Buffer-dependent fragmentation of a humanized full-length monoclonal antibody

Journal of Pharmaceutical Sciences

Volumn 99, Issue 7, 2010, Pages 2962-2974

  Salinas, Branden A ^a,c   Sathish, Hasige A ^a,b,c   Shah, Ambarish U ^b   Carpenter, John F ^c,d   Randolph, Theodore W ^a,c  

^a University of Colorado at Boulder   (United States)

^b MEDIMMUNE   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF COLORADO   (United States)

Author keywords

Biotechnology; Chemical stability; Formulation; Protein folding refolding; Protein formulation; Proteins

Indexed keywords

BUFFER; HISTIDINE; METAL ION; MONOCLONAL ANTIBODY; TRYPTOPHAN;

ARTICLE; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HYDROLYSIS; IONIC STRENGTH; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN HYDROLYSIS;

EID: 77953317481     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22056     Document Type: Article

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