In search of a vaccine for mouse allergy: Significant reduction of mus m 1 allergenicity by structure-guided single-point mutations

International Archives of Allergy and Immunology

Volumn 157, Issue 3, 2012, Pages 226-237

  Ferrari, Elena ^a   Breda, Daniela ^b   Longhi, Renato ^c   Vangelista, Luca ^b   Nakaie, Clóvis R ^d   Elviri, Lisa ^a   Casali, Emanuela ^a   Pertinhez, Thelma A ^a   Spisni, Alberto ^a   Burastero, Samuele E ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

^c CNR   (Italy)

^d FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Allergen mutants; Allergenicity; Allergens; Allergoid; Basophil activation test; Lipocalin; Recombinant allergens; Recombinant hypoallergenic allergens; T cell epitopes

Indexed keywords

IMMUNOGLOBULIN E; LIPOCALIN; MUS M1 ALLERGEN; MUTANT PROTEIN; RECOMBINANT PROTEIN; T LYMPHOCYTE ANTIGEN; UNCLASSIFIED DRUG; VACCINE;

ALLERGENICITY; ALLERGY; ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; BASOPHIL DEGRANULATION; CIRCULAR DICHROISM; CONTROLLED STUDY; DRUG SAFETY; FLUORESCENCE; HUMAN; HUMAN CELL; MOUSE ALLERGY; NONHUMAN; NUCLEOTIDE SEQUENCE; OCCUPATIONAL DISEASE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; T LYMPHOCYTE; URINE; VACCINE PRODUCTION;

ADULT; ALLERGENS; ANIMALS; BASOPHIL DEGRANULATION TEST; BLOTTING, WESTERN; CIRCULAR DICHROISM; EPITOPES, T-LYMPHOCYTE; HUMANS; HYPERSENSITIVITY; IMMUNOGLOBULIN E; IMMUNOTHERAPY; MICE; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; SPECTROMETRY, FLUORESCENCE; T-LYMPHOCYTES; VACCINES, SYNTHETIC;

EID: 80054993020     PISSN: 10182438     EISSN: 14230097     Source Type: Journal    
DOI: 10.1159/000327551     Document Type: Article

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