Gene therapy for traumatic central nervous system injury and stroke using an engineered zinc finger protein that upregulates VEGF-A

Journal of Neurotrauma

Volumn 28, Issue 9, 2011, Pages 1863-1879

  D'Onofrio, Philippe M ^a   Thayapararajah, Mahinthan ^a   Lysko, Meghan D ^a   Magharious, Mark ^a,b   Spratt, S Kaye ^c   Lee, Gary ^c   Ando, Dale ^c   Surosky, Richard ^c   Fehlings, Michael G ^a   Koeberle, Paulo D ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c NONE   (United States)

Author keywords

CNS; ischemia; retinal ganglion cell; trauma; VEGF

Indexed keywords

ADENOVIRUS VECTOR; VASCULOTROPIN A; ZINC FINGER PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTERY LIGATION; ARTICLE; BEHAVIOR; CELL SURVIVAL; CONTROLLED STUDY; DISEASE SEVERITY; GENE THERAPY; HISTOPATHOLOGY; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; MOTOR CORTEX; NERVE TRANSECTION; NERVOUS SYSTEM INJURY; NEURONAL SURVIVAL; NEUROPROTECTION; NONHUMAN; OPHTHALMIC ARTERY LIGATION; OPTIC NERVE SECTION; PUPIL REFLEX; QUANTITATIVE ANALYSIS; RAT; RETINA BLOOD VESSEL; RETINA DEGENERATION; RETINA GANGLION CELL; RETINA INJURY; RETINA ISCHEMIA; STROKE; TRAUMATIC CENTRAL NERVOUS SYSTEM INJURY; TRAUMATIC CENTRAL NERVOUS SYTEM INJURY; UPREGULATION; WOUND CONTRACTION;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN INJURIES; GENE THERAPY; OPTIC NERVE INJURIES; PROTEIN ENGINEERING; RATS; RECOVERY OF FUNCTION; STROKE; TREATMENT OUTCOME; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; ZINC FINGERS;

EID: 80054801936     PISSN: 08977151     EISSN: 15579042     Source Type: Journal    
DOI: 10.1089/neu.2011.1896     Document Type: Article

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