Toxic effects of the non-steroidal anti-inflammatory drug diclofenac: Part II. Cytological effects in liver, kidney, gills and intestine of rainbow trout (Oncorhynchus mykiss)

Aquatic Toxicology

Volumn 68, Issue 2, 2004, Pages 151-166

  Triebskorn, R ^a   Casper, H ^b   Heyd, A ^a   Eikemper, R ^b   Kohler H R ^b   Schwaiger, J ^c  

^a Steinbeis Transf Ctr E   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c Bavarian Water Management Agency   (Germany)

Author keywords

Diclofenac; Fish; Trout; Ultrastructure

Indexed keywords

DICLOFENAC;

POLLUTION EFFECT; SALMONID; TOXICITY; ULTRASTRUCTURE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BASEMENT MEMBRANE; CELL COMPARTMENTALIZATION; CELL INFILTRATION; CONCENTRATION RESPONSE; CYTOLOGY; CYTOPATHOLOGY; DESMOSOME; DRUG TOXICITY; ENDOPLASMIC RETICULUM; ENDOTHELIUM CELL; GILL; GLOMERULUS; HYALINE DEGENERATION; INTESTINE; KIDNEY; KIDNEY TUBULE CELL; LIVER; MACROPHAGE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; RAINBOW TROUT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DICLOFENAC; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIUM; GILLS; GLYCOGEN; HEPATOCYTES; INTESTINES; KIDNEY; MICROSCOPY, ELECTRON; ONCORHYNCHUS MYKISS; ORGANELLES; TIME FACTORS;

ONCORHYNCHUS; ONCORHYNCHUS MYKISS; SALMONIDAE;

EID: 2442535152     PISSN: 0166445X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aquatox.2004.03.015     Document Type: Article

References (37)

1. Bhogaraju A., Nazeer S., Al-Baghdadi Y., Rahman M., Wrestler F., Patel N. Diclofenac-associated hepatitis. South. Med. J. 92(7):1999;711-713
2. Braunbeck, T., 1998. Cytological alterations in fish hepatocytes following in vivo and in vitro sublethal exposure to xenobiotics - structural biomarkers of environmental contaminations. In: Braunbeck, T., Streit, B., Hinton, D. (Eds.), Fish Ecotoxicology. Birkhäuser, Basel, pp. 61-139.
3. Braunbeck T., Storch V., Nagel R. Sex-specific reaction of liver ultrastructure in zebra fish (Brachydanio rerio) after prolonged sublethal exposure to 4-nitrophenol. Aquat. Toxicol. 14:1989;185-202
4. Braunbeck T., Burkhardt-Holm P., Görge G., Nagel R., Negele R.-D., Storch V. Regenbogenforelle und Zebrabärbling, zwei Modelle für verlängerte Toxizitätstests: relative Empfindlichkeit. Gustav Fischer Verlag, Stuttgart. 89:1992;109-145
5. Bucher F., Hofer R. The effects of treated domestic sewage on three organs (gills, kidney, liver) of brown trout (Salmo trutta). Water Res. 27(2):1993;255-261
6. Daughton C.G., Ternes T.A. Pharmaceuticals and personal care products in the environment: agents of subtle change? Environ. Health Perspect. 107(6):1999;907-938
7. EMEA, 2003. Note for guidance on environmental risk assessment of medicinal products for human use. Draft of the European Agency for the evaluation of medicinal products (EMEA), 24 July 2003.
8. Fischer-Scherl T., Veeser A., Hoffman R.W., Kühnhauser C., Negele R.-D., Euringmann T. Morphological effects of acute and chronic atrazine exposure in rainbow trout (Oncorhynchus mykiss). Arch. Environ. Contamin. Toxicol. 20:1991;454-461
9. Flower R.J. Non-steroidal anti-inflammatory drugs: back to the future. Rheumatology. 38:1999;693-696
10. Gernhöfer M., Pawert M., Schramm M., Müller E., Triebskorn R. Ultrastructural biomarkers as tools to characterize the health status of fish in contaminated streams. J. Aquat. Ecosys. Stress Recov. 8(3-4):2001;241-260
11. Ghadially, F.N., 1997. Ultrastructural Pathology of the Cell and Matrix, vols. I and II. Butterworths, London, 1340 pp.
12. Gori P. Ponceau 2 R staining on semi-thin sections of tissues fixed in glutaraldehyde - osmium tetroxide and embedded in epoxy resins. J. Microsc. 110:1977;163-165
13. Heberer T., Schmidt-Bäumler K., Stan H.-J. Occurrence and distribution of organic contaminants in the aquatic system in Berlin. Part I: Drug residues and other polar contaminants in Berlin surface and ground water. Acta Hydrochim. Hydrobiol. 26(5):1998;272-278
14. Karnovsky M.J. Use of ferrocyanide-reduced osmium tetroxide in electric microscopy. J. Cell Biol. 51:1971;284
15. Köhler H.-R., Triebskorn R. Assessment of the cytotoxic impact of heavy metals on soil invertebrates using a protocol integrating qualitative and quantitative components. Biomarkers. 3(2):1998;109-127
16. Kümmerer, K. (Ed.), 2001. Pharmaceuticals in the Environment. Springer, Berlin, Heidelberg, New York, 265 pp.
17. Lee N.-S., Nomura Y., Miyazaki T. Gill lamellar pillar cell necrosis, a new binavirus disease in Japanese eels. Dis. Aquat. Org. 37:1999;13-21
18. Lehmann, M., 2000. Arzneimittel und hormonell wirksame Stoffe in Fließgewässern Baden-Württembergs. In: 25 Jahre LFU. Jahresbericht 1998/1999. LFU Baden-Württemberg.
19. Mallat J. Fish gill structural changes induced by toxicants and other irritants: a statistical review. Can. J. Fish. Aquat. Sci. 42:1985;630-648
20. Oaks J.L., Gilbert M., Virani M.Z., Watson R.T., Meteyer C.U., Rideout B.A., Shivaprasad H.L., Ahmed S., Chaudhry M.J.I., Arshad M., Mahmood S., Ali A., Khan A.A. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature. 427:2004;630-633
21. Oulmi Y., Negele R.D., Braunbeck T. Cytopathology of liver and kidney in rainbow trout Oncorhynchus mykiss after long-term exposure to sublethal concentrations of linuron. Dis. Aquat. Org. 21:1995;35-52
22. Patrignani P., Panara M.R., Santini G. Differential inhibition of the cyclooxygenase activity of prostaglandin endoperoxide synthase isozymes in vitro and in vivo in man. Prostagland. Leukot. Essent Fatty Acids. 55(1):1996;115
23. Pawert M., Müller E., Triebskorn R. Ultrastructural changes in fish gills as biomarker to assess small stream pollution. Tissue Cell. 30(6):1998;617-626
24. Ramesh N., Jayakumar K., Narayana K., Vijayasarathi S.K. A study on toxicity of diclofenac in dogs. Indian Vet. J. 79:2002;668-671
25. Reynolds E.S. The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J. Cell Biol. 17:1963;208-212
26. Revai T., Harmos G. Nephoroc syndrome and acute interstitial nephritis associated with the use of diclofenac. Wien. Klin. Wochenschr. 111(13):1999;523-524
27. Sacher F., Lange F.T., Brauch H.-J., Blankenhorn I. Pharmaceuticals in groundwaters. Analytical methods and results of a monitoring in Baden-Württemberg, Germany. J. Chromatogr. A. 938:2001;199-210
28. Sacher F. Vorkommen von Arzneimittelrückständen in Grund- und Oberflächenwässern in Baden-Württemberg. Stuttgarter Berichte zur Siedlungswasserwirtschaft. 168:2002;59-69
29. Schramm M., Müller E., Triebskorn R. Brown trout (Salmo trutta f. fario) liver ultrastructure as a biomarker for assessment of small stream pollution. Biomarkers. 3:1998;93-108
30. Schwaiger, J., Ferling, H., Mallow, U., Wintermayr, H., Negele, R.D., 2004. Toxic effects of the non-steroidal anti-inflammatory drug diclofenac. Part I. Histopathological alterations and bioaccumulation in rainbow trout. Aquat. Toxicol. 68, 141-150.
31. Segner H., Burkhardt P., Avila E.M., Juario J., Storch V. Nutrition-related histopathology of the intestine of milkfish Chanos chanos fry. Dis. Aquat. Org. 2:1987;99-107
32. Singh I. A modification of the Masson-Hamperl method for staining of argentaffin cells. Anat. Anz. 115:1964;81-82
33. Ternes T. Occurrence of drugs in German sewage treatment plants and rivers. Water Res. 32(11):1998;3245-3260
34. Ternes T. Vorkommen von Pharmaka in Gewässern. Wasser Boden. 53(4):2001;9-14
35. Triebskorn R., Köhler H.-R. Plasticity of the endoplasmic reticulum in three cell types of slugs poisoned by molluscicides. Protoplasma. 169:1992;120-129
36. Triebskorn R., Köhler H.-R., Honnen W., Schramm M., Adams S.M., Müller E.F. Induction of heat shock proteins, changes in liver ultrastructure, and alterations of fish behaviour: are these biomarkers related and are they useful to reflect the state of pollution in the field? J. Aquat. Ecosys. Stress Recov. 6:1997;57-73
37. Vane J.R. Inhibition of prostaglandin synthesis as mechanism of action for aspirin-like drugs. Nature. 231:1971;232-235