Thermodynamic consequences of disrupting a water-mediated hydrogen bond network in a protein:pheromone complex

Protein Science

Volumn 14, Issue 1, 2005, Pages 249-256

  Sharrow, Scott D ^a,b   Edmonds, Katherine A ^a   Goodman, Michael A ^a   Novotny, Milos V ^a   Stone, Martin J ^a  

^a INDIANA UNIVERSITY   (United States)

^b ELI LILLY AND COMPANY   (United States)

Author keywords

Enthalpy; Hydrogen bond; Major urinary protein; Pheromone; Thermodynamics; Water

Indexed keywords

2 SEC BUTYL 2 THIAZOLINE; 6 HYDROXY 6 METHYL 3 HEPTANONE; BINDING PROTEIN; HYDROGEN; HYDROXYL GROUP; LIGAND; MAJOR URINARY PROTEIN 1; NITROGEN; PHENOL; PHEROMONE; THIAZOLE DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CALORIMETRY; ENTHALPY; ENTROPY; HYDROGEN BOND; HYDROPHOBICITY; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; THERMODYNAMICS; TITRIMETRY;

ANIMALS; HYDROGEN BONDING; KETONES; LIGANDS; MACROMOLECULAR SUBSTANCES; MICE; MOLECULAR STRUCTURE; MUTATION; PHEROMONES; PROTEIN BINDING; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS; THIAZOLES; WATER;

EID: 11144241920     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.04912605     Document Type: Article

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