Identification of protein pheromones that promote aggressive behaviour

Nature

Volumn 450, Issue 7171, 2007, Pages 899-902

  Chamero, Pablo ^a   Marton, Tobias F ^a   Logan, Darren W ^a   Flanagan, Kelly ^a   Cruz, Jason R ^a   Saghatelian, Alan ^b   Cravatt, Benjamin F ^a   Stowers, Lisa ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; LIPOCALIN; PHEROMONE;

AGGREGATION BEHAVIOR; CALCIUM; GENETIC ANALYSIS; LIGAND; MATING BEHAVIOR; OLFACTORY CUE; PHEROMONE; PROTEIN; RODENT; SIGNALING; SUCKLING;

AGGRESSION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; GENOMICS; MALE; MOUSE; NERVE TRACT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; SENSORY NERVE CELL; VOMERONASAL ORGAN;

MUS;

EID: 36849029805     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05997     Document Type: Article

References (24)

1. Stowers, L. & Marton, T. What is a pheromone? Mammalian pheromones reconsidered. Neuron 46, 699-702 (2005).
2. Dulac, C. & Torello, A. T. Molecular detection of pheromone signals in mammals: from genes to behaviour. Nature Rev. Neurosci. 4, 551-562 (2003).
3. 2U-globulins and aphrodisin. Biochim. Biophys. Acta 1482, 218-228 (2000).
4. Flower, D. R. The lipocalin protein family: structure and function. Biochem. J. 318, 1-14 (1996).
5. Mugford, R. A. & Nowell, N. W. Pheromones and their effect on aggression in mice. Nature 226, 967-968 (1970).
6. Stowers, L. et al. Loss of sex discrimination and male-male aggression in mice deficient for TRP2. Science 295, 1493-1500 (2002).
7. Bean, N. J. Modulation of agonistic behavior by the dual olfactory system in male mice. Physiol. Behav. 29, 433-437 (1982).
8. Leypold, B. G. et al. Altered sexual and social behaviors in trp2 mutant mice. Proc. Natl Acad. Sci. USA 99, 6376-6381 (2002).
9. Shi, P.& Zhang, J. Comparative genomic analysis identifies an evolutionary shift of vomeronasal receptor gene repertoires in the vertebrate transition from water to land. Genome Res. 17, 166-174 (2007).
10. Schwende, F. J. et al. Urinary volatile constituents of the house mouse, Mus musculus, and their endocrine dependency. J. Chem. Ecol. 12, 277-296 (1986).
11. Hastie, N. D., Held, W. A. & Toole, J. J. Multiple genes coding for the androgen-regulated major urinary proteins of the mouse. Cell 17, 449-457 (1979).
12. Robertson, D. H. et al. Molecular heterogeneity of urinary proteins in wild house mouse populations. Rapid Commun. Mass Spectrom. 11, 786-790 (1997).
13. Timm, D. E. et al. Structural basis of pheromone binding to mouse major urinary protein (MUP-I). Protein Sci. 10, 997-1004 (2001).
14. Novotny, M., Harvey, S., Jemiolo, B. & Alberts, J. Synthetic pheromones that promote inter-male aggression in mice. Proc. Natl Acad. Sci. USA 82, 2059-2061 (1985).
15. Leinders-Zufall, T. et al. Ultrasensitive pheromone detection by mammalian vomeronasal neurons. Nature 405, 792-796 (2000).
16. Hurst, J. L., Robertson, D. H. L., Tolladay, U. & Beynon, R. J. Proteins in urine scent marks of male house mice extend the longevity of olfactory signals. Anim. Behav. 55, 1289-1297 (1998).
17. Hurst, J. L. et al. Individual recognition in mice mediated by major urinary proteins. Nature 414, 631-634 (2001).
18. Xia, J. et al. Urinary pheromones promote ERK/Akt phosphorylation, regeneration and survival of vomeronasal (V2R) neurons. Eur. J. Neurosci. 24, 3333-3342 (2006).
19. Loconto, J. et al. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Cell 112, 607-618 (2003).
20. Takigami, S., Mori, Y., Tanioka, Y. & Ichikawa, M. Morphological evidence for two types of mammalian vomeronasal system. Chem. Senses 29, 301-310 (2004).
21. Mandiyan, V. S., Coats, J. K. & Shah, N. M. Deficits in sexual and aggressive behaviors in Cnga2 mutant mice. Nature Neurosci. 8, 1660-1662 (2005).
22. Wang, Z. et al. Pheromone detection in male mice depends on signaling through the type 3 adenylyl cyclase in the main olfactory epithelium. J. Neurosci. 26, 7375-7379 (2006).
23. Holy, T. E., Dulac, C. & Meister, M. Responses of vomeronasal neurons to natural stimuli. Science 289, 1569-1572 (2000).
24. Lucas, P., Ukhanov, K., Leinders-Zufall, T. & Zufall, F. Adiacylglycerol-gated cation channel in vomeronasal neuron dendrites is impaired in TRPC2 mutant mice: mechanism of pheromone transduction. Neuron 40, 551-561 (2003).