메뉴 건너뛰기




Volumn 45, Issue 2, 2011, Pages 256-268

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin

Author keywords

DNA damage; Huntingtin; Huntington's disease; p53

Indexed keywords

HUNTINGTIN; MUTANT PROTEIN; PROTEIN MDM2; PROTEIN P300; PROTEIN P53;

EID: 80054883676     PISSN: 08958696     EISSN: 15591166     Source Type: Journal    
DOI: 10.1007/s12031-011-9516-4     Document Type: Article
Times cited : (24)

References (60)
  • 1
    • 3242884449 scopus 로고    scopus 로고
    • The Chk2 protein kinase
    • DOI 10.1016/j.dnarep.2004.03.033, PII S1568786404001053
    • M Ahn M Urist C Prives 2004 The Chk2 protein kinase DNA Repair 3 1039 1047 15279791 10.1016/j.dnarep.2004.03.033 1:CAS:528:DC%2BD2cXmtVeqt7s%3D (Pubitemid 38997946)
    • (2004) DNA Repair , vol.3 , Issue.8-9 , pp. 1039-1047
    • Ahn, J.1    Urist, M.2    Prives, C.3
  • 2
    • 0034818446 scopus 로고    scopus 로고
    • Post-translational modifications and activation of p53 by genotoxic stresses
    • DOI 10.1046/j.1432-1327.2001.02225.x
    • E Appella CW Anderson 2001 Post-translational modifications and activation of p53 by genotoxic stresses Eur J Biochem 268 2764 2772 11358490 10.1046/j.1432-1327.2001.02225.x 1:CAS:528:DC%2BD3MXktVSktr8%3D (Pubitemid 32862957)
    • (2001) European Journal of Biochemistry , vol.268 , Issue.10 , pp. 2764-2772
    • Appella, E.1    Anderson, C.W.2
  • 3
    • 26444600839 scopus 로고    scopus 로고
    • Tree measures and the number of segregating sites in time-structured population samples
    • DOI 10.1186/1471-2350-6-35
    • L Arning PH Kraus C Saft J Andrich JT Epplen 2005 Age of onset of Huntington disease is not modulated by the R72P variation in TP53 and the R196K variation in the gene coding for the human caspase activated DNase (hCAD) BMC Med Genet 6 35 37 16202123 10.1186/1471-2350-6-35 (Pubitemid 41554975)
    • (2005) BMC Medical Genetics , vol.6 , pp. 35
    • Forsberg, R.1    Drummond, A.J.2    Hein, J.3
  • 4
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • DOI 10.1038/nature01368
    • CJ Bakkenist MB Kastan 2003 DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation Nature 421 499 506 12556884 10.1038/nature01368 1:CAS:528:DC%2BD3sXntFSqsQ%3D%3D (Pubitemid 36168436)
    • (2003) Nature , vol.421 , Issue.6922 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 6
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • DOI 10.1016/S0955-0674(03)00003-6
    • CL Brooks W Gu 2003 Ubiquitination, phosphorylation, and acetylation: the molecular basis of p53 regulation Curr Opin Cell Biol 15 165 171 10.1016/S0955-0674(03)00003-6 (Pubitemid 36332191)
    • (2003) Current Opinion in Cell Biology , vol.15 , Issue.2 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 7
    • 61449190667 scopus 로고    scopus 로고
    • Modifications of p53: Competing for the lysines
    • 10.1016/j.gde.2008.11.010 1:CAS:528:DC%2BD1MXisFKnsrc%3D
    • S Carter KH Vousden 2009 Modifications of p53: competing for the lysines Curr Opin Genet Development 19 18 24 10.1016/j.gde.2008.11.010 1:CAS:528:DC%2BD1MXisFKnsrc%3D
    • (2009) Curr Opin Genet Development , vol.19 , pp. 18-24
    • Carter, S.1    Vousden, K.H.2
  • 8
    • 11844250016 scopus 로고    scopus 로고
    • Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes
    • DOI 10.1016/j.neulet.2004.10.018, PII S0304394004012704
    • B Chattopadhyay K Baksi S Mukhopadhyay NP Bhattacharyya 2005 Modulation of age of onset of Huntington's disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes Neurosci Lett 2 81 86 10.1016/j.neulet. 2004.10.018 (Pubitemid 40092201)
    • (2005) Neuroscience Letters , vol.374 , Issue.2 , pp. 81-86
    • Chattopadhyay, B.1    Baksi, K.2    Mukhopadhyay, S.3    Bhattacharyya, N.P.4
  • 9
    • 0033598754 scopus 로고    scopus 로고
    • Phosphorylation of ser-20 mediates stabilization of human p53 in response to DNA damage
    • 10570149 10.1073/pnas.96.24.13777 1:CAS:528:DyaK1MXns1Oqt74%3D
    • NH Chehab A Malikzay ES Stavridi TD Halazonetis 1999 Phosphorylation of ser-20 mediates stabilization of human p53 in response to DNA damage Proc Natl Acad Sci 96 13777 13782 10570149 10.1073/pnas.96.24.13777 1:CAS:528: DyaK1MXns1Oqt74%3D
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 13777-13782
    • Chehab, N.H.1    Malikzay, A.2    Stavridi, E.S.3    Halazonetis, T.D.4
  • 12
    • 60649090420 scopus 로고    scopus 로고
    • P53 and MDM2: Antagonists or partners in crime?
    • 10.1016/j.ccr.2009.02.004 1:CAS:528:DC%2BD1MXltFSmtb4%3D
    • CM Eischen G Lozano 2009 p53 and MDM2: antagonists or partners in crime? Cancer Cell Previews 15 161 162 10.1016/j.ccr.2009.02.004 1:CAS:528: DC%2BD1MXltFSmtb4%3D
    • (2009) Cancer Cell Previews , vol.15 , pp. 161-162
    • Eischen, C.M.1    Lozano, G.2
  • 14
    • 0242329884 scopus 로고    scopus 로고
    • P53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage
    • DOI 10.1016/S1097-2765(03)00359-9
    • JM Espinosa RE Verdun BM Emerson 2003 p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage Mol Cell 12 1015 1027 14580351 10.1016/S1097-2765(03)00359-9 1:CAS:528:DC%2BD3sXovVKjurk%3D (Pubitemid 37352792)
    • (2003) Molecular Cell , vol.12 , Issue.4 , pp. 1015-1027
    • Espinosa, J.M.1    Verdun, R.E.2    Emerson, B.M.3
  • 15
    • 33745558938 scopus 로고    scopus 로고
    • Proteomics for the early detection and treatment of hepatocellular carcinoma
    • DOI 10.1038/sj.onc.1209551, PII 1209551
    • Z Feng S Jin A Zupnick J Hoh E de Stanchina S Lowe C Prives AJ Levine 2006 p53 tumor suppressor protein regulates the levels of huntingtin gene expression Oncogene 25 1 7 16278683 10.1038/sj.onc.1209551 (Pubitemid 43980476)
    • (2006) Oncogene , vol.25 , Issue.27 , pp. 3810-3817
    • Feng, J.T.1    Shang, S.2    Beretta, L.3
  • 16
    • 0031724593 scopus 로고    scopus 로고
    • Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6
    • DA Freedman AJ Levine 1998 Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6 Mol Cell Biol 18 7288 7293 9819415 1:CAS:528:DyaK1cXnvVKlurk%3D (Pubitemid 28533048)
    • (1998) Molecular and Cellular Biology , vol.18 , Issue.12 , pp. 7288-7293
    • Freedman, D.A.1    Levine, A.J.2
  • 18
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • DOI 10.1016/S0092-8674(00)80521-8
    • W Gu RG Roeder 1997 Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain Cell 90 595 606 9288740 10.1016/S0092-8674(00)80521-8 1:CAS:528:DyaK2sXlvFKmtLc%3D (Pubitemid 27357952)
    • (1997) Cell , vol.90 , Issue.4 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 19
    • 0033614742 scopus 로고    scopus 로고
    • Huntington's disease: A clinical, genetic, and molecular model for polyglutamine repeat disorders
    • 10434293 10.1098/rstb.1999.0446 1:CAS:528:DyaK1MXltVWrtr8%3D
    • PS Harper 1999 Huntington's disease: a clinical, genetic, and molecular model for polyglutamine repeat disorders Philos Trans R Soc Lond B Biol Sci 354 957 961 10434293 10.1098/rstb.1999.0446 1:CAS:528:DyaK1MXltVWrtr8%3D
    • (1999) Philos Trans R Soc Lond B Biol Sci , vol.354 , pp. 957-961
    • Harper, P.S.1
  • 20
    • 0036500862 scopus 로고    scopus 로고
    • Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with β-tubulin: Relevance to Huntington's disease
    • G Hoffner P Kahlem P Djian 2002 Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with B-tubulin: relevance to Huntington's disease J Cell Sci 115 941 948 11870213 1:CAS:528:DC%2BD38Xitl2rtLw%3D (Pubitemid 34257379)
    • (2002) Journal of Cell Science , vol.115 , Issue.5 , pp. 941-948
    • Hoffner, G.1    Kahlem, P.2    Djian, P.3
  • 21
    • 0031583962 scopus 로고    scopus 로고
    • Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53
    • DOI 10.1016/S0014-5793(97)01480-4, PII S0014579397014804
    • R Honda H Tanaka H Yasuda 1997 Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53 FEBS Lett 420 25 27 9450543 10.1016/S0014-5793(97) 01480-4 1:CAS:528:DyaK2sXotVyjtrg%3D (Pubitemid 28037193)
    • (1997) FEBS Letters , vol.420 , Issue.1 , pp. 25-27
    • Honda, R.1    Tanaka, H.2    Yasuda, H.3
  • 23
    • 62849122468 scopus 로고    scopus 로고
    • DNA damage response proteins precede the appearance of visible mutant huntingtin aggregate
    • 18831068 10.1002/jnr.21881 1:CAS:528:DC%2BD1MXit1Whsrs%3D
    • J Illuzzi S Yerkes H Parekh-Olmedo EB Kmiec 2009 DNA damage response proteins precede the appearance of visible mutant huntingtin aggregate J Neurosci Res 87 733 747 18831068 10.1002/jnr.21881 1:CAS:528: DC%2BD1MXit1Whsrs%3D
    • (2009) J Neurosci Res , vol.87 , pp. 733-747
    • Illuzzi, J.1    Yerkes, S.2    Parekh-Olmedo, H.3    Kmiec, E.B.4
  • 24
    • 64149108150 scopus 로고    scopus 로고
    • P53 oligomerization is essential for its C-terminal lysine acetylation
    • Y Itahana H Ke Y Zhang 2009 p53 oligomerization is essential for its C-terminal lysine acetylation J Biol Chem 281 5158 5164
    • (2009) J Biol Chem , vol.281 , pp. 5158-5164
    • Itahana, Y.1    Ke, H.2    Zhang, Y.3
  • 25
    • 33747170869 scopus 로고    scopus 로고
    • Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin
    • DOI 10.1016/j.nbd.2006.04.011, PII S0969996106000969
    • H Jiang MA Poirier Y Liang Z Pei CE Wiskittel WW Smith DB DeFranco CA Ross 2006 Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin Neurobiol Dis 23 543 551 16766198 10.1016/j.nbd.2006.04.011 1:CAS:528:DC%2BD28XotlWnsLY%3D (Pubitemid 44234090)
    • (2006) Neurobiology of Disease , vol.23 , Issue.3 , pp. 543-551
    • Jiang, H.1    Poirier, M.A.2    Liang, Y.3    Pei, Z.4    Weiskittel, C.E.5    Smith, W.W.6    DeFranco, D.B.7    Ross, C.A.8
  • 26
    • 33644990074 scopus 로고    scopus 로고
    • Charge modifications at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking
    • 16291740 10.1074/jbc.M505772200 1:CAS:528:DC%2BD28XksFOgtA%3D%3D
    • Y Kawaguchi A Ito E Appella T Yao 2006 Charge modifications at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking J Biol Chem 281 1394 1400 16291740 10.1074/jbc.M505772200 1:CAS:528:DC%2BD28XksFOgtA%3D%3D
    • (2006) J Biol Chem , vol.281 , pp. 1394-1400
    • Kawaguchi, Y.1    Ito, A.2    Appella, E.3    Yao, T.4
  • 27
    • 0025815451 scopus 로고
    • Identification of p53 as a sequence-specific DNA-binding protein
    • SE Kern KW Kinzler A Bruskin D Jarosz P Friedman C Prives B Vogelstein 1991 Identification of p53 as a sequence-specific DNA binding protein Science 252 1708 1711 2047879 10.1126/science.2047879 1:CAS:528:DyaK3MXkvVKmurs%3D (Pubitemid 21917093)
    • (1991) Science , vol.252 , Issue.5013 , pp. 1708-1711
    • Kern, S.E.1    Kinzler, K.W.2    Bruskin, A.3    Jarosz, D.4    Friedman, P.5    Prives, C.6    Vogelstein, B.7
  • 28
    • 0036173896 scopus 로고    scopus 로고
    • Interaction of Huntington disease protein with transcriptional activator Sp1
    • DOI 10.1128/MCB.22.5.1277-1287.2002
    • SH Li AL Cheng H Zhou S Lam M Rao H Li XJ Li 2002 Interaction of Huntington disease protein with the transcriptional activator Sp1 Mol Cell Biol 22 1277 1287 11839795 10.1128/MCB.22.5.1277-1287.2002 1:CAS:528: DC%2BD38XhtlKgsbc%3D (Pubitemid 34150765)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.5 , pp. 1277-1287
    • Li, S.-H.1    Cheng, A.L.2    Zhou, H.3    Lam, S.4    Rao, M.5    Li, H.6    Li, X.-J.7
  • 29
    • 0348134742 scopus 로고    scopus 로고
    • Mono- Versus Polyubiquitination: Differential Control of p53 Fate by Mdm2
    • DOI 10.1126/science.1091362
    • M Li CL Brooks F Wu-Baer D Chen R Baer W Gu 2003 Mono- versus polyubiquitination: differential control of p53 fate by MDM2 Science 302 1972 1975 14671306 10.1126/science.1091362 1:CAS:528:DC%2BD3sXps1amsLw%3D (Pubitemid 37523506)
    • (2003) Science , vol.302 , Issue.5652 , pp. 1972-1975
    • Li, M.1    Brooks, C.L.2    Wu-Baer, F.3    Chen, D.4    Baer, R.5    Gu, W.6
  • 32
    • 33847276654 scopus 로고    scopus 로고
    • Monoubiquitylation promotes mitochondrial p53 translocation
    • 17268548 10.1038/sj.emboj.7601560 1:CAS:528:DC%2BD2sXhvFWksrs%3D
    • N Marchenko S Wolff S Erster K Becker U Moll 2007 Monoubiquitylation promotes mitochondrial p53 translocation EMBO J 26 923 934 17268548 10.1038/sj.emboj.7601560 1:CAS:528:DC%2BD2sXhvFWksrs%3D
    • (2007) EMBO J , vol.26 , pp. 923-934
    • Marchenko, N.1    Wolff, S.2    Erster, S.3    Becker, K.4    Moll, U.5
  • 33
    • 33646794425 scopus 로고    scopus 로고
    • Keeping p53 in check: Essential and synergistic functions of Mdm2 and Mdm4
    • 16543935 10.1038/sj.cdd.4401912 1:CAS:528:DC%2BD28Xks1Ortbo%3D
    • J Marine S Francoz M Maetens G Wahl F Toledo G Lozano 2006 Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4 Cell Death Differ 13 927 934 16543935 10.1038/sj.cdd.4401912 1:CAS:528:DC%2BD28Xks1Ortbo%3D
    • (2006) Cell Death Differ , vol.13 , pp. 927-934
    • Marine, J.1    Francoz, S.2    Maetens, M.3    Wahl, G.4    Toledo, F.5    Lozano, G.6
  • 34
    • 32244436592 scopus 로고    scopus 로고
    • P53 suppresses the self-renewal of adult neural stem cells
    • DOI 10.1242/dev.02208
    • K Meletis V Wirta SM Hede M Nister J Lundeberg J Frisen 2006 p53 suppresses the self-renewal of adult neural stem cells Development 133 363 369 16368933 10.1242/dev.02208 1:CAS:528:DC%2BD28XhsFamsrk%3D (Pubitemid 43210724)
    • (2006) Development , vol.133 , Issue.2 , pp. 363-369
    • Meletis, K.1    Wirta, V.2    Hede, S.-M.3    Nister, M.4    Lundeberg, J.5    Frisen, J.6
  • 35
    • 70349438905 scopus 로고    scopus 로고
    • The expanding universe of p53 targets
    • 1:CAS:528:DC%2BD1MXhtFKmsb7M
    • D Menendez A Inga MA Resnick 2009 The expanding universe of p53 targets Nature 9 724 737 1:CAS:528:DC%2BD1MXhtFKmsb7M
    • (2009) Nature , vol.9 , pp. 724-737
    • Menendez, D.1    Inga, A.2    Resnick, M.A.3
  • 36
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • DOI 10.1016/S1044-579X(02)00099-8, PII S1044579X02000998
    • D Michael M Oren 2003 The p53-Mdm2 module and the ubiquitin system Semin Cancer Biol 13 49 58 12507556 10.1016/S1044-579X(02)00099-8 1:CAS:528: DC%2BD38XpvVWksrw%3D (Pubitemid 36269180)
    • (2003) Seminars in Cancer Biology , vol.13 , Issue.1 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 37
    • 8844232663 scopus 로고    scopus 로고
    • The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
    • DOI 10.1016/j.molcel.2004.10.016, PII S1097276504006422
    • N Minksy M Oren 2004 The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression Mol Cell 16 631 639 10.1016/j.molcel.2004.10.016 (Pubitemid 39531885)
    • (2004) Molecular Cell , vol.16 , Issue.4 , pp. 631-639
    • Minsky, N.1    Oren, M.2
  • 38
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
    • 1535557 10.1016/0092-8674(92)90644-R 1:CAS:528:DyaK3sXit1Ogs7o%3D
    • J Momand GP Zambetti DC Olson D George AJ Levine 1992 The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell 69 1237 1245 1535557 10.1016/0092-8674(92)90644-R 1:CAS:528:DyaK3sXit1Ogs7o%3D
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 39
    • 0027325132 scopus 로고
    • Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
    • DOI 10.1038/362857a0
    • JD Oliner JA Pietenpol S Thiagalingam J Gyuris KW Kinzler B Vogelstein 1993 Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53 Nature 362 857 860 8479525 10.1038/362857a0 1:CAS:528:DyaK3sXkt1ait7g%3D (Pubitemid 23132165)
    • (1993) Nature , vol.362 , Issue.6423 , pp. 857-860
    • Oliner, J.D.1    Pietenpol, J.A.2    Thiagalingam, S.3    Gyuris, J.4    Kinzler, K.W.5    Vogelstein, B.6
  • 41
    • 77949414415 scopus 로고    scopus 로고
    • Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors
    • 20128802 10.1111/j.1476-5381.2009.00607.x 1:CAS:528:DC%2BC3cXjs1ektbc%3D
    • I Pires T Ward C Dive 2010 Oxaliplatin responses in colorectal cancer cells are modulated by CHK2 kinase inhibitors Br J Pharmacol 159 1326 1338 20128802 10.1111/j.1476-5381.2009.00607.x 1:CAS:528:DC%2BC3cXjs1ektbc%3D
    • (2010) Br J Pharmacol , vol.159 , pp. 1326-1338
    • Pires, I.1    Ward, T.2    Dive, C.3
  • 42
    • 0032931517 scopus 로고    scopus 로고
    • The P53 pathway
    • DOI 10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2- 3
    • C Prives PA Hall 1999 The p53 pathway J Pathol 187 112 126 10341712 10.1002/(SICI)1096-9896(199901)187:1<112::AID-PATH250>3.0.CO;2-3 1:CAS:528:DyaK1MXmvVKrtQ%3D%3D (Pubitemid 29009841)
    • (1999) Journal of Pathology , vol.187 , Issue.1 , pp. 112-126
    • Prives, C.1    Hall, P.A.2
  • 44
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • DOI 10.1074/jbc.273.10.5858
    • EP Rogakou DR Pilch AH Orr VS Ivanova WM Bonner 1998 DNA double-strand breaks induce histone H2AX phosphorylation on serine 139 J Biol Chem 273 5858 5868 9488723 10.1074/jbc.273.10.5858 1:CAS:528:DyaK1cXhsleiu7g%3D (Pubitemid 28124064)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.10 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 45
    • 0032518917 scopus 로고    scopus 로고
    • Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein
    • DOI 10.1093/emboj/17.2.554
    • J Roth M Dobbelstein D Freedman T Shenk AJ Levine 1997 Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein Eur Mol Biol Organization 17 554 564 10.1093/emboj/17.2.554 (Pubitemid 28045495)
    • (1998) EMBO Journal , vol.17 , Issue.2 , pp. 554-564
    • Roth, J.1    Dobbelstein, M.2    Freedman, D.A.3    Shenk, T.4    Levine, A.J.5
  • 47
    • 3943107573 scopus 로고    scopus 로고
    • Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints
    • DOI 10.1146/annurev.biochem.73.011303.073723
    • A Sancar LA Lindsey-Boltz K Unsal-Kacmaz S Linn 2004 Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints Annu Rev Biochem 73 39 85 15189136 10.1146/annurev.biochem.73.011303.073723 1:CAS:528: DC%2BD2cXmslagsrk%3D (Pubitemid 39050363)
    • (2004) Annual Review of Biochemistry , vol.73 , pp. 39-85
    • Sancar, A.1    Lindsey-Boltz, L.A.2    Unsal-Kacmaz, K.3    Linn, S.4
  • 49
    • 0033230581 scopus 로고    scopus 로고
    • The cellular response to p53: The decision between life and death
    • 10557106 10.1038/sj.onc.1203130 1:CAS:528:DyaK1MXns1Oqs7w%3D
    • RV Sionov Y Haupt 1999 The cellular response to p53: the decision between life and death Oncogene 18 6145 6157 10557106 10.1038/sj.onc.1203130 1:CAS:528:DyaK1MXns1Oqs7w%3D
    • (1999) Oncogene , vol.18 , pp. 6145-6157
    • Sionov, R.V.1    Haupt, Y.2
  • 53
    • 33947534030 scopus 로고    scopus 로고
    • P53 in health and disease
    • DOI 10.1038/nrm2147, PII NRM2147
    • KH Vousden DP Lane 2007 p53 in health and disease Nat Rev Mol Cell Biol 8 275 283 17380161 10.1038/nrm2147 1:CAS:528:DC%2BD2sXjtlygsr0%3D (Pubitemid 46474662)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.4 , pp. 275-283
    • Vousden, K.H.1    Lane, D.P.2
  • 54
    • 33646787483 scopus 로고    scopus 로고
    • Mouse bites dogma: How mouse models are changing our views of how p53 is regulated in vivo
    • 16575406 10.1038/sj.cdd.4401911 1:CAS:528:DC%2BD28Xks1Ortb0%3D
    • GM Wahl 2006 Mouse bites dogma: how mouse models are changing our views of how p53 is regulated in vivo Cell Death Differ 13 973 983 16575406 10.1038/sj.cdd.4401911 1:CAS:528:DC%2BD28Xks1Ortb0%3D
    • (2006) Cell Death Differ , vol.13 , pp. 973-983
    • Wahl, G.M.1
  • 55
    • 57049120143 scopus 로고    scopus 로고
    • Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: Implications for histone acetyltranferase evolution and function
    • 10.1016/j.sbi.2008.09.004 1:CAS:528:DC%2BD1cXhsVOisr%2FI
    • L Wang Y Tang PA Cole R Marmorstein 2008 Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltranferase evolution and function Curr Opin Struct Biology 18 741 747 10.1016/j.sbi.2008.09.004 1:CAS:528:DC%2BD1cXhsVOisr%2FI
    • (2008) Curr Opin Struct Biology , vol.18 , pp. 741-747
    • Wang, L.1    Tang, Y.2    Cole, P.A.3    Marmorstein, R.4
  • 56
    • 0031840253 scopus 로고    scopus 로고
    • ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins
    • DOI 10.1038/542
    • MJF Waterman ES Stavridi JLF Waterman TD Halazonetis 1998 ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins Nat Genet 19 175 178 9620776 10.1038/542 1:CAS:528:DyaK1cXls1Cru7Y%3D (Pubitemid 28248801)
    • (1998) Nature Genetics , vol.19 , Issue.2 , pp. 175-178
    • Waterman, M.J.F.1    Stavridi, E.S.2    Waterman, J.L.F.3    Halazonetis, T.D.4
  • 58
    • 65649101212 scopus 로고    scopus 로고
    • Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding
    • 19339993 10.1038/emboj.2009.83 1:CAS:528:DC%2BD1MXjvV2ksrs%3D
    • S Wu C Chiang 2009 Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding EMBO J 28 1246 1259 19339993 10.1038/emboj.2009.83 1:CAS:528:DC%2BD1MXjvV2ksrs%3D
    • (2009) EMBO J , vol.28 , pp. 1246-1259
    • Wu, S.1    Chiang, C.2
  • 59
    • 29244462838 scopus 로고    scopus 로고
    • In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets
    • DOI 10.1016/j.cell.2005.10.030, PII S0092867405012286
    • W Zhai H Jeong L Cui D Krainc R Tjian 2005 In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets Cell 123 1241 1253 16377565 10.1016/j.cell.2005.10.030 1:CAS:528:DC%2BD28XktlWitg%3D%3D (Pubitemid 41821782)
    • (2005) Cell , vol.123 , Issue.7 , pp. 1241-1253
    • Zhai, W.1    Jeong, H.2    Cui, L.3    Krainc, D.4    Tjian, R.5
  • 60
    • 0035827335 scopus 로고    scopus 로고
    • A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation
    • DOI 10.1126/science.1058637
    • Y Zhang Y Xiong 2001 A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation Science 292 1910 1915 11397945 10.1126/science.1058637 1:CAS:528:DC%2BD3MXksVaqurs%3D (Pubitemid 32538366)
    • (2001) Science , vol.292 , Issue.5523 , pp. 1910-1915
    • Zhang, Y.1    Xiong, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.