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Volumn 5, Issue 8, 2010, Pages 1226-1231

Design and synthesis of thiadiazoles and thiazoles targeting the Bcr-Abl T315I mutant: From docking false positives to ATP-noncompetitive inhibitors

(9) Radi, Marco a Crespan, Emmanuele b Falchi, Federico a Bernardo, Vincenzo a Zanoli, Samantha b Manetti, Fabrizio a Schenone, Silvia c Maga, Giovanni b Botta, Maurizio a,d

a UNIVERSITY OF SIENA (Italy)

b CNR (Italy)

c UNIVERSITY OF GENOA (Italy)

d TEMPLE UNIVERSITY (United States)

Author keywords

Bcr Abl; Chronic myeloid leukemia; T315I; Thiadiazoles; Thiazoles

Indexed keywords

BCR ABL PROTEIN; THIADIAZOLE DERIVATIVE; THIAZOLE DERIVATIVE;

ARTICLE; CHRONIC MYELOID LEUKEMIA; COMPETITIVE INHIBITION; DRUG DESIGN; DRUG MECHANISM; DRUG PENETRATION; DRUG SYNTHESIS; DRUG TARGETING; LIPOPHILICITY; POINT MUTATION; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; BENZAMIDES; BINDING SITES; COMPUTER SIMULATION; DRUG DESIGN; FUSION PROTEINS, BCR-ABL; MUTAGENESIS, SITE-DIRECTED; THIADIAZOLES; THIAZOLES;

EID: 77955122860 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201000066 Document Type: Article

Times cited : (22)

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