Safety and complications reporting on the re-implantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique

Current Stem Cell Research and Therapy

Volumn 5, Issue 1, 2010, Pages 81-93

  Centeno, Christopher J ^a   Schultz, John R ^a   Cheever, Michelle ^b   Robinson, Brent ^a   Freeman, Michael ^c   Marasco, Wayne ^d,e  

^a Centeno Schultz Clinic   (United States)

^b Regenerative Sciences LLC   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Complications; Culture expansion; Mesenchymal stem cell; Mesenchymal stem cells; Orthopedic; Orthopedics; Platelet lysate; Safety

Indexed keywords

ADULT; AGED; ARTICLE; AUTOLOGOUS PLATELET LYSATE TECHNIQUE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BONE MARROW; BONE MARROW TRANSPLANTATION; CARCINOGENESIS; CARTILAGE; CELL CULTURE; CELL LYSATE; CONTROLLED STUDY; DISEASE SURVEILLANCE; FEMALE; FLUOROSCOPY; FOLLOW UP; HUMAN; INTERVERTEBRAL DISK; MAJOR CLINICAL STUDY; MALE; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MONOLAYER CULTURE; NUCLEAR MAGNETIC RESONANCE IMAGING; ORTHOPEDICS; PATIENT SAFETY; PHENOTYPE; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY CONTROL; REIMPLANTATION; TENDON; TISSUE;

ADULT; AGED; BLOOD PLATELETS; CELL CULTURE TECHNIQUES; CELL EXTRACTS; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; FLUOROSCOPY; FOLLOW-UP STUDIES; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STEM CELLS; MIDDLE AGED; ORTHOPEDIC PROCEDURES; POSTOPERATIVE COMPLICATIONS; REGENERATIVE MEDICINE; TRANSPLANTATION, AUTOLOGOUS;

EID: 77949355110     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/157488810790442796     Document Type: Article

References (43)

1. Alhadlaq A, Mao JJ. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev 2004; 13: 436-48.
2. Barry F. Mesenchymal stem cell therapy in joint disease. Novartis Found Symp 2003; 249: 86-241.
3. Bruder S, Fink DJ, Caplan AL. Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy. J Cell Biochem 1994; 56: 283-94.
4. Cha J, Falanga V. Stem cells in cutaneous wound healing. Clin Dermatol 2007; 25: 73-8.
5. Gangji V, Toungouz M, Hauzeur JP. Stem cell therapy for osteonecrosis of the femoral head. Expert Opin Biol Ther 2005; 5: 437-42.
6. Miura M, Miura Y, Padilla-Nash HM, et al. Accumulated chromosomal instability in murine bone marrow mesenchymal stem cells leads to malignant transformation. Stem Cells 2006; 24: 1095-103.
7. Keith WN. From stem cells to cancer: balancing immortality and neoplasia. Oncogene 2004; 23: 5092-4.
8. Bochkov NP, Voronina ES, Kosyakova NV, et al. Chromosome variability of human multipotent mesenchymal stromal cells. Bull Exp Biol Med 2007; 143: 122-6.
9. Izadpanah R, Kaushal D, Kriedt C, et al. Long-term in vitro expansion alters the biology of adult mesenchymal stem cells. Cancer Res 2008; 68: 4229-38.
10. Bernardo ME, Zaffaroni N, Novara F, et al. Human bone marrow derived mesenchymal stem cells do not undergo transformation after long-term in vitro culture and do not exhibit telomere maintenance mechanisms. Cancer Res 2007; 67: 9142-9.
11. Vacanti V, Kong E, Suzuki G, et al. Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in culture. J Cell Physiol 2005; 205: 194-201.
12. Amrani DL, Port S. Cardiovascular disease: potential impact of stem cell therapy. Expert Rev Cardiovasc Ther 2003; 1: 453-61.
13. Bielby R, Jones E, McGonagle D, et al. The role of mesenchymal stem cells in maintenance and repair of bone. Injury 2007; 38 (Suppl 1): S26-32.
14. Chamberlain G, Fox J, Ashton B, et al. Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing. Stem Cells 2007; 25: 2739-49.
15. Ando W, Tateishi K, Hart D, et al. Cartilage repair using an in vitro generated scaffold-free tissue-engineered construct derived from porcine synovial mesenchymal stem cells. Biomaterials 2007; 28: 5462-70.
16. Ando W, Tateishi K, Katakai D, et al. In vitro Generation of a Scaffold-Free Tissue-Engineered Construct (TEC) derived from human synovial mesenchymal stem cells: Biological and mechanical properties, and further chondrogenic potential. Tissue Eng Part A 2008; 14: 2041-90.
17. Horie M, Sekiya I, Muneta T, et al. Intra-articular Injected synovial stem cells differentiate into meniscal cells directly and promote meniscal regeneration without mobilization to distant organs in rat massive meniscal defect. Stem Cells 2009; 27: 878-87.
18. Koga H, Shimaya M, Muneta T, et al. Local adherent technique for transplanting mesenchymal stem cells as a potential treatment of cartilage defect. Arthritis Res Ther 2008; 10: R84.
19. Murphy JM, Fink DJ, Hunziker EB, et al. Stem cell therapy in a caprine model of osteoarthritis. Arthritis Rheum 2003; 48: 3464-74.
20. Edwards SH, Cake MA, Spoelstra G, et al. Biodistribution and clearance of intra-articular liposomes in a large animal model using a radiographic marker. J Liposome Res 2007; 17: 249-61.
21. Kraus VB, Stabler TV, Kong SY, et al. Measurement of synovial fluid volume using urea. Osteoarthritis Cartilage 2007; 15: 1217-20.
22. Kirkaldy-Willis WH, Hill RJ. A more precise diagnosis for lowback pain. Spine (Phila Pa 1976) 1979; 4: 102-9.
23. Doucet C, Ernou I, Zhang Y, et al. Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J Cell Physiol 2005; 205: 228-36.
24. Muller I, Kordowich S, Holzwarth C, et al. Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy 2006; 8: 437-44.
25. Schallmoser K, Bartmann C, Rohde E, et al. Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion 2007; 47: 1436-46.
26. Murphy JM, Dixon K, Beck S, et al. Reduced chondrogenic and adipogenic activity of mesenchymal stem cells from patients with advanced osteoarthritis. Arthritis Rheum 2002; 46: 704-13.
27. Agashi K, Chau DY, Shakesheff KM. The effect of delivery via narrow-bore needles on mesenchymal cells. Regener Med 2009; 4: 49-64.
28. Katsube Y, Hirose M, Nakamura C, et al. Correlation between proliferative activity and cellular thickness of human mesenchymal stem cells. Biochem Biophys Res Commun 2008; 368: 256-60.
29. Delorme B, Charbord P. Culture and characterization of human bone marrow mesenchymal stem cells. Methods Mol Med 2007; 140: 67-81.
30. Mareddy S, Crawford R, Brooke G, et al. Clonal isolation and characterization of bone marrow stromal cells from patients with osteoarthritis. Tissue Eng 2007; 13: 819-29.
31. Broberg K, Hoglund M, Lindstrand A, et al. Polyclonal expansion of cells with trisomy 7 in synovia from patients with osteoarthritis. Cytogenet Cell Genet 1998; 83: 30-4.
32. Dahlen A, Broberg K, Domanski HA, et al. Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis. Cancer Genet Cytogenet 2001; 131: 19-24.
33. Mertens F, Palsson E, Lindstrand A, et al. Evidence of somatic mutations in osteoarthritis. Hum Genet 1996; 98: 651-6.
34. Cremer C. DNA ploidy and chromosome (FISH) pattern analysis of peripheral nerve sheath tumors. Cell Oncol 2005; 27: 359-61.
35. Hruska, A, Bollmann R, Kovacs RB, et al. DNA ploidy and chromosome (FISH) pattern analysis of peripheral nerve sheath tumors. Cell Oncol 2004; 26: 335-45.
36. Mertens F, Dal Cin P, De Wever, et al. Cytogenetic characterization of peripheral nerve sheath tumours: a report of the CHAMP study group. J Pathol 2000; 190: 31-8.
37. Romano G, Briguori C, Quintavalle C, et al. Contrast agents and renal cell apoptosis. Eur Heart J 2008; 29: 2569-76.
38. Martineau I, Lacoste E, Gagnon G. Effects of calcium and thrombin on growth factor release from platelet concentrates: kinetics and regulation of endothelial cell proliferation. Biomaterials 2004; 25: 4489-502.
39. Luyten FP. Mesenchymal stem cells in osteoarthritis. Curr Opin Rheumatol 2004; 16: 599-603.
40. Moskowitz RW. Mesenchymal stem cell dysregulation in hereditary osteoarthritis. J Rheumatol 2005; 32: 1138-9.
41. Srour EF, Brandt JE, Briddell RA, et al. Human CD34+ HLA-DR-bone marrow cells contain progenitor cells capable of self-renewal, multilineage differentiation, and long-term in vitro hematopoiesis. Blood Cells 1991; 17: 287-95.
42. Gloeckler Ries LA, Reichman ME, Lewis DR, et al. Cancer survival and incidence from the Surveillance, Epidemiology, and End Results (SEER) program. Oncologist 2003; 8: 541-52.
43. Shaffer LG, Slovak ML, Campbell LJ. ISCN 2009: An International System for Human Cytogenetic Nomenclature (2009): Recommendations of the International Standing Comittee on Human Cytogetic Nomenclature AG Switerland 2009.