Targeted deletion of the cytosolic Cu/Zn-superoxide dismutase gene (Sod1) increases susceptibility to noise-induced hearing loss

Audiology and Neuro-Otology

Volumn 4, Issue 5, 1999, Pages 237-246

  Ohlemiller, Kevin K ^a   McFadden, Sandra L ^b   Ding, Da Lian ^b   Flood, Dorothy G ^c   Reaume, Andrew G ^c   Hoffman, Eric K ^c   Scott, Richard W ^c   Wright, James S ^a   Putcha, Girish V ^d   Salvi, Richard J ^b  

^a CENTRAL INSTITUTE FOR THE DEAF   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c CEPHALON INC   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Free radical; Knockout mouse; Permanent threshold shift; Reactive oxygen species

Indexed keywords

REACTIVE OXYGEN METABOLITE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY THRESHOLD SHIFT; CONTROLLED STUDY; ENZYME DEFICIENCY; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; GENE DELETION; GENETIC SUSCEPTIBILITY; MALE; MOUSE; NOISE INJURY; NONHUMAN; PRIORITY JOURNAL;

ALLELES; ANIMALS; AUDITORY THRESHOLD; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; FEMALE; GENE AMPLIFICATION; GENE DELETION; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAIR CELLS; HEARING LOSS, NOISE-INDUCED; MALE; MICE; MICE, KNOCKOUT; NOISE; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 0032767363     PISSN: 14203030     EISSN: None     Source Type: Journal    
DOI: 10.1159/000013847     Document Type: Article

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