Characterisation of CTL directed towards non-inherited maternal alloantigens in human cord blood

Bone Marrow Transplantation

Volumn 24, Issue 11, 1999, Pages 1161-1166

  Moretta, A ^a   Locatelli, F ^a   Mingrat, G ^b   Rondini, G ^a,b   Montagna, D ^a   Comoli, P ^a   Gandossini, S ^a   Montini, E ^a   Labirio, M ^a   Maccario, R ^a,c  

^a UNIVERSITY OF PAVIA   (Italy)

^b Neonatology and Neonatal Intensive Care Unit   (Italy)

^c FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

Alloreactive response; Cord blood; Lymphocyte subsets; Transplantation

Indexed keywords

ALLOANTIGEN; CD3 ANTIGEN; CD8 ANTIGEN;

ADULT; ALLOTRANSPLANTATION; ARTICLE; BLOOD TRANSFUSION; CHILDHOOD CANCER; CYTOTOXIC T LYMPHOCYTE; EFFECTOR CELL; FATHER; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IMMUNOPHENOTYPING; MONONUCLEAR CELL; MOTHER; NATURAL KILLER CELL; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL; PROLYMPHOCYTE; T LYMPHOCYTE; UMBILICAL CORD BLOOD;

EID: 17144450007     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1702054     Document Type: Article

References (44)

1. Wagner JE, Kernan NA, Steinbuch M et al. Allogeneic sibling umbilical-cord-blood transplantation in children with malignant and non-malignant disease. Lancet 1995; 346: 214-219.
2. Kurtzberg J, Laughlin M, Graham ML et al. Placental blood as a source of hematopoietic stem cells for transplantation into unrelated recipients. New Engl J Med 1996; 335: 157-166.
3. Wagner JE, Rosenthal J, Sweetman R et al. Successful transplantation of HLA-matched and HLA-mismatched umbilical cord blood from unrelated donors: analysis of engraftment and acute graft-versus-host disease. Blood 1996; 88: 795-802.
4. Gluckman E, Rocha V, Boyer-Chammard A et al. Outcome of cord blood transplantation from related and unrelated donors. New Engl J Med 1997; 337: 373-381.
5. Rocha V, Wagner J, Sobocisnki K et al. Comparative study of graft-versus-host disease in HLA identical sibling cord blood or bone marrow transplant in children. Blood; 1998; 92 (Suppl. 1): 685a.
6. Maccario R, Nespoli L, Mingrat G et al. Lymphocyte subpopulations in the neonate: identification of an immature subset of OKT8-positive, OKT3-negative cells. J Immunol 1983; 130: 1129-1131.
7. Griffiths-Chu S, Patterson JAK, Berger CL et al. Characterization of immature T cell subpopulutions in neonatal blood. Blood 1984; 64: 296-300.
8. Maccario R, Burgio GR. T and NK lymphocyte subpopulations in the neonate. In: Burgio GR, Hanson LA, Ugazio AG (eds). Immunology of the Neonate. Springer-Verlag: Berlin, 1987, pp 120-129.
9. Montagna D, Maccario R, Ugazio AG et al. Natural cytotoxicity in the neonate: high levels of lymphokine activated killer (LAK) activity. Clin Exp Immunol 1988; 71: 177-181.
10. + cells in the human neonate. J Immunol 1990; 145: 102-108.
11. Harris DT, Schumacher MJ, Locascio J et al. Phenotypic and functional immaturity of human cord blood T lymphocytes. Proc Natl Acad Sci USA 1992; 89: 10006-100010.
12. Han P, Hodge G, Story C, Xu X. Phenotypic analysis of functional T-lymphocytes subtypes and natural killer cells in human cord blood: relevance to umbilical cord blood transplantation. Br J Haematol 1995; 89: 733-740.
13. Berthou C, Legros-Maida S, Soulié A et al. Cord blood T lymphocytes lack constitutive perform expression in contrast to adult peripheral blood T lymphocytes. Blood 1995; 85: 1540-1546.
14. Saito S, Morii T, Umekage H et al. Expression of interleukin-2 receptor γ chain on cord blood mononuclear cells. Blood 1996; 87: 3344-3350.
15. Gardiner CM, O'Meara A, Reen DJ. Differential cytotoxicity of cord blood and bone marrow-derived natural killer cells. Blood 1998; 91: 207-213.
16. Garderet L, Dulphy N, Douay C et al. The umbilical cord blood αβ T-cell repertoire: characteristics of a polyclonal and naive but completely formed repertoire. Blood 1998; 91: 340-346.
17. Oldstone MBA, Tishon A, Moretta L. Active thymus derived suppressor lymphocytes in human cord blood. Nature 1977; 330: 479-481.
18. Jacoby DR, Olding LB, Oldstone MBA. Immunological regulation of fetal-maternal balance. Adv Immunol 1984; 35: 157-208.
19. Clerici M, Depalma L, Roilides E et al. Analysis of T helper and antigen-presenting cell functions in cord blood and peripheral blood leukocytes from healthy children of different ages. J Clin Invest 1993; 91: 2829-2836.
20. Risdon G, Gaddy J, Stehman FB, Broxmeyer HE. Proliferative and cytotoxic responses of human cord blood T lymphocytes following allogeneic stimulation. Cell Immunol 1994; 154: 14-24.
21. Harris DT, LoCascio J, Besencon FJ. Analysis of the alloreactive capacity of human umbilical cord blood: implications for graft-versus-host disease. Bone Marrow Transplant 1994; 14: 545-553.
22. Keever CA, Abu-Hajir M, Graf W et al. Characterization of the alloreactivity and anti-leukemia reactivity of cord blood mononuclear cells. Bone Marrow Transplant 1995; 15: 407-419.
23. Risdon G, Gaddy J, Masato H, Broxmeyer HE. Alloantigen priming induces a state of unresponsiveness in human umbilical cord blood T cells. Proc Natl Acad Sci USA 1995; 92: 2413-2417.
24. Deacock SJ, Schwarer AP, Bridge J et al. Evidence that umbilical cord blood contains a higher frequency of HLA class II-specitic alloreactive T cells than adult peripheral blood. Transplantation 1992; 53: 1128-1134.
25. Paiva A, Freitas A, Loureiro A et al. Functional aspects of cord blood lymphocytes response to polyclonal and allogeneic activation. Bone Marrow Transplant 1998; 22 (Suppl. 1): S31-S34.
26. Roncarolo MG. Immune responses of cord blood cells. Bone Marrow Transplant 1998; 22 (Suppl. 1): S55.
27. Barbey C, Irion O, Helg C et al. Characterization of the cytotoxic alloresponse of cord blood. Bone Marrow Transplant 1998; 22 (Suppl. 1): S26-S30.
28. Claas FHJ, Gijbels Y, Van Der Velden-DeMunck J, Van Rood JJ. Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life. Science 1988; 241: 1815-1817.
29. Burlingham WJ, Grailer AP, Heisey DM et al. The effect of tolerance to noninherited maternal HLA antigens on the survival of renal transplants from sibling donors. New Engl J Med 1998; 339: 1657-1664.
30. Van Rood JJ, Claas FH. The influence of allogeneic cells on the human T and B cell repertoire. Science 1990; 248: 1388-1393.
31. Montagna D, Maccario R, Ugazio AG et al. Unresponsiveness of neonatal human cytotoxic T lymphocytes to maternal alloantigens in vitro. Int J Feto-Maternal Med 1990; 3: 158-165.
32. Hadley GA, Phelan D, Duffy BF, Mohanakumar T. Lack of T-cell tolerance of noninherited maternal HLA antigens in normal human. Hum Immunol 1990; 28: 373-381.
33. Zhang L, van Rood JJ, Claas FHJ. The T-cell repertoire is not dictated by self antigens alone. Res Immunol 1991; 142: 441-445.
34. Zhang L, Van Bree S, Van Rood JJ, Claas FHJ. Influence of the breast feeding on the cytotoxic T cell allorepertoire in man. Transplantation 1991; 52: 914-916.
35. Roelen DL, van Bree FPMJ, van Beelen E et al. No evidence of an influence of the alloreactive T cell repertoire in healthy individuals. Transplantation 1995; 12: 1728-1733.
36. + human cytotoxic T lymphocytes. J Immunol 1998; 150: 1437-1445.
37. Sharrock CEM, Kaminski E, Man S. Limiting dilution analysis of human T cells: a useful clinical tool. Immunol Today 1990; 11: 281-286.
38. Ciccone E, Viale O, Pende D et al. Specific lysis of allogeneic cells after activation of CD3-lymphocytes in mixed lymphocyte culture. J Exp Med 1988; 168: 2403-2412.
39. Ciccone E, Grossi Ce, Velardi A. Opposing function of activatory T-cell receptors and inhibitory NK-cell receptors on cytotoxic T lymphocytes. Immunol Today 1996; 17: 450-453.
40. Ruggeri L, Capanni M, Casucci C et al. Role of natural cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 1999; 94: 333-339.
41. Aversa F, Tabilio A, Velardi A et al. Transplantation for high-risk acute leukemia with high doses of T cell-depleted hematopoietic stem cells from haploidentical 'three loci' incompatible donors. New Engl J Med 1998; 339: 1186-1193.
42. Kos FJ, Engleman EG. Immune regulation: a critical link between NK cells and CTLs. Immunol Today 1996; 17: 174-176.
43. Moretta A, Comoli P, Montagna D et al. High frequency of Epstein-Barr virus (EBV) lymphoblastoid cell line-reactive lymphocytes in cord blood: evaluation of cytolytic activity and IL-2 production. Clin Exp Immunol 1997; 107: 312-320.
44. Burrows SR, Khanna R, Burrows JM, Moss DJ. An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease. J Exp Med 1994; 179: 1155-1161.