Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/β-catenin pathway

Journal of Experimental and Clinical Cancer Research

Volumn 30, Issue 1, 2011, Pages

  Xu, Weiru ^a,b   Lin, Hongsheng ^a   Zhang, Ying ^a   Chen, Xinyi ^b   Hua, Baojin ^a   Hou, Wei ^a   Qi, Xin ^a   Pei, Yingxia ^a   Zhu, Xiaoyun ^a   Zhao, Zhizheng ^a   Yang, Liangliang ^a  

^a INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^b BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

cancer stem like cells; cisplatin; Compound Kushen Injection; MCF 7; side population; Wnt catenin signaling

Indexed keywords

BETA CATENIN; CHINESE DRUG; CISPLATIN; COMPOUND KUSHEN INJECTION; UNCLASSIFIED DRUG; WNT PROTEIN; ANTINEOPLASTIC AGENT; HERBACEOUS AGENT; KUSHEN; MESSENGER RNA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER STEM CELL; CARCINOGENESIS; CELL STRAIN MCF 7; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CHEMISTRY; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; MOUSE MUTANT; NONOBESE DIABETIC MOUSE; TUMOR CELL LINE; WNT SIGNALING PATHWAY;

ANIMALS; ANTINEOPLASTIC AGENTS; BETA CATENIN; CELL LINE, TUMOR; DOWN-REGULATION; DRUGS, CHINESE HERBAL; FEMALE; HUMANS; MICE; MICE, INBRED NOD; MICE, SCID; NEOPLASTIC STEM CELLS; RNA, MESSENGER; WNT PROTEINS; WNT SIGNALING PATHWAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80054998123     PISSN: None     EISSN: 17569966     Source Type: Journal    
DOI: 10.1186/1756-9966-30-103     Document Type: Article

References (46)

1. Stem cells, cancer, and cancer stem cells. Reya T, Morrison SJ, Clarke MF, Weissman IL, Nature 2001 414 105 111 10.1038/35102167 11689955 (Pubitemid 33041634)
2. Mechanisms of cancer drug resistance. Gottesman MM, Annu Rev Med 2002 53 615 627 10.1146/annurev.med.53.082901.103929 11818492 (Pubitemid 34177898)
3. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP, Nat Med 2001 7 1028 1034 10.1038/nm0901-1028 11533706 (Pubitemid 32937383)
4. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Bao S, Wu Q, Mclendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN, Nature 2006 444 756 760 10.1038/nature05236 17051156 (Pubitemid 44949604)
5. Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro. Graham SM, Jorgensen HG, Allan E, Pearson C, Alcorn MJ, Richmond L, Holyoake TL, Blood 2002 99 319 325 10.1182/blood.V99.1.319 11756187 (Pubitemid 34532999)
6. Immunoselection of breast and ovarian cancer cells with trastuzumab and natural killer cells: selective escape of CD44high/CD24low/HER2low breast cancer stem cells. Reim F, Dombrowski Y, Ritter C, Buttmann M, Hausler S, Ossadnik M, Krockenberger M, Beier D, Beier CP, Dietl J, Becker JC, Honig A, Wischhusen J, Cancer Res 2009 69 8058 8066 10.1158/0008-5472.CAN-09-0834 19826050
7. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Bonnet D, Dick JE, Nat Med 1997 3 730 737 10.1038/nm0797-730 9212098 (Pubitemid 27298715)
8. Prospective identification of tumorigenic breast cancer cells. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF, Proc Natl Acad Sci USA 2003 100 3983 3988 10.1073/pnas.0530291100 12629218 (Pubitemid 36418143)
9. Identification of human brain tumour initiating cells. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, Henkelman RM, Cusimano MD, Dirks PB, Nature 2004 432 396 401 10.1038/nature03128 15549107 (Pubitemid 39551674)
10. CD133, a novel marker for human prostatic epithelial stem cells. Richardson GD, Robson CN, Lang SH, Neal DE, Maitland NJ, Collins AT, J Cell Sci 2004 117 3539 3545 10.1242/jcs.01222 15226377 (Pubitemid 39206394)
11. Cancer stem cells in human gastrointestinal cancers. Haraguchi N, Inoue H, Tanaka F, Mimori K, Utsunomiya T, Sasaki A, Mori M, Hum Cell 2006 19 24 29 10.1111/j.1749-0774.2005.00004.x 16643604
12. Persistence of a small subpopulation of cancer stem-like cells in the C6 glioma cell line. Kondo T, Setoguchi T, Taga T, Proc Natl Acad Sci USA 2004 101 781 786 10.1073/pnas.0307618100 14711994 (Pubitemid 38121035)
13. Characterization of a side population of cancer cells from human gastrointestinal system. Haraguchi N, Utsunomiya T, Inoue H, Tanaka F, Mimori K, Barnard GF, Mori M, Stem Cells 2006 24 506 513 10.1634/stemcells.2005-0282 16239320 (Pubitemid 44464754)
14. Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic. Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG, Cancer Res 2005 65 6207 6219 10.1158/0008-5472.CAN-05-0592 16024622 (Pubitemid 40994406)
15. Identification of cancer stem cell-like side population cells in human nasopharyngeal carcinoma cell line. Wang J, Guo LP, Chen LZ, Zeng YX, Lu SH, Cancer Res 2007 67 3716 3724 10.1158/0008-5472.CAN-06-4343 17440084 (Pubitemid 46762157)
16. Characterization of benign and malignant prostate epithelial Hoechst 33342 side populations. Brown MD, Gilmore PE, Hart CA, Samuel JD, Ramani VA, George NJ, Clarke NW, Prostate 2007 67 1384 1396 10.1002/pros.20620 17639507 (Pubitemid 47435786)
17. Cancer stem cell characteristics in retinoblastoma. Seigel GM, Campbell LM, Narayan M, Gonzalez-Fernandez F, Mol Vis 2005 11 729 737 16179903 (Pubitemid 41410200)
18. [Determination of matrine, sophoridine and oxymatrine in Compound Kushen Injection by HPLC]. Tian J, Wang WH, Gao HM, Wang ZM, Zhongguo Zhong Yao Za Zhi 2007 32 222 224 17432143
19. [Clinical observation on treatment of 75 mid-late stage cancer patients with yanshu Injection]. Wang ZY, Li GS, Huang HX, Zhongguo Zhong Xi Yi Jie He Za Zhi 2006 26 681 684 16970087
20. [Effects of Matrine Injection on T-lymphocyte subsets of patients with malignant tumor after gamma knife radiosurgery]. Chen J, Mei Q, Xu YC, Du J, Wei Y, Xu ZM, Zhong Xi Yi Jie He Xue Bao 2006 4 78 79 10.3736/jcim20060121 16409978
21. [Apoptotic mechanism of gastric carcinoma cells induced by matrine injection]. Dai ZJ, Gao J, Wang XJ, Ji ZZ, Wu WY, Liu XX, Kang HF, Guan HT, Ren HT, Zhonghua Wei Chang Wai Ke Za Zhi 2008 11 261 265 18478473
22. [Effect of matrine injections on invasion and metastasis of gastric carcinoma SGC-7901 cells in vitro]. Dai ZJ, Gao J, Wu WY, Wang XJ, Li ZF, Kang HF, Liu XX, Ma XB, Zhong Yao Cai 2007 30 815 819 17944193
23. Wnt signaling in breast cancer: have we come full circle? Brown AM, Breast Cancer Res 2001 3 351 355 10.1186/bcr321 11737884 (Pubitemid 34196359)
24. Wnt/β-catenin signaling contributes to activation of normal and tumorigenic liver progenitor cells. Yang W, Yan HX, Chen L, Liu Q, He YQ, Yu LX, Zhang SH, Huang DD, Tang L, Kong XN, Chen C, Liu SQ, Wu MC, Wang HY, Cancer Res 2008 68 4287 4295 10.1158/0008-5472.CAN-07-6691 18519688
25. Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Ysebaert L, Chicanne G, Demur C, De Toni F, Prade-Houdellier N, Ruidavets JB, Mansat-De Mas V, Rigal-Huguet F, Laurent G, Payrastre B, Manenti S, Racaud-Sultan C, Leukemia 2006 20 1211 1216 10.1038/sj.leu.2404239 16688229 (Pubitemid 43905823)
26. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Malanchi I, Peinado H, Kassen D, Hussenet T, Metzger D, Chambon P, Huber M, Hohl D, Cano A, Birchmeier W, Huelsken J, Nature 2008 452 650 653 10.1038/nature06835 18385740 (Pubitemid 351483363)
27. [Isolation of CD44+/CD24 -/low and side population cells from MDA-MB-453 cells and the analysis of their activation of Wnt and Notch pathway]. Li X, Ren J, Beijing Da Xue Xue Bao 2008 40 471 475 18931707
28. Oxymatrine diminishes the side population and inhibits the expression of beta-catenin in MCF-7 breast cancer cells. Zhang Y, Piao B, Hua B, Hou W, Xu W, Qi X, Zhu X, Pei Y, Lin H, Med Oncol 2010
29. Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo. Goodell MA, Brose K, Paradis G, Conner AS, Mulligan RC, J Exp Med 1996 183 1797 1806 10.1084/jem.183.4.1797 8666936 (Pubitemid 26134320)
30. Efficacy of treatment of colon, lung and breast human carcinoma xenografts with: doxorubicin, cisplatin, irinotecan or topotecan. Hardman WE, Moyer MP, Cameron IL, Anticancer Res 1999 19 2269 2274 10472342 (Pubitemid 29392533)
31. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Livak KJ, Schmittgen TD, Methods 2001 25 402 408 10.1006/meth.2001.1262 11846609 (Pubitemid 34164012)
32. A monoclonal antibody against Wnt-1 induces apoptosis in human cancer cells. He B, You L, Uematsu K, Xu Z, Lee AY, Matsangou M, Mccormick F, Jablons DM, Neoplasia 2004 6 7 14 15068666 (Pubitemid 38391944)
33. Wnt proteins are lipid-modified and can act as stem cell growth factors. Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR, Nusse R, Nature 2003 423 448 452 10.1038/nature01611 12717451 (Pubitemid 36626997)
34. Functional interaction of beta-catenin with the transcription factor LEF-1. Behrens J, Von Kries JP, Kuhl M, Bruhn L, Wedlich D, Grosschedl R, Birchmeier W, Nature 1996 382 638 642 10.1038/382638a0 8757136 (Pubitemid 26268958)
35. Wnt signaling: a common theme in animal development. Cadigan KM, Nusse R, Genes Dev 1997 11 3286 3305 10.1101/gad.11.24.3286 9407023 (Pubitemid 28023954)
36. Activation of Wnt/β-catenin pathway mediates growth and survival in B-cell progenitor acute lymphoblastic leukaemia. Khan NI, Bradstock KF, Bendall LJ, Br J Haematol 2007 138 338 348 10.1111/j.1365-2141.2007.06667.x 17614820 (Pubitemid 47035396)
37. WNT/beta-catenin mediates radiation resistance of mouse mammary progenitor cells. Woodward WA, Chen MS, Behbod F, Alfaro MP, Buchholz TA, Rosen JM, Proc Natl Acad Sci USA 2007 104 618 623 10.1073/pnas.0606599104 17202265 (Pubitemid 46123074)
38. CD44-positive colorectal adenoma cells express the potential stem cell markers musashi antigen (msi1) and ephrin B2 receptor (EphB2). Schulenburg A, Cech P, Herbacek I, Marian B, Wrba F, Valent P, Ulrich-Pur H, J Pathol 2007 213 152 160 10.1002/path.2220 17708598 (Pubitemid 47612237)
39. Wnt signaling in oncogenesis and embryogenesis - a look outside the nucleus. Peifer M, Polakis P, Science 2000 287 1606 1609 10.1126/science.287. 5458.1606 10733430 (Pubitemid 30127755)
40. Linking colorectal cancer to Wnt signaling. Bienz M, Clevers H, Cell 2000 103 311 320 10.1016/S0092-8674(00)00122-7 11057903
41. Wnt signaling and cancer. Polakis P, Genes Dev 2000 14 1837 1851 10921899 (Pubitemid 30639518)
42. Convergence of Wnt, beta-catenin, and cadherin pathways. Nelson WJ, Nusse R, Science 2004 303 1483 1487 10.1126/science.1094291 15001769 (Pubitemid 38314410)
43. Asymmetric and symmetric stem-cell divisions in development and cancer. Morrison SJ, Kimble J, Nature 2006 441 1068 1074 10.1038/nature04956 16810241 (Pubitemid 43990718)
44. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Bertolini G, Roz L, Perego P, Tortoreto M, Fontanella E, Gatti L, Pratesi G, Fabbri A, Andriani F, Tinelli S, Roz E, Caserini R, Lo Vullo S, Camerini T, Mariani L, Delia D, Calabro E, Pastorino U, Sozzi G, Proc Natl Acad Sci USA 2009 106 16281 16286 10.1073/pnas.0905653106 19805294
45. Putative cancer stem cells in malignant pleural mesothelioma show resistance to cisplatin and pemetrexed. Cortes-Dericks L, Carboni GL, Schmid RA, Karoubi G, Int J Oncol 2010 37 437 444 20596671
46. Possible involvement of stem-like populations with elevated ALDH1 in sarcomas for chemotherapeutic drug resistance. Honoki K, Fujii H, Kubo A, Kido A, Mori T, Tanaka Y, Tsujiuchi T, Oncol Rep 2010 24 501 505 20596639