality in a diabetic population
    • Moss SE, Klein R, Klein BE, et al. The association of glycemia and cause specific mortality in a diabetic population. Arch Intern Med 1994; 154: 2473-2479
    • (1994) Arch Intern Med , vol.154 , pp. 2473-2479
    • Moss, S.E.1    Klein, R.2    Klein, B.E.3
  • 5
    • 65649106228 scopus 로고    scopus 로고
    • Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: A meta-analysis of randomised controlled trials
    • Ray KK, Seshasai SR, Wijesuriya S, et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet 2009; 373: 1765-1772
    • (2009) Lancet , vol.373 , pp. 1765-1772
    • Ray, K.K.1    Seshasai, S.R.2    Wijesuriya, S.3
  • 6
    • 39149145482 scopus 로고    scopus 로고
    • Prevalence, treatment and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004
    • Ong KL, Cheung BM, Wong LY, et al. Prevalence, treatment and control of diagnosed diabetes in the U.S. National Health and Nutrition Examination Survey 1999-2004. Ann Epidemiol 2008; 18: 222-229
    • (2008) Ann Epidemiol , vol.18 , pp. 222-229
    • Ong, K.L.1    Cheung, B.M.2    Wong, L.Y.3
  • 7
    • 53049091868 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: A systematic review
    • Wani JH, John-Kalarickal J, Fonseca VA. Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: a systematic review. Cardiol Clin 2008; 26: 639-648
    • (2008) Cardiol Clin , vol.26 , pp. 639-648
    • Wani, J.H.1    John-Kalarickal, J.2    Fonseca, V.A.3
  • 8
    • 33744968835 scopus 로고    scopus 로고
    • Achievement of American Diabetes Association clinical practice recommendations among U.S. adults with diabetes 1999-2002: The National Health and Nutrition Examination Survey
    • Resnick HE, Foster GL, Bardsley J, et al. Achievement of American Diabetes Association clinical practice recommendations among U.S. adults with diabetes, 1999-2002: the National Health and Nutrition Examination Survey. Diabetes Care 2006; 29: 531-537
    • (2006) Diabetes Care , vol.29 , pp. 531-537
    • Resnick, H.E.1    Foster, G.L.2    Bardsley, J.3
  • 9
    • 0028817815 scopus 로고
    • Overview of 6 years' therapy of type II diabetes: A progressive disease
    • U.K. Prospective Diabetes Study Group. U.K. prospective diabetes study 16
    • U.K. Prospective Diabetes Study Group. U.K. prospective diabetes study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. Diabetes 1995; 44: 1249-1258
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 10
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49) UK Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, et al. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group. JAMA 1999; 281: 2005-2012
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3
  • 11
    • 1242272759 scopus 로고    scopus 로고
    • The sodium/glucose cotransport family SLC5
    • Wright EM, Turk E. The sodium/glucose cotransport family SLC5. Eur J Physiol 2004; 447: 510-518
    • (2004) Eur J Physiol , vol.447 , pp. 510-518
    • Wright, E.M.1    Turk, E.2
  • 12
    • 0028044629 scopus 로고
    • The human kidney low affinity Na+/glucose cotransporter SGLT2
    • Kanai Y, Lee W-S, You G, et al. The human kidney low affinity Na+/glucose cotransporter SGLT2. J Clin Invest 1994; 93: 397-404
    • (1994) J Clin Invest , vol.93 , pp. 397-404
    • Kanai, Y.1    Lee, W.-S.2    You, G.3
  • 13
    • 3242890250 scopus 로고    scopus 로고
    • SGLT as a therapeutic target
    • Asano T, Anai M, Sakoda H, et al. SGLT as a therapeutic target. Drugs Fut 2004; 29: 461-466
    • (2004) Drugs Fut , vol.29 , pp. 461-466
    • Asano, T.1    Anai, M.2    Sakoda, H.3
  • 14
    • 4544278198 scopus 로고    scopus 로고
    • Glucose cotransporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugs
    • Asano T, Ogihara T, Katagiri H, et al. Glucose cotransporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugs. Curr Med Chem 2004; 11: 2717-2724
    • (2004) Curr Med Chem , vol.11 , pp. 2717-2724
    • Asano, T.1    Ogihara, T.2    Katagiri, H.3
  • 17
    • 77949302627 scopus 로고    scopus 로고
    • Metabolic basis of solute transport
    • Brenner BM, editor 6th ed. Philadelphia (PA): W.B. Saunders Company
    • Gullans SR. Metabolic basis of solute transport. In: Brenner BM, editor. Brenner and Rector's, the kidney. 6th ed. Philadelphia (PA): W.B. Saunders Company, 2000: 234-235
    • (2000) Brenner and rector'S, the Kidney , pp. 234-235
    • Gullans, S.R.1
  • 18
    • 0030851974 scopus 로고    scopus 로고
    • Renal glucose production and utilization: New aspects in humans
    • Stumvoll M, Meyer C, Mitrakou A, et al. Renal glucose production and utilization: new aspects in humans. Diabetologia 1997; 40: 749-757
    • (1997) Diabetologia , vol.40 , pp. 749-757
    • Stumvoll, M.1    Meyer, C.2    Mitrakou, A.3
  • 19
    • 0032146567 scopus 로고    scopus 로고
    • Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus
    • Meyer C, Stumvoll M, Nadkarni V, et al. Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus. J Clin Invest 1998; 102: 619-624
    • (1998) J Clin Invest , vol.102 , pp. 619-624
    • Meyer, C.1    Stumvoll, M.2    Nadkarni, V.3
  • 22
    • 0014191210 scopus 로고
    • Renal glucose threshold variations with age
    • Butterfield WJH, Keen H, Whichelow MJ. Renal glucose threshold variations with age. BMJ 1967; 4: 505-507
    • (1967) BMJ , vol.4 , pp. 505-507
    • Butterfield, W.J.H.1    Keen, H.2    Whichelow, M.J.3
  • 23
    • 0003038618 scopus 로고    scopus 로고
    • Renal transport of glucose, amino acids, sodium, chloride, and water
    • Brenner BM, editor 6th ed. Philadelphia (PA): W.B. Saunders Company
    • Moe OW, Berry CA, Rector FC. Renal transport of glucose, amino acids, sodium, chloride, and water. In: Brenner BM, editor. Brenner and Rector's, the kidney. 6th ed. Philadelphia (PA): W.B. Saunders Company, 2000: 378-380
    • (2000) Brenner and rector'S, the Kidney , pp. 378-380
    • Moe, O.W.1    Berry, C.A.2    Rector, F.C.3
  • 24
    • 67349189212 scopus 로고    scopus 로고
    • Renal sodiumglucose transport: Role in diabetes mellitus and potential clinical implications
    • Bakris GL, Fonseca V, Sharma K, et al. Renal sodiumglucose transport: role in diabetes mellitus and potential clinical implications. Kidney International 2009; 75: 1272-1277
    • (2009) Kidney International , vol.75 , pp. 1272-1277
    • Bakris, G.L.1    Fonseca, V.2    Sharma, K.3
  • 25
    • 33846023326 scopus 로고    scopus 로고
    • Active sugar transport in health and disease
    • Wright EM, Hirayama BA, Loo DF. Active sugar transport in health and disease. J Intern Med 2007; 261: 32-43
    • (2007) J Intern Med , vol.261 , pp. 32-43
    • Wright, E.M.1    Hirayama, B.A.2    Loo, D.F.3
  • 26
    • 64749089393 scopus 로고    scopus 로고
    • Inhibition of renal glucose reabsorption: A novel strategy for achieving glucose control in type 2 diabetes mellitus
    • Abdul-Ghani MA, DeFronzo R. Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitus. Endocrine Practice 2008; 14 (6): 782-790
    • (2008) Endocrine Practice , vol.14 , Issue.6 , pp. 782-790
    • Abdul-Ghani, M.A.1    Defronzo, R.2
  • 27
    • 0028872833 scopus 로고
    • Uptake and release of glucose by the human kidney: Postabsorptive rates and responses to epinephrine
    • Stumvoll M, Chintalapudi U, Perriello G, et al. Uptake and release of glucose by the human kidney: postabsorptive rates and responses to epinephrine. J Clin Invest 1995; 96: 2528-2533
    • (1995) J Clin Invest , vol.96 , pp. 2528-2533
    • Stumvoll, M.1    Chintalapudi, U.2    Perriello, G.3
  • 28
    • 0036084280 scopus 로고    scopus 로고
    • Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis
    • Meyer C, Dostou JM, Welle SL, et al. Role of human liver, kidney, and skeletal muscle in postprandial glucose homeostasis. Am J Physiol Endocrinol Met 2002; 282: E419-27
    • (2002) Am J Physiol Endocrinol Met , vol.282
    • Meyer, C.1    Dostou, J.M.2    Welle, S.L.3
  • 30
    • 4544233390 scopus 로고    scopus 로고
    • Glycosylated dihydrochalcones as potent and selective sodium glucose co-transporters 2 (SGLT2) inhibitors
    • Dudash Jr J, Zhang X, Zeck RE, et al. Glycosylated dihydrochalcones as potent and selective sodium glucose co-transporters 2 (SGLT2) inhibitors. Bioorg Med Chem Lett 2004; 14: 5121-5125
    • (2004) Bioorg Med Chem Lett , vol.14 , pp. 5121-5125
    • Dudash Jr, J.1    Zhang, X.2    Zeck, R.E.3
  • 31
    • 1842618397 scopus 로고
    • The action of phlorizin on the excretion of glucose, xylose, sucrose, creatinine and urea by man
    • Chassis H, Joliffe N, Smith H. The action of phlorizin on the excretion of glucose, xylose, sucrose, creatinine and urea by man. J Clin Invest 1933; 12: 1083-1089
    • (1933) J Clin Invest , vol.12 , pp. 1083-1089
    • Chassis, H.1    Joliffe, N.2    Smith, H.3
  • 32
    • 0028234548 scopus 로고
    • The high affinity NA/ glucose cotransporter: Re-evaluation and distribution of expression
    • Lee WS, Wells RG, Hediger MA. The high affinity NA/ glucose cotransporter: re-evaluation and distribution of expression. J Biol Chem 1994; 269: 12032-12039
    • (1994) J Biol Chem , vol.269 , pp. 12032-12039
    • Lee, W.S.1    Wells, R.G.2    Hediger, M.A.3
  • 33
    • 58149357463 scopus 로고    scopus 로고
    • Sodium-glucose co-transporter-2 inhibitors: An emerging new class of oral antidiabetic drug
    • Idris I, Donnelly R. Sodium-glucose co-transporter-2 inhibitors: an emerging new class of oral antidiabetic drug. Diabetes Obes Metab 2009; 11: 79-88
    • (2009) Diabetes Obes Metab , vol.11 , pp. 79-88
    • Idris, I.1    Donnelly, R.2
  • 34
    • 65349196064 scopus 로고    scopus 로고
    • Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes
    • List JF, Woo V, Morales E, et al. Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetes. Diabetes Care 2009; 32: 650-657
    • (2009) Diabetes Care , vol.32 , pp. 650-657
    • List, J.F.1    Woo, V.2    Morales, E.3
  • 35
    • 64749099761 scopus 로고    scopus 로고
    • Glucose control by the kidney: An emerging target in diabetes
    • Marsenic O. Glucose control by the kidney: an emerging target in diabetes. Am J Kidney Dis 2009; 53: 875-883
    • (2009) Am J Kidney Dis , vol.53 , pp. 875-883
    • Marsenic, O.1
  • 36
    • 47149118686 scopus 로고    scopus 로고
    • Sodium glucose co-transporter 2 inhibitors: Blocking renal tubular re-absorption of glucose to improve glycaemic control in patients with diabetes
    • Jabbour SA, Goldstein BJ. Sodium glucose co-transporter 2 inhibitors: blocking renal tubular re-absorption of glucose to improve glycaemic control in patients with diabetes. Int J Clin Pract 2008; 62: 1279-1284
    • (2008) Int J Clin Pract , vol.62 , pp. 1279-1284
    • Jabbour, S.A.1    Goldstein, B.J.2
  • 37
    • 67349180574 scopus 로고    scopus 로고
    • Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects
    • Komoroski B, Vachharajani N, Boulton D, et al. Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjects. Clin Pharm Ther 2009; 85: 520-524
    • (2009) Clin Pharm Ther , vol.85 , pp. 520-524
    • Komoroski, B.1    Vachharajani, N.2    Boulton, D.3
  • 38
    • 67349275999 scopus 로고    scopus 로고
    • Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mel-litus
    • Komoroski B, Vachharajani N, Feng Y, et al. Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mel-litus. Clin Pharm Ther 2009; 85: 513-519
    • (2009) Clin Pharm Ther , vol.85 , pp. 513-519
    • Komoroski, B.1    Vachharajani, N.2    Feng, Y.3
  • 39
    • 75449116963 scopus 로고    scopus 로고
    • Dapagliflozin as an add-on to metformin lowers hyperglycemia in type 2 diabetes patients inadequately controlled with metformin alone [abstract no. OP169]
    • Bailey CJ, Gross JL, Bastone L, et al. Dapagliflozin as an add-on to metformin lowers hyperglycemia in type 2 diabetes patients inadequately controlled with metformin alone [abstract no. OP169]. Diabetologia 2009; 52 Suppl. 1: S76
    • (2009) Diabetologia , vol.52 , Issue.SUPPL. 1
    • Bailey, C.J.1    Gross, J.L.2    Bastone, L.3
  • 40
    • 69549095914 scopus 로고    scopus 로고
    • A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers
    • Wilding JPH, Norwood P, T'joen C, et al. A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers. Diabetes Care 2009; 32: 1656-1662
    • (2009) Diabetes Care , vol.32 , pp. 1656-1662
    • Wilding, J.P.H.1    Norwood, P.2    T'Joen, C.3
  • 41
    • 77949287286 scopus 로고    scopus 로고
    • US National Institutes of Health. ClinicalTrials.gov [online] [Accessed 2009 Oct 10]
    • US National Institutes of Health. ClinicalTrials.gov [online]. Available from URL: http://www.clinicaltrials.gov [Accessed 2009 Oct 10]
  • 42
    • 79952239785 scopus 로고    scopus 로고
    • Renal effects of the sodiumglucose co-transporter 2 (SGLT2) inhibitor depagliflozin (BMS-512148) in patients with type 2 diabetes mellitus (T2DM) [abstract no. PO1022]
    • Lesli B, Tang W, List JF. Renal effects of the sodiumglucose co-transporter 2 (SGLT2) inhibitor depagliflozin (BMS-512148) in patients with type 2 diabetes mellitus (T2DM) [abstract no. PO1022]. J Am Soc Nephrol 2008; 19
    • (2008) J Am Soc Nephrol , vol.19
    • Lesli, B.1    Tang, W.2    List, J.F.3
  • 43
    • 77949289404 scopus 로고    scopus 로고
    • Kissei Pharmaceutical Co. Ltd. Discontinuation of the development of "Remogliflozin" by GlaxoSmithKline [online] [Accessed 2009 Oct 10]
    • Kissei Pharmaceutical Co., Ltd. Discontinuation of the development of "Remogliflozin" by GlaxoSmithKline [online]. Available from URL: http://www.kissei.co.fp/e-contents/ press-e/2009/e20090703.html [Accessed 2009 Oct 10]
  • 44
    • 68849127256 scopus 로고    scopus 로고
    • Discontinued drugs in 2008 endocrine and metabolic
    • Colca JR. Discontinued drugs in 2008: endocrine and metabolic. Exp Opin Invest Drugs 2009; 18: 1243-1255
    • (2009) Exp Opin Invest Drugs , vol.18 , pp. 1243-1255
    • Colca, J.R.1
  • 46
    • 33845873376 scopus 로고    scopus 로고
    • Sergliflozin, a novel selective inhibitor of low-affinity sodium glucosa cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level
    • Katsuno K, Fujimori Y, Takemura Y, et al. Sergliflozin, a novel selective inhibitor of low-affinity sodium glucosa cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose level. J Pharmacol Exp Ther 2007; 320: 323-330
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 323-330
    • Katsuno, K.1    Fujimori, Y.2    Takemura, Y.3
  • 47
    • 48249146624 scopus 로고    scopus 로고
    • Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats
    • Han S, Hagan DL, Taylor JR, et al. Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic rats. Diabetes 2008; 57: 1723-1729
    • (2008) Diabetes , vol.57 , pp. 1723-1729
    • Han, S.1    Hagan, D.L.2    Taylor, J.R.3
  • 48
    • 52649083832 scopus 로고    scopus 로고
    • Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models
    • Fujimori Y, Katsuno K, Nakashima I, et al. Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent models. J Pharmacol Exp Ther 2008; 327: 268-276
    • (2008) J Pharmacol Exp Ther , vol.327 , pp. 268-276
    • Fujimori, Y.1    Katsuno, K.2    Nakashima, I.3
  • 49
    • 41649087328 scopus 로고    scopus 로고
    • Discovery of dapagliflozin: A potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes
    • Meng W, Ellsworth BA, Nirschl AA, et al. Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes. J Med Chem 2008; 51: 1145-1149
    • (2008) J Med Chem , vol.51 , pp. 1145-1149
    • Meng, W.1    Ellsworth, B.A.2    Nirschl, A.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.