G-protein coupled receptor 35 (GPR35) activation and inflammatory pain: Studies on the antinociceptive effects of kynurenic acid and zaprinast

Neuropharmacology

Volumn 60, Issue 7-8, 2011, Pages 1227-1231

  Cosi, Cristina ^b   Mannaioni, Guido ^a   Cozzi, Andrea ^a   Carl, Vincenzo ^a   Sili, Maria ^a   Cavone, Leonardo ^a   Maratea, Dario ^a   Moroni, Flavio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Analgesia; GPR35; Kynurenic acid; Kynurenine; Pain; Zaprinast

Indexed keywords

ACETIC ACID; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 35; KYNURENIC ACID; PROBENECID; UNCLASSIFIED DRUG; ZAPRINAST; KYNURENINE;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE COMPARISON; DRUG POTENTIATION; DRUG RECEPTOR BINDING; DRUG TARGETING; DRUG TISSUE LEVEL; GLIA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFLAMMATORY PAIN; LOW DRUG DOSE; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SPINAL CORD; SPINAL GANGLION; WRITHING TEST; ANALYTICAL PARAMETERS; ANTINOCICEPTION; BLOOD LEVEL; CONCENTRATION (PARAMETERS); DRUG ACTIVITY; PROTEIN TARGETING; RECEPTOR AFFINITY; RECEPTOR UPREGULATION; SPINAL CORD LEVEL; TRYPTOPHAN METABOLISM;

ANALGESICS; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EXCITATORY AMINO ACID ANTAGONISTS; GANGLIA, SPINAL; GENE EXPRESSION; INFLAMMATION; KYNURENIC ACID; KYNURENINE; MALE; MICE; NEUROGLIA; PAIN; PAIN MEASUREMENT; PHOSPHODIESTERASE INHIBITORS; PROBENECID; PURINONES; RECEPTORS, G-PROTEIN-COUPLED; SPINAL CORD; TRYPTOPHAN;

EID: 79954585445     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.11.014     Document Type: Article

References (45)

1. L. Bacciottini, D.E. Pellegrini-Giampietro, F. Bongianni, G. De Luca, M. Beni, V. Politi, and F. Moroni Biochemical and behavioural studies on indole-pyruvic acid: a keto-analogue of tryptophan Pharmacological Research Communications 19 1987 803 817 (Pubitemid 18030717)
2. M.C. Barth, N. Ahluwalia, T.J. Anderson, G.J. Hardy, S. Sinha, J.A. Alvarez-Cardona, I.E. Pruitt, E.P. Rhee, R.A. Colvin, and R.E. Gerszten Kynurenic acid triggers firm arrest of leukocytes to vascular endothelium under flow conditions Journal of Biological Chemistry 284 2009 19189 19195
3. R. Carpenedo, A. Chiarugi, P. Russi, G. Lombardi, V. Carl, R. Pellicciari, L. Mattoli, and F. Moroni Inhibitors of kynurenine hydroxylase and kynureninase increase cerebral formation of kynurenic acid and have sedative and anticonvulsant activities Neuroscience 61 1994 237 244 (Pubitemid 24219003)
4. R. Carpenedo, A. Pittaluga, A. Cozzi, S. Attucci, A. Galli, M. Raiteri, and F. Moroni Presynaptic kynurenate sensitive receptors inhibit glutamate release European Journal of Neuroscience 13 2001 2141 2147 (Pubitemid 32578800)
5. R. Carpenedo, E. Meli, F. Peruginelli, D.E. Pellegrini-Giampietro, and F. Moroni Kynurenine 3-mono-oxygenase inhibitors attenuate post-ischemic neuronal death in organotypic hippocampal slice cultures Journal of Neurochemistry 82 2002 1465 1471
6. S.R. Chen, G. Samoriski, and H.L. Pan Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain Neuropharmacology 57 2009 121 126
7. A. Chiarugi, R. Carpenedo, and F. Moroni Kynurenine disposition in blood and brain of mice: effects of selective inhibitors of kynurenine hydroxylase and of kynureninase J. Neurochem 67 1996 692 698 (Pubitemid 26255666)
8. H.O. Collier, L.C. Dinneen, C.A. Johnson, and C. Schneider The abdominal constriction response and its suppression by analgesic drugs in the mouse British Journal of Pharmacology and Chemotherapy 32 1968 295 310
9. C. Di Serio, A. Cozzi, I. Angeli, L. Doria, I. Micucci, S. Pellerito, P. Mirone, G. Masotti, F. Moroni, and F. Tarantini Kynurenic acid inhibits the release of the neurotrophic fibroblast growth factor (FGF)-1 and enhances proliferation of glia cells, in vitro Cellular and Molecular Neurobiology 25 2005 981 993 (Pubitemid 43154822)
10. F. Du, W.J. Schmidt, E. Okuno, R. Kido, R.C. Koehler, and R. Schwarcz Localization of kynurenine aminotransferase immunoreactivity in the rat hippocampus Journal of Comparative Neurology 321 1992 477 487
11. S. Erhardt, M. Hajos, A. Lindberg, and G. Engberg Nicotine-induced excitation of locus coeruleus neurons is blocked by elevated levels of endogenous kynurenic acid Synapse 37 2000 104 108 (Pubitemid 30447941)
12. A. Foster, A. Vezzani, E.D. French, and R. Schwarcz Kynurenic acid blocks neurotoxicity and seizures induced in rats by the related brain metabolite quinolinic acid Neuroscience Letters 48 1984 273 278 (Pubitemid 14054435)
13. P. Guidetti, E. Okuno, and R. Schwarcz Characterization of rat brain kynurenine aminotransferases I and II Journal of Neuroscience Research 50 1997 457 465 (Pubitemid 27488325)
14. J. Guo, D.J. Williams, H.L. Puhl III, and S.R. Ikeda Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons Journal of Pharmacology and Experimental Therapeutics 324 2008 342 351 (Pubitemid 350294182)
15. S.O. Heyliger, C.B. Goodman, J.M. Ngong, and K.F. Soliman The analgesic effects of tryptophan and its metabolites in the rat Pharmacological Research 38 1998 243 250 (Pubitemid 28466743)
16. R. Kapoor, E. Okuno, R. Kido, and V. Kapoor Immuno-localization of kynurenine aminotransferase in the rat medulla and spinal cord NeuroReport 8 1997 3619 3623 (Pubitemid 27497494)
17. I.P. Lapin Depressor effect of kynurenine and its metabolites in rats Life Sciences 19 1976 1479 1484
18. I.P. Lapin Experimental studies on kynurenine as neuroactive tryptophan metabolites: past, present and future Trends in Pharmacological Sciences 1 1980 410 413
19. C.J. Lee, G. Mannaioni, H. Yuan, D.H. Woo, M.B. Gingrich, and S.F. Traynelis Astrocytic control of synaptic NMDA receptors Journal of Physiology 581 2007 1057 1081 (Pubitemid 46887980)
20. G.L. Lou, C. Pinsky, and D.S. Sitar Kynurenic acid distribution into brain and peripheral tissues of mice Canadian Journal of Physiology and Pharmacology 72 1994 161 167 (Pubitemid 24156231)
21. A.F. Miranda, R.J. Boegman, R.J. Beninger, and K. Jhamandas Protection against quinolinic-acid mediated excitotoxicity in nigrostriatal dopaminergic neurons by endogenous kynurenic acid Neuroscience 78 1997 967 975 (Pubitemid 27223703)
22. F. Moroni Tryptophan metabolism and brain function: focus on kynurenine and other indole metabolites European Journal of Pharmacology 375 1999 87 100 (Pubitemid 29317595)
23. F. Moroni, P. Russi, V. Carl, and G. Lombardi Kynurenic acid is present in the rat brain and its content increases during development and aging processes Neuroscience Letters 94 1988 145 150
24. F. Moroni, P. Russi, G. Lombardi, M. Beni, and V. Carl Presence of kynurenic acid in the mammalian brain Journal of Neurochemistry 51 1988 177 181
25. F. Moroni, D.E. Pellegrini-Giampietro, M. Alesiani, G. Cherici, F. Mori, and A. Galli Glycine and kynurenate modulate the glutamate receptors present in the myenteric plexus and in cortical membranes European Journal of Pharmacology 163 1989 123 126 (Pubitemid 19107551)
26. F. Moroni, P. Russi, M.A. Gallo-Mezo, G. Moneti, and R. Pellicciari Modulation of quinolinic and kynurenic acid content in the rat brain: effects of endotoxins and nicotinylalanine Journal of Neurochemistry 57 1991 1630 1635 (Pubitemid 21922799)
27. K. Nozaki, and M.F. Beal Neuroprotective effects of L-kynurenine on hypoxia-ischemia and NMDA lesions in neonatal rats Journal of Cerebral Blood Flow and Metabolism 12 1992 400 407
28. B.F. O'Dowd, T. Nguyen, A. Marchese, R. Cheng, K.R. Lynch, H.H. Heng, L.F. Kolakowski Jr., and S.R. George Discovery of three novel G-protein-coupled receptor genes Genomics 47 1998 310 313 (Pubitemid 28086858)
29. H. Ohshiro, H. Tonai-Kachi, and K. Ichikawa GPR35 is a functional receptor in rat dorsal root ganglion neurons Biochemical and Biophysical Research Communications 365 2008 344 348 (Pubitemid 350137295)
30. E. Okuno, M. Nakamura, and R. Schwarcz Two kynurenine aminotransferases in human brain Brain Research 542 1991 307 312
31. D.E. Pellegrini-Giampietro, A. Galli, M. Alesiani, G. Cherici, and F. Moroni Quinoxalines interact with the glycine recognition site of NMDA receptors: studies in guinea-pig myenteric plexus and in rat cortical membranes British Journal of Pharmacology 98 1989 1281 1286 (Pubitemid 20011084)
32. M.N. Perkins, and T.W. Stone Specificity of kynurenic acid as an antagonist of synaptic transmission in rat hippocampal slices Neuroscience Letters 18 1982 432
33. S. Pezet, and S.B. McMahon Neurotrophins: mediators and modulators of pain Annual Review of Neuroscience 29 2006 507 538 (Pubitemid 44476854)
34. P. Russi, V. Carl, and F. Moroni Indolpyruvic acid administration increases the brain content of kynurenic acid: is this a new avenue to modulate excitatory amino acid receptors in vivo? Biochemical Pharmacology 38 1989 2405 2409 (Pubitemid 19188402)
35. P. Russi, M. Alesiani, G. Lombardi, P. Davolio, R. Pellicciari, and F. Moroni Nicotinylalanine increases the formation of kynurenic acid in the brain and antagonizes convulsions Journal of Neurochemistry 59 1992 2076 2080
36. R. Schwarcz, and R. Pellicciari Manipulation of brain kynurenines: glial targets, neuronal effects, and clinical opportunities Journal of Pharmacology and Experimental Therapeutics 303 2002 1 10
37. C. Speciale, K. Hares, R. Schwarcz, and A. Brooks High affinity uptake of L-kynurenine by a Na+-inependent transporter of neutral amino acids in astrocytes Journal of Neuroscience 9 1989 2066 2072 (Pubitemid 19156993)
38. K.J. Swartz, M.J. During, A. Freese, and M.F. Beal Cerebral synthesis and release of kynurenic acid: an endogenous antagonist of excitatory amino acid receptors Journal of Neuroscience 10 1990 2965 2973
39. Y. Taniguchi, H. Tonai-Kachi, and K. Shinjo Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35 FEBS Letters 580 2006 5003 5008 (Pubitemid 44332369)
40. W.A. Turski, M. Nakamura, W.P. Todd, B.K. Carpenter, W.O. Whetsell, and R. Schwarcz Identification and quantification of kynurenic acid in human brain tissue Brain Research 454 1988 164 169
41. V. Vellani, O. Zachrisson, and P.A. McNaughton Functional bradykinin B1 receptors are expressed in nociceptive neurones and are upregulated by the neurotrophin GDNF Journal of Physiology 560 2004 391 401 (Pubitemid 39440102)
42. L. Vécsei, J. Miller, U. MacGarvey, and M.F. Beal Kynurenine and probenecid inhibit pentylenetetrazol and NMDA-induced seizures and increase kynurenic acid concentrations in the brain Brain Research Bulletin 28 1991 233 238
43. J. Wang, N. Simonavicius, X. Wu, G. Swaminath, J. Reagan, H. Tian, and L. Ling Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35 Journal of Biological Chemistry 281 2006 22021 22028 (Pubitemid 44181906)
44. Y. Wang, H. Liu, G. McKenzie, P.K. Witting, J.P. Stasch, M. Hahn, D. Changsirivathanathamrong, B.J. Wu, H.J. Ball, S.R. Thomas, V. Kapoor, D.S. Celermajer, A.L. Mellor, J.F. Keaney Jr., N.H. Hunt, and R. Stocker Kynurenine is an endothelium-derived relaxing factor produced during inflammation Nature Medicine 16 2010 279 285
45. P. Zhao, H. Sharir, A. Kapur, A. Cowan, E.B. Geller, M.W. Adler, H.H. Seltzman, P.H. Reggio, S. Heynen-Genel, M. Sauer, T.D. Chung, Y. Bai, W. Chen, M.G. Caron, L.S. Barak, and M.E. Abood Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and beta-arrestin2 with antinociceptive activity Molecular Pharmacology 78 2010 560 568