Neurotoxic effect of statins on mouse neuroblastoma NB2a cell line

European Review for Medical and Pharmacological Sciences

Volumn 15, Issue 9, 2011, Pages 985-991

  Vural, Kamil ^a   Tuglu, M I ^a  

^a CELAL BAYAR UNIVERSITY   (Turkey)

Author keywords

MTT; Neuroblastoma NB2a cell line; Neurotoxicity; Statins

Indexed keywords

ATORVASTATIN; COMPACTIN; CYCLIC AMP; MEVINOLIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; COMPUTER PROGRAM; CONCENTRATION RESPONSE; IMAGE ANALYSIS; MOUSE; NERVE FIBER GROWTH; NEUROBLASTOMA; NEUROTOXICITY; NONHUMAN;

ANIMALS; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LOVASTATIN; MICE; NEURITES; NEUROBLASTOMA; PYRROLES;

EID: 80054875296     PISSN: 11283602     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. HAMELIN BA, TURGEON J. Hydrophilicity/lipophilicity: relevance for the pharmacology and clinical effects of HMG-CoA reductase inhibitors. Trends Pharmacol Sci 1998; 19: 26-37.
2. TAKEMOTO M, LIAO JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors. Arterioscler Thromb Vasc Biol 2001; 21: 1712-1719.
3. WANG CY, ZHONG WB, CHANG TC, LAI SM, TSAI YF. Lovastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, induces apoptosis and differentiation in human anaplastic thyroid carcinoma cells. J Clin Endocrinol Metab 2003; 88: 3021-3026.
4. MALTESE WA, DEFENDINI R, GREEN RA, SHERIDAN KM, DONLEY DK. Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase. J Clin Invest 1985; 76: 1748-1754.
5. FUJITA M, YAMAZAKI T, HAYASHI D, KOHRO T, OKADA Y, NAGAI R. The JCAD Study Investigators. Pleiotropic effects of statins on cardiovascular events in the Japanese Coronary Artery Disease study. Int J Cardiol 2008; 129: 294-296.
6. LIM JH, LEE JC, LEE YH, CHOI IY, OH YK, KIM HS, PARK JS, KIM WK. Simvastatin prevents oxygen and glucose deprivation/reoxygenation-induced death of cortical neurons by reducing the production and toxicity of 4-hydroxy-2E-nonenal. J Neurochem 2006; 97: 140-150.
7. ZACCO A, TOGO J, SPENCE K, ELLIS A, LLOYD D, FURLONG S, PISER T. 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors protect cortical neurons from excitotoxicity. J Neurosci 2003; 23: 11104-1111.
8. WILLEY JZ, ELKIND MS. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors in the treatment of central nervous system diseases. Arch Neurol 2010; 67: 1062-1067.
9. JICK H, ZORNBERG GL, JICK SS, SESHADRI S, DRACHMAN DA. Statins and the risk of dementia. Lancet 2000; 356: 1627-1631.
10. PAVLOV OV, BOBRYSHEV YUV, BALABANOV YUV, ASHWELL K. An in vitro study of the effects of lovastatin on human fetal brain cells. Neurotoxicol Teratol 1995; 17: 31-39.
11. MAUCH DH, NAGLER K, SCHUMACHER S, GORITZ C, MULLER EC, OTTO A, PFRIEGER FW. CNS synaptogenesis promoted by glia-derived cholesterol. Science 2001; 294: 1354-1357.
12. BACKES JM, HOWARD PA. Association of HMG-CoA reductase inhibitors with neuropathy. Ann Pharmacother 2003; 37: 274-278.
13. GAIST D, JEPPESEN U, ANDERSEN M, GARCÍA RODRÍGUEZ LA, HALLAS J, SINDRUP SH. Statins and risk of polyneuropathy: a case-control study. Neurology 2002; 58: 1333-1337.
14. SATO-SUZUKI I, MUROTA S. Simvastatin inhibits the division and induces neurite-like outgrowth in PC12 cells, Neurosci Lett 1996; 220: 21-24.
15. POOLER AM, XI SC, WURTMAN RJ. The 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor pravastatin enhances neurite outgrowth in hippocampal neurons. J Neurochem 2006; 97: 716-723.
16. KUMANO T, MUTOH T, NAKAGAWA H, KURIYAMA M. HMG-CoA reductase inhibitor induces a transient activation of high affinity nerve growth factor receptor, trk, and morphological differentiation with fatal outcome in PC12 cells. Brain Res 2000; 859: 169-172.
17. LUDWIG A, FRIEDEL B, METZKOW S, MEINERS S, STANGL V, BAUMANN G, STANGL K. Effect of statins on the proteasomal activity in mammalian endothelial and vascular smooth muscle cells. Biochem Pharmacol 2005; 70: 520-526.
18. SMITH SL, FISHWICK J, MCLEAN WG, EDWARDS G, WARD SA. Enhanced in vitro neurotoxicity of artemisinin derivatives in the presence of haemin. Biochem Pharmacol 1997; 53: 5-10.
19. DELILOGLU-GÜRHAN SI, VATANSEVER HS, ÖZDAL-KURT F, TUGLU I. Characterization analysis of osteoblast derived from bone marrow in modified culture system. Acta Histochem 2006; 108: 49-57.
20. KUMAR B, COLE WC, PRASAD KN. Alpha tocopheryl succinate, retinoic acid and polar carotenoids enhanced the growth-inhibitory effect of a cholesterol-lowering drug on immortalized and transformed nerve cells in culture. J Am Coll Nutr 2001; 20: 628-636.
21. KUMAR B, ANDREATTA C, KOUSTAS WT, COLE WC, EDWARDS-PRASAD J, PRASAD KN. Mevastatin induces degeneration and decreases viability of cAMP-induced differentiated neuroblastoma cells in culture by inhibiting proteasome activity, and mevalonic acid lactone prevents these effects. J Neurosci Res 2002; 68: 627-635.
22. MICHIKAWA M, YANAGISAWA K. Apolipoprotein E4 induces neuronal cell death under conditions of suppressed de novo cholesterol synthesis. J Neurosci Res 1998; 54: 58-67.
23. PRASAD KN, LA ROSA FG, PRASAD JE. Prostaglandins act as neurotoxin for differentiated neuroblastoma cells in culture and increase levels of ubiquitin and beta-amyloid. In vitro Cell Dev Biol Anim 1998; 34: 265-274.
24. FOURNIER AE, TAKIZAWA BT, STRITTMATTER SM. Rho kinase inhibition enhances axonal regeneration in the injured CNS. J Neurosci 2003; 23: 1416-1423.
25. FERNANDEZ-HERNANDO C, SUAREZ Y, LASUNCION MA. Lovastatin-induced PC-12 cell differentiation is associated with RhoA/RhoA kinase pathway inactivation. Mol Cell Neurosci 2005; 29: 591-602.
26. SEBOK A, NUSSER N, DEBRECENI B, GUO Z, SANTOS MF. SZEBERENYI J, TIGYI G. Different roles for RhoA during neurite initiation, elongation, and regeneration in PC12 cells. J Neurochem 1999; 73: 949-960.
27. MÄRZ P, OTTEN U, MISEREZ AR. Statins induce differentiation and cell death in neurons and astroglia. Glia 2007; 55: 1-12.
28. HUGHES M, SNETKOV V, ROSE RS, TROUSIL S, MERMOUD JE, DINGWALL C. Neurite-like structures induced by mevalonate pathway blockade are due to the stability of cell adhesion foci and are enhanced by the presence of APR J Neurochem 2010; 114: 832-842.
29. MALTESE WA, SHERIDAN KM. Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis. J Cell Physiol 1985; 125: 540-558.
30. PARIS D, TOWNSEND KR HUMPHREY J, OBREGON DF, YOKOTA K, MULLAN M. Statins inhibit A beta-neurotoxicity in vitro and A beta-induced vasoconstriction and inflammation in rat aortae. Atherosclerosis 2002; 161: 293-299.