TRPC5 channels undergo changes in gating properties during the activation-deactivation cycle

Journal of Cellular Physiology

Volumn 216, Issue 1, 2008, Pages 162-171

  Obukhov, Alexander G ^a,b   Nowycky, Martha C ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EBP 50 PROTEIN; LANTHANUM; MAGNESIUM; SCAFFOLD PROTEIN; TRANSIENT RECEPTOR POTENTIAL CHANNEL 5; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); HISTAMINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC5 PROTEIN, RAT;

ARTICLE; BIOPHYSICS; CELL STRAIN HEK293; CHANNEL GATING; CONDUCTANCE; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DEPOLARIZATION; DESENSITIZATION; ELECTRIC POTENTIAL; EMBRYO; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KINETICS; MODULATION; MUTATION; NUCLEOTIDE SEQUENCE; PATCH CLAMP; PHASE TRANSITION; PRIORITY JOURNAL; RECORDING; REGULATORY MECHANISM; REST; ANIMAL; CELL LINE; CELL MEMBRANE POTENTIAL; GENETICS; METABOLISM; PHYSIOLOGY; RAT;

RATTUS;

ANIMALS; CELL LINE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HISTAMINE; HUMANS; ION CHANNEL GATING; LANTHANUM; MEMBRANE POTENTIALS; PATCH-CLAMP TECHNIQUES; RATS; TRPC CATION CHANNELS;

EID: 44449123638     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21388     Document Type: Article

References (23)

1. 2+ signaling microdomains: Platforms for the assembly and regulation of TRPC channels. Trends Pharmacol Sci 27:25-32.
2. Bezzerides VJ, Ramsey IS, Kotecha S, Greka A, Clapham DE. 2004. Rapid vesicular translocation and insertion of TRP channels. Nat Cell Biol 6:709-720.
3. Clapham DE. 2003. TRP channels as cellular sensors. Nature 426:517-524.
4. Hofmann T, Obukhov AG, Schaefer M, Harteneck C, Gudermann T, Schultz G. 1999. Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature 397:259-263.
5. Jung S, Muhle A, Schaefer M, Strotmann R, Schultz G, Plant TD. 2003. Lanthanides potentiate TRPC5 currents by an action at extracellular sites close to the pore mouth. J Biol Chem 278:3562-3571.
6. Nilius B, Talavera K, Owsianik G, Prenen J, Droogmans G, Voets T. 2005. Gating of TRP channels: A voltage connection? J Physiol 547:33-44.
7. Nilius B, Mahleu F, Karashima Y, Voets T. 2007. Regulation of TRP channels: A voltage-lipid connection. Biochem Soc Trans 35:105-108.
8. 2+ to trigger exocytosis in neuroendocrine cells. J Biol Chem 277:16172-16178.
9. Obukhov AG, Nowycky MC. 2004. TRPC5 activation kinetics are modulated by the scaffolding protein ezrin/radixin/moesin-binding phosphoprotein-50 (EBPS0). J Cell Physiol 201:227-235.
10. 2+ block and regulates inward current amplitude of a transient receptor potential channel. J Neurosci 25:1234-1239.
11. 2+-permeable nonselective cation channels. Cell Calcium 33:441-450.
12. Putney JW. 2005. Physiological mechanisms of TRPC activation. Pflugers Arch 451:29-34.
13. Ramsey IS, Delling M, Clapham DE. 2006. An introduction to trp channels. Annu Rev Physiol 68:619-647.
14. Schaefer M, Plant TD, Obukhov AG, Hofmann T, Gudermann T, Schultz G. 2000. Receptor-mediated regulation of the nonselective cation channels TRPC4 and TRPC5. J Biol Chem 275:17517-17526.
15. Semtner M, Schaefer M, Pinkenburg O, Plant TD. 2007. Potentiation of TRPC5 by protons. J Biol Chem 282:33868-33878.
16. Strübing C, Krapivinsky G, Krapivinsky L, Clapham DE. 2001. TRPC1 and TRPC5 form a novel cation channel in mammalian brain. Neuron 29:645-655.
17. Vazquez G, Wedel BJ, Aziz O, Trebak M, Putney JW, Jr. 2004. The mammalian TRPC cation channels. Biochim Biophys Acta 1742:21-36.
18. Venkatachalam K, Zheng F, Gill DL. 2003. Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J Biol Chem 278:29031-29040.
19. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B. 2004. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430:748-754.
20. Voets T, Owsianik G, Janssens A, Talavera K, Nilius B. 2007. TRPM8 voltage sensor mutants reveal a mechanism for integrating thermal and chemical stimuli. Nat Chem Biol 3:174-182.
21. Yamada H, Wakamori M, Hara Y, Takahashi Y, Konishi K, Imoto K, Mori Y. 2000. Spontaneous single-channel activity of neuronal TRP5 channel recombinantly expressed in HEK293 cells. Neurosci Lett 285:111-114.
22. Yu FH, Yarov-Yarovoy V, Gutman GA, Catterall WA. 2005. Overview of molecular relationships in the voltage-gated ion channel superfamily. Pharmacol Rev 57:387-395.
23. Zhu MH, Chae MR, Kim HJ, Lee YM, Kim MJ, Jin NG, Yang Dk1 so I, Kim KW. 2005. Desensitization of canonical transient receptor potential channel 5 by protein kinase C. Am J Physiol Cell Physiol 289:C591-C600.