메뉴 건너뛰기




Volumn 6, Issue 3, 2011, Pages 341-346

The therapeutic potential of stem cells in amyotrophic lateral sclerosis

Author keywords

Administration route; Amyotrophic lateral sclerosis; Cell transplantation; Clinical trials; Regenerative medicine; Stem cells

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GLUTAMIC ACID; SOMATOMEDIN C; VASCULOTROPIN;

EID: 80054945036     PISSN: 15743624     EISSN: None     Source Type: Journal    
DOI: 10.2174/157436211797483985     Document Type: Article
Times cited : (3)

References (63)
  • 1
    • 73849134614 scopus 로고    scopus 로고
    • Application of neural stem cells in treatments of animal models of neurodegenerative diseases: Experiences from amyotrophic lateral sclerosis
    • Mitrei D, Gajovi S, Pochet R. Application of neural stem cells in treatments of animal models of neurodegenerative diseases: experiences from amyotrophic lateral sclerosis. Anat Rec 2009; 292: 1962-7.
    • (2009) Anat Rec , vol.292 , pp. 1962-1967
    • Mitrei, D.1    Gajovi, S.2    Pochet, R.3
  • 4
    • 74049164709 scopus 로고    scopus 로고
    • Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
    • Ilieva H, Polymenidou M, Cleveland DW. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J Cell Biol 2009; 187: 761-72.
    • (2009) J Cell Biol , vol.187 , pp. 761-772
    • Ilieva, H.1    Polymenidou, M.2    Cleveland, D.W.3
  • 5
    • 0035664213 scopus 로고    scopus 로고
    • Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues
    • DOI 10.1006/nbdi.2001.0443
    • Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiol Dis 2001; 8: 933-41. (Pubitemid 34017087)
    • (2001) Neurobiology of Disease , vol.8 , Issue.6 , pp. 933-941
    • Watanabe, M.1    Dykes-Hoberg, M.2    Cizewski Culotta, V.3    Price, D.L.4    Wong, P.C.5    Rothstein, J.D.6
  • 6
    • 77953890823 scopus 로고    scopus 로고
    • TDP-43 and FUS/TLS: Emerging roles in RNA processing and neurodegeneration
    • Lagier-Tourenne C, Polymenidou M, Cleveland DW. TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration. Hum Mol Genet 2009; 19: R46-64.
    • (2009) Hum Mol Genet , vol.19
    • Lagier-Tourenne, C.1    Polymenidou, M.2    Cleveland, D.W.3
  • 7
    • 77953609956 scopus 로고    scopus 로고
    • Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis
    • Sasaki S, Takeda T, Shibata N, Kobayashi M. Alterations in subcellular localization of TDP-43 immunoreactivity in the anterior horns in sporadic amyotrophic lateral sclerosis. Neurosci Lett 2010; 478: 72-6.
    • (2010) Neurosci Lett , vol.478 , pp. 72-76
    • Sasaki, S.1    Takeda, T.2    Shibata, N.3    Kobayashi, M.4
  • 8
    • 77952932485 scopus 로고    scopus 로고
    • FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis
    • Deng HX, Zhai H, Bigio EH, et al. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Ann Neurol 2010; 67: 739-48.
    • (2010) Ann Neurol , vol.67 , pp. 739-748
    • Deng, H.X.1    Zhai, H.2    Bigio, E.H.3
  • 10
    • 77956224840 scopus 로고    scopus 로고
    • Mitochondrial dysfunction is a converging point of multiple pathological pathways in amyotrophic lateral sclerosis
    • Shi P, Wei Y, Zhang J, Gal J, Zhu H. Mitochondrial dysfunction is a converging point of multiple pathological pathways in amyotrophic lateral sclerosis. J Alzheimers Dis 2010; 20 Suppl 2: S311-24.
    • (2010) J Alzheimers Dis , vol.20 , Issue.SUPPL. 2
    • Shi, P.1    Wei, Y.2    Zhang, J.3    Gal, J.4    Zhu, H.5
  • 11
    • 70449417623 scopus 로고    scopus 로고
    • Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities
    • Magrane J, Hervias I, Henning MS, Damiano M, Kawamata H, Manfredi G. Mutant SOD1 in neuronal mitochondria causes toxicity and mitochondrial dynamics abnormalities. Hum Mol Genet 2009; 18: 4552-64.
    • (2009) Hum Mol Genet , vol.18 , pp. 4552-4564
    • Magrane, J.1    Hervias, I.2    Henning, M.S.3    Damiano, M.4    Kawamata, H.5    Manfredi, G.6
  • 14
    • 35548991459 scopus 로고    scopus 로고
    • Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
    • Nov 15
    • De Vos KJ, Chapman AL, Tennant ME, et al. Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content. Hum Mol Genet 2007 Nov 15; 16: 2720-8.
    • (2007) Hum Mol Genet , vol.16 , pp. 2720-2708
    • De Vos, K.J.1    Chapman, A.L.2    Tennant, M.E.3
  • 16
    • 60849093466 scopus 로고    scopus 로고
    • Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
    • Rothstein JD. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann Neurol 2009; 65 Suppl 1: S3-9.
    • (2009) Ann Neurol , vol.65 , Issue.SUPPL. 1
    • Rothstein, J.D.1
  • 18
    • 73149105494 scopus 로고    scopus 로고
    • Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
    • Zhao W, Beers DR, Henkel JS, et al. Extracellular mutant SOD1 induces microglial-mediated motoneuron injury. Glia 2010; 58: 231-43.
    • (2010) Glia , vol.58 , pp. 231-243
    • Zhao, W.1    Beers, D.R.2    Henkel, J.S.3
  • 21
    • 0002287124 scopus 로고
    • Early repair processes in marrow cells irradiated and proliferating in vivo
    • Till JE, Mc CE. Early repair processes in marrow cells irradiated and proliferating in vivo. Radiat Res 1963; 18: 96-105.
    • (1963) Radiat Res , vol.18 , pp. 96-105
    • Till, J.E.1    Mc, C.E.2
  • 22
    • 0018222043 scopus 로고
    • Morphological and quantitative analysis of spermatogonia in mouse testes using whole mounted seminiferous tubules, I. The normal testes
    • Huckins C, Oakberg EF. Morphological and quantitative analysis of spermatogonia in mouse testes using whole mounted seminiferous tubules, I. The normal testes. Anat Rec 1978; 192: 519-28.
    • (1978) Anat Rec , vol.192 , pp. 519-528
    • Huckins, C.1    Oakberg, E.F.2
  • 24
    • 0024166354 scopus 로고
    • Establishement and characterization of osteogenic cell lines from a spontaneous murine osteosarcoma
    • DOI 10.1111/j.1432-0436.1988.tb00090.x
    • Schmidt J, Strauss GP, Schon A, et al. Establishment and characterization of osteogenic cell lines from a spontaneous murine osteosarcoma. Differentiation 1988; 39: 151-60. (Pubitemid 19082658)
    • (1988) Differentiation , vol.39 , Issue.3 , pp. 151-160
    • Schmidt, J.1    Strauss, G.P.2    Schon, A.3    Luz, A.4    Murray, A.B.5    Melchiori, A.6    Aresu, O.7    Erfle, V.8
  • 25
    • 0030444243 scopus 로고    scopus 로고
    • Establishment of an embryonic stem cell line from 8-cell stage mouse embryos
    • DOI 10.1076/ejom.34.4.237.13046
    • Delhaise F, Bralion V, Schuurbiers N, Dessy F. Establishment of an embryonic stem cell line from 8-cell stage mouse embryos. Eur J Morphol 1996; 34: 237-43. (Pubitemid 27014087)
    • (1996) European Journal of Morphology , vol.34 , Issue.4 , pp. 237-243
    • Delhaise, F.1    Bralion, V.2    Schuurbiers, N.3    Dessy, F.4
  • 27
    • 33645381052 scopus 로고    scopus 로고
    • Intra-coronary high-dose CD34+ stem cells in patients with chronic ischemic heart disease: A 12-month follow-up
    • Boyle AJ, Whitbourn R, Schlicht S, et al. Intra-coronary high-dose CD34+ stem cells in patients with chronic ischemic heart disease: a 12-month follow-up. Int J Cardiol 2006; 109: 21-7.
    • (2006) Int J Cardiol , vol.109 , pp. 21-27
    • Boyle, A.J.1    Whitbourn, R.2    Schlicht, S.3
  • 28
    • 33745686121 scopus 로고    scopus 로고
    • Recovery from paralysis in adult rats using embryonic stem cells
    • Deshpande DM, Kim YS, Martinez T, et al. Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol 2006; 60: 32-44.
    • (2006) Ann Neurol , vol.60 , pp. 32-44
    • Deshpande, D.M.1    Kim, Y.S.2    Martinez, T.3
  • 29
    • 0033853860 scopus 로고    scopus 로고
    • The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice
    • Chen R, Ende N. The potential for the use of mononuclear cells from human umbilical cord blood in the treatment of amyotrophic lateral sclerosis in SOD1 mice. J Med 2000; 31: 21-30. (Pubitemid 30614798)
    • (2000) Journal of Medicine , vol.31 , Issue.1-2 , pp. 21-30
    • Chen, R.1    Ende, N.2
  • 31
    • 8144229995 scopus 로고    scopus 로고
    • Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues
    • DOI 10.1093/brain/awh273
    • Corti S, Locatelli F, Donadoni C, et al. Wild-type bone marrow cells ameliorate the phenotype of SOD1-G93A ALS mice and contribute to CNS, heart and skeletal muscle tissues. Brain 2004; 127: 2518-32. (Pubitemid 39472980)
    • (2004) Brain , vol.127 , Issue.11 , pp. 2518-2532
    • Corti, S.1    Locatelli, F.2    Donadoni, C.3    Guglieri, M.4    Papadimitriou, D.5    Strazzer, S.6    Del Bo, R.7    Comi, G.P.8
  • 32
    • 49349085868 scopus 로고    scopus 로고
    • Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis
    • Vercelli A, Mereuta OM, Garbossa D, et al. Human mesenchymal stem cell transplantation extends survival, improves motor performance and decreases neuroinflammation in mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 2008; 31: 395-405.
    • (2008) Neurobiol Dis , vol.31 , pp. 395-405
    • Vercelli, A.1    Mereuta, O.M.2    Garbossa, D.3
  • 33
    • 70349265930 scopus 로고    scopus 로고
    • Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis
    • Ohnishi S, Ito H, Suzuki Y, et al. Intra-bone marrow-bone marrow transplantation slows disease progression and prolongs survival in G93A mutant SOD1 transgenic mice, an animal model mouse for amyotrophic lateral sclerosis. Brain Res 2009; 1296: 216-24.
    • (2009) Brain Res , vol.1296 , pp. 216-224
    • Ohnishi, S.1    Ito, H.2    Suzuki, Y.3
  • 34
    • 77349087521 scopus 로고    scopus 로고
    • Selection of optimal passage of bone marrow-derived mesenchymal stem cells for stem cell therapy in patients with amyotrophic lateral sclerosis
    • Mar 19 472
    • Choi MR, Kim HY, Park JY, et al. Selection of optimal passage of bone marrow-derived mesenchymal stem cells for stem cell therapy in patients with amyotrophic lateral sclerosis. Neurosci Lett 2010 Mar 19; 472: 94-8.
    • (2010) Neurosci Lett , pp. 94-98
    • Choi, M.R.1    Kim, H.Y.2    Park, J.Y.3
  • 35
    • 0037047320 scopus 로고    scopus 로고
    • Directed differentiation of embryonic stem cells into motor neurons
    • Wichterle H, Lieberam I, Porter JA, Jessell TM. Directed differentiation of embryonic stem cells into motor neurons. Cell 2002; 110: 385-97.
    • (2002) Cell , vol.110 , pp. 385-397
    • Wichterle, H.1    Lieberam, I.2    Porter, J.A.3    Jessell, T.M.4
  • 36
    • 75149132873 scopus 로고    scopus 로고
    • Transient recovery in a rat model of familial amyotrophic lateral sclerosis after transplantation of motor neurons derived from mouse embryonic stem cells
    • Lopez-Gonzalez R, Kunckles P, Velasco I. Transient recovery in a rat model of familial amyotrophic lateral sclerosis after transplantation of motor neurons derived from mouse embryonic stem cells. Cell Transplant 2009; 18: 1171-81.
    • (2009) Cell Transplant , vol.18 , pp. 1171-1181
    • Lopez-Gonzalez, R.1    Kunckles, P.2    Velasco, I.3
  • 37
    • 54949126674 scopus 로고    scopus 로고
    • Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
    • Lepore AC, Rauck B, Dejea C, et al. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci 2008; 11: 1294-301.
    • (2008) Nat Neurosci , vol.11 , pp. 1294-1301
    • Lepore, A.C.1    Rauck, B.2    Dejea, C.3
  • 40
    • 78651081165 scopus 로고    scopus 로고
    • Brain and spinal cord affected by amyotrophic lateral sclerosis induce differential growth factors expression in rat mesenchymal and neural stem cells
    • Nicaise C, Mitrei D, Pochet R. Brain and spinal cord affected by amyotrophic lateral sclerosis induce differential growth factors expression in rat mesenchymal and neural stem cells. Neuropathol Appl Neurobiol 2011; 37: 179-88.
    • (2011) Neuropathol Appl Neurobiol , vol.37 , pp. 179-188
    • Nicaise, C.1    Mitrei, D.2    Pochet, R.3
  • 41
    • 0042528664 scopus 로고    scopus 로고
    • Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model
    • DOI 10.1126/science.1086137
    • Kaspar BK, Llado J, Sherkat N, Rothstein JD, Gage FH. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science 2003; 301: 839-42. (Pubitemid 36962626)
    • (2003) Science , vol.301 , Issue.5634 , pp. 839-842
    • Kaspar, B.K.1    Llado, J.2    Sherkat, N.3    Rothstein, J.D.4    Gage, F.H.5
  • 44
    • 56749154435 scopus 로고    scopus 로고
    • Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS
    • Suzuki M, McHugh J, Tork C, et al. Direct muscle delivery of GDNF with human mesenchymal stem cells improves motor neuron survival and function in a rat model of familial ALS. Mol Ther 2008; 16: 2002-10.
    • (2008) Mol Ther , vol.16 , pp. 2002-2010
    • Suzuki, M.1    McHugh, J.2    Tork, C.3
  • 45
    • 70350167840 scopus 로고    scopus 로고
    • Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice
    • Hwang DH, Lee HJ, Park IH, et al. Intrathecal transplantation of human neural stem cells overexpressing VEGF provide behavioral improvement, disease onset delay and survival extension in transgenic ALS mice. Gene Ther 2009; 16: 1234-44.
    • (2009) Gene Ther , vol.16 , pp. 1234-1244
    • Hwang, D.H.1    Lee, H.J.2    Park, I.H.3
  • 46
    • 33749872454 scopus 로고    scopus 로고
    • Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats
    • DOI 10.1097/01.tp.0000235532.00920.7a, PII 0000789020061015000003
    • Xu L, Yan J, Chen D, et al. Human neural stem cell grafts ameliorate motor neuron disease in SOD-1 transgenic rats. Transplantation 2006; 82: 865-75. (Pubitemid 44564030)
    • (2006) Transplantation , vol.82 , Issue.7 , pp. 865-875
    • Xu, L.1    Yan, J.2    Chen, D.3    Welsh, A.M.4    Hazel, T.5    Johe, K.6    Hatfield, G.7    Koliatsos, V.E.8
  • 47
    • 73849083781 scopus 로고    scopus 로고
    • Vvo morphological changes in animal models of amyotrophic lateral sclerosis and Alzheimer's-like disease: MRI approach
    • Andjus PR, Bataveljic D, Vanhoutte G, et al. In vvo morphological changes in animal models of amyotrophic lateral sclerosis and Alzheimer's-like disease: MRI approach. Anat Rec (Hoboken) 2009; 292: 1882-92.
    • (2009) Anat Rec (Hoboken) , vol.292 , pp. 1882-1892
    • Andjus, P.R.1    Bataveljic, D.2    Vanhoutte, G.3
  • 48
    • 71849084133 scopus 로고    scopus 로고
    • Impaired blood-brain and blood-spinal cord barriers in mutant SOD1-linked ALS rat
    • Nicaise C, Mitrecic D, Demetter P, et al. Impaired blood-brain and blood-spinal cord barriers in mutant SOD1-linked ALS rat. Brain Res 2009; 1301: 152-62.
    • (2009) Brain Res , vol.1301 , pp. 152-162
    • Nicaise, C.1    Mitrecic, D.2    Demetter, P.3
  • 49
    • 49849094080 scopus 로고    scopus 로고
    • Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS
    • Garbuzova-Davis S, Saporta S, Haller E, et al. Evidence of compromised blood-spinal cord barrier in early and late symptomatic SOD1 mice modeling ALS. PLoS ONE 2007; 2: e1205.
    • (2007) PLoS ONE , vol.2
    • Garbuzova-Davis, S.1    Saporta, S.2    Haller, E.3
  • 50
    • 77954906493 scopus 로고    scopus 로고
    • Distribution, differentiation, and survival of intravenously administered neural stem cells in a rat model of amyotrophic lateral sclerosis
    • Mitrecic D, Nicaise C, Gajovic S, Pochet R. Distribution, differentiation, and survival of intravenously administered neural stem cells in a rat model of amyotrophic lateral sclerosis. Cell Transplant 2010; 19: 537-48.
    • (2010) Cell Transplant , vol.19 , pp. 537-548
    • Mitrecic, D.1    Nicaise, C.2    Gajovic, S.3    Pochet, R.4
  • 51
    • 72549101159 scopus 로고    scopus 로고
    • Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice
    • Kim H, Kim HY, Choi MR, et al. Dose-dependent efficacy of ALS-human mesenchymal stem cells transplantation into cisterna magna in SOD1-G93A ALS mice. Neurosci Lett 14; 468: 190-4.
    • Neurosci Lett , vol.14 , Issue.468 , pp. 190-194
    • Kim, H.1    Kim, H.Y.2    Choi, M.R.3
  • 54
    • 70450197718 scopus 로고    scopus 로고
    • Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase i clinical trial
    • Mazzini L, Ferrero I, Luparello V, et al. Mesenchymal stem cell transplantation in amyotrophic lateral sclerosis: A Phase I clinical trial. Exp Neurol 2009 .
    • (2009) Exp Neurol
    • Mazzini, L.1    Ferrero, I.2    Luparello, V.3
  • 55
    • 62149135220 scopus 로고    scopus 로고
    • Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: A 1-year follow-up
    • Deda H, Inci MC, Kurekci AE, et al. Treatment of amyotrophic lateral sclerosis patients by autologous bone marrow-derived hematopoietic stem cell transplantation: a 1-year follow-up. Cytotherapy 2009; 11: 18-25.
    • (2009) Cytotherapy , vol.11 , pp. 18-25
    • Deda, H.1    Inci, M.C.2    Kurekci, A.E.3
  • 56
    • 55449090370 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis
    • Appel SH, Engelhardt JI, Henkel JS, et al. Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis. Neurology 2008; 71: 1326-34.
    • (2008) Neurology , vol.71 , pp. 1326-1334
    • Appel, S.H.1    Engelhardt, J.I.2    Henkel, J.S.3
  • 58
    • 56349111924 scopus 로고    scopus 로고
    • Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: A controlled pilot study
    • Huang H, Chen L, Xi H, et al. Fetal olfactory ensheathing cells transplantation in amyotrophic lateral sclerosis patients: a controlled pilot study. Clin Transplant 2008; 22: 710-8.
    • (2008) Clin Transplant , vol.22 , pp. 710-718
    • Huang, H.1    Chen, L.2    Xi, H.3
  • 59
    • 77952185237 scopus 로고    scopus 로고
    • No benefits from experimental treatment with olfactory ensheathing cells in patients with ALS
    • Piepers S, van den Berg LH. No benefits from experimental treatment with olfactory ensheathing cells in patients with ALS. Amyotroph Lateral Scler; 11: 328-30.
    • Amyotroph Lateral Scler , vol.11 , pp. 328-330
    • Piepers, S.1    Van Den Berg, L.H.2
  • 62
    • 37549065020 scopus 로고    scopus 로고
    • GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS
    • Suzuki M, McHugh J, Tork C, et al. GDNF secreting human neural progenitor cells protect dying motor neurons, but not their projection to muscle, in a rat model of familial ALS. PLoS ONE 2007; 2: e689.
    • (2007) PLoS ONE , vol.2
    • Suzuki, M.1    McHugh, J.2    Tork, C.3
  • 63
    • 68049110630 scopus 로고    scopus 로고
    • Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice
    • Park S, Kim HT, Yun S, et al. Growth factor-expressing human neural progenitor cell grafts protect motor neurons but do not ameliorate motor performance and survival in ALS mice. Exp Mol Med 2009; 41: 487-500.
    • (2009) Exp Mol Med , vol.41 , pp. 487-500
    • Park, S.1    Kim, H.T.2    Yun, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.