Anti-ribosomal P antibodies and lupus nephritis

Clinical and Experimental Nephrology

Volumn 15, Issue 4, 2011, Pages 478-485

  Hosoya, Ken Ichi ^a   Tachikawa, Masanori ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

Blood brain barrier; Blood cerebrospinal fluid barrier; Creatinine; Indoxyl sulfate; Organic anion transporter; Organic cation transporter

Indexed keywords

3 (3 CARBOXY 4 METHYL 5 PROPYL 2 FURYL)PROPIONIC ACID; ANTIHYPERTENSIVE AGENT; ANTIINFLAMMATORY AGENT; ANTIVIRUS AGENT; BETA LACTAM ANTIBIOTIC; BIGUANIDE DERIVATIVE; CREATININE; DIURETIC AGENT; HIPPURIC ACID; INDICAN; INDOLEACETIC ACID; NEUROTRANSMITTER; ORGANIC ANION TRANSPORTER 3; ORGANIC CATION TRANSPORTER 3; TRICYCLIC ANTIDEPRESSANT AGENT; UNCLASSIFIED DRUG; UREMIC TOXIN; URICOSURIC AGENT; ORGANIC ANION TRANSPORTER; ORGANIC CATION TRANSPORTER; SOLUTE CARRIER FAMILY 22 (ORGANIC CATION TRANSPORTER), MEMBER 3; TOXIN; UREMIA MIDDLE MOLECULE TOXINS;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; BLOOD CEREBROSPINAL FLUID BARRIER; CHRONIC KIDNEY DISEASE; CREATININE CLEARANCE; DISEASE ASSOCIATION; DISEASE COURSE; HUMAN; KIDNEY FAILURE; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; RISK FACTOR; TRANSPORT KINETICS; UREMIA; URINARY EXCRETION; BRAIN; CEREBROSPINAL FLUID; CHOROID PLEXUS; ION TRANSPORT; KIDNEY; METABOLIC ENCEPHALOPATHY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

BLOOD-BRAIN BARRIER; BRAIN; BRAIN DISEASES, METABOLIC; CEREBROSPINAL FLUID; CHOROID PLEXUS; CREATININE; INDICAN; ION TRANSPORT; KIDNEY; ORGANIC ANION TRANSPORTERS; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; ORGANIC CATION TRANSPORT PROTEINS; TOXINS, BIOLOGICAL;

EID: 80054753812     PISSN: 13421751     EISSN: 14377799     Source Type: Journal    
DOI: 10.1007/s10157-011-0460-y     Document Type: Review

References (60)

1. Hosoya K, Ohtsuki S, Terasaki T. Recent advances in the brainto- blood efflux transport across the blood-brain barrier. Int J Pharm. 2002;248:15-29 (Pubitemid 35341406)
2. Hosoya K, Hori S, Ohtsuki S, Terasaki T. A new in vitro model for blood-cerebrospinal fluid barrier transport studies: An immortalized choroid plexus epithelial cell line derived from the tsA58 SV40 large T-antigen gene transgenic rat. Adv Drug Deliv Rev. 2004;56:1875-85 (Pubitemid 39286164)
3. Ohtsuki S, Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm Res. 2007;24:1745-58 (Pubitemid 47206624)
4. Duarte CG, Preuss HG. Assessment of renal function-glomerular and tubular. Clin Lab Med. 1993;13:33-52
5. Spector R, Johanson CE. Vectorial ligand transport through mammalian choroid plexus. Pharm Res. 2010;27:2054-62
6. Inui KI, Masuda S, Saito H. Cellular and molecular aspects of drug transport in the kidney. Kidney Int. 2000;58:944-58
7. Tsuji A, Tamai I. Carrier-mediated intestinal transport of drugs. Pharm Res. 1996;13:963-77 (Pubitemid 26258994)
8. Hagenbuch B. Drug uptake systems in liver and kidney: A historic perspective. Clin Pharmacol Ther. 2010;87:39-47
9. Tachikawa M, Hosoya K. Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: Relevance to neural disorders. Fluids Barriers CNS. 2011;8:13
10. Brouns R, De Deyn PP. Neurological complications in renal failure: A review. Clin Neurol Neurosurg. 2004;107:1-16 (Pubitemid 39556672)
11. Davenport A. The brain and the kidney-organ cross talk and interactions. Blood Purif. 2008;26:526-36
12. Vanholder R, De Smet R, Glorieux G, Argilés A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, Descamps-Latscha B, Henle T, Jörres A, Lemke HD, Massy ZA, Passlick-Deetjen J, Rodriguez M, Stegmayr B, Stenvinkel P, Tetta C, Wanner C, Zidek W. Review on uremic toxins: Classification, concentration, and interindividual variability. Kidney Int. 2003;63:1934-43 (Pubitemid 36513344)
13. Koepsell H, Endou H. The SLC22 drug transporter family. Pflugers Arch. 2004;447:666-76 (Pubitemid 38241452)
14. Mori S, Takanaga H, Ohtsuki S, Deguchi T, Kang YS, Hosoya K, Terasaki T. Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J Cereb Blood Flow Metab. 2003;23:432-40 (Pubitemid 36403025)
15. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, Nigam SK. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem. 2002;277:26934-43 (Pubitemid 34951703)
16. Koepsell H. Organic cation transporters in intestine, kidney, liver, and brain. Annu Rev Physiol. 1998;60:243-66 (Pubitemid 28157873)
17. Nakayama H, Kitaichi K, Ito Y, Hashimoto K, Takagi K, Yokoi T, Takagi K, Ozaki N, Yamamoto T, Hasegawa T. The role of organic cation transporter-3 in methamphetamine disposition and its behavioral response in rats. Brain Res. 2007;1184:260-9 (Pubitemid 350160590)
18. Hagenbuch B, Meier PJ. The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta. 2003;1609:1-18 (Pubitemid 36044060)
19. Gao B, Stieger B, Noé B, Fritschy JM, Meier PJ. Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroids plexus epithelium of rat brain. J Histochem Cytochem. 1999;47:1255-64
20. Ohtsuki S, Takizawa T, Takanaga H, Terasaki N, Kitazawa T, Sasaki M, Abe T, Hosoya K, Terasaki T. In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate. Mol Pharmacol. 2003;63:532-7 (Pubitemid 36297322)
21. Sugiyama D, Kusuhara H, Taniguchi H, Ishikawa S, Nozaki Y, Aburatani H, Sugiyama Y. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood- brain barrier: High affinity transporter for thyroxine. J Biol Chem. 2003;278:43489-95 (Pubitemid 37345972)
22. Dean M, Rzhetsky A, Allikmets R. The human ATP-binding cassette (ABC) transporter superfamily. Genome Res. 2001;11: 1156-66 (Pubitemid 32677289)
23. Ambudkar SV, Kimchi-Sarfaty C, Sauna ZE, Gottesman MM. P-glycoprotein: From genomics to mechanism. Oncogene. 2003; 22:7468-85 (Pubitemid 37487170)
24. de Lange EC. Potential role of ABC transporters as a detoxification system at the blood-CSF barrier. Adv Drug Deliv Rev. 2004;56:1793-809 (Pubitemid 39286161)
25. Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, Mercer KE, Zhuang Y, Panetta JC, Johnston B, Scheper RJ, Stewart CF, Schuetz JD. Mrp4 confers resistance to topotecan and protects the brain from chemotherapy. Mol Cell Biol. 2004;24:7612-21 (Pubitemid 39121487)
26. Hori S, Ohtsuki S, Tachikawa M, Kimura N, Kondo T, Watanabe M, Nakashima E, Terasaki T. Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s). J Neurochem. 2004;90:526-36 (Pubitemid 38989383)
27. Niwa T. Uremic toxicity of indoxyl sulfate. Nagoya J Med Sci. 2010;72:1-11
28. Niwa T, Ise M. Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J Lab Clin Med. 1994;124:96-104 (Pubitemid 2125685)
29. Sakai T, Maruyama T, Imamura H, Shimada H, Otagiri M. Mechanism of stereoselective serum binding of ketoprofen after hemodialysis. J Pharmacol Exp Ther. 1996;278:786-92 (Pubitemid 27167047)
30. Enomoto A, Takeda M, Tojo A, Sekine T, Cha SH, Khamdang S, Takayama F, Aoyama I, Nakamura S, Endou H, Niwa T. Role of organic anion transporters in the tubular transport of indoxyl sulfate and the induction of its nephrotoxicity. J Am Soc Nephrol. 2002;13:1711-20 (Pubitemid 34700595)
31. Deguchi T, Ohtsuki S, Otagiri M, Takanaga H, Asaba H, Mori S, Terasaki T. Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney. Kidney Int. 2002;61:1760-8 (Pubitemid 34437929)
32. Deguchi T, Kusuhara H, Takadate A, Endou H, Otagiri M, Sugiyama Y. Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int. 2004;65:162-74 (Pubitemid 38037501)
33. Deguchi T, Kouno Y, Terasaki T, Takadate A, Otagiri M. Differential contributions of rOat1 (Slc22a6) and rOat3 (Slc22a8) to the in vivo renal uptake of uremic toxins in rats. Pharm Res. 2005;22:619-27 (Pubitemid 40603260)
34. Deguchi T, Takemoto M, Uehara N, Lindup WE, Suenaga A, Otagiri M. Renal clearance of endogenous hippurate correlates with expression levels of renal organic anion transporters in uremic rats. J Pharmacol Exp Ther. 2005;314:932-8 (Pubitemid 41043880)
35. Schneider R, Sauvant C, Betz B, Otremba M, Fischer D, Holzinger H, Wanner C, Galle J, Gekle M. Downregulation of organic anion transporters OAT1 and OAT3 correlates with impaired secretion of para-aminohippurate after ischemic acute renal failure in rats. Am J Physiol Renal Physiol. 2007;292:F1599-605 (Pubitemid 46701888)
36. Sakurai Y, Motohashi H, Ueo H, Masuda S, Saito H, Okuda M, Mori N, Matsuura M, Doi T, Fukatsu A, Ogawa O, Inui K. Expression levels of renal organic anion transporters (OATs) and their correlation with anionic drug excretion in patients with renal diseases. Pharm Res. 2004;21:61-7 (Pubitemid 38122293)
37. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev. 2000;80:1107-213 (Pubitemid 30452013)
38. De Deyn PP, Vanholder R, Eloot S, Glorieux G. Guanidino compounds as uremic (neuro)toxins. Semin Dial. 2009;22:340-5
39. Namba S, Okuda Y, Morimoto A, Kojima T, Morita T. A serum indoxyl sulfate is a useful predictor for progression of chronic kidney disease. Rinsho Byori. 2010;58:448-53
40. Urakami Y, Kimura N, Okuda M, Inui K. Creatinine transport by basolateral organic cation transporter hOCT2 in the human kidney. Pharm Res. 2004;21:976-81 (Pubitemid 38870147)
41. Urakami Y, Kimura N, Okuda M, Masuda S, Katsura T, Inui K. Transcellular transport of creatinine in renal tubular epithelial cell line LLC-PK1. Drug Metab Pharmacokinet. 2005;20:200-5
42. Müting D. Studies on the pathogenesis of uremia. Comparative determinations of glucuronic acid, indican, free and bound phenols in the serum, cerebrospinal fluid, and urine of renal diseases with and without uremia. Clin Chim Acta. 1965;12:551-4
43. Kikuchi R, Kusuhara H, Sugiyama D, Sugiyama Y. Contribution of organic anion transporter 3 (Slc22a8) to the elimination of p-aminohippuric acid and benzylpenicillin across the blood-brain barrier. J Pharmacol Exp Ther. 2003;306:51-8 (Pubitemid 36734356)
44. Kakee A, Terasaki T, Sugiyama Y. Blood-brain barrier: In vivo evidence by use of the brain efflux index method. J Pharmacol Exp Ther. 1997;283:1018-25
45. Ohtsuki S, Asaba H, Takanaga H, Deguchi T, Hosoya K, Otagiri M, Terasaki T. Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: Its involvement in neurotransmitter metabolite clearance from the brain. J Neurochem. 2002;83:57-66
46. Deguchi T, Isozaki K, Yousuke K, Terasaki T, Otagiri M. Involvement of organic anion transporters in the efflux of uremic toxins across the blood-brain barrier. J Neurochem. 2006;96 :1051-9
47. Tachikawa M, Hosoya K, Ohtsuki S, Terasaki T. A novel relationship between creatine transport at the blood-brain and blood- retinal barriers, creatine biosynthesis, and its use for brain and retinal energy homeostasis. Subcell Biochem. 2007;46:83-98
48. Marescau B, Deshmukh DR, Kockx M, Possemiers I, Qureshi IA, Wiechert P, De Deyn PP. Guanidino compounds in serum, urine, liver, kidney, and brain of man and some ureotelic animals. Metabolism. 1992;41:526-32
49. De Deyn PP, D'Hooge R, Van Bogaert PP, Marescau B. Endogenous guanidino compounds as uremic neurotoxins. Kidney Int Suppl. 2001;78:S77-83 (Pubitemid 32144075)
50. Ku CP, Passow H. Creatine and creatinine transport in old and young human red blood cells. Biochim Biophys Acta. 1980;600: 212-27 (Pubitemid 11192810)
51. Tachikawa M, Kasai Y, Takahashi M, Fujinawa J, Kitaichi K, Terasaki T, Hosoya K. The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: Involvement of transporter-mediated process. J Neurochem. 2008;107:432-42
52. Hayer-Zillgen M, Brüss M, Bönisch H. Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002;136:829-36 (Pubitemid 34836857)
53. Noé B, Hagenbuch B, Stieger B, Meier PJ. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA. 1997;94:10346-50
54. Lim CF, Bernard BF, de Jong M, Docter R, Krenning EP, Hennemann G. A furan fatty acid and indoxyl sulfate are the putative inhibitors of thyroxine hepatocyte transport in uremia. J Clin Endocrinol Metab. 1993;76:318-24 (Pubitemid 23073048)
55. Porter RD, Cathcart-Rake WF, Wan SH, Whittier FC, Grantham JJ. Secretory activity and aryl acid content of serum, urine, and cerebrospinal fluid in normal and uremic man. J Lab Clin Med. 1975;85:723-31
56. Sullivan PA, Murnaghan D, Callaghan N, Kantamaneni BD, Curzon G. Cerebral transmitter precursors and metabolites in advanced renal disease. J Neurol Neurosurg Psychiatry. 1978;41: 581-8 (Pubitemid 8371472)
57. Burke WJ, Li SW, Schmitt CA, Xia P, Chung HD, Gillespie KN. Accumulation of 3,4-dihydroxyphenylglycolaldehyde, the neurotoxic monoamine oxidase A metabolite of norepinephrine, in locus ceruleus cell bodies in Alzheimer's disease: Mechanism of neuron death. Brain Res. 1999;816:633-7 (Pubitemid 29225414)
58. Lamensdorf I, Eisenhofer G, Harvey-White J, Hayakawa Y, Kirk K, Kopin IJ. Metabolic stress in PC12 cells induces the formation of the endogenous dopaminergic neurotoxin, 3,4-dihydroxyphenylacetaldehyde. J Neurosci Res. 2000;60:552-8 (Pubitemid 30252918)
59. Marescau B, Nagels G, Possemiers I, De Broe ME, Becaus I, Billiouw JM, Lornoy W, De Deyn PP. Guanidino compounds in serum and urine of nondialyzed patients with chronic renal insufficiency. Metabolism. 1997;46:1024-31 (Pubitemid 27371819)
60. Ohtsuki S, Tomi M, Hata T, Nagai Y, Hori S, Mori S, Hosoya K, Terasaki T. Dominant expression of androgen receptors and their functional regulation of organic anion transporter 3 in rat brain capillary endothelial cells; comparison of gene expression between the blood-brain and -retinal barriers. J Cell Physiol. 2005;204:896-900. (Pubitemid 41099275)