N-[2-methyl-5-(triazol-1-yl)phenyl]pyrimidin-2-amine as a Scaffold for the synthesis of inhibitors of Bcr-Abl

ChemMedChem

Volumn 6, Issue 11, 2011, Pages 2009-2018

  Arioli, Federica ^a   Borrelli, Stella ^a   Colombo, Francesco ^a   Falchi, Federico ^b   Filippi, Irene ^b   Crespan, Emmanuele ^c   Naldini, Antonella ^b   Scalia, Giusy ^b   Silvani, Alessandra ^a   Maga, Giovanni ^c   Carraro, Fabio ^b   Botta, Maurizio ^b   Passarella, Daniele ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c CNR   (Italy)

Author keywords

Bcr Abl; CuAAC; Imatinib; Inhibitors; Leukemia; Triazoles

Indexed keywords

BCR ABL PROTEIN; COPPER; FA 030; IMATINIB; PROTEIN TYROSINE PHOSPHATASE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONTROLLED STUDY; CYCLOADDITION; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CDC25 PHOSPHATASES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FUSION PROTEINS, BCR-ABL; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; MODELS, MOLECULAR; MUTATION; PHOSPHORYLATION; PIPERAZINES; PROTEIN KINASE INHIBITORS; PYRIMIDINES; SRC-FAMILY KINASES; STAT5 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 80055001778     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100304     Document Type: Article

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