Ligusticum chuanxiong Hort: A review of chemistry and pharmacology

Pharmaceutical Biology

Volumn 49, Issue 11, 2011, Pages 1180-1189

  Ran, Xia ^a,b   Ma, Li ^c   Peng, Cheng ^d   Zhang, Hong ^a   Qin, Lu Ping ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b EAST CHINA NORMAL UNIVERSITY   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Component; Plant; Traditional Chinese medicine; Umbelliferae

Indexed keywords

6,7,3',8' DILIGUSTILIDE; ALKALOID DERIVATIVE; ANTIINFLAMMATORY AGENT; BUTYLIDENEPHTHALIDE; ESSENTIAL OIL; FERULIC ACID; LEVISTOLIDE A; LIGUSTICUM CHUANXIONG EXTRACT; LIGUSTILIDE; LIVER PROTECTIVE AGENT; PENTOBARBITAL; PLANT MEDICINAL PRODUCT; SENKYUNOLIDE A; TETRAMETHYLPYRAZINE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTINOCICEPTION; ANTIOXIDANT ACTIVITY; ANTIPYRETIC ACTIVITY; ASTHMA; ATHEROSCLEROSIS; BRAIN INFARCTION; BRAIN ISCHEMIA; CHONDROPROTECTION; DRUG DETERMINATION; DRUG MECHANISM; DRUG POTENTIATION; ENDOTHELIAL DYSFUNCTION; EPILEPTIC STATE; EXCITOTOXICITY; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HUMAN; LIGUSTICUM CHUANXIONG; LIVER FIBROSIS; NEUROPROTECTION; NONHUMAN; PAIN; REPERFUSION INJURY; REVIEW; STROKE; VASODILATATION;

ANIMALS; DRUGS, CHINESE HERBAL; HUMANS; LIGUSTICUM; MEDICINE, CHINESE TRADITIONAL; MOLECULAR STRUCTURE; PLANTS, MEDICINAL; STRUCTURE-ACTIVITY RELATIONSHIP;

APIACEAE; LIGUSTICUM CHUANXIONG;

EID: 80054944928     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2011.576346     Document Type: Review

References (82)

1. Bi WF, Yang HY, Liu JC, Cheng TH, Chen CH, Shih CM, Lin H, Wang TC, Lian WS, Chen JJ, Chiu HC, Chang NC. (2005). Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine. Clin Exp Pharmacol Physiol, 32, 536-540.
2. Bie BH, Chen Y, Zhao ZQ. (2006). Ligustrazine inhibits high voltagegated Ca(2+) and TTX-resistant Na(+) channels of primary sensory neuron and thermal nociception in the rat: A study on peripheral mechanism. Neurosci Bull, 22, 79-84.
3. Chan SS, Cheng TY, Lin G. (2007). Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta. J Ethnopharmacol, 111, 677-680.
4. Chan SS, Choi AO, Jones RL, Lin G. (2006). Mechanisms underlying the vasorelaxing effects of butylidenephthalide, an active constituent of Ligusticum chuanxiong, in rat isolated aorta. Eur J Pharmacol, 537, 111-117.
5. Chan SS, Jones RL, Lin G. (2009). Synergistic interaction between the Ligusticum chuanxiong constituent butylidenephthalide and the nitric oxide donor sodium nitroprusside in relaxing rat isolated aorta. J Ethnopharmacol, 122, 308-312.
6. Chang XL, Jiang ZY, Ma YB, Zhang XM, Tsim KW, Chen JJ. (2009). Two new compounds from the roots of Ligusticum chuanxiong. J Asian Nat Prod Res, 11, 805-810.
7. Chang XL, Ma YB, Zhang XM, Jiang ZY, Chen JJ. (2007). Studies on chemical constituents of rhizomes of Ligusticum chuanxiong. China J Chin Mat Med, 32, 1533-1536.
8. Chao HM, Lin DE, Chang Y, Hsu WM, Lee SM, Lee FL, Chi CW, Pan WH, Liu TY, Lui WY, Ho LT, Kuo CD, Chan CC, Chao FP. (2008). Ferulic acid, but not tetramethylpyrazine, significantly attenuates retinal ischemia/reperfusion- induced alterations by acting as a hydroxyl radical scavenger. J Ocul Pharmacol Ther, 24, 461-472.
9. Chen ZL, Guan YQ, Chen X, Chen XL, Chen JC. (2004). Effect of Chinese herbal medicine 1023 Recipe in blocking cancer transformation of experimental precancerous lesion and its mechanism. Chin J Integr Med, 2, 281-284.
10. Cheng CY, Ho TY, Lee EJ, Su SY, Tang NY, Hsieh CL. (2008). Ferulic acid reduces cerebral infarct through its antioxidative and antiinflammatory effects following transient focal cerebral ischemia in rats. Am J Chin Med, 36, 1105-1119.
11. Chor SY, Hui AY, To KF, Chan KK, Go YY, Chan HL, Leung WK, Sung JJ. (2005). Anti-proliferative and pro-apoptotic effects of herbal medicine on hepatic stellate cell. J Ethnopharmacol, 100, 180-186.
12. Dai Y, But PP, Chan YP, Matsuda H, Kubo M. (2002). Antipruritic and antiinflammatory effects of aqueous extract from Si-Wu-Tang. Biol Pharm Bull, 25, 1175-1178.
13. Gao W, Liang RX, Xiao YQ, Yang HJ. (2005). Protective effect of the pretreatment with Chuanxiong-phthalide A on the vascular endothelial cells impaired by the ischemia and reperfusion in isolated rats hearts. China J Chin Mat Med, 30, 1448-1451.
14. Guo J, Duan JA, Tang Y, Jia N, Li X, Zhang J. (2010). Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma chuanxiong after nasal administration. Pharmazie, 65, 296-299.
15. Hou YZ, Zhao GR, Yang J, Yuan YJ, Zhu GG, Hiltunen R. (2004). Protective effect of Ligusticum chuanxiong and Angelica sinensis on endothelial cell damage induced by hydrogen peroxide. Life Sci, 75, 1775-1786.
16. Hou YZ, Zhao GR, Yuan YJ, Zhu GG, Hiltunen R. (2005). Inhibition of rat vascular smooth muscle cell proliferation by extract of Ligusticum chuanxiong and Angelica sinensis. J Ethnopharmacol, 100, 140-144.
17. Jeong JB, Ju SY, Park JH, Lee JR, Yun KW, Kwon ST, Lim JH, Chung GY, Jeong HJ. (2009). Antioxidant activity in essential oils of Cnidium officinale makino and Ligusticum chuanxiong Hort and their inhibitory effects on DNA damage and apoptosis induced by ultraviolet B in mammalian cell. Cancer Epidemiol, 33, 41-46.
18. Jia RR, Gou YL, Ho LS, Ng CP, Tan NH, Chan HC. (2005). Antiapoptotic activity of Bak Foong Pills and its ingredients on 6-hydroxydopamine-induced neurotoxicity in PC12 cells. Cell Biol Int, 29, 835-842.
19. Ju XD, Deng M, Ao YF, Yu CL, Wang JQ, Yu JK, Cui GQ, Hu YL. (2010). The protective effect of tetramethylpyrazine on cartilage explants and chondrocytes. J Ethnopharmacol, 132, 414-420.
20. Juan SH, Chen CH, Hsu YH, Hou CC, Chen TH, Lin H, Chu YL, Sue YM. (2007). Tetramethylpyrazine protects rat renal tubular cell apoptosis induced by gentamicin. Nephrol Dial Transplant, 22, 732-739.
21. Ko WC, Liao CC, Shih CH, Lei CB, Chen CM. (2002). Relaxant effects of butylidenephthalide in isolated dog blood vessels. Planta Med, 68, 1004-1009.
22. Lee TF, Lin YL, Huang YT. (2007). Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells. Planta Med, 73, 527-534.
23. Li L, Yang H, Xiao Y, Zhang C, Wang Y. (2009). Effect of Chuanxiong Fangfeng Baizhi prescription on isolated rabbit basilar artery. China J Chin Mat Med, 34, 1415-1417.
24. Li M, Handa S, Ikeda Y, Goto S. (2001). Specific inhibiting characteristics of tetramethylpyrazine, one of the active ingredients of the Chinese herbal medicine "Chuanxiong," on platelet thrombus formation under high shear rates. Thromb Res, 104, 15-28.
25. Li M, Zhao C, Wong RN, Goto S, Wang Z, Liao F. (2004). Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B. Clin Hemorheol Microcirc, 31, 97-103.
26. Li QX, Liao YH, Zhang HL, Jiang YY, Wang YF. (2007). Inhibitory effect and mechanism of ChUanxiOngzine on multiplication. J Nanjing Med Univ, 21, 82-85.
27. Li SY, Jia YH, Sun WG, Tang Y, An GS, Ni JH, Jia HT. (2010). Stabilization of mitochondrial function by tetramethylpyrazine protects against kainate-induced oxidative lesions in the rat hippocampus. Free Radic Biol Med, 48, 597-608.
28. Li Y, Xu C, Zhang Q, Liu JY, Tan RX. (2005). In vitro anti-Helicobacter pylori action of 30 Chinese herbal medicines used to treat ulcer diseases. J Ethnopharmacol, 98, 329-333.
29. Li YH, Peng SL, Zhou Y, Yu KB, Ding LS. (2006). Two new phthalides from Ligusticum chuanxiong. Planta Med, 72, 652-656.
30. Liang MJ, He LC, Yang GD. (2005). Screening, analysis and in vitro vasodilatation of effective components from Ligusticum chuanxiong. Life Sci, 78, 128-133.
31. Lim LS, Shen P, Gong YH, Lee LS, Yong EL. (2006a). Dynamics of progestogenic activity in serum following administration of Ligusticum chuanxiong. Life Sci, 79, 1274-1280.
32. Lim LS, Shen P, Gong YH, Yong EL. (2006b). Dimeric progestins from rhizomes of Ligusticum chuanxiong. Phytochemistry, 67, 728-734.
33. Lin YL, Hsu YC, Chiu YT, Huang YT. (2008). Antifibrotic effects of a herbal combination regimen on hepatic fibrotic rats. Phytother Res, 22, 69-76.
34. Lin YL, Lee TF, Huang YJ, Huang YT. (2006). Inhibitory effects of Ligusticum chuanxiong on the proliferation of rat hepatic stellate cells. J Gastroenterol Hepatol, 21, 1257-1265.
35. Lin YL, Lee YC, Huang CL, Lai WL, Lin YR, Huang NK. (2007). Ligusticum chuanxiong prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis through a protein kinase A-dependent pathway. J Ethnopharmacol, 109, 428-434.
36. Lin YL, Wang GJ, Huang CL, Lee YC, Liao WC, Lai WL, Lin YJ, Huang NK. (2009). Ligusticum chuanxiong as a potential neuroprotectant for preventing serum deprivation-induced apoptosis in rat pheochromocytoma cells: Functional roles of mitogen-activated protein kinases. J Ethnopharmacol, 122, 417-423.
37. Liu L, Ning ZQ, Shan S, Zhang K, Deng T, Lu XP, Cheng YY. (2005). Phthalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNFalpha- mediated NF-kappaB activation. Planta Med, 71, 808-813.
38. Liu PY, Sheu JJ, Lin PC, Lin CT, Liu YJ, Ho LI, Chang LF, Wu WC, Chen SR, Chen J, Harn YC, Lin SZ, Tsai CH, Chiou TW, Harn HJ. (2010). Expression of Nur77 induced by an n-butylidenephthalide derivative promotes apoptosis and inhibits cell growth in oral squamous cell carcinoma. Invest New Drugs, doi:10.1007/s10637- 010-9518-z
39. Liu YJ, Huang GY, Yang MW, Gong P, Lu F. (2004). Effect of jiantai liquid on expression of estrogen and progesterone receptors in uterus of mice with embryo implantation dysfunction induced by mifepristone. China J Chin Mat Med, 24, 816-819.
40. Lu Y, Hu YL, Kong XF, Wang DY. (2008). Selection of component drug in activating blood flow and removing blood stasis of Chinese herbal medicinal formula for dairy cow mastitis by hemorheological method. J Ethnopharmacol, 116, 313-317.
41. Lu ZM, Yu YR, Tang H, Zhang XX. (2005). The protective effects of Radix Astragali and Rhizoma Ligustici chuanxiong on endothelial dysfunction in type 2 diabetic patients with microalbuminuria. J Sichuan Univ (Medical Science Edition), 36, 529-532.
42. Meng H, Guo J, Sun JY, Pei JM, Wang YM, Zhu MZ, Huang C. (2008). Angiogenic effects of the extracts from Chinese herbs: Angelica and Chuanxiong. Am J Chin Med, 36, 541-554.
43. Meng H, Zhu MZ, Guo J, Sun JY, Pei JM, Huang C. (2006). The study on angiogenesis activity of danggui, chuanxiong and danshen. J Chin Med Mater, 29, 574-576.
44. Miao C, Wu S, Luo B, Wang J, Chen Y. (2010). A new sesquiterpenoid from Ligusticum chuanxiong Hort. Fitoterapia, 81, 1088-1090.
45. Or TCT, Yang CLH, Law AHY, Li JCB, Lau ASY. (2010). Isolation and identification of anti-inflammatory constituents from Ligusticum chuanxiong and their underlying mechanisms of action on microglia. Neuropharmacology, doi:10.1016/j. neuropharm.2010.12.002
46. Peng C, Xie X, Wang L, Guo L, Hu T. (2009). Pharmacodynamic action and mechanism of volatile oil from Rhizoma Ligustici chuanxiong Hort. on treating headache. Phytomedicine, 16, 25-34.
47. Qi H, Siu SO, Chen Y, Han Y, Chu IK, Tong Y, Lau AS, Rong J. (2010). Senkyunolides reduce hydrogen peroxide-induced oxidative damage in human liver HepG2 cells via induction of heme oxygenase-1. Chem Biol Interact, 183, 380-389.
48. Ren DC, Yang NY, Qian SH, Xie N, Zhou XM, Duan JA. (2007a). Chemical study on aerial parts of Ligusticum chuanxiong. Chin Tradit Herb Drugs, 32, 1418-1420.
49. Ren XY, Ruan QR, Zhu DH, Zhu M, Qu ZL, Lu J. (2007b). Tetramethylpyrazine inhibits agiontensin II-induced nuclear factor-kappaB activation and bone morphogenetic protein-2 downregulation in rat vascular smooth muscle cells. Acta Physiol Sin, 59, 339-344.
50. Shih YH, Wu SL, Chiou WF, Ku HH, Ko TL, Fu YS. (2002). Protective effects of tetramethylpyrazine on kainate-induced excitotoxicity in hippocampal culture. Neuroreport, 13, 515-519.
51. Shu D, He J, Chen J. (2009). Neuroprotective effects and mechanisms of Chuanxiong Chatiao pulvis against MPTP-induced dopaminergic neurotoxicity in mice model of Parkinsons disease. Chin Tradit Herb Drugs, 34, 2494-2497.
52. Sim Y, Shin S. (2008). Combinatorial anti-Trichophyton effects of Ligusticum chuanxiong essential oil components with antibiotics. Arch Pharm Res, 31, 497-502.
53. Sue YM, Cheng CF, Chang CC, Chou Y, Chen CH, Juan SH. (2009). Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethylpyrazine against gentamicin-induced apoptosis in murine renal tubular cells. Nephrol Dial Transplant, 24, 769-777.
54. Tian JW, Fu FH, Jiang WL, Wang CY, Sun F, Zhang TP. (2005). Protective effect of Ligusticum chuanxiong phthalides on focai cerebral ischemia in rats and its related mechanism of action. Chin Tradit Herb Drugs, 30, 466-468.
55. Tian Y, Liu Y, Chen X, Zhang H, Shi Q, Zhang J, Yang P. (2010). Tetramethylpyrazine promotes proliferation and differentiation of neural stem cells from rat brain in hypoxic condition via mitogenactivated protein kinases pathway in vitro. Neurosci Lett, 474, 26-31.
56. Tsai CC, Lai TY, Huang WC, Liu IM, Cheng JT. (2002). Inhibitory effects of potassium channel blockers on tetramethylpyrazine-induced relaxation of rat aortic strip in vitro. Life Sci, 71, 1321-1330.
57. Wang H, Tang Y, Guo J, Ding A, Li W, Jiang W, Duan J. (2010a). Antidysmenorrheic effects of Radix angelica and Rhizoma chuanxiong with different proportions and preparation methods on dysmenorrhea model mice. Chin Tradit Herb Drugs, 35, 892-895.
58. Wang J, Liu XR, Shi YM. (1995). Observation of the preventive and therapeutic effect of Chuanxiong on the atherosclerosis of rabbits. Chin J Integr Med, 1, 52-55.
59. Wang S, Gao Z, Chen X, Lian X, Zhu H, Zheng J, Sun L. (2008). The anticoagulant ability of ferulic acid and its applications for improving the blood compatibility of silk fibroin. Biomed Mater, 3, 044106.
60. Wang WX, Gu M, Jiang XL. (2002). Studies on chemical constituents of the rhizomae of Ligusticum chuanxiong. Chin Tradit Herb Drugs, 33, 4-5.
61. Wang X, Wang D, Li L, Niu X. (2010b). Effect of Ligusticum chuanxiong extract on lifespan of Caenorhabditis elegans and its underlying molecular mechanisms. Chin Tradit Herb Drugs, 35, 1042-1045.
62. Wang X, Wang D, Li L, Niu X. (2010c). Expression changes of agerelated genes in different aging stages of Caenorhabiditis elegans and the regulating effects of Chuanxiong extract. Chin Tradit Herb Drugs, 35, 1599-1602.
63. Wang XB, Wang SS, Zhang QF, Liu M, Li HL, Liu Y, Wang JN, Zheng F, Guo LY, Xiang JZ. (2010d). Inhibition of tetramethylpyrazine on P-gp, MRP2, MRP3 and MRP5 in multidrug resistant human hepatocellular carcinoma cells. Oncol Rep, 23, 211-215.
64. Wang ZY, Qian RQ, Guan SH. (2003). Study on free radical mechanism of guanxin II in antagonizing ischemic myocardial damage. Chin J Integr Med, 23, 363-366.
65. Wong KL, Chan P, Huang WC, Yang TL, Liu IM, Lai TY, Tsai CC, Cheng JT. (2003). Effect of tetramethylpyrazine on potassium channels to lower calcium concentration in cultured aortic smooth muscle cells. Clin Exp Pharmacol Physiol, 30, 793-798.
66. Wong KL, Wu KC, Wu RS, Chou YH, Cheng TH, Hong HJ. (2007). Tetramethylpyrazine inhibits angiotensin II-increased NAD(P)H oxidase activity and subsequent proliferation in rat aortic smooth muscle cells. Am J Chin Med, 35, 1021-1035.
67. Wu JG, Ma L, Zhang SY, Zhu ZZ, Zhang H, Qin LP, Wei YJ. (2011). Essential oil from rhizomes of Ligusticum chuanxiong induces apoptosis in hypertrophic scar fibroblasts. Pharm Biol, 49, 86-93.
68. Wu JG, Wei YJ, Ran X, Zhang H, Nian H, Qin LP. (2010). Inhibitory effects of essential oil from rhizomes of Ligusticum chuanxiong on hypertrophic scarring in the rabbit ear model. Pharm Biol, doi:10. 3109/13880209.2010.542761
69. Xiao HJ, Wang T, Chen J, Fan LC, Yin CP, Liu JH, Gao X. (2010). Chuanxiongzine relaxes isolated corpus cavernosum strips and raises intracavernous pressure in rabbits. Int J Impot Res, 22, 120-126.
70. Xiao Y, Liu TJ, Huang ZW, Zhou XD, Li JY. (2004). The effects of natural medicine on adherence of Streptococcus mutans to salivary acquired pellicle. J Sichuan Univ (Med Sci Ed), 35, 687-689.
71. Xiao YQ, Li L, You XL, Taniguchi M, Baba K. (2002). Studies on chemical constituents of the rhizomae of Ligusticum chuanxiong. Chin Tradit Herb Drugs, 27, 519-522.
72. Xiong L, Fang ZY, Tao XN, Bai M, Feng G. (2007). Effect and mechanism of ligustrazine on Th1/Th2 cytokines in a rat asthma model. Am J Chin Med, 35, 1011-1020.
73. Xu H, Wen C, Chen KJ. (2007). Study on the effect of rhizoma Chuanxiong, radix paeoniae rubra and the compound of their active ingredients, Xiongshao Capsule, on stability of atherosclerotic plaque in ApoE(-/-) mice. Chin J Integr Med, 27, 513-518.
74. Yang J, Lei Y, Cui W, Fang S, Chen K. (2009a). Mechanisms of delay endothelial cell replicative senescence by extracts from Panax ginseng, Panax notoginseng and Ligusticum chuanxiong. Chin Tradit Herb Drugs, 34, 1544-1548.
75. Yang J, Lei Y, Fang SP. (2009b). Study on acting mechanism of extracts from ginseng, notoginseng and chuanxiong for delaying the aging of endothelial cells induced by angiotensin II. Chin J Integr Med, 29, 524-528.
76. Yang X, Zeng X, Wu T. (2010). Chuanxiong preparations for preventing stroke. Cochrane Database Syst Rev, CD006765.
77. Yuan J, Zhang Z, Fan Z, Yang J. (2008). Antioxidant effects and cytotoxicity of three purified polysaccharides from Ligusticum chuanxiong Hort. Carbohyd Polym, 74, 822-827.
78. Zhang DW, Liu JG, Feng JT, Zhang L, Yang XP, Shi DZ, Liang XM. (2010). Effects of effective components compatibility of aqueous extracts of Salviae miltiorrhizae and Rhizoma Chuanxiong on rat myocardial ischemia/reperfusion injury. Chin Crit Care Med, 22, 109-112.
79. Zhang L, Jiang YR, Guo CY, Wu CF, Chen KJ, Yin HJ. (2009a). Effects of active components of Red Paeonia and Rhizoma chuanxiong on angiogenesis in atherosclerosis plaque in rabbits. Chin J Integr Med, 15, 359-364.
80. Zhang L, Xue M, Ma XJ. (2009b). Effect of the active components of red paeonia and rhizoma chuanxiong on matrix metalloproteinases in rabbits with atherosclerosis. Chin J Integr Med, 29, 514-518.
81. Zhang YN, Yue XF, Zhang ZQ. (2004). Study on the interactions between four components in Ligusticum chuanxiong rhizome and acceptors on cardiac muscle membrane. China J Chin Mat Med, 29, 660-662.
82. Zhulun L, Jinrong Y, Rong F, Jun S. (2003). The antipyretic effect of the essential oil of Ligusticum chuanxiong Hort. on endotoxin-induced fever and hypothalamic content of 5-HT DA in rabbits. Pharmacol Clin Chin Mat Med, 19, 17-19.