Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13

Biochemical Journal

Volumn 432, Issue 3, 2010, Pages 451-459

  Jenkins, Laura ^a   Brea, Jose ^b   Smith, Nicola J ^a   Hudson, Brian D ^a   Reilly, Graeme ^a   Bryant, Nia J ^a   Castro, Marian ^b   Loza, María Isabel ^b   Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

arrestin 2; Agonist; Drug discovery; G protein coupled receptor (GPCR); GPR35; Screening

Indexed keywords

AGONIST; ARRESTINS; DRUG DISCOVERY; G-PROTEIN COUPLED RECEPTORS; GPR35;

GROWTH KINETICS; PROTEINS; YEAST;

LIGANDS;

BETA ARRESTIN 2; CHIMERIC PROTEIN; CROMOGLYCATE DISODIUM; DICOUMAROL; EMBONIC ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 35; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); LUTEOLIN; NIFLUMIC ACID; UNCLASSIFIED DRUG; ZAPRINAST;

ANIMAL CELL; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DRUG IDENTIFICATION; EPITOPE MAPPING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN INTERACTION; RAT; SACCHAROMYCES CEREVISIAE;

ANIMALS; ARRESTINS; CELL PROLIFERATION; CROMOLYN SODIUM; DICUMAROL; DRUG DISCOVERY; GENES, REPORTER; GTP-BINDING PROTEIN ALPHA SUBUNITS, G12-G13; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HEK293 CELLS; HUMANS; LIGANDS; OSMOLAR CONCENTRATION; PURINONES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS; SMALL MOLECULE LIBRARIES; SPECIES SPECIFICITY;

RATTUS; SACCHAROMYCES CEREVISIAE;

EID: 78649859393     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20101287     Document Type: Article

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