Synthesis, biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin

Journal of Medicinal Chemistry

Volumn 48, Issue 12, 2005, Pages 4068-4075

  García, Mario A ^a   Martín Santamaría, Sonsoles ^a   Cacho, Mónica ^a,c   Moreno De La Llave, Fernando ^a   Julían, Miguel ^a   Martínez, Alfredo ^b   De Pascual Teresa, Beatriz ^a   Ramos, Ana ^a  

^a UNIVERSIDAD SAN PABLO CEU   (Spain)

^b INSTITUTO CAJAL   (Spain)

^c INSTITUTO DE QUÍMICA MÉDICA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 BIS(4 BENZYL 5 PHENOXYMETHYL[1,2,4]TRIAZOL 3 YL)BUTANE; 1,4 BIS(5 PHENOXYMETHYL[1,3,4]OXADIAZOL 2 YL)BUTANE; 1,5 BIS(4 BENZYL 5 PHENOXYMETHYL[1,2,4]TRIAZOL 3 YL)PENTANE; 1,5 BIS(5 PHENOXYMETHYL[1,3,4]OXADIAZOL 2 YL)PENTANE; 1,6 BIS(4 BENZYL 5 PHENOXYMETHYL[1,2,4]TRIAZOL 3 YL)HEXANE; 1,6 BIS(5 PHENOXYMETHYL[1,3,4]OXADIAZOL 2 YL)HEXANE; 1,7 BIS(4 BENZYL 5 PHENOXYMETHYL[1,2,4]TRIAZOL 3 YL)HEPTANE; 1,7 BIS(5 PHENOXYMETHYL[1,3,4]OXADIAZOL 2 YL)HEPTANE; 1,8 BIS(4 BENZYL 5 PHENOXYMETHYL[1,2,4]TRIAZOL 3 YL)OCTANE; 1,8 BIS(5 PHENOXYMETHYL[1,3,4]OXADIAZOL 2 YL)OCTANE; ADRENOMEDULLIN; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; MOLECULAR DYNAMICS; MOLECULAR MODEL; STRUCTURE ACTIVITY RELATION;

ADRENOMEDULLIN; ANTIHYPERTENSIVE AGENTS; ANTINEOPLASTIC AGENTS; BENZENE DERIVATIVES; CALCITONIN GENE-RELATED PEPTIDE; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NAPHTHALENES; PEPTIDES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 20444400806     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm050021+     Document Type: Article

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