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Volumn 41, Issue 11, 2011, Pages 3281-3290

Mesenchymal stem cells expanded in human platelet lysate display a decreased inhibitory capacity on T- and NK-cell proliferation and function

Author keywords

Graft versus host disease; Hematopoietic stem cell transplantation; Human platelet lysate; Mesenchymal stromal cells; NK cells

Indexed keywords

5' NUCLEOTIDASE; ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ALLOANTIGEN; ALPHA4 INTEGRIN; BETA1 INTEGRIN; CD14 ANTIGEN; CD146 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; CD56 ANTIGEN; ENDOGLIN; HERMES ANTIGEN; HLA ANTIGEN CLASS 1; HLA DR ANTIGEN; INTERLEUKIN 6; INTERLEUKIN 8; NATURAL KILLER CELL RECEPTOR NKG2D; NECTIN 1; NECTIN 2; RANTES; THY 1 ANTIGEN;

EID: 80054892015     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201141542     Document Type: Article
Times cited : (112)

References (48)
  • 2
    • 67649871059 scopus 로고    scopus 로고
    • Mesenchymal stem cells for therapeutic purposes
    • Sensebe, L. and Bourin, P., Mesenchymal stem cells for therapeutic purposes. Transplantation 2009. 87: S49-S53.
    • (2009) Transplantation , vol.87
    • Sensebe, L.1    Bourin, P.2
  • 3
    • 69249167891 scopus 로고    scopus 로고
    • Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy
    • Perez-Ilzarbe, M., Diez-Campelo, M., Aranda, P., Tabera, S., Lopez, T., del Canizo, C., Merino, J. et al., Comparison of ex vivo expansion culture conditions of mesenchymal stem cells for human cell therapy. Transfusion 2009. 49: 1901-1910.
    • (2009) Transfusion , vol.49 , pp. 1901-1910
    • Perez-Ilzarbe, M.1    Diez-Campelo, M.2    Aranda, P.3    Tabera, S.4    Lopez, T.5    del Canizo, C.6    Merino, J.7
  • 4
    • 70349850496 scopus 로고    scopus 로고
    • Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow
    • Bieback, K., Hecker, A., Kocaomer, A., Lannert, H., Schallmoser, K., Strunk, D. and Kluter, H., Human alternatives to fetal bovine serum for the expansion of mesenchymal stromal cells from bone marrow. Stem Cells 2009. 27: 2331-2341.
    • (2009) Stem Cells , vol.27 , pp. 2331-2341
    • Bieback, K.1    Hecker, A.2    Kocaomer, A.3    Lannert, H.4    Schallmoser, K.5    Strunk, D.6    Kluter, H.7
  • 5
    • 77957338676 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: facilitators of successful transplantation?
    • English, K., French, A. and Wood, K. J., Mesenchymal stromal cells: facilitators of successful transplantation? Cell Stem Cell 2010. 7: 431-442.
    • (2010) Cell Stem Cell , vol.7 , pp. 431-442
    • English, K.1    French, A.2    Wood, K.J.3
  • 6
    • 21244476175 scopus 로고    scopus 로고
    • Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications
    • Doucet, C., Ernou, I., Zhang, Y., Llense, J. R., Begot, L., Holy, X. and Lataillade, J. J., Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J. Cell. Physiol. 2005. 205: 228-236.
    • (2005) J. Cell. Physiol. , vol.205 , pp. 228-236
    • Doucet, C.1    Ernou, I.2    Zhang, Y.3    Llense, J.R.4    Begot, L.5    Holy, X.6    Lataillade, J.J.7
  • 7
    • 33847652908 scopus 로고    scopus 로고
    • Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute
    • Bernardo, M. E., Avanzini, M. A., Perotti, C., Cometa, A. M., Moretta, A., Lenta, E., Del Fante, C. et al., Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for cell-therapy approaches: further insights in the search for a fetal calf serum substitute. J. Cell. Physiol. 2007. 211: 121-130.
    • (2007) J. Cell. Physiol. , vol.211 , pp. 121-130
    • Bernardo, M.E.1    Avanzini, M.A.2    Perotti, C.3    Cometa, A.M.4    Moretta, A.5    Lenta, E.6    Del Fante, C.7
  • 8
    • 0027404805 scopus 로고
    • Platelha-granules
    • Harrison, P. and Cramer, E. M., Platelet alpha-granules. Blood Rev. 1993. 7: 52-62.
    • (1993) Blood Rev. , vol.7 , pp. 52-62
    • Harrison, P.1    Cramer, E.M.2
  • 10
    • 80055116622 scopus 로고    scopus 로고
    • Preparation of pooled human platelet lysate (pHPL) as an efficient supplement for animal serum-free human stem cell cultures
    • DOI: 10.3791/1523.
    • Schallmoser, K. and Strunk, D., Preparation of pooled human platelet lysate (pHPL) as an efficient supplement for animal serum-free human stem cell cultures. J. Vis. Exp. 2010. DOI: 10.3791/1523.
    • (2010) J. Vis. Exp.
    • Schallmoser, K.1    Strunk, D.2
  • 11
    • 34948849730 scopus 로고    scopus 로고
    • Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts
    • Capelli, C., Domenghini, M., Borleri, G., Bellavita, P., Poma, R., Carobbio, A., Mico, C. et al., Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. Bone Marrow Transplant. 2007. 40: 785-791.
    • (2007) Bone Marrow Transplant. , vol.40 , pp. 785-791
    • Capelli, C.1    Domenghini, M.2    Borleri, G.3    Bellavita, P.4    Poma, R.5    Carobbio, A.6    Mico, C.7
  • 12
    • 51449124598 scopus 로고    scopus 로고
    • Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum
    • Schallmoser, K., Rohde, E., Reinisch, A., Bartmann, C., Thaler, D., Drexler, C., Obenauf, A. C. et al., Rapid large-scale expansion of functional mesenchymal stem cells from unmanipulated bone marrow without animal serum. Tissue Eng. Part C Methods 2008. 14: 185-196.
    • (2008) Tissue Eng. Part C Methods , vol.14 , pp. 185-196
    • Schallmoser, K.1    Rohde, E.2    Reinisch, A.3    Bartmann, C.4    Thaler, D.5    Drexler, C.6    Obenauf, A.C.7
  • 13
    • 34547115673 scopus 로고    scopus 로고
    • Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells
    • Schallmoser, K., Bartmann, C., Rohde, E., Reinisch, A., Kashofer, K., Stadelmeyer, E., Drexler, C. et al., Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion 2007. 47: 1436-1446.
    • (2007) Transfusion , vol.47 , pp. 1436-1446
    • Schallmoser, K.1    Bartmann, C.2    Rohde, E.3    Reinisch, A.4    Kashofer, K.5    Stadelmeyer, E.6    Drexler, C.7
  • 14
    • 71849112100 scopus 로고    scopus 로고
    • Adipose tissue mesenchymal stem cell expansion in animal serum-free medium supplemented with autologous human platelet lysate
    • Blande, I. S., Bassaneze, V., Lavini-Ramos, C., Fae, K. C., Kalil, J., Miyakawa, A. A., Schettert, I. T. and Krieger, J. E., Adipose tissue mesenchymal stem cell expansion in animal serum-free medium supplemented with autologous human platelet lysate. Transfusion 2009. 49: 2680-2685.
    • (2009) Transfusion , vol.49 , pp. 2680-2685
    • Blande, I.S.1    Bassaneze, V.2    Lavini-Ramos, C.3    Fae, K.C.4    Kalil, J.5    Miyakawa, A.A.6    Schettert, I.T.7    Krieger, J.E.8
  • 15
    • 77953206944 scopus 로고    scopus 로고
    • Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions
    • Schallmoser, K., Bartmann, C., Rohde, E., Bork, S., Guelly, C., Obenauf, A. C., Reinisch, A. et al., Replicative senescence-associated gene expression changes in mesenchymal stromal cells are similar under different culture conditions. Haematologica 2010. 95: 867-874.
    • (2010) Haematologica , vol.95 , pp. 867-874
    • Schallmoser, K.1    Bartmann, C.2    Rohde, E.3    Bork, S.4    Guelly, C.5    Obenauf, A.C.6    Reinisch, A.7
  • 16
    • 77949890037 scopus 로고    scopus 로고
    • Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation
    • Tarte, K., Gaillard, J., Lataillade, J. J., Fouillard, L., Becker, M., Mossafa, H., Tchirkov, A. et al., Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation. Blood 2010. 115: 1549-1553.
    • (2010) Blood , vol.115 , pp. 1549-1553
    • Tarte, K.1    Gaillard, J.2    Lataillade, J.J.3    Fouillard, L.4    Becker, M.5    Mossafa, H.6    Tchirkov, A.7
  • 18
    • 80055120295 scopus 로고    scopus 로고
    • Isolation and animal serum free expansion of human umbilical cord derived mesenchymal stromal cells (MSCs) and endothelial colony forming progenitor cells (ECFCs)
    • DOI 10.3791/1525.
    • Reinisch, A. and Strunk, D., Isolation and animal serum free expansion of human umbilical cord derived mesenchymal stromal cells (MSCs) and endothelial colony forming progenitor cells (ECFCs). J. Vis. Exp. 2010. DOI 10.3791/1525.
    • (2010) J. Vis. Exp.
    • Reinisch, A.1    Strunk, D.2
  • 22
    • 73149120260 scopus 로고    scopus 로고
    • Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors
    • Avanzini, M. A., Bernardo, M. E., Cometa, A. M., Perotti, C., Zaffaroni, N., Novara, F., Visai, L. et al., Generation of mesenchymal stromal cells in the presence of platelet lysate: a phenotypic and functional comparison of umbilical cord blood- and bone marrow-derived progenitors. Haematologica 2009. 94: 1649-1660.
    • (2009) Haematologica , vol.94 , pp. 1649-1660
    • Avanzini, M.A.1    Bernardo, M.E.2    Cometa, A.M.3    Perotti, C.4    Zaffaroni, N.5    Novara, F.6    Visai, L.7
  • 23
    • 32644438233 scopus 로고    scopus 로고
    • Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation
    • Spaggiari, G. M., Capobianco, A., Becchetti, S., Mingari, M. C. and Moretta, L., Mesenchymal stem cell-natural killer cell interactions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood 2006. 107: 1484-1490.
    • (2006) Blood , vol.107 , pp. 1484-1490
    • Spaggiari, G.M.1    Capobianco, A.2    Becchetti, S.3    Mingari, M.C.4    Moretta, L.5
  • 24
    • 15044348816 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms
    • Rasmusson, I., Ringden, O., Sundberg, B. and Le Blanc, K., Mesenchymal stem cells inhibit lymphocyte proliferation by mitogens and alloantigens by different mechanisms. Exp. Cell Res. 2005. 305: 33-41.
    • (2005) Exp. Cell Res. , vol.305 , pp. 33-41
    • Rasmusson, I.1    Ringden, O.2    Sundberg, B.3    Le Blanc, K.4
  • 25
    • 77949355110 scopus 로고    scopus 로고
    • Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique
    • Centeno, C. J., Schultz, J. R., Cheever, M., Robinson, B., Freeman, M. and Marasco, W., Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr. Stem Cell Res. Ther. 2010. 5: 81-93.
    • (2010) Curr. Stem Cell Res. Ther. , vol.5 , pp. 81-93
    • Centeno, C.J.1    Schultz, J.R.2    Cheever, M.3    Robinson, B.4    Freeman, M.5    Marasco, W.6
  • 26
    • 78649879709 scopus 로고    scopus 로고
    • FGF-2 and PDGF, but not Platelet Lysate (PL), induce proliferation dependent, functional MHC-classII antigen in human mesenchymal stem cells (hMSC)
    • Bocelli-Tyndall, C., Zajac, P., Di Maggio, N., Trella, E., Benvenuto, F., Iezzi, G., Scherberich, A. et al., FGF-2 and PDGF, but not Platelet Lysate (PL), induce proliferation dependent, functional MHC-classII antigen in human mesenchymal stem cells (hMSC). Arthritis Rheum. 2010. 62: 3815-3825.
    • (2010) Arthritis Rheum. , vol.62 , pp. 3815-3825
    • Bocelli-Tyndall, C.1    Zajac, P.2    Di Maggio, N.3    Trella, E.4    Benvenuto, F.5    Iezzi, G.6    Scherberich, A.7
  • 27
    • 34548483870 scopus 로고    scopus 로고
    • Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine
    • Lange, C., Cakiroglu, F., Spiess, A. N., Cappallo-Obermann, H., Dierlamm, J. and Zander, A. R., Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine. J. Cell. Physiol. 2007. 213: 18-26.
    • (2007) J. Cell. Physiol. , vol.213 , pp. 18-26
    • Lange, C.1    Cakiroglu, F.2    Spiess, A.N.3    Cappallo-Obermann, H.4    Dierlamm, J.5    Zander, A.R.6
  • 28
    • 33750195530 scopus 로고    scopus 로고
    • Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM
    • Muller, I., Kordowich, S., Holzwarth, C., Spano, C., Isensee, G., Staiber, A., Viebahn, S. et al., Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy 2006. 8: 437-444.
    • (2006) Cytotherapy , vol.8 , pp. 437-444
    • Muller, I.1    Kordowich, S.2    Holzwarth, C.3    Spano, C.4    Isensee, G.5    Staiber, A.6    Viebahn, S.7
  • 29
    • 53949121833 scopus 로고    scopus 로고
    • Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells
    • Centeno, C. J., Busse, D., Kisiday, J., Keohan, C., Freeman, M. and Karli, D., Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells. Med. Hypotheses 2008. 71: 900-908.
    • (2008) Med. Hypotheses , vol.71 , pp. 900-908
    • Centeno, C.J.1    Busse, D.2    Kisiday, J.3    Keohan, C.4    Freeman, M.5    Karli, D.6
  • 30
    • 35048898697 scopus 로고    scopus 로고
    • New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy
    • Lataillade, J. J., Doucet, C., Bey, E., Carsin, H., Huet, C., Clairand, I., Bottollier-Depois, J. F. et al., New approach to radiation burn treatment by dosimetry-guided surgery combined with autologous mesenchymal stem cell therapy. Regen. Med. 2007. 2: 785-794.
    • (2007) Regen. Med. , vol.2 , pp. 785-794
    • Lataillade, J.J.1    Doucet, C.2    Bey, E.3    Carsin, H.4    Huet, C.5    Clairand, I.6    Bottollier-Depois, J.F.7
  • 31
    • 78649840207 scopus 로고    scopus 로고
    • Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease
    • Bernardo, M. E., Avanzini, M. A., Ciccocioppo, R., Perotti, C., Cometa, A. M., Moretta, A., Marconi, M. et al., Phenotypical/functional characterization of in vitro-expanded mesenchymal stromal cells from patients with Crohn's disease. Cytotherapy 2009: 1-12.
    • (2009) Cytotherapy , pp. 1-12
    • Bernardo, M.E.1    Avanzini, M.A.2    Ciccocioppo, R.3    Perotti, C.4    Cometa, A.M.5    Moretta, A.6    Marconi, M.7
  • 33
    • 77952376195 scopus 로고    scopus 로고
    • Characterization of platelet lysate cultured mesenchymal stromal cells and their potential use in tissue-engineered osteogenic devices for the treatment of bone defects
    • Salvade, A., Della Mina, P., Gaddi, D., Gatto, F., Villa, A., Bigoni, M., Perseghin, P. et al., Characterization of platelet lysate cultured mesenchymal stromal cells and their potential use in tissue-engineered osteogenic devices for the treatment of bone defects. Tissue Eng. Part C Methods 2010. 16: 201-214.
    • (2010) Tissue Eng. Part C Methods , vol.16 , pp. 201-214
    • Salvade, A.1    Della Mina, P.2    Gaddi, D.3    Gatto, F.4    Villa, A.5    Bigoni, M.6    Perseghin, P.7
  • 34
    • 77955509074 scopus 로고    scopus 로고
    • Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population
    • Lucchini, G., Introna, M., Dander, E., Rovelli, A., Balduzzi, A., Bonanomi, S., Salvade, A. et al., Platelet-lysate-expanded mesenchymal stromal cells as a salvage therapy for severe resistant graft-versus-host disease in a pediatric population. Biol. Blood Marrow Transplant. 2010. 16: 1293-1301.
    • (2010) Biol. Blood Marrow Transplant. , vol.16 , pp. 1293-1301
    • Lucchini, G.1    Introna, M.2    Dander, E.3    Rovelli, A.4    Balduzzi, A.5    Bonanomi, S.6    Salvade, A.7
  • 36
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study
    • Le Blanc, K., Frassoni, F., Ball, L., Locatelli, F., Roelofs, H., Lewis, I., Lanino, E. et al., Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet 2008. 371: 1579-1586.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3    Locatelli, F.4    Roelofs, H.5    Lewis, I.6    Lanino, E.7
  • 37
    • 50249158511 scopus 로고    scopus 로고
    • Mesenchymal stem cells in health and disease
    • Uccelli, A., Moretta, L. and Pistoia, V., Mesenchymal stem cells in health and disease. Nat. Rev. Immunol. 2008. 8: 726-736.
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 726-736
    • Uccelli, A.1    Moretta, L.2    Pistoia, V.3
  • 38
    • 77950550604 scopus 로고    scopus 로고
    • Mesenchymal stromal cells inhibit graft-versus-host disease of mice in a dose-dependent manner
    • Joo, S. Y., Cho, K. A., Jung, Y. J., Kim, H. S., Park, S. Y., Choi, Y. B., Hong, K. M. et al., Mesenchymal stromal cells inhibit graft-versus-host disease of mice in a dose-dependent manner. Cytotherapy 2010. 12: 361-370.
    • (2010) Cytotherapy , vol.12 , pp. 361-370
    • Joo, S.Y.1    Cho, K.A.2    Jung, Y.J.3    Kim, H.S.4    Park, S.Y.5    Choi, Y.B.6    Hong, K.M.7
  • 40
    • 26944435565 scopus 로고    scopus 로고
    • Dendritic cells in allogeneic hematopoietic stem cell transplantation
    • Nachbaur, D. and Kircher, B., Dendritic cells in allogeneic hematopoietic stem cell transplantation. Leuk. Lymphoma 2005. 46: 1387-1396.
    • (2005) Leuk. Lymphoma , vol.46 , pp. 1387-1396
    • Nachbaur, D.1    Kircher, B.2
  • 41
    • 38949183675 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2
    • Spaggiari, G. M., Capobianco, A., Abdelrazik, H., Becchetti, F., Mingari, M. C. and Moretta, L., Mesenchymal stem cells inhibit natural killer-cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2, 3-dioxygenase and prostaglandin E2. Blood 2008. 111: 1327-1333.
    • (2008) Blood , vol.111 , pp. 1327-1333
    • Spaggiari, G.M.1    Capobianco, A.2    Abdelrazik, H.3    Becchetti, F.4    Mingari, M.C.5    Moretta, L.6
  • 42
    • 73949101184 scopus 로고    scopus 로고
    • Natural killer alloeffector responses in haploidentical hemopoietic stem cell transplantation to treat high-risk leukemias
    • Moretta, L., Locatelli, F., Pende, D., Mingari, M. C. and Moretta, A., Natural killer alloeffector responses in haploidentical hemopoietic stem cell transplantation to treat high-risk leukemias. Tissue Antigens 2010. 75: 103-109.
    • (2010) Tissue Antigens , vol.75 , pp. 103-109
    • Moretta, L.1    Locatelli, F.2    Pende, D.3    Mingari, M.C.4    Moretta, A.5
  • 43
    • 78751689960 scopus 로고    scopus 로고
    • Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation
    • Moretta, L., Locatelli, F., Pende, D., Marcenaro, E., Mingari, M. C. and Moretta, A., Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation. Blood 2010. 117: 764-771.
    • (2010) Blood , vol.117 , pp. 764-771
    • Moretta, L.1    Locatelli, F.2    Pende, D.3    Marcenaro, E.4    Mingari, M.C.5    Moretta, A.6
  • 44
    • 70349762668 scopus 로고    scopus 로고
    • Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference
    • Locatelli, F., Pende, D., Maccario, R., Mingari, M. C., Moretta, A. and Moretta, L., Haploidentical hemopoietic stem cell transplantation for the treatment of high-risk leukemias: how NK cells make the difference. Clin. Immunol. 2009. 133: 171-178.
    • (2009) Clin. Immunol. , vol.133 , pp. 171-178
    • Locatelli, F.1    Pende, D.2    Maccario, R.3    Mingari, M.C.4    Moretta, A.5    Moretta, L.6
  • 45
    • 69249227552 scopus 로고    scopus 로고
    • MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2
    • Spaggiari, G. M., Abdelrazik, H., Becchetti, F. and Moretta, L., MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood 2009. 113: 6576-6583.
    • (2009) Blood , vol.113 , pp. 6576-6583
    • Spaggiari, G.M.1    Abdelrazik, H.2    Becchetti, F.3    Moretta, L.4
  • 47
    • 0033571491 scopus 로고    scopus 로고
    • Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells
    • Pende, D., Parolini, S., Pessino, A., Sivori, S., Augugliaro, R., Morelli, L., Marcenaro, E. et al., Identification and molecular characterization of NKp30, a novel triggering receptor involved in natural cytotoxicity mediated by human natural killer cells. J. Exp. Med. 1999. 190: 1505-1516.
    • (1999) J. Exp. Med. , vol.190 , pp. 1505-1516
    • Pende, D.1    Parolini, S.2    Pessino, A.3    Sivori, S.4    Augugliaro, R.5    Morelli, L.6    Marcenaro, E.7
  • 48
    • 10344255635 scopus 로고    scopus 로고
    • CD107a as a functional marker for the identification of natural killer cell activity
    • Alter, G., Malenfant, J. M. and Altfeld, M., CD107a as a functional marker for the identification of natural killer cell activity. J. Immunol Methods 2004. 294: 15-22.
    • (2004) J. Immunol Methods , vol.294 , pp. 15-22
    • Alter, G.1    Malenfant, J.M.2    Altfeld, M.3


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