In vitro study of the functional expression of organic anion transporting polypeptide 3 at rat choroid plexus epithelial cells and its involvement in the cerebrospinal fluid-to-blood transport of estrone-3-sulfate

Molecular Pharmacology

Volumn 63, Issue 3, 2003, Pages 532-537

  Ohtsuki, Sumio ^a   Takizawa, Takuya ^a   Takanaga, Hitomi ^a   Terasaki, Nobuyuki ^a   Kitazawa, Takeo ^a   Sasaki, Masako ^a   Abe, Takaaki ^b   Hosoya, Ken Ichi ^c   Terasaki, Tetsuya ^a  

^a TOHOKU UNIVERSITY   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOYAMA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOHIPPURIC ACID; BROMSULFOPHTHALEIN; CHOLIC ACID; DIGOXIN; ESTRONE SULFATE; LIOTHYRONINE; METHOTREXATE; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 3; PRASTERONE SULFATE; PROBENECID; TAUROCHOLIC ACID; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD CEREBROSPINAL FLUID BARRIER; BRUSH BORDER; CELL ISOLATION; CHOROID PLEXUS; EPITHELIUM CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; XENOPUS LAEVIS;

ANIMALS; BIOLOGICAL TRANSPORT; BLOOD; CEREBROSPINAL FLUID; CHOROID PLEXUS; EPITHELIAL CELLS; ESTRONE; IMMUNOHISTOCHEMISTRY; MALE; OOCYTES; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRITIUM; XENOPUS LAEVIS;

EID: 0037334615     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.3.532     Document Type: Article

References (36)

1. Abe T, Kakyo M, Sakagami H, Tokui T, Nishio T, Tanemoto M, Nomura H, Hebert SC, Matsuno S, Kondo H, et al. (1998) Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J Biol Chem 273:22395-22401.
2. Angeletti RH, Novikoff PM, Juvvadi SR, Fritschy JM, Meier PJ, and Wolkoff AW (1997) The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proc Natl Acad Sci USA 94:283-286.
3. Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DK, Winterhalter KH, Meier PJ, and Hagenbuch B (2001) Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflueg Arch Eur J Physiol 443:188-195.
4. Connolly PB and Resko JA (1989) Estrone sulfatase activity in rat brain and pituitary: effects of gonadectomy and the estrous cycle. J Steroid Biochem 33:1013-1018.
5. Decleves X, Regina A, Laplanche JL, Roux F, Boval B, Launay JM, and Scherrmann JM (2000) Functional expression of P-glycoprotein and multidrug resistance-associated protein (Mrp1) in primary cultures of rat astrocytes. J Neurosci Res 60:594-601.
6. Forn J (1972) Active transport of 5-hydroxyindoleacetic acid by the rabbit choroid plexus in vitro. Blockade by probenecid and metabolic inhibitors. Biochem Pharmacol 21:619-624.
7. Gao B and Meier PJ (2001) Organic anion transport across the choroid plexus. Microsc Res Tech 52:60-64.
8. Gao B, Stieger B, Noe B, Fritschy JM, and Meier PJ (1999) Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain. J Histochem Cytochem 47:1255-1264.
9. Goldin AL (1992) Maintenance of Xenopus laevis and oocyte injection. Methods Enzymol 207:266-279.
10. Honjo H, Ogino Y, Naitoh K, Urabe M, Kitawaki J, Yasuda J, Yamamoto T, Ishihara S, Okada H, Yonezawa T, et al. (1989) In vivo effects by estrone sulfate on the central nervous system-senile dementia (Alzheimer's type). J Steroid Biochem 34:521-525.
11. Ito A, Yamaguchi K, Onogawa T, Unno M, Suzuki T, Nishio T, Sasano H, Abe T, and Tamai M (2002) Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina. Invest Ophthalmol Vis Sci 43:858-863.
12. +-independent organic anion transporter. Proc Natl Acad Sci USA 91:133-137.
13. Kakyo M, Sakagami H, Nishio T, Nakai D, Nakagomi R, Tokui T, Naitoh T, Matsuno S, Abe T, and Yawo H (1999) Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2). FEBS Lett 445:343-346.
14. Kanai N, Lu R, Bao Y, Wolkoff AW, and Schuster VL (1996) Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol 270:F319-F325.
15. Kitazawa T, Hosoya K, Takahashi T, Sugiyama Y, and Terasaki T (2000) In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier. J Pharm Pharmacol 52:281-288.
16. Kitazawa T, Hosoya K, Watanabe M, Takashima T, Ohtsuki S, Takanaga H, Ueda M, Yanai N, Obinata M, and Terasaki T (2001) Characterization of the amino acid transport of new immortalized choroid plexus epithelial cell lines: a novel in vitro system for investigating transport functions at the blood-cerebrospinal fluid barrier. Pharm Res 18:16-22.
17. Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, and Endou H (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem 274:13675-13680.
18. Li L, Meier PJ, and Ballatori N (2000) Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione. Mol Pharmacol 58:335-340.
19. Nagata Y, Kusuhara H, Endou H, and Sugiyama Y (2002) Expression and functional characterization of rat organic anion transporter 3 (rOat3) in the chornid plexus. Mol Pharmacol 61:982-988.
20. Nishino J, Suzuki H, Sugiyama D, Kitazawa T, Ito K, Hanano M, and Sugiyama Y (1999) Transepithelial transport of organic anions across the choroid plexus: possible involvement of organic anion transporter and multidrug resistance-associated protein. J Pharmacol Exp Ther 290:289-294.
21. Noe B, Hagenbuch B, Stieger B, and Meier PJ (1997) Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc Natl Acad Sci USA 94:10346-10350.
22. Platia MP, Fencl MD, Elkind-Hirsch KE, Canick JA, and Tulchinsky D (1984) Estrone sulfatase activity in the human brain and estrone sulfate levels in the normal menstrual cycle. J Steroid Biochem 21:237-241.
23. Porterfield SP and Hendrich CE (1993) The role of thyroid hormones in prenatal and neonatal neurological development-current perspectives. Endocr Rev 14:94-106.
24. Qian YM, Song WC, Cui H, Cole SP, and Deeley RG (2001) Glutathione stimulates sulfated estrogen transport by multidrug resistance protein 1. J Biol Chem 276:6404-6411.
25. Rami A and Krieglstein J (1992) Thyroxine attenuates hippocampal neuronal damage caused by ischemia in the rat. Life Sci 50:645-650.
26. Rao VV, Dahlheimer JL, Bardgett ME, Snyder AZ, Finch RA, Sartorelli AC, and Piwnica-Worms D (1999) Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci USA 96:3900-3905.
27. Sekine T, Watanabe N, Hosoyamada M, Kanai Y, and Endou H (1997) Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem 272:18526-18529.
28. Steingold KA, Cefalu W, Pardridge W, Judd HL, and Chaudhuri G (1986) Enhanced hepatic extraction of estrogens used for replacement therapy. J Clin Endocrinol Metab 62:761-766.
29. Sugiyama D, Kusuhara H, Shitara Y, Abe T, Meier PJ, Sekine T, Endou H, Suzuki H, and Sugiyama Y (2001) Characterization of the efflux transport of 17β-estradiol-D-17β-glucuronide from the brain across the blood-brain barrier. J Pharmacol Exp Ther 298:316-322.
30. Suzuki H, Terasaki T, and Sugiyama Y (1997) Role of efflux transport across the blood-brain barrier and blood-cerebrospinal fluid barrier on the disposition of xenobiotics in the central nervous system. Adv Drug Deliv Rev 25:257-285.
31. Sweet DH, Miller DS, Pritchard JB, Fujiwara Y, Beier DR, and Nigam SK (2002) Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. J Biol Chem 277:26934-26943.
32. Tremont G and Stern RA (1997) Use of thyroid hormone to diminish the cognitive side effects of psychiatric treatment. Psychopharmacol Bull 33:273-280.
33. Walters HC, Craddock AL, Fusegawa H, Willingham MC, and Dawson PA (2000) Expression, transport properties and chromosomal location of organic anion transporter subtype 3. Am J Physiol 279:G1188-G1200.
34. Wong SL, Van Belle K, and Sawchuk RJ (1993) Distributional transport kinetics of zidovudine between plasma and brain extracellular fluid/cerebrospinal fluid in the rabbit: investigation of the inhibitory effect of probenecid utilizing microdialysis. J Pharmacol Exp Ther 264:899-909.
35. Yamaoka K, Tanigawara Y, Nakagawa T, and Uno T (1981) A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobiodyn 4:879-885.
36. Zwain IH and Yen SS (1999) Dehydroepiandrosterone: biosynthesis and metabolism in the brain. Endocrinology 140:880-887.