Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells

Planta Medica

Volumn 73, Issue 6, 2007, Pages 527-534

  Lee, Ting Fang ^a   Lin, Yun Lian ^b   Huang, Yi Tsau ^a  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Apoptosis; Hepatic stellate cells; Ligusticum chuanxiong; Phthalides; Platelet derived growth factor; Umbelliferae

Indexed keywords

6,8',7,3' DILIGUSTILIDE; ACTIN; BROXURIDINE; CASPASE 3; CASPASE 9; COLLAGEN; LEVISTOLIDE; LIGUSTICUM CHUANXIONG EXTRACT; PHTHALIDE DERIVATIVE; PLATELET DERIVED GROWTH FACTOR; PROTEIN P21; PROTEIN P27; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; DOWN REGULATION; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LIGUSTICUM CHUANXIONG; LIVER CELL; LIVER FIBROSIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RAT; STELLATE CELL; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BENZOFURANS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FLOW CYTOMETRY; HEPATOCYTES; HUMANS; IN SITU NICK-END LABELING; LIGUSTICUM; LIVER CIRRHOSIS; PHYTOTHERAPY; PLANT EXTRACTS; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; RHIZOME;

APIACEAE; LIGUSTICUM CHUANXIONG; RATTUS;

EID: 34250899339     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-981520     Document Type: Article

References (27)

1. Bataller R, Brenner DA. Liver fibrosis. J Clin Invest 2005; 115: 209-18.
2. Friedman S. Liver fibrosis - from bench to bedside. J Hepatol 2003; 38: S38-53.
3. Pinzani M, Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis 2001; 21: 397-416.
4. Gebhardt R. Oxidative stress, plant-derived antioxidants and liver fibrosis. Planta Med 2002; 68: 289-96.
5. Schuppan D, Jia JD, Brinkhaus B, Hahn EG. Herbal products for liver diseases: a therapeutic challenge for the new millennium. Hepatology 1999; 30: 1099-104.
6. Shimizu I, Ma YR, Mizobuchi Y, Liu F, Miura T, Nakai Y et al. Effects of Sho-saiko-to, a Japanese herbal medicine, on hepatic fibrosis in rats. Hepatology 1999; 29: 149-60.
7. Boigk G, Stroedter L, Herbst H, Waldschmidt J, Riecken EO, Schuppan D. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Hepatology 1997; 26: 643-9.
8. Hsu YT, Lin YL, Chiu YT, Shiao MS, Lee CY, Huang YT. Anti-fibrotic effects of Salvia miltiorrhiza on dimethylnitrosamine-intoxicated rats. J Biomed Sci 2005; 12: 185-95.
9. Sakaida I, Tsuchiya M, Kawaguchi K, Kimura T, Terai S, Okita K. Herbal medicine Inchin-ko-to (TJ-135) prevents liver fibrosis and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-deficient diet. J Hepatol 2003; 38: 762-9.
10. Chang HS, But PPH. Chuanxiong. Pharmacology and Applications of Chinese Materia Medica. Singapore: World Scientific Publishing; 1986: 131-40.
11. Lin YL, Lee TF, Huang YJ, Huang YT. Inhibitory effects of Ligusticum chuanxiong on the proliferation of rat hepatic stellate cells. J Gastroenterol Hepatol 2006; 21: 1257-66.
12. Kaouadji M, De Pachtere F, Pouget C, Chulia AJ. Three additional phthalide derivatives, an epoxymonomer and two dimers, from Ligusticum wallichi rhizomes. J Nat Prod 1986; 49: 872-7.
13. Li SL, Chan S, Lin G, Ling L, Yan R, Chung HS et al. Simultaneous analysis if seventeen chemical ingredients of Ligusticum chuanxiong by online high performance liquid chromatography-diode array detector-mass spectrometry. Planta Med 2003; 96: 445-51.
14. Naito T, Katsuhara T, Niitsu K, Ikeya Y, Okada M, Mitsuhashi LH. Phthalide dimers, from Ligusticum chuanxiong Hort. Heterocycles 1991; 32: 2433-42.
15. Cascales C, Mangiapane EH, Brindley DN. Oleic acid promotes the activation and translocation of phosphatidate phosphydrolase from the cytosol to particulate fractions of isolated rat hepatocytes. Biochem J 1984; 219: 911-6.
16. Kim KY, Rhim TY, Choi I, Kim SS. N-Acetylcysteine induces cell cycle arrest in hepatic stellate cell through its reducing activity. J Biol Chem 2001; 27: 40 591-8.
17. Aggarwal S, Gollapudi S, Gupta S. Increased TNF-α-induced apoptosis in lymphocytes from aged humans: changes in TNF-α receptor expression and activation of caspases. J Immunol 1999; 162: 2154-61.
18. Liu L, Ning ZQ Shan S, Zhang K, Deng T, Lu XP et al. Phthalide lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-α production and TNF-α-mediated NF-κB activation. Planta Med 2005; 71: 808-13.
19. Canbay A, Taimer P, Higuchi H, Friedman S, Gores GJ. Apoptotic body engulfment by human stellate cell line is profibrogenic. Lab Invest 2003; 83: 655-63.
20. Issa R, Williams E, Trim N, Kendall T, Arthu MJ, Reichen J et al. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 2001; 48: 548-57.
21. Kweon YO, Paik YH, Schnabl B, Qian T, Lemasters JJ, Brenner DA. Gliotoxin-mediated apoptosis of activated human hepatic stellate cells. J Hepatol 2003; 39: 38-46.
22. Xu J, Fu Y, Chen A. Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am J Physiol Gastrointest Liver Physiol 2003; 285: G20-30.
23. Kawada N, Ikeda KS, Kuroki T. Expression of cyclins D1, D2, and E correlate with proliferation of rat stellate cells in culture. J Hepatol 1999; 30: 1057-64.
24. Lin YL, Lee TF, Huang YJ, Huang YT. Antiproliferative effect of salvianolic acid A on rat hepatic stellate cells. J Pharm Pharmacol 2006; 58: 933-9.
25. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13: 1899-991.
26. Franke TF, Cantley LC. Apoptosis: A Bad kinase makes good. Nature 1997; 390: 116-7.
27. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000; 103: 239-52.