The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis

Journal of Immunology

Volumn 183, Issue 7, 2009, Pages 4705-4714

  Carmi, Yaron ^a   Voronov, Elena ^a   Dotan, Shahar ^a   Lahat, Nitza ^b   Rahat, Michal A ^b   Fogel, Mina ^c   Huszar, Monika ^c   White, Malka R ^a   Dinarello, Charles A ^d   Apte, Ron N ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c KAPLAN MEDICAL CENTER   (Israel)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1; INTERLEUKIN 1BETA; SYNAPTOTAGMIN I; VASCULOTROPIN; ANGIOGENIC PROTEIN; AUTACOID; COLLAGEN; INTERLEUKIN 1ALPHA; LAMININ; LIPOPOLYSACCHARIDE; MATRIGEL; PROTEOGLYCAN; VASCULOTROPIN A;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; FLOW CYTOMETRY; HYPOXIA; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VASCULAR RING; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG COMBINATION; ENDOTHELIUM CELL; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MIGRATION INHIBITION; MOUSE MUTANT; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PERITONEUM MACROPHAGE; PHYSIOLOGY; SECRETION; TRANSGENIC MOUSE;

ANGIOGENIC PROTEINS; ANIMALS; CELL MIGRATION INHIBITION; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; ENDOTHELIAL CELLS; INFLAMMATION MEDIATORS; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; LAMININ; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MYELOID CELLS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEOGLYCANS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 70449732756     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901511     Document Type: Article

References (49)

1. Semenza, G. L. 2009. Regulation of oxygen homeostasis by hypoxia-inducible factor 1. Physiology 24: 97-106.
2. Fraisl, P., M. Mazzone, T. Schmidt, and P. Carmeliet. 2009. Regulation of angiogenesis by oxygen and metabolism. Dev. Cell 16: 167-179.
3. Mantovani, A., P. Allavena, A. Sica, and F. Balkwill. 2008. Cancer-related inflammation. Nature 454: 436-444.
4. Cramer, T., Y. Yamanishi, B. E. Clausen, I. Forster, R. Pawlinski, N. Mackman, V. H. Haase, R. Jaenisch, M. Corr, V. Nizet, et al. 2003. HIF-1α is essential for myeloid cell-mediated inflammation. Cell 112: 645-657.
5. Biswas, S. K., A. Sica, and C. E. Lewis. 2008. Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J. Immunol. 180: 2011-2017.
6. Lewis, C. E., M. De Palma, and L. Naldini. 2007. Tie2-expressing monocytes and tumor angiogenesis: regulation by hypoxia and angiopoietin-2. Cancer Res. 67: 8429-8432. (Pubitemid 47437413)
7. Murdoch, C., M. Muthana, S. B. Coffelt, and C. E. Lewis. 2008. The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 8: 618-631.
8. Bosco, M. C., M. Puppo, F. Blengio, T. Fraone, P. Cappello, M. Giovarelli, and L. Varesio. 2008. Monocytes and dendritic cells in a hypoxic environment: spotlights on chemotaxis and migration. Immunobiology 213: 733-749.
9. Pollard, J. W. 2009. Trophic macrophages in development and disease. Nat. Rev. Immunol. 9: 259-270.
10. Martinez, F. O., L. Helming, and S. Gordon. 2009. Alternative activation of macrophages: an immunologic functional perspective. Annu. Rev. Immunol. 27: 451-483.
11. Medzhitov, R. 2008. Origin and physiological roles of inflammation. Nature 454: 428-435.
12. Dirkx, A. E., M. G. Oude Egbrink, J. Wagstaff, and A. W. Griffioen. 2006. Monocyte/macrophage infiltration in tumors: modulators of angiogenesis. J. Leukocyte Biol. 80: 1183-1196.
13. Johansson, M., D. G. Denardo, and L. M. Coussens. 2008. Polarized immune responses differentially regulate cancer development. Immunol. Rev. 222: 145-154. (Pubitemid 351430362)
14. Strieter, R. M., M. D. Burdick, B. N. Gomperts, J. A. Belperio, and M. P. Keane. 2005. CXC chemokines in angiogenesis. Cytokine Growth Factor Rev. 16: 593-609.
15. Bosco, M. C., M. Puppo, C. Santangelo, L. Anfosso, U. Pfeffer, P. Fardin, F. Battaglia, and L. Varesio. 2006. Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene. J. Immunol. 177: 1941-1955.
16. White, J. R., R. A. Harris, S. R. Lee, M. H. Craigon, K. Binley, T. Price, G. L. Beard, C. R. Mundy, and S. Naylor. 2004. Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis. Genomics 83: 1-8.
17. Folkman, J. 2006. Angiogenesis. Annu. Rev. Med. 57: 1-18. (Pubitemid 43261975)
18. Carmeliet, P., and R. K. Jain. 2000. Angiogenesis in cancer and other diseases. Nature 407: 249-257.
19. Adams, R. H., and K. Alitalo. 2007. Molecular regulation of angiogenesis and lymphangiogenesis. Nat. Rev. Mol. Cell Biol. 8: 464-478.
20. Kerbel, R. S. 2008. Tumor angiogenesis. N. Engl. J. Med. 358: 2039-2049.
21. Kopp, H. G., C. A. Ramos, and S. Rafii. 2006. Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr. Opin. Hematol. 13: 175-181. (Pubitemid 43755858)
22. Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood 87: 2095-2147.
23. Dinarello, C. A. 2009. Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 27: 519-550.
24. Apte, R. N., S. Dotan, M. Elkabets, M. R. White, E. Reich, Y. Carmi, X. Song, T. Dvozkin, Y. Krelin, and E. Voronov. 2006. The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev. 25: 387-408.
25. Apte, R. N., and E. Voronov. 2008. Is interleukin-1 a good or bad "guy" in tumor immunobiology and immunotherapy? Immunol. Rev. 222: 222-241.
26. Krelin, Y., E. Voronov, S. Dotan, M. Elkabets, E. Reich, M. Fogel, M. Huszar, Y. Iwakura, S. Segal, C. A. Dinarello, and R. N. Apte. 2007. Interleukin-1β-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors. Cancer Res. 67: 1062-1071.
27. Nazarenko, I., R. Marhaba, E. Reich, E. Voronov, M. Vitacolonna, D. Hildebrand, E. Elter, M. Rajasagi, R. N. Apte, and M. Zoller. 2008. Tumorigenicity of IL-1α- and IL-1β-deficient fibrosarcoma cells. Neoplasia 10: 549-562.
28. Song, X., E. Voronov, T. Dvorkin, E. Fima, E. Cagnano, D. Benharroch, Y. Shendler, O. Bjorkdahl, S. Segal, C. A. Dinarello, and R. N. Apte. 2003. Differential effects of IL-1α and IL-1β on tumorigenicity patterns and invasiveness. J. Immunol. 171: 6448-6456.
29. + immature myeloid cells mediate suppression of T cells in mice bearing tumors of IL-1β-secreting cells. J. Immunol. 175: 8200-8208.
30. Marhaba, R., I. Nazarenko, D. Knofler, E. Reich, E. Voronov, M. Vitacolonna, D. Hildebrand, E. Elter, R. N. Apte, and M. Zoller. 2008. Opposing effects of fibrosarcoma cell-derived IL-1α and IL-1β on immune response induction. Int. J. Cancer 123: 134-145. (Pubitemid 351705201)
31. Voronov, E., D. S. Shouval, Y. Krelin, E. Cagnano, D. Benharroch, Y. Iwakura, C. A. Dinarello, and R. N. Apte. 2003. IL-1 is required for tumor invasiveness and angiogenesis. Proc. Natl. Acad. Sci. USA 100: 2645-2650.
32. Bar, D., R. N. Apte, E. Voronov, C. A. Dinarello, and S. Cohen. 2004. A continuous delivery system of IL-1 receptor antagonist reduces angiogenesis and inhibits tumor development. FASEB J. 18: 161-163.
33. Nakao, S., T. Kuwano, C. Tsutsumi-Miyahara, S. Ueda, Y. N. Kimura, S. Hamano, K. H. Sonoda, Y. Saijo, T. Nukiwa, R. M. Strieter, et al. 2005. Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1β-induced neovascularization and tumor growth. J. Clin. Invest. 115: 2979-2991.
34. Coxon, A., B. Bolon, J. Estrada, S. Kaufman, S. Scully, A. Rattan, D. Duryea, Y. L. Hu, K. Rex, E. Pacheco, et al. 2002. Inhibition of interleukin-1 but not tumor necrosis factor suppresses neovascularization in rat models of corneal angiogenesis and adjuvant arthritis. Arthritis Rheum. 46: 2604-2612.
35. Horai, R., M. Asano, K. Sudo, H. Kanuka, M. Suzuki, M. Nishihara, M. Takahashi, and Y. Iwakura. 1998. Production of mice deficient in genes for interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 receptor antagonist shows that IL-1β is crucial in turpentine-induced fever development and glucocorticoid secretion. J. Exp. Med. 187: 1463-1475.
36. Rahat, M. A., B. Marom, H. Bitterman, L. Weiss-Cerem, A. Kinarty, and N. Lahat. 2006. Hypoxia reduces the output of matrix metalloproteinase-9 (MMP-9) in monocytes by inhibiting its secretion and elevating membranal association. J. Leukocyte Biol. 79: 706-718.
37. Grunewald, M., I. Avraham, Y. Dor, E. Bachar-Lustig, A. Itin, S. Jung, S. Chimenti, L. Landsman, R. Abramovitch, and E. Keshet. 2006. VEGF-induced adult neovascularization: recruitment, retention, and role of accessory cells. Cell 124: 175-189.
38. Karin, M., and F. R. Greten. 2005. NF-κB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 5: 749-759. (Pubitemid 41400849)
39. Ruiz de Almodovar, C., A. Luttun, and P. Carmeliet. 2006. An SDF-1 trap for myeloid cells stimulates angiogenesis. Cell 124: 18-21.
40. Crawford, Y., and N. Ferrara. 2009. VEGF inhibition: insights from preclinical and clinical studies. Cell Tissue Res. 335: 261-269.
41. Zinkernagel, A. S., R. S. Johnson, and V. Nizet. 2007. Hypoxia-inducible factor (HIF) function in innate immunity and infection. J. Mol. Med. 85: 1339-1346.
42. Rius, J., M. Guma, C. Schachtrup, K. Akassoglou, A. S. Zinkernagel, V. Nizet, R. S. Johnson, G. G. Haddad, and M. Karin. 2008. NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α. Nature 453: 807-811.
43. Sethi, G., B. Sung, and B. B. Aggarwal. 2008. TNF: a master switch for inflammation to cancer. Front. Biosci. 13: 5094-5107. (Pubitemid 351599660)
44. Lohela, M., M. Bry, T. Tammela, and K. Alitalo. 2009. VEGFs and receptors involved in angiogenesis versus lymphangiogenesis. Curr. Opin. Cell Biol. 21: 154-165.
45. Mantovani, A., and E. Dejana. 1989. Cytokines as communication signals between leukocytes and endothelial cells. Immunol. Today 10: 370-375. (Pubitemid 19242062)
46. Lyden, D., K. Hattori, S. Dias, C. Costa, P. Blaikie, L. Butros, A. Chadburn, B. Heissig, W. Marks, L. Witte, et al. 2001. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat. Med. 7: 1194-1201.
47. Purhonen, S., J. Palm, D. Rossi, N. Kaskenpaa, I. Rajantie, S. Yla-Herttuala, K. Alitalo, I. L. Weissman, and P. Salven. 2008. Bone marrow-derived circulating endothelial precursors do not contribute to vascular endothelium and are not needed for tumor growth. Proc. Natl. Acad. Sci. USA 105: 6620-6625.
48. Zengin, E., F. Chalajour, U. M. Gehling, W. D. Ito, H. Treede, H. Lauke, J. Weil, H. Reichenspurner, N. Kilic, and S. Ergun. 2006. Vascular wall resident progenitor cells: a source for postnatal vasculogenesis. Development 133: 1543-1551. (Pubitemid 43732967)
49. Aicher, A., M. Rentsch, K. Sasaki, J. W. Ellwart, F. Fandrich, R. Siebert, J. P. Cooke, S. Dimmeler, and C. Heeschen. 2007. Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Circ. Res. 100: 581-589. (Pubitemid 46673268)