Diclofenac in fish: Blood plasma levels similar to human therapeutic levels affect global hepatic gene expression

Environmental Toxicology and Chemistry

Volumn 30, Issue 9, 2011, Pages 2126-2134

  Cuklev, Filip ^a   Kristiansson, Erik ^a,b   Fick, Jerker ^c   Asker, Noomi ^a,d   Förlin, Lars ^d   Larsson, D G Joakim ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b CHALMERS UNIVERSITY OF TECHNOLOGY   (Sweden)

^c UMEÅ UNIVERSITY   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Bioconcentration; Diclofenac; Gene expression; Microarray; Rainbow trout

Indexed keywords

AQUATIC ENVIRONMENTS; BIOCONCENTRATION; BIOCONCENTRATION FACTOR; BIOLOGICAL PROCESS; BLOOD PLASMA; DICLOFENAC; DIFFERENTIALLY EXPRESSED GENE; EXPOSURE CONCENTRATION; HISTOLOGICAL CHANGES; HUMAN THERAPEUTICS; IMMUNE RESPONSE; INTERNAL EXPOSURE; MODE OF ACTION; MULTIPLE GENES; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; OLIGONUCLEOTIDE MICROARRAY; ONCORHYNCHUS MYKISS; PHARMACOLOGICAL EFFECTS; PLASMA CONCENTRATION; PLASMA LEVELS; QUANTITATIVE PCR; RAINBOW TROUT; SEWAGE EFFLUENTS; WATER CONCENTRATIONS;

BLOOD; CONCENTRATION (PROCESS); EFFLUENTS; FISH; GENE THERAPY; MAMMALS; OLIGONUCLEOTIDES; PLASMAS; POLYMERASE CHAIN REACTION; SEWAGE;

GENE EXPRESSION;

DICLOFENAC; SURFACE WATER;

BIOACCUMULATION; DRUG; EFFLUENT; GENE EXPRESSION; HISTOLOGY; IMMUNE RESPONSE; POLLUTION EXPOSURE; POLYMERASE CHAIN REACTION; SALMONID; SEWAGE; SURFACE WATER;

ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MECHANISM; FEMALE; GENE EXPRESSION; LIVER; MALE; MAXIMUM PLASMA CONCENTRATION; MICROARRAY ANALYSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAINBOW TROUT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; FRESH WATER; GENE EXPRESSION; GILLS; HUMANS; KIDNEY; LIVER; ONCORHYNCHUS MYKISS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK ASSESSMENT; RNA, MESSENGER; SEWAGE; WATER POLLUTANTS, CHEMICAL;

MAMMALIA; ONCORHYNCHUS MYKISS;

EID: 80054844071     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.599     Document Type: Article

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