Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration

Pharmazie

Volumn 65, Issue 4, 2010, Pages 296-299

  Duan, Jin Ao ^a   Guo, Jianming ^b   Tang, Yuping ^b   Jia, Ning ^b   Li, Xinghu ^b   Zhang, Ji ^b  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ESSENTIAL OIL; SEDATIVE AGENT;

ANALGESIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; FEMALE; HOT PLATE TEST; LIGUSTICUM CHUANXIONG; MOUSE; NOCICEPTION; NONHUMAN; SEDATION; SLEEP TIME; WRITHING TEST;

ACETIC ACID; ADMINISTRATION, INTRANASAL; ANALGESICS, NON-NARCOTIC; ANIMALS; DRUG SYNERGISM; FEMALE; HOT TEMPERATURE; HYPNOTICS AND SEDATIVES; INDICATORS AND REAGENTS; LIGUSTICUM; MICE; MICE, INBRED ICR; OILS, VOLATILE; PAIN MEASUREMENT; PENTOBARBITAL; PLANT EXTRACTS; REACTION TIME; SLEEP;

EID: 77950626076     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2010.9728     Document Type: Article

References (24)

1. Cao YX, Zhang W, He JY, He LC, Xu CB (2006) Ligustilide induces vasodilatation via inhibiting voltage dependent calcium channel and receptor-mediated Ca2+ influx and release. Vascul Pharmacol 45: 171-176.
2. Chan SS, Cheng TY, Lin G (2007) Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta. J Ethnopharmacol 111: 677-680.
3. China Pharmcopoeia, Vol. I [in Chinese]. Beijing, Chemical Industry Press, State Pharmacopoeia Commission of P.R. China, 2005, 28.
4. Chong ZZ, Feng YP (1999) dl-3-n-Butylphthalide improves regional cerebral blood flow after experimental subarachnoid hemorrhage in rats. Acta Pharmacol Sin 20: 509-512.
5. Christensen K, Rogers E, Green GA, Hamilton DA, Mermelstein Fred, Liao Edward, Wright Curtis, Carr Daniel B (2007) Safety and efficacy of intranasal ketamine for acute postoperative pain. Acute Pain 9: 183-192.
6. Du J, Yu Y, Ke Y, Wang C, Zhu L, Qian ZM (2007) Ligustilide attenuates pain behavior induced by acetic acid or formalin. J Ethnopharmacol 112: 211-214.
7. Eddy NB, Leimback D (1953) Synthetic analgesics. II. Dithienylbutenyland dithienylbutylamines. J Pharmacol Exper Ther 107: 385-393.
8. Guo JM, Duan JA, Shang EX, Tang YP, Qian DW (2009) Determination of ligustilide in rat brain after nasal administration of essential oil from Rhizoma Chuanxiong. Fitoterapia 80: 168-172.
9. Illum L (2000) Transport of drugs from the nasal cavity to the central nervous system. Eur J Pharm Sci 11: 1-18.
10. Illum L (2003) Nasal drug delivery-possibilities, problems and solutions. J Control Release 87: 187-198.
11. Ko WC, Liao CC, Shih CH, Lei CB, Chen CM (2002) Relaxant effects of butylidenephthalide in isolated dog blood vessels. Planta Med 68: 1004-1009.
12. Ko WC, Sheu JR, Leu YR, Tzeng SH, Chen CM (1997) Stereoselectivity of butylidenephthalide on voltage-dependent calcium channels in guinea-pig isolated ileum. J Pharm Pharmacol 49: 1121-1125.
13. Kuang X, Yao Y, Du JR, Liu YX, Wang CY, Qian ZM (2006) Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice. Brain Res 1102: 145-153.
14. Liu PZ, Wu W, Chen HG (2004) The progress of intranasal administration in the treatment of migraine. J Liaoning Coll of TCM 6: 125-126.
15. Lu Q, Qiu TQ, Yang H (2006) Ligustilide inhibits vascular smooth muscle cells proliferation. Eur J Pharmacol 542: 136-140.
16. Matsumoto K, Kohno SI, Ojima K, Tezuka Y, Kadota S,Watanabe H (1998) Effects of methylenechloride-soluble fraction of Japanese Angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated rats. Life Sci 62: 2073-2082.
17. Naito T, Kubota K, Shimoda Y, Sato T, Ikeya Y, Okada M, Maruno M (1995) Effects of constituents in a Chinese crude drug Ligustici Chuanxion Rhizoma on vasoconstriction and blood viscosity. Natural Med 49: 288-292.
18. Nakamura H, Shimoda A, Ishii K, Kadokawa T (1986) Central and peripheral analgesic action of non-acidic non-steroidal anti-inflammatory drugs in mice and rats. Arch Int Pharmacodynam Ther 282: 16-25.
19. Peng HY, Du JR, Zhang GY, Kuang X, Liu YX, Qian ZM, Wang CY (2007) Neuroprotective effect of Z-ligustilide against permanent focal ischemic damage in rats. Biol Pharm Bull 30: 309-312.
20. Song ZH, Ji ZN, Lo CK, Dong TT, Zhao KJ, Li OT, Haines CJ, Kung SD, Tsim KW (2004) Chemical and biological assessment of a traditional chinese herbal decoction prepared from Radix Astragali and Radix Angelicae Sinensis, orthogonal array design to optimize the extraction of chemical constituents. Planta Med 70: 1222-1227.
21. Sun SR, Huang X, Zhang L (2002) Advances in studies on pharmacokinetics, phamacodynamics and clinical research of Suxiao Jiuxin Wan. Chinese Traditional Herbal Drugs 33: 89-91.
22. Xie XQ, Zhan K, Yin RL, Yang LH (2007) Progress of Chuanxiong Essential Oil. Lishizhen Med Materia Medica Res 18: 1508-1510.
23. Yan R, Lin G, Ko NL, Tam YK (2007) Low oral bioavailability and pharmacokinetics of senkyunolide a, a major bioactive component in Rhizoma Chuanxiong, in the rat. Therap Drug Monitor 29: 49-56.
24. Yan R, Ko NL, Li SL, Tam YK, Lin G (2008) Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat. Drug Metab Dispos 36: 400-408.