Distribution of intraperitoneally injected diclofenac in brown trout (Salmo trutta f. fario)

Ecotoxicology and Environmental Safety

Volumn 71, Issue 2, 2008, Pages 412-418

  Hoeger, Birgit ^a   Dietrich, Daniel R ^a   Schmid, Daniela ^a   Hartmann, Andreas ^b   Hitzfeld, Bettina ^c  

^a UNIVERSITY OF KONSTANZ   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

^c Bundesamt fur Umweltschutz   (Switzerland)

Author keywords

Brown trout; Diclofenac; NSAID; Pharmaceuticals in the environment; Salmo trutta

Indexed keywords

CARBON 14; DICLOFENAC; NONSTEROID ANTIINFLAMMATORY AGENT; SURFACE WATER;

BIOACCUMULATION; CONCENTRATION (COMPOSITION); DETECTION METHOD; DETOXIFICATION; DIGESTIVE SYSTEM; DRUG; NATIVE SPECIES; SALMONID; SURFACE WATER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUATIC ENVIRONMENT; ARTICLE; BILE; BROWN TROUT; DRUG DETOXIFICATION; DRUG DISTRIBUTION; DRUG RETENTION; ENTEROHEPATIC CIRCULATION; INTESTINE; ISOTOPE LABELING; NONHUMAN; PYLORUS; SALMONID; SINGLE DRUG DOSE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARBON RADIOISOTOPES; DICLOFENAC; DRUG RESIDUES; INFUSIONS, PARENTERAL; MOLECULAR STRUCTURE; TISSUE DISTRIBUTION; TROUT; WATER POLLUTANTS, CHEMICAL;

SALMO TRUTTA; SALMONIDAE;

EID: 50949127764     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2007.10.020     Document Type: Article

References (30)

1. Atchison C.R., West A.B., Balakumaran A., Hargus S.J., Pohl L.R., Daiker D.H., Aronson J.F., Hoffmann W.E., Shipp B.K., and Treinen-Moslen M. Drug enterocyte adducts: possible causal factor for diclofenac enteropathy in rats. Gastroenterology 119 (2000) 1537-1547
2. Banks A.T., Zimmerman H.J., Ishak K.G., and Harter J.G. Diclofenac-associated hepatotoxicity: analysis of 180 cases reported to the food and drug administration as adverse reactions. Hepatology 22 (1995) 820-827
3. Barbato F., La Rotonda M.I., and Quaglia F. Interactions of nonsteroidal antiinflammatory drugs with phospholipids: comparison between octanol/buffer partition coefficients and chromatographic indexes on immobilized artificial membranes. J. Pharm. Sci. 86 (1997) 225-229
4. Beck W.S., Schneider H.T., Dietzel K., Nuernberg B., and Brune K. Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physicochemical and biochemical factors involved. Arch. Toxicol. 64 (1990) 210-217
5. Boelsterli U.A. Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity. Toxicol. Appl. Pharm. 192 (2003) 307-322
6. Buser H.R., Poiger T., and Müller M.D. Occurrence and fate of the pharmaceutical drug diclofenac in surface waters: rapid photodegradation in a lake. Environ. Sci. Technol. 32 (1998) 3449-3456
7. In: Dietrich D.R., Webb S., and Petry T. (Eds). Hot Spot Pollutants: Pharmaceuticals in the Environment (2004), Elsevier Academic Press, Amsterdam
8. Dietrich D.R., Hitzfeld B.C., and O'Brien E. Toxicology and risk assessment of polar organic pollutans. In: Reemtsma T. (Ed). Organic Pollutants in the Water Cycle (2006), Wiley-VCH, Weinheim 287-310
9. Fitzsimmons P.N., Fernandez J.D., Hoffman A.D., Butterworth B.C., and Nichols J.W. Branchial elimination of superhydrophobic organic compounds by rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 55 (2001) 23-34
10. Fukuyama T., Yamaoka K., Ohata Y., and Nakagawa T. A new analysis method for disposition kinetics of enterohepatic circulation of diclofenac in rats. Drug Metab. Dispos. 22 (1994) 479-485
11. Grillo M.P., Hua F., Knutson C.G., Ware J.A., and Li C. Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes. Chem. Res. Toxicol. 16 (2003) 1410-1417
12. Grillo M.P., Knutson C.G., Sanders P.E., Waldon D.J., Hua F., and Ware J.A. Studies on the chemical reactivity of diclofenac acyl glucuronide with glutathione: identification of diclofenac-S-acyl-glutathione in rat bile. Drug Metab. Dispos. 31 (2003) 1327-1336
13. Grosser T., Yusuff S., Cheskis E., Pack M.A., and FitzGerald G.A. Developmental expression of functional cyclooxygenases in zebrafish. Proc. Natl. Acad. Sci. USA 99 (2002) 8418-8423
14. Hargus S.J., Amouzedeh H.R., Pumford N.R., Myers T.G., McCoy S.C., and Pohl L.R. Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac. Chem. Res. Toxicol. 7 (1994) 575-582
15. Hargus S.J., Martin B.M., George J.W., and Pohl L.R. Covalent modification of rat liver dipeptidyl peptidase IV (CD26) by the nonsteroidal anti-inflammatory drug diclofenac. Chem. Res. Toxicol. 8 (1995) 993-996
16. Hickey E.J., Raje R.R., Reid V.E., Gross S.M., and Ray S.D. Diclofenac induced in vivo nephrotoxicity may involve oxidative stress-mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radic. Biol. Med. 31 (2001) 139-152
17. Hoeger B., Kollner B., Dietrich D.R., and Hitzfeld B.C. Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario). Aquat. Toxicol. 75 (2005) 53-64
18. Huggett D.B., Cook J.C., Ericson J.F., and Williams R.T. A theoretical model for utilizing mammalian pharmacology and safety data to prioritize potential impacts of human pharmaceuticals to fish. Hum. Ecol. Risk Assess. 9 (2003) 1789-1799
19. Itazawa Y., Takeda T., Yamamoto K., and Azuma T. Determination of circulating blood volume in three teleosts, carp, yellowtail and porgy. Jpn. J. Ichthyol. 30 (1983) 94-107
20. Kretz-Rommel A., and Boelsterli U.A. Mechanism of covalent adduct formation of diclofenac to rat hepatic microsomal proteins. Retention of the glucuronic acid moiety in the adduct. Drug Metab. Dispos. 22 (1994) 956-961
21. Oaks J.L., Gilbert M., Virani M.Z., Watson R.T., Meteyer C.U., Rideout B.A., Shivaprasad H.L., Ahmed S., Chaudhry M.J., Arshad M., Mahmood S., Ali A., and Khan A.A. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 427 (2004) 630-633
22. Reuter B.K., Davies N.M., and Wallace J.L. Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation. Gastroenterology 112 (1997) 109-117
23. Risebrough R. Conservation biology: fatal medicine for vultures. Nature 427 (2004) 596-598
24. Rowley A.F., Knight J., Lloyd-Evans P., Holland J.W., and Vickers P.J. Eicosanoids and their role in immune modulation in fish: a brief overview. Fish Shellfish Immunol. 5 (1995) 549-567
25. Sanchez S., Alarcon de la Lastra C., Ortiz P., Motilva V., and Martin M.J. Gastrointestinal tolerability of metamizol, acetaminophen, and diclofenac in subchronic treatment in rats. Dig. Dis. Sci. 47 (2002) 2791-2798
26. Schwaiger J., Ferling H., Mallow U., Wintermayr H., and Negele R.D. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac; Part I: Histopathological alterations and bioaccumulation in rainbow trout. Aquat. Toxicol. 68 (2004) 141-150
27. Seitz S., and Boelsterli U.A. Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats. Gastroenterology 115 (1998) 1476-1482
28. Tort L., González-Arch F., Torres P., and Hidalgo J. On the blood volume of the mediterranean dogfish, Scyliorhinus canicula. Fish Physiol. Biochem. 9 (1991) 173-177
29. Triebskorn R., Casper H., Heyd A., Eikemper R., Kohler H.R., and Schwaiger J. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac; Part II. Cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss). Aquat. Toxicol. 68 (2004) 151-166
30. Zou J., Hong S., Holland J., Stewart I., and Secombes C.J. Differential modulation of cyclooxygenases 1 and 2 in rainbow trout. Dev. Comp. Immunol. 24 (2000) S60