Inhibition of cyclic strain-induced endothelin-1 secretion by tetramethylpyrazine

Clinical and Experimental Pharmacology and Physiology

Volumn 32, Issue 7, 2005, Pages 536-540

  Bi, Wei Fung ^a   Yang, Hung Yu ^b   Liu, Ju Chi ^b   Cheng, Tzu Hurng ^b   Chen, Cheng Hsien ^b   Shih, Chun Ming ^a   Lin, Heng ^a   Wang, Tze Che ^a   Lian, Wei Shiung ^c   Chen, Jin Jer ^c   Chiu, Heng Cheng ^d   Chang, Nen Chung ^a  

^a TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^d CATHAY GENERAL HOSPITAL   (Taiwan)

Author keywords

Endothelial cells; Endothelin 1; Extracellular signal regulated kinases 1 2; Reactive oxygen species; Strain; Tetramethylpyrazine

Indexed keywords

ACETYLCYSTEINE; ENDOTHELIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; REACTIVE OXYGEN METABOLITE; TETRAMETHYLPYRAZINE; TRANSCRIPTION FACTOR AP 1; CHUANGXIONG; HERBACEOUS AGENT; MITOGEN ACTIVATED PROTEIN KINASE; PYRAZINE DERIVATIVE;

ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; PROTEIN SECRETION; REPORTER GENE; SIGNAL TRANSDUCTION; CELL CULTURE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; METABOLISM; SECRETION; VASCULAR ENDOTHELIUM;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENDOTHELIN-1; ENDOTHELIUM, VASCULAR; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASES; PYRAZINES; REACTIVE OXYGEN SPECIES; TRANSCRIPTION FACTOR AP-1;

EID: 22544456876     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2005.04227.x     Document Type: Article

References (30)

1. Dai XZ, Bache RJ. Coronary and systemic hemodynamic effects of tetramethylpyrazine in the dog. J. Cardiovasc. Pharmacol. 1985; 7: 841-9.
2. Wu CC, Chiou WF, Yen MH. A possible mechanism of action of tetramethylpyrazine on vascular smooth muscle in rat aorta. Eur. J. Pharmacol. 1989; 169: 189-95.
3. Cai YN, Barer GR. Effect of ligustrazine on pulmonary vascular changes induced by chronic hypoxia in rats. Clin. Sci. 1989; 77: 515-20.
4. Chang FC, Chen KJ, Lin JG, Hong CY, Huang YT. Effects of tetramethylpyrazine on portal hypertensive rats. J. Pharm. Pharmacol. 1998; 50: 881-4.
5. 2+ mobilization in vascular smooth muscle: Tetramethylpyrazine and tetrandrine. Stem Cells 1994; 12: 64-7.
6. Pang PK, Shan JJ, Chiu KW. Tetramethylpyrazine, a calcium antagonist. Planta Med. 1996; 62: 431-5.
7. Gielen S, Schuler G, Hambrecht R. Exercise training in coronary artery disease and coronary vasomotion. Circulation 2001; 103 (Suppl.): E1-6.
8. Schiffrin EL. Role of endothelin-1 in hypertension and vascular disease. Am. J. Hypertens. 2001; 14 (Suppl.): S83-9.
9. Wenzel RR, Czyborra P, Luscher T, Philipp T. Endothelin in cardiovascular control: The role of endothelin antagonists. Curr. Hypertens. Rep. 1999; 1: 79-87.
10. Mundhenke M, Schwartzkopff B, Kostering M, Deska U, Klein RM, Strauer BE. Endogenous plasma endothelin concentrations and coronary circulation in patients with mild dilated cardiomyopathy. Heart 1999; 81: 278-84.
11. Schiffrin EL, Touyz RM. Vascular biology of endothelin. J. Cardiovasc. Pharmacol. 1998; 32 (Suppl. 3): S2-13.
12. Tonnessen T, Giaid A, Saleh D, Naess PA, Yanagisawa M, Christensen G. Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia. Circ. Res. 1995; 76: 767-72.
13. Hoffmann E, Assennato P, Donatelli M, Colletti I, Valenti TM. Plasma endothelin-1 levels in patients with angina pectoris and normal coronary angiograms. Am. Heart J. 1998; 135: 684-8.
14. Pernow J, Wang QD. Endothelin in myocardial ischaemia and reperfusion. Cardiovasc. Res. 1997; 33: 518-26.
15. Webb DJ, Monge JC, Rabelink TJ, Yanagisawa M. Endothelin: New discoveries and rapid progress in the clinic. Trends Pharmacol. Sci. 1998; 19: 5-8.
16. Witztum JL. The oxidation hypothesis of atherosclerosis. Lancet 1994; 344: 793-5.
17. Drexler H. Endothelial dysfunction: Clinical implications. Prog. Cardiovasc. Dis. 1997; 39: 287-324.
18. Griendling KK, Alexander RW. Oxidative stress and cardiovascular disease. Circulation 1997; 96: 3264-5.
19. Wung BS, Cheng JJ, Hsieh HJ, Shy YJ, Wang DL. Cyclic strain-induced monocyte chemotactic protein-1 gene expression in endothelial cells involves reactive oxygen species activation of activator protein 1. Circ. Res. 1997; 81: 1-7.
20. Cheng JJ, Wung BS, Chao YJ, Wang DL. Cyclic strain-induced reactive oxygen species involved in ICAM-1 gene induction in endothelial cells. Hypertension 1998; 31: 125-30.
21. Cheng TH, Shih NL, Chen SY et al. Reactive oxygen species mediate cyclic strain-induced endothelin-1 gene expression via Ras/Raf/extracellular signal-regulated kinase pathway in endothelial cells. J. Mol. Cell. Cardiol. 2001; 33: 1805-14.
22. Cheng JJ, Chao YJ, Wang DL. Cyclic strain activates redox-sensitive proline-rich tyrosine kinase 2 (PYK2) in endothelial cells. J. Biol. Chem. 2002; 277: 48 152-7.
23. Cheng CM, Hong HJ, Liu JC et al. Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts. Mol. Pharmacol. 2003; 63: 1002-11.
24. Ziegler T, Bouzourene K, Harrison VJ, Brunner HR, Hayoz D. Influence of oscillatory and unidirectional flow environments on the expression of endothelin and nitric oxide synthase in cultured endothelial cells. Arterioscler. Thromb. Vasc. Biol. 1998; 18: 686-92.
25. Wang DL, Wung BS, Peng YC, Wang JJ. Mechanical strain increases endothelin-1 gene expression via protein kinase C pathway in human endothelial cells. J. Cell. Physiol. 1995; 163: 400-6.
26. Matsushita H, Lee Kh K, Tsao PS. Cyclic strain induces reactive oxygen species production via an endothelial NAD(P)H oxidase. J. Cell. Biochem. 2001; 81: 99-106.
27. Zhang Z, Wei T, Hou J, Li G, Yu S, Xin W. Tetramethylpyrazine scavenges superoxide anion and decreases nitric oxide production in human polymorphonuclear leukocytes. Life Sci. 2003; 72: 2465-72.
28. Zhang Z, Wei T, Hou J, Li G, Yu S, Xin W. Iron-induced oxidative damage and apoptosis in cerebellar granule cells. Attenuation by tetramethylpyrazine and ferulic acid. Eur. J. Pharmacol. 2003; 467: 41-7.
29. Sano M, Fukuda K, Sato T et al. ERK and p38 MAPK, but not NF-kappaB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts. Circ. Res. 2001; 89: 661-9.
30. Tanaka K, Honda M, Takabatake T. Redox regulation of MAPK pathways and cardiac hypertrophy in adult rat cardiac myocyte. J. Am. Coll. Cardiol. 2001; 37: 676-85.