Saponins from the roots of Platycodon grandiflorum suppress ultraviolet A-induced matrix metalloproteinase-1 expression via MAPKs and NF-κB/AP-1-dependent signaling in HaCaT cells

Food and Chemical Toxicology

Volumn 49, Issue 12, 2011, Pages 3374-3382

  Hwang, Yong Pil ^a,d   Kim, Hyung Gyun ^a   Choi, Jae Ho ^a   Han, Eun Hee ^a   Kwon, Kwang il ^a   Lee, Young Chun ^b   Choi, Jun Min ^c   Chung, Young Chul ^c   Jeong, Tae Cheon ^e   Jeong, Hye Gwang ^a  

^a Chungnam National University   (South Korea)

^b JangSaeng Doraji Co Ltd   (South Korea)

^c Korea International University   (South Korea)

^d International University of Korea   (South Korea)

^e Yeungnam University   (South Korea)

Author keywords

Collagen; HaCaT cells; MMP 1; Platycodon grandiflorum; Saponins; Ultraviolet A

Indexed keywords

GELATINASE B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERSTITIAL COLLAGENASE; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN C FOS; PROTEIN C JUN; REACTIVE OXYGEN METABOLITE; SAPONIN; TRANSCRIPTION FACTOR AP 1;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL IMMORTALIZATION; CELL SURVIVAL; CELL VIABILITY; COLLAGEN DEGRADATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DETERMINATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; KERATINOCYTE; PHYTOCHEMISTRY; PLANT ROOT; PLATYCODON; PLATYCODON GRANDILFORUM; PROTEIN EXPRESSION; RADIATION PROTECTION; ULTRAVIOLET A RADIATION; UPREGULATION;

BLOTTING, WESTERN; CELL LINE, TUMOR; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; KERATINOCYTES; MATRIX METALLOPROTEINASE 1; MATRIX METALLOPROTEINASE 9; NF-KAPPA B; PHOSPHORYLATION; PLANT EXTRACTS; PLANT ROOTS; PLATYCODON; PROTO-ONCOGENE PROTEINS C-FOS; SAPONINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1; ULTRAVIOLET RAYS;

PLATYCODON GRANDIFLORUM;

EID: 80054985873     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.10.002     Document Type: Article

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