Pterocarpanquinones, aza-pterocarpanquinone and derivatives: Synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on Leishmania amazonensis

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 22, 2011, Pages 6885-6891

  Buarque, Camilla D ^a,b   Militão, Gardenia C G ^c   Lima, Daisy J B ^d   Costa Lotufo, Leticia V ^d   Pessoa, Cláudia ^d   De Moraes, Manoel Odorico ^d   Cunha Junior, Edézio Ferreira ^e   Torres Santos, Eduardo Caio ^e   Netto, Chaquip D ^b   Costa, Paulo R R ^b  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

^d FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^e INSTITUTO OSWALDO CRUZ   (Brazil)

Author keywords

Antileishmanial activity; Antineoplasic activity; Aza Heck; Aza pterocarpanquinone; Azaarylation; Oxa Heck; Pterocarpanquinone

Indexed keywords

ANTILEISHMANIAL AGENT; ANTINEOPLASTIC AGENT; AZAPTEROCARPANQUINONE DERIVATIVE; DOXORUBICIN; PALLADIUM; PTEROCARPANQUINONE DERIVATIVE; UNCLASSIFIED DRUG;

AMASTIGOTE; ANTILEISHMANIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARYLATION; AZAARYLATION; CANCER CELL CULTURE; CATALYSIS; CONFERENCE PAPER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HECK REACTION; HUMAN; HUMAN CELL; IC 50; LEISHMANIA; LEUKEMIA CELL; NONHUMAN; OXYARYLATION; PROMASTIGOTE; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HL-60 CELLS; HUMANS; K562 CELLS; LEISHMANIA MEXICANA; MICE; MICE, INBRED BALB C; PTEROCARPANS; QUINONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS;

LEISHMANIA AMAZONENSIS;

EID: 80055005112     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.025     Document Type: Conference Paper

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