Synthesis and toll-like receptor 4 (TLR4) activity of phosphatidylinositol dimannoside analogues

Journal of Medicinal Chemistry

Volumn 54, Issue 20, 2011, Pages 7268-7279

  Ainge, Gary D ^a,b   Martin, William John ^c   Compton, Benjamin J ^a   Hayman, Colin M ^a   Larsen, David S ^b   Yoon, Sung Il ^d   Wilson, Ian A ^d   Harper, Jacquie L ^c   Painter, Gavin F ^a  

^a CALLAGHAN INNOVATION   (New Zealand)

^b UNIVERSITY OF OTAGO   (New Zealand)

^c MALAGHAN INSTITUTE OF MEDICAL RESEARCH   (New Zealand)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 O (1 O HEXADECANOYL 2 O HEXADECYL SN GLYCERO 3 PHOSPHORYL) 2 O (6 O HEXADECANOYL ALPHA DEXTRO MANNOPYRANOSYL) 6 O(ALPHA DEXTRO MANNOPYRANOSYL)DEXTRO MYO INOSITOL; 2 O (1 O HEXADECANOYL 2 O HEXADECYL SN GLYCERO 3 PHOSPHORYL) 1,3 BIS O(ALPHA DEXTRO MANNOPYRANOSYL)GLYCEROL; 2,6 (DI O ALPHA DEXTRO MANNOPYRANOSYL) 1 O(2 DEOXY 1 O HEXADECANOYL 2 N HEXADECANOYLAMINO SN GLYCERO 3 PHOSPHORYL)DEXTRO MYO INOSITOL; 2,6 (DI O ALPHA DEXTRO MANNOPYRANOSYL) 1 O(2 O HEXADECANOYL 1 O HEXADECYL SN GLYCERO 3 PHOSPHORYL)DEXTRO MYO INOSITOL; AMIDE; ESTER DERIVATIVE; ETHER; FATTY ACID ESTER; GLYCEROL; INOSITOL; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MANNOSIDE; PHOSPHATIDYLGLYCEROL DIMANNOSIDE DERIVATIVE; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL MANNOSIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; RECEPTOR BLOCKING AGENT; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; COMPLEX FORMATION; CYTOKINE PRODUCTION; DRUG STRUCTURE; DRUG SYNTHESIS; GLYCOSYLATION; MACROPHAGE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE;

ANIMALS; ESTERS; ETHERS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LIPOPROTEINS; LYMPHOCYTE ANTIGEN 96; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHATIDYLINOSITOLS; PROTEIN MULTIMERIZATION; SIGNAL TRANSDUCTION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TOLL-LIKE RECEPTOR 4;

EID: 80054927544     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2008419     Document Type: Article

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