Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 21, 2011, Pages 6316-6328

  Tan, Chen Ming ^a   Chen, Grace Shiahuy ^a,b   Chen, Chien Shu ^a,c   Chang, Pei Teh ^a   Chern, Ji Wang ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b PROVIDENCE UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

5 Lipoxygenase; Cyclooxygenase 2; dual inhibitor; Structure activity relationship

Indexed keywords

(3 BENZYLOXY 5 FLUOROPHENYL)BROMIDE; 2 (3,5 DIMETHOXYPHENOXY)ETHANETHIOL; 2 (3,5 DIMETHOXYPHENOXY)ETHYL BROMIDE; 2 (4 BROMOPHENYLSULFANYL) 5 (HYDROXYCARBONYL)BENZENESULFONAMIDE; 2 BROMO 4 CHLOROBENZENE 1,5 DISULFONAMIDE; 2 BROMO 5 METHYLSULFONYLBENZENESULFONAMIDE; 2 IODO 5 METHYLBENZENESULFONAMIDE; 2 IODO BENZENESULFONAMIDE; 2 IODOBENZENE 1,4 DISULFONAMIDE; 2 IODOBENZENE 1,4 DISULFONIC ACID; 2,4 DISULFAMYLTOLUENE; 3 (4 TERT BUTYLPHENYL) 6 NITROBENZO[1.3.2]DITHIAZOLIUM YLIDE 1,1 DIOXIDE; 4 (3 BENZYLOXY 5 FLUOROPHENYL) 4 HYDROXY 3,4,5,6 TETRAHYDRO 2H PYRAN; 4 (3 BENZYLOXY 5 FLUOROPHENYL) 4 METHOXY 3,4,5,6 TETRAHYDRO 2H PYRAN; 4 (3 FLUORO 5 HYDROPHENYL) 4 METHOXY 3,4,5,6 TETRAHYDRO 2H PYRAN; 4 BROMOBENZENE 1,3 DISULFONAMIDE; 4 [3 (2 BROMOETHOXY) 5 FLUOROPHENYL] 4 METHOXY 3,4,5,6 TETRAHYDRO 2H PYRAN; 4 [3 FLUORO 5 (2 MERCAPTOETHOXY)PHENYL] 4 METHOXY 3,4,5,6 TETRAHYDRO 2H PYRAN; 5 AMINOSULFONYL 3 (3 BROMOPHENYL)BENZO[1.3.2]DITHIAZOLIUM YLIDE 1,1 DIOXIDE; 5 AMINOSULFONYL 3 (4 BROMOPHENYL)BENZO[1.3.2]DITHIAZOLIUM YLIDE 1,1 DIOXIDE; 5 AMINOSULFONYL 3 (4 CHLOROPHENYL)BENZO[1.3.2]DITHIAZOLIUM YLIDE 1,1 DIOXIDE; 5 AMINOSULFONYL 3 (4 FLUOROPHENYL)BENZO[1.3.2]DITHIAZOLIUM YLIDE 1,1 DIOXIDE; 5 AMINOSULFONYL 3 (4 METHYLPHENYL)BENZO[1.3.2]DITHIAZOLIUM YLIDE 1,1 DIOXIDE; ACETYLSALICYLIC ACID; ANTIINFLAMMATORY AGENT; BENZO[1.3.2]DITHIAZOLIUM YLIDE 1,1 DIOXIDE DERIVATIVE; CYCLOOXYGENASE 2 INHIBITOR; LIPOXYGENASE INHIBITOR; ROFECOXIB; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; LIPOPHILICITY; MALE; NONHUMAN; PAW EDEMA; RAT; STRUCTURE ACTIVITY RELATION;

EID: 80054937444     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.09.003     Document Type: Article

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