Pharmaceutical industry effluent diluted 1:500 affects global gene expression, cytochrome P450 1A activity, and plasma phosphate in fish

Environmental Toxicology and Chemistry

Volumn 28, Issue 12, 2009, Pages 2639-2647

  Gunnarsson, Lina ^a   Kristiansson, Erik ^a,b   Rutgersson, Carolin ^a   Sturve, Joachim ^b   Fick, Jerker ^c   Förlin, Lars ^b   Larsson, D G Joakim ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

Fish; Industrial effluent; Microarray; Pharmaceutical manufacturing

Indexed keywords

ANTIOXIDANT ENZYME ACTIVITY; BLOOD CHEMISTRY; BULK DRUGS; CAUSATIVE AGENTS; CHEMICAL EXPOSURE; CYTOCHROME P450; GLUTATHIONES; HEPATIC GENES; HYDERABAD , INDIA; INDUSTRIAL EFFLUENT; KIDNEY FUNCTION; ONCORHYNCHUS MYKISS; PHARMACEUTICAL INDUSTRY; PHARMACEUTICAL MANUFACTURING; PHOSPHATE LEVELS; PRODUCTION SITES; RAINBOW TROUT; REGULATED GENES; SUBLETHAL TOXICITY; TREATED EFFLUENT; TREATMENT PLANTS; UNDERLYING MECHANISM;

BIOACTIVITY; DRUG PRODUCTS; DRUG PRODUCTS PLANTS; ENZYME ACTIVITY; ENZYMES; FISH; GENE EXPRESSION; MEATS; SEWAGE; TOXICITY; WASTEWATER; WASTEWATER TREATMENT;

EFFLUENTS;

ANTIOXIDANT; CYTOCHROME P450 1A; ESTROGEN; GLUTATHIONE; INDUSTRIAL EFFLUENT; PHOSPHATE;

BIOCHEMISTRY; BLOOD; CYTOCHROME; ENZYME ACTIVITY; GENE EXPRESSION; INDUSTRIAL WASTE; PHARMACEUTICAL INDUSTRY; POLLUTION EXPOSURE; SALMONID; SUBLETHAL EFFECT; TOXICITY TEST;

ANIMAL EXPERIMENT; AQUATIC FAUNA; ARTICLE; BLOOD CHEMISTRY; CONTROLLED STUDY; DRUG INDUSTRY; EFFLUENT TOXICITY; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; KIDNEY DYSFUNCTION; LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PHOSPHATE BLOOD LEVEL; PRIORITY JOURNAL; RAINBOW TROUT; UPREGULATION;

ANIMALS; CYTOCHROME P-450 CYP1A1; DRUG INDUSTRY; ESTROGEN RECEPTOR ALPHA; GENE EXPRESSION PROFILING; INDUSTRIAL WASTE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCORHYNCHUS MYKISS; OXIDATIVE STRESS; PHOSPHATES; WATER POLLUTANTS, CHEMICAL;

ONCORHYNCHUS MYKISS; VERTEBRATA;

EID: 68949113148     PISSN: 07307268     EISSN: None     Source Type: Journal    
DOI: 10.1897/09-120.1     Document Type: Article

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