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Volumn 3, Issue 9, 2008, Pages 1345-1355

Small-molecule negative modulators of adrenomedullin: Design, synthesis, and 3D-QSAR study

(8) Roldós, Virginia a Martín Santamaría, Sonsoles a Julián, Miguel a Martínez, Alfredo b Choulier, Laurence c Altschuh, Danièle c De Pascual Teresa, Beatriz a Ramos, Ana a

a UNIVERSIDAD SAN PABLO CEU (Spain)

b INSTITUTO CAJAL (Spain)

c UNIVERSITÉ DE STRASBOURG (France)

Author keywords

Adrenomedullin; Drug design; Negative modulators; Organic synthesis; Structure activity relationships

Indexed keywords

ADRENOMEDULLIN; CYCLIC AMP; LIGAND; MONOCLONAL ANTIBODY; PIPERAZINE DERIVATIVE;

ANIMAL; ARTICLE; BINDING COMPETITION; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; FIBROBLAST; HYDROGEN BOND; HYDROPHOBICITY; METABOLISM; MOLECULAR WEIGHT; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; SURFACE PLASMON RESONANCE; SYNTHESIS; THREE DIMENSIONAL IMAGING; TIME;

ADRENOMEDULLIN; ANIMALS; ANTIBODIES, MONOCLONAL; BINDING, COMPETITIVE; CELL LINE; CYCLIC AMP; DRUG EVALUATION, PRECLINICAL; FIBROBLASTS; HYDROGEN BONDING; HYDROPHOBICITY; IMAGING, THREE-DIMENSIONAL; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PIPERAZINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; SURFACE PLASMON RESONANCE; TIME FACTORS;

EID: 54849413586 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.200800066 Document Type: Article

Times cited : (9)

References (34)

1
- 0027197671
- K. Kitamura, K. Kangawa, M. Kawamoto, Y. Ichiki, S. Nakamura, H. Matsuo, T. Eto, Biochem. Biophys. Res. Commun. 1993, 192, 553.
- (1993) Biochem. Biophys. Res. Commun , vol.192 , pp. 553
- Kitamura, K.¹ Kangawa, K.² Kawamoto, M.³ Ichiki, Y.⁴ Nakamura, S.⁵ Matsuo, H.⁶ Eto, T.⁷

2
- 0034453838
- J. P. Hinson, S. Kapas, D. M. Smith, Endocr. Rev. 2000, 21, 138.
- (2000) Endocr. Rev , vol.21 , pp. 138
- Hinson, J.P.¹ Kapas, S.² Smith, D.M.³

3
- 0036443430
- J. López, A. Martínez, Int. Rev. Cytol. 2002, 221, 1.
- (2002) Int. Rev. Cytol , vol.221 , pp. 1
- López, J.¹ Martínez, A.²

4
- 0037090641
- J. López, N. Cuesta, Microsc. Res. Tech. 2002, 57, 61.
- (2002) Microsc. Res. Tech , vol.57 , pp. 61
- López, J.¹ Cuesta, N.²

5
- 0033029032
- W. K. Samson, Annu. Rev. Physiol. 1999, 61, 363.
- (1999) Annu. Rev. Physiol , vol.61 , pp. 363
- Samson, W.K.¹

6
- 0030724823
- G. G. Nussdorfer, G. P. Rossi, G. Mazzocchi, Peptides 1997, 18, 1079.
- (1997) Peptides , vol.18 , pp. 1079
- Nussdorfer, G.G.¹ Rossi, G.P.² Mazzocchi, G.³

7
- 33645782206
- M. A. García, S. Martín-Santamaria, B. de Pascual-Teresa, A. Ramos, M. Julian Viñals, A. Martínez, Expert Opin. Ther. Targets 2006, 10, 303.
- (2006) Expert Opin. Ther. Targets , vol.10 , pp. 303
- García, M.A.¹ Martín-Santamaria, S.² de Pascual-Teresa, B.³ Ramos, A.⁴ Julian Viñals, M.⁵ Martínez, A.⁶

8
- 0028063424
- T. Ishimitsu, T. Nishikimi, Y. Saito, K. Kitamura, T. Eto, K. Kangawa, H. Matsuo, T. Omae, H. Matsuoka, J. Clin. Invest. 1994, 94, 2158.
- (1994) J. Clin. Invest , vol.94 , pp. 2158
- Ishimitsu, T.¹ Nishikimi, T.² Saito, Y.³ Kitamura, K.⁴ Eto, T.⁵ Kangawa, K.⁶ Matsuo, H.⁷ Omae, T.⁸ Matsuoka, H.⁹

9
- 0034284180
- J. J. Zhang, H. Yoshida, L. Chao, J. Chao, Hum. Gene Ther. 2000, 11, 1817.
- (2000) Hum. Gene Ther , vol.11 , pp. 1817
- Zhang, J.J.¹ Yoshida, H.² Chao, L.³ Chao, J.⁴

10
- 0031454520
- J. Chao, L. Jin, K. F. Lin, L. Chao, Hypertens. Res. 1997, 20, 269.
- (1997) Hypertens. Res , vol.20 , pp. 269
- Chao, J.¹ Jin, L.² Lin, K.F.³ Chao, L.⁴

11
- 0030860164
- T. Sumimoto, T. Nishikimi, M. Mukai, K. Matsuzaki, E. Murakami, S. Takishita, A. Miyata, H. Matsuo, K. Kangawa, Hypertension 1997, 30, 741.
- (1997) Hypertension , vol.30 , pp. 741
- Sumimoto, T.¹ Nishikimi, T.² Mukai, M.³ Matsuzaki, K.⁴ Murakami, E.⁵ Takishita, S.⁶ Miyata, A.⁷ Matsuo, H.⁸ Kangawa, K.⁹

12
- 0035688596
- J. Chao, K. Kato, J. J. Zhang, E. Dobrzynski, C. Wang, J. Agata, L. Chao, Peptides 2001, 22, 1731.
- (2001) Peptides , vol.22 , pp. 1731
- Chao, J.¹ Kato, K.² Zhang, J.J.³ Dobrzynski, E.⁴ Wang, C.⁵ Agata, J.⁶ Chao, L.⁷

13
- 0037154960
- J. Serrano, D. Alonso, J. M. Encinas, J. C. López, A. P. Fernandez, S. Castro-Blanco, P. Fernández-Vizarra, A. Richart, M. L. Bentura, M. Santacana, L. O. Uttenthal, F. Cuttitta, J. Rodrigo, A. Martínez, Neuroscience 2002, 109, 717.
- (2002) Neuroscience , vol.109 , pp. 717
- Serrano, J.¹ Alonso, D.² Encinas, J.M.³ López, J.C.⁴ Fernandez, A.P.⁵ Castro-Blanco, S.⁶ Fernández-Vizarra, P.⁷ Richart, A.⁸ Bentura, M.L.⁹ Santacana, M.¹⁰ Uttenthal, L.O.¹¹ Cuttitta, F.¹² Rodrigo, J.¹³ Martínez, A.¹⁴

14
- 0037299218
- S
- T. Shimosawa, H. Matsui, G. Xing, K. Itakura, K. Ando, T. Fujita, Hypertens. Res. 2003, 26 Suppl., S109.
- (2003) Hypertens. Res , vol.26 , Issue.SUPPL. , pp. 109
- Shimosawa, T.¹ Matsui, H.² Xing, G.³ Itakura, K.⁴ Ando, K.⁵ Fujita, T.⁶

15
- 0037445799
- E. Zudaire, A. Martínez, F. Cuttitta, Regul. Pept. 2003, 112, 175.
- (2003) Regul. Pept , vol.112 , pp. 175
- Zudaire, E.¹ Martínez, A.² Cuttitta, F.³

16
- 0032556955
- Y. Zhao, S. Hague, S. Manek, L. Zhang, R. Bicknell, M. C. Rees, Oncogene 1998, 16, 409.
- (1998) Oncogene , vol.16 , pp. 409
- Zhao, Y.¹ Hague, S.² Manek, S.³ Zhang, L.⁴ Bicknell, R.⁵ Rees, M.C.⁶

17
- 0037151394
- A. Martínez, M. Vos, L. Guedez, G. Kaur, Z. Chen, M. Garayoa, R. Pio, T. Moody, W. G. Stetler-Stevenson, H. K. Kleinman, F. Cuttitta, J. Natl. Cancer Inst. 2002, 94, 1226.
- (2002) J. Natl. Cancer Inst , vol.94 , pp. 1226
- Martínez, A.¹ Vos, M.² Guedez, L.³ Kaur, G.⁴ Chen, Z.⁵ Garayoa, M.⁶ Pio, R.⁷ Moody, T.⁸ Stetler-Stevenson, W.G.⁹ Kleinman, H.K.¹⁰ Cuttitta, F.¹¹

18
- 0037171952
- M. K. Oehler, S. Hague, M. C. Rees, R. Bicknell, Oncogene 2002, 21, 2815.
- (2002) Oncogene , vol.21 , pp. 2815
- Oehler, M.K.¹ Hague, S.² Rees, M.C.³ Bicknell, R.⁴

19
- 0037468266
- T. Ishikawa, J. Chen, J. X. Wang, F. Okada, T. Sugiyama, T. Kobayashi, M. Shindo, F. Higashino, H. Katoh, M. Asaka, T. Kondo, M. Hosokawa, M. Kobayashi, Oncogene 2003, 22, 1238.
- (2003) Oncogene , vol.22 , pp. 1238
- Ishikawa, T.¹ Chen, J.² Wang, J.X.³ Okada, F.⁴ Sugiyama, T.⁵ Kobayashi, T.⁶ Shindo, M.⁷ Higashino, F.⁸ Katoh, H.⁹ Asaka, M.¹⁰ Kondo, T.¹¹ Hosokawa, M.¹² Kobayashi, M.¹³

20
- 0037090715
- F. Cuttitta, R. Pio, M. Garayoa, E. Zudaire, M. Julian, T. H. Elsasser, L. M. Montuenga, A. Martínez, Microsc. Res. Tech. 2002, 57, 110.
- (2002) Microsc. Res. Tech , vol.57 , pp. 110
- Cuttitta, F.¹ Pio, R.² Garayoa, M.³ Zudaire, E.⁴ Julian, M.⁵ Elsasser, T.H.⁶ Montuenga, L.M.⁷ Martínez, A.⁸

21
- 0029834198
- M. J. Miller, A. Martínez, E. J. Unsworth, C. J. Thiele, T. W. Moody, T. Elsasser, F. Cuttitta, J. Biol. Chem. 1996, 271, 23345.
- (1996) J. Biol. Chem , vol.271 , pp. 23345
- Miller, M.J.¹ Martínez, A.² Unsworth, E.J.³ Thiele, C.J.⁴ Moody, T.W.⁵ Elsasser, T.⁶ Cuttitta, F.⁷

22
- 0030974584
- H. C. Champion, D. E. Friedman, D. G. Lambert, W. A. Murphy, D. H. Coy, P. J. Kadowitz, Peptides 1997, 18, 133.
- (1997) Peptides , vol.18 , pp. 133
- Champion, H.C.¹ Friedman, D.E.² Lambert, D.G.³ Murphy, W.A.⁴ Coy, D.H.⁵ Kadowitz, P.J.⁶

23
- 0035682209
- K. Kitamura, E. Matsui, H. Kato, F. Katoh, T. Kita, T. Tsuji, K. Kangawa, T. Eto, Peptides 2001, 22, 1713.
- (2001) Peptides , vol.22 , pp. 1713
- Kitamura, K.¹ Matsui, E.² Kato, H.³ Katoh, F.⁴ Kita, T.⁵ Tsuji, T.⁶ Kangawa, K.⁷ Eto, T.⁸

24
- 3843069804
- A. Martínez, M. Julián, C. Bregonzio, L. Notari, T. Moody, F. Cuttita, Endocrinology 2004, 145, 3858.
- (2004) Endocrinology , vol.145 , pp. 3858
- Martínez, A.¹ Julián, M.² Bregonzio, C.³ Notari, L.⁴ Moody, T.⁵ Cuttita, F.⁶

25
- 20444400806
- M. A. Garcia, S. Martín-Santamaría, M. Cacho, F. M. de La Llave, M. Julian, A. Martínez, B. de Pascual-Teresa, A. Ramos, J. Med. Chem. 2005, 48, 4068.
- (2005) J. Med. Chem , vol.48 , pp. 4068
- Garcia, M.A.¹ Martín-Santamaría, S.² Cacho, M.³ de La Llave, F.M.⁴ Julian, M.⁵ Martínez, A.⁶ de Pascual-Teresa, B.⁷ Ramos, A.⁸

26
- 33947463769
- F. Blicke, H. Zinnes, J. Am. Chem. Soc. 1955, 77, 5168.
- (1955) J. Am. Chem. Soc , vol.77 , pp. 5168
- Blicke, F.¹ Zinnes, H.²

27
- 0006009610
- P. S. Engel, M. A. Schexnayder, J. Am. Chem. Soc. 1975, 97, 145.
- (1975) J. Am. Chem. Soc , vol.97 , pp. 145
- Engel, P.S.¹ Schexnayder, M.A.²

28
- 54849412030
- Molecular Discovery, Ltd., Perugia (Italy) 2004
- last access July 31
- G. Cruciani, F. Fontaine, M. Pastor: Molecular Discovery, Ltd., Perugia (Italy) 2004: http://www.moldiscovery.com/index.php (last access July 31, 2008).
- (2008)
- Cruciani, G.¹ Fontaine, F.² Pastor, M.³

29
- 2442659094
- F. Fontaine, M. Pastor, F. Sanz, J. Med. Chem. 2004, 47, 2805.
- (2004) J. Med. Chem , vol.47 , pp. 2805
- Fontaine, F.¹ Pastor, M.² Sanz, F.³

30
- 0021871375
- P. J. Goodford, J. Med. Chem. 1985, 28, 849.
- (1985) J. Med. Chem , vol.28 , pp. 849
- Goodford, P.J.¹

31
- 0033557890
- H. A. Coppock, A. A. Owji, C. Austin, P. D. Upton, M. L. Jackson, J. V. Gardiner, M. A. Ghatei, S. R. Bloom, D. M. Smith, Biochem. J. 1999, 338, 15.
- (1999) Biochem. J , vol.338 , pp. 15
- Coppock, H.A.¹ Owji, A.A.² Austin, C.³ Upton, P.D.⁴ Jackson, M.L.⁵ Gardiner, J.V.⁶ Ghatei, M.A.⁷ Bloom, S.R.⁸ Smith, D.M.⁹

32
- 0035853722
- R. Pio, A. Martínez, E. J. Unsworth, J. A. Kowalak, J. A. Bengoechea, P. F. Zipfel, T. H. Elsasser, F. Cuttitta, J. Biol. Chem. 2001, 276, 12292.
- (2001) J. Biol. Chem , vol.276 , pp. 12292
- Pio, R.¹ Martínez, A.² Unsworth, E.J.³ Kowalak, J.A.⁴ Bengoechea, J.A.⁵ Zipfel, P.F.⁶ Elsasser, T.H.⁷ Cuttitta, F.⁸

33
- 0034087890
- A. Frostell-Karlsson, A. Remaeus, H. Roos, K. Andersson, P. Borg, M. Hämäläinen, R. Karlsson, J. Med. Chem. 2000, 43, 1986.
- (1986) J. Med. Chem , vol.2000 , pp. 43
- Frostell-Karlsson, A.¹ Remaeus, A.² Roos, H.³ Andersson, K.⁴ Borg, P.⁵ Hämäläinen, M.⁶ Karlsson, R.⁷

34
- 0004209464
- Pittsburgh, PA USA
- M. J. Frisch et al.: Gaussian Inc., Pittsburgh, PA (USA) 2001.
- (2001) Gaussian Inc
- Frisch, M.J.¹

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