Bromoenol lactone inhibits voltage-gated Ca 2+ and transient receptor potential canonical channels

Journal of Pharmacology and Experimental Therapeutics

Volumn 339, Issue 2, 2011, Pages 329-340

  Chakraborty, Saikat ^a   Berwick, Zachary C ^a   Bartlett, Paula J ^b   Kumar, Sanjay ^a   Thomas, Andrew P ^b   Sturek, Michael ^a   Tune, Johnathan D ^a   Obukhov, Alexander G ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROMOENOL LACTONE; PHENYLEPHRINE; PHOSPHOLIPASE A2; PHOSPHOLIPASE C BETA; POTASSIUM CHLORIDE; THAPSIGARGIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL; TRANSIENT RECEPTOR POTENTIAL CHANNEL 1; TRANSIENT RECEPTOR POTENTIAL CHANNEL 2; TRANSIENT RECEPTOR POTENTIAL CHANNEL 3; TRANSIENT RECEPTOR POTENTIAL CHANNEL 4; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; CALCIUM TRANSPORT; CELL ACTIVITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT;

ANIMALS; BEHAVIOR, ADDICTIVE; CALCIUM CHANNELS; CARBAZOLES; COCAINE; CONDITIONING, OPERANT; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; NAPHTHALENES; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASES; PYRONES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; SELF ADMINISTRATION; SWINE; THAPSIGARGIN; TRANSIENT RECEPTOR POTENTIAL CHANNELS;

EID: 80054787641     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.183673     Document Type: Article

References (40)

1. Albert AP, Saleh SN, and Large WA (2009) Identification of canonical transient receptor potential (TRPC) channel proteins in native vascular smooth muscle cells. Curr Med Chem 16:1158-1165.
2. Balsinde J, Bianco ID, Ackermann EJ, Conde-Frieboes K, and Dennis EA (1995) Inhibition of calcium-independent phospholipase A2 prevents arachidonic acid incorporation and phospholipid remodeling in P388D1 macrophages. Proc Natl Acad Sci USA 92:8527-8531.
3. Beech DJ (2005) Emerging functions of 10 types of TRP cationic channel in vascular smooth muscle. Clin Exp Pharmacol Physiol 32:597-603.
4. Beech DJ, Bahnasi YM, Dedman AM, and Al-Shawaf E (2009) TRPC channel lipid specificity and mechanisms of lipid regulation. Cell Calcium 45:583-588.
5. Berridge MJ, Downes CP, and Hanley MR (1982) Lithium amplifies agonistdependent phosphatidylinositol responses in brain and salivary glands. Biochem J 206:587-595. (Pubitemid 13199531)
6. Bolotina VM and Csutora P (2005) CIF and other mysteries of the store-operated Ca2+-entry pathway. Trends Biochem Sci 30:378-387. (Pubitemid 40942033)
7. Catterall WA (2000) Structure and regulation of voltage-gated Ca2+ channels. Annu Rev Cell Dev Biol 16:521-555.
8. Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517-524. (Pubitemid 37522633)
9. Dietrich A, Kalwa H, and Gudermann T (2010a) TRPC channels in vascular cell function. Thromb Haemost 103:262-270.
10. Dietrich HH, Abendschein DR, Moon SH, Nayeb-Hashemi N, Mancuso DJ, Jenkins CM, Kaltenbronn KM, Blumer KJ, Turk J, and Gross RW (2010b) Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine. Am J Physiol Heart Circ Physiol 298:H2208-H2220.
11. Edwards JM, Neeb ZP, Alloosh MA, Long X, Bratz IN, Peller CR, Byrd JP, Kumar S, Obukhov AG, and Sturek M (2010) Exercise training decreases store-operated Ca2+ entry associated with metabolic syndrome and coronary atherosclerosis. Cardiovasc Res 85:631-640.
12. Guo Z, Su W, Ma Z, Smith GM, and Gong MC (2003) Ca2+-independent phospholipase A2 is required for agonist-induced Ca2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 278:1856-1863. (Pubitemid 36801424)
13. Harris DM, Cohn HI, Pesant S, and Eckhart AD (2008) GPCR signalling in hypertension: role of GRKs. Clin Sci 115:79-89.
14. Hazen SL, Zupan LA, Weiss RH, Getman DP, and Gross RW (1991) Suicide inhibition of canine myocardial cytosolic calcium-independent phospholipase A2. Mechanism- based discrimination between calcium-dependent and -independent phospholipases A2. J Biol Chem 266:7227-7232. (Pubitemid 21906356)
15. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, and Schultz G (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259-263.
16. Hogan PG, Lewis RS, and Rao A (2010) Molecular basis of calcium signaling in lymphocytes: STIM and ORAI. Annu Rev Immunol 28:491-533.
17. Institute of Laboratory Animal Resources (1996) Guide for the Care and Use of Laboratory Animals 7th ed. Institute of Laboratory Animal Resources, Commission on Life Sciences, National Research Council, Washington DC.
18. Jenkins CM, Han X, Yang J, Mancuso DJ, Sims HF, Muslin AJ, and Gross RW (2003) Purification of recombinant human cPLA2 gamma and identification of C-terminal farnesylation, proteolytic processing, and carboxymethylation by MALDI-TOFTOF analysis. Biochemistry 42:11798-11807. (Pubitemid 37243640)
19. Jenkinson S, Nahorski SR, and Challiss RA (1994) Disruption by lithium of phosphatidylinositol- 4,5-bisphosphate supply and inositol-1,4,5-trisphosphate generation in Chinese hamster ovary cells expressing human recombinant m1 muscarinic receptors. Mol Pharmacol 46:1138-1148.
20. Johnson CD, Melanaphy D, Purse A, Stokesberry SA, Dickson P, and Zholos AV (2009) Transient receptor potential melastatin 8 channel involvement in the regulation of vascular tone. Am J Physiol Heart Circ Physiol 296:H1868-H1877.
21. Jörs S, Kazanski V, Foik A, Krautwurst D, and Harteneck C (2006) Receptor-induced activation of Drosophila TRP gamma by polyunsaturated fatty acids. J Biol Chem 281:29693-29702. (Pubitemid 44536978)
22. Li J, Sukumar P, Milligan CJ, Kumar B, Ma ZY, Munsch CM, Jiang LH, Porter KE, and Beech DJ (2008) Interactions, functions, and independence of plasma membrane STIM1 and TRPC1 in vascular smooth muscle cells. Circ Res 103:e97-104.
23. Liu CH, Wang T, Postma M, Obukhov AG, Montell C, and Hardie RC (2007) In vivo identification and manipulation of the Ca2+ selectivity filter in the Drosophila transient receptor potential channel. J Neurosci 27:604-615. (Pubitemid 46143764)
24. McElroy SP, Drummond RM, and Gurney AM (2009) Regulation of store-operated Ca2+ entry in pulmonary artery smooth muscle cells. Cell Calcium 46:99-106.
25. Moosmang S, Schulla V, Welling A, Feil R, Feil S, Wegener JW, Hofmann F, and Klugbauer N (2003) Dominant role of smooth muscle L-type calcium channel Cav1.2 for blood pressure regulation. EMBO J 22:6027-6034. (Pubitemid 37463246)
26. Obukhov AG and Nowycky MC (2004) TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBP50). J Cell Physiol 201:227-235. (Pubitemid 39305100)
27. Obukhov AG and Nowycky MC (2008) TRPC5 channels undergo changes in gating properties during the activation-deactivation cycle. J Cell Physiol 216:162-171. (Pubitemid 351813107)
28. Park KM, Trucillo M, Serban N, Cohen RA, and Bolotina VM (2008) Role of iPLA2 and store-operated channels in agonist-induced Ca2+ influx and constriction in cerebral, mesenteric, and carotid arteries. Am J Physiol Heart Circ Physiol 294:H1183-H1187. (Pubitemid 351468713)
29. Ramsey IS, Delling M, and Clapham DE (2006) An introduction to TRP channels. Annu Rev Physiol 68:619-647.
30. Ratz PH, Miner AS, and Barbour SE (2009) Calcium-independent phospholipase A2 participates in KCl-induced calcium sensitization of vascular smooth muscle. Cell Calcium 46:65-72.
31. Schaefer M, Plant TD, Obukhov AG, Hofmann T, Gudermann T, and Schultz G (2000) Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 275:17517-17526. (Pubitemid 30430793)
32. Seegers HC, Gross RW, and Boyle WA (2002) Calcium-independent phospholipase A(2)-derived arachidonic acid is essential for endothelium-dependent relaxation by acetylcholine. J Pharmacol Exp Ther 302:918-923. (Pubitemid 34920211)
33. Sitter H, Torossian A, Duda D, and Sattler J (2004) Classification of perioperative histamine-related reactions. Inflamm Res 53:S164-S168. (Pubitemid 39149874)
34. Smani T, Zakharov SI, Csutora P, Leno E, Trepakova ES, and Bolotina VM (2004) A novel mechanism for the store-operated calcium influx pathway. Nat Cell Biol 6:113-120. (Pubitemid 38425710)
35. Song H, Ramanadham S, Bao S, Hsu FF, and Turk J (2006) A bromoenol lactone suicide substrate inactivates group VIA phospholipase A2 by generating a diffusible bromomethyl keto acid that alkylates cysteine thiols. Biochemistry 45:1061-1073. (Pubitemid 43124112)
36. Várnai P and Balla T (1998) Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools. J Cell Biol 143:501-510. (Pubitemid 28487866)
37. Wolf MJ and Gross RW (1996) The calcium-dependent association and functional coupling of calmodulin with myocardial phospholipase A2. Implications for cardiac cycle-dependent alterations in phospholipolysis. J Biol Chem 271:20989-20992. (Pubitemid 26292941)
38. Wolf MJ, Wang J, Turk J, and Gross RW (1997) Depletion of intracellular calcium stores activates smooth muscle cell calcium-independent phospholipase A2. A novel mechanism underlying arachidonic acid mobilization. J Biol Chem 272:1522-1526. (Pubitemid 27043230)
39. Wong MS, Man RY, and Vanhoutte PM (2010) Calcium-independent phospholipase A(2) plays a key role in the endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol 298:H1260-H1266.
40. Yu Y, Fantozzi I, Remillard CV, Landsberg JW, Kunichika N, Platoshyn O, Tigno DD, Thistlethwaite PA, Rubin LJ, and Yuan JX (2004) Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension. Proc Natl Acad Sci USA 101:13861-13866. (Pubitemid 39298498)