-
1
-
-
0034810885
-
Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium
-
Ahmed A, Kandola P, Ziada G et al. (2001) Purification and partial amino acid sequence of proteins from human epidermal keratinocyte conditioned medium. J Protein Chem 20:273-8
-
(2001)
J Protein Chem
, vol.20
, pp. 273-278
-
-
Ahmed, A.1
Kandola, P.2
Ziada, G.3
-
2
-
-
0036174691
-
Netherton syndrome: Disease expression and spectrum of SPINK5 mutations in 21 families
-
DOI 10.1046/j.1523-1747.2002.01603.x
-
Bitoun E, Chavanas S, Irvine A et al. (2002) Netherton syndrome: Disease expression and spectrum of SPINK5 mutations in 21 families. J Invest Dermatol 118:352-61 (Pubitemid 34158493)
-
(2002)
Journal of Investigative Dermatology
, vol.118
, Issue.2
, pp. 352-361
-
-
Bitoun, E.1
Chavanas, S.2
Irvine, A.D.3
Lonie, L.4
Bodemer, C.5
Paradisi, M.6
Hamel-Teillac, D.7
Ansai, S.-I.8
Mitsuhashi, Y.9
Taieb, A.10
De Prost, Y.11
Zambruno, G.12
Harper, J.I.13
Hovnanian, A.14
-
3
-
-
10744224015
-
LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome
-
DOI 10.1093/hmg/ddg247
-
Bitoun E, Micheloni A, Lamant L et al. (2003) LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome. Hum Mol Genet 12:2417-30 (Pubitemid 37220407)
-
(2003)
Human Molecular Genetics
, vol.12
, Issue.19
, pp. 2417-2430
-
-
Bitoun, E.1
Micheloni, A.2
Lamant, L.3
Bonnart, C.4
Tartaglia-Polcini, A.5
Cobbold, C.6
Al Saati, T.7
Mariotti, F.8
Mazareeuw-Hautier, J.9
Boralevi, F.10
Hohl, D.11
Harper, J.12
Bodemer, C.13
D'Alessio, M.14
Hovnanian, A.15
-
4
-
-
77949752021
-
Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing
-
Bonnart C, Deraison C, Lacroix M et al. (2010) Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. J Clin Invest 120:871-82
-
(2010)
J Clin Invest
, vol.120
, pp. 871-882
-
-
Bonnart, C.1
Deraison, C.2
Lacroix, M.3
-
5
-
-
33947498991
-
A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation
-
DOI 10.1074/jbc.M607567200
-
Borgoño CA, Michael IP, Komatsu N et al. (2007) A potential role for multiple tissue kallikrein serine proteases in epidermal desquamation. J Biol Chem 282:3640-52 (Pubitemid 47084449)
-
(2007)
Journal of Biological Chemistry
, vol.282
, Issue.6
, pp. 3640-3652
-
-
Borgono, C.A.1
Michael, I.P.2
Komatsu, N.3
Jayakumar, A.4
Kapadia, R.5
Clayman, G.L.6
Sotiropoulou, G.7
Diamandis, E.P.8
-
6
-
-
11944270052
-
A proteolytic cascade of kallikreins in the stratum corneum
-
DOI 10.1111/j.0022-202X.2004.23547.x
-
Brattsand M, Stefansson K, Lundh C et al. (2005) A proteolytic cascade of kallikreins in the stratum corneum. J Invest Dermatol 124:198-203 (Pubitemid 40100969)
-
(2005)
Journal of Investigative Dermatology
, vol.124
, Issue.1
, pp. 198-203
-
-
Brattsand, M.1
Stefansson, K.2
Lundh, C.3
Haasum, Y.4
Egelrud, T.5
-
7
-
-
67449159025
-
SPINK9: A selective, skin-specific Kazal-type serine protease inhibitor
-
Brattsand M, Stefansson K, Hubiche T et al. (2009) SPINK9: A selective, skin-specific Kazal-type serine protease inhibitor. J Invest Dermatol 129:1656-65
-
(2009)
J Invest Dermatol
, vol.129
, pp. 1656-1665
-
-
Brattsand, M.1
Stefansson, K.2
Hubiche, T.3
-
8
-
-
66049125101
-
Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome
-
Briot A, Deraison C, Lacroix M et al. (2009) Kallikrein 5 induces atopic dermatitis-like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome. J Exp Med 206:1135-47
-
(2009)
J Exp Med
, vol.206
, pp. 1135-1147
-
-
Briot, A.1
Deraison, C.2
Lacroix, M.3
-
9
-
-
78149464736
-
Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model
-
Briot A, Lacroix M, Robin A et al. (2010) Par2 inactivation inhibits early production of TSLP, but not cutaneous inflammation, in Netherton syndrome adult mouse model. J Invest Dermatol 130:2736-42
-
(2010)
J Invest Dermatol
, vol.130
, pp. 2736-2742
-
-
Briot, A.1
Lacroix, M.2
Robin, A.3
-
10
-
-
0034120666
-
Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
-
DOI 10.1038/75977
-
Chavanas S, Bodemer C, Rochat A et al. (2000) Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome. Nat Genet 25:141-2 (Pubitemid 30394980)
-
(2000)
Nature Genetics
, vol.25
, Issue.2
, pp. 141-142
-
-
Chavanas, S.1
Bodemer, C.2
Rochat, A.3
Hamel-Teillac, D.4
Ali, M.5
Irvine, A.D.6
Bonafe, J.-L.7
Wilkinson, J.8
Taieb, A.9
Barrandon, Y.10
Harper, J.I.11
De Prost, Y.12
Hovnanian, A.13
-
11
-
-
34548515280
-
LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction
-
DOI 10.1091/mbc.E07-02-0124
-
Deraison C, Bonnart C, Lopez F et al. (2007) LEKTI fragments specifically inhibit KLK5, KLK7, and KLK14 and control desquamation through a pH-dependent interaction. Mol Biol Cell 18:3607-19 (Pubitemid 47378698)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.9
, pp. 3607-3619
-
-
Deraison, C.1
Bonnart, C.2
Lopez, F.3
Besson, C.4
Robinson, R.5
Jayakumar, A.6
Wagberg, F.7
Brattsand, M.8
Hachem, J.P.9
Leonardsson, G.10
Hovnanian, A.11
-
12
-
-
19944427605
-
Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity
-
DOI 10.1038/ng1493
-
Descargues P, Deraison C, Bonnart C et al. (2005) Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity. Nat Genet 37:56-65 (Pubitemid 40070940)
-
(2005)
Nature Genetics
, vol.37
, Issue.1
, pp. 56-65
-
-
Descargues, P.1
Draison, C.2
Bonnart, C.3
Kreft, M.4
Kishibe, M.5
Ishida-Yamamoto, A.6
Elias, P.7
Barrandon, Y.8
Zambruno, G.9
Sonnenberg, A.10
Hovnanian, A.11
-
13
-
-
33745187792
-
Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome
-
Descargues P, Deraison C, Prost C et al. (2006) Corneodesmosomal cadherins are preferential targets of stratum corneum trypsin- and chymotrypsin-like hyperactivity in Netherton syndrome. J Invest Dermatol 126:1622-32
-
(2006)
J Invest Dermatol
, vol.126
, pp. 1622-1632
-
-
Descargues, P.1
Deraison, C.2
Prost, C.3
-
14
-
-
28844473475
-
HK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6
-
DOI 10.1111/j.1365-2133.2005.06834.x
-
Egelrud T, Brattsand M, Kreutzmann P et al. (2005) hK5 and hK7, two serine proteinases abundant in human skin, are inhibited by LEKTI domain 6. Br J Dermatol 153:1200-3 (Pubitemid 41779577)
-
(2005)
British Journal of Dermatology
, vol.153
, Issue.6
, pp. 1200-1203
-
-
Egelrud, T.1
Brattsand, M.2
Kreutzmann, P.3
Walden, M.4
Vitzithum, K.5
Marx, U.C.6
Forssmann, W.G.7
Magert, H.-J.8
-
15
-
-
80051794818
-
Infliximab infusions for Netherton syndrome: Sustained clinical improvement correlates with a reduction of thymic stromal lymphopoietin levels in the skin
-
Fontao L, Laffitte E, Briot A et al. (2011) Infliximab infusions for Netherton syndrome: Sustained clinical improvement correlates with a reduction of thymic stromal lymphopoietin levels in the skin. J Invest Dermatol 131:1947-50
-
(2011)
J Invest Dermatol
, vol.131
, pp. 1947-1950
-
-
Fontao, L.1
Laffitte, E.2
Briot, A.3
-
16
-
-
80054746489
-
Proteolytic activation cascade of the Netherton syndrome-defective protein, LEKTI, in the epidermis: Implications for skin homeostasis
-
Fortugno P, Bresciani A, Paolini C et al. (2011) Proteolytic activation cascade of the Netherton syndrome-defective protein, LEKTI, in the epidermis: Implications for skin homeostasis. J Invest Dermatol 131:2223-32
-
(2011)
J Invest Dermatol
, vol.131
, pp. 2223-2232
-
-
Fortugno, P.1
Bresciani, A.2
Paolini, C.3
-
17
-
-
78149358426
-
Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)
-
Goettig P, Magdolen V, Brandstetter H (2010) Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs). Biochimie 92:1546-67
-
(2010)
Biochimie
, vol.92
, pp. 1546-1567
-
-
Goettig, P.1
Magdolen, V.2
Brandstetter, H.3
-
18
-
-
33747339417
-
Serine protease signaling of epidermal permeability barrier homeostasis
-
Hachem JP, Houben E, Crumrine D et al. (2006) Serine protease signaling of epidermal permeability barrier homeostasis. J Invest Dermatol 126:2074-86
-
(2006)
J Invest Dermatol
, vol.126
, pp. 2074-2086
-
-
Hachem, J.P.1
Houben, E.2
Crumrine, D.3
-
19
-
-
12744274778
-
Lethal, neonatal ichthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome
-
Hewett DR, Simons AL, Mangan NE et al. (2005) Lethal, neonatal ichthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome. Hum Mol Genet 14:335-46
-
(2005)
Hum Mol Genet
, vol.14
, pp. 335-346
-
-
Hewett, D.R.1
Simons, A.L.2
Mangan, N.E.3
-
20
-
-
19944431526
-
LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum
-
DOI 10.1111/j.0022-202X.2004.23583.x
-
Ishida-Yamamoto A, Deraison C et al. (2005) LEKTI is localized in lamellar granules, separated from KLK5 and KLK7, and is secreted in the extracellular spaces of the superficial stratum granulosum. J Invest Dermatol 124:360-6 (Pubitemid 40175883)
-
(2005)
Journal of Investigative Dermatology
, vol.124
, Issue.2
, pp. 360-366
-
-
Ishida-Yamamoto, A.1
Deraison, C.2
Bonnart, C.3
Bitoun, E.4
Robinson, R.5
O'Brien, T.J.6
Wakamatsu, K.7
Ohtsubo, S.8
Takahashi, H.9
Hashimoto, Y.10
Dopping-Hepenstal, P.J.C.11
McGrath, J.A.12
Iizuka, H.13
Richard, G.14
Hovnanian, A.15
-
21
-
-
4444223718
-
Expression of LEKTI domains 6-9′ in the baculovirus expression system: Recombinant LEKTI domains 6-9′ inhibit trypsin and subtilisin A
-
DOI 10.1016/j.pep.2003.12.004
-
Jayakumar A, Kang Y, Mitsudo K et al. (2004) Expression of LEKTI domains 6-9' in the baculovirus expression system: Recombinant LEKTI domains 6-9' inhibit trypsin and subtilisin A. Protein Expr Purif 35:93-101 (Pubitemid 38497911)
-
(2004)
Protein Expression and Purification
, vol.35
, Issue.1
, pp. 93-101
-
-
Jayakumar, A.1
Kang, Y.2
Mitsudo, K.3
Henderson, Y.4
Frederick, M.J.5
Wang, M.6
El-Naggar, A.K.7
Marx, U.C.8
Briggs, K.9
Clayman, G.L.10
-
22
-
-
24144457010
-
Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases
-
DOI 10.1111/j.1365-2133.2005.06754.x
-
Komatsu N, Saijoh K, Toyama T et al. (2005) Multiple tissue kallikrein mRNA and protein expression in normal skin and skin diseases. Br J Dermatol 153:274-81 (Pubitemid 41228422)
-
(2005)
British Journal of Dermatology
, vol.153
, Issue.2
, pp. 274-281
-
-
Komatsu, N.1
Saijoh, K.2
Toyama, T.3
Ohka, R.4
Otsuki, N.5
Hussack, G.6
Takehara, K.7
Diamandis, E.P.8
-
23
-
-
1542719189
-
Recombinant production, purification and biochemical characterization of domain 6 of LEKTI: A temporary Kazal-type-related serine proteinase inhibitor
-
DOI 10.1016/j.jchromb.2003.07.016, PII S1570023203006755
-
Kreutzmann P, Schulz A, Standker L et al. (2004) Recombinant production, purification and biochemical characterization of domain 6 of LEKTI: A temporary Kazal-type-related serine proteinase inhibitor. J Chromatogr B Analyt Technol Biomed Life Sci 803:75-81 (Pubitemid 38340640)
-
(2004)
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
, vol.803
, Issue.1
, pp. 75-81
-
-
Kreutzmann, P.1
Schulz, A.2
Standker, L.3
Forssmann, W.-G.4
Magert, H.-J.5
-
24
-
-
0039702803
-
LEKTI, a novel 15-domain type of human serine proteinase inhibitor
-
Magert HJ, Standker L, Kreutzmann P et al. (1999) LEKTI, a novel 15-domain type of human serine proteinase inhibitor. J Biol Chem 274:21499-502
-
(1999)
J Biol Chem
, vol.274
, pp. 21499-21502
-
-
Magert, H.J.1
Standker, L.2
Kreutzmann, P.3
-
25
-
-
20444446698
-
Serine proteinase inhibitors in the skin: Role in homeostasis and disease
-
DOI 10.2174/1389203054065374
-
Magert HJ, Drogemuller K, Raghunath M (2005) Serine proteinase inhibitors in the skin: Role in homeostasis and disease. Curr Protein Pept Sci 6:241-54 (Pubitemid 40812748)
-
(2005)
Current Protein and Peptide Science
, vol.6
, Issue.3
, pp. 241-254
-
-
Magert, H.-J.1
Drogemuller, K.2
Raghunath, M.3
-
26
-
-
69549091576
-
Reddish, scaly, and itchy: How proteases and their inhibitors contribute to inflammatory skin diseases
-
Meyer-Hoffert U (2009) Reddish, scaly, and itchy: How proteases and their inhibitors contribute to inflammatory skin diseases. Arch Immunol Ther Exp (Warsz) 57:345-54
-
(2009)
Arch Immunol Ther Exp (Warsz)
, vol.57
, pp. 345-354
-
-
Meyer-Hoffert, U.1
-
27
-
-
77957808698
-
Isolation of SPINK6 in human skin: Selective inhibitor of kallikrein-related peptidases
-
Meyer-Hoffert U, Wu Z, Kantyka T et al. (2010) Isolation of SPINK6 in human skin: Selective inhibitor of kallikrein-related peptidases. J Biol Chem 285:32174-81
-
(2010)
J Biol Chem
, vol.285
, pp. 32174-32181
-
-
Meyer-Hoffert, U.1
Wu, Z.2
Kantyka, T.3
-
28
-
-
0037426357
-
Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: A kinetic analysis
-
DOI 10.1021/bi027029v
-
Mitsudo K, Jayakumar A, Henderson Y et al. (2003) Inhibition of serine proteinases plasmin, trypsin, subtilisin A, cathepsin G, and elastase by LEKTI: A kinetic analysis. Biochemistry 42:3874-81 (Pubitemid 36402680)
-
(2003)
Biochemistry
, vol.42
, Issue.13
, pp. 3874-3881
-
-
Mitsudo, K.1
Jayakumar, A.2
Henderson, Y.3
Frederick, M.J.4
Kang, Y.5
Wang, M.6
El-Naggar, A.K.7
Clayman, G.L.8
-
29
-
-
69749103212
-
The emerging roles of serine protease cascades in the epidermis
-
Ovaere P, Lippens S, Vandenabeele P (2009) The emerging roles of serine protease cascades in the epidermis. Trends Biochem Sci 34:453-63
-
(2009)
Trends Biochem Sci
, vol.34
, pp. 453-463
-
-
Ovaere, P.1
Lippens, S.2
Vandenabeele, P.3
-
30
-
-
28244435723
-
Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI)
-
DOI 10.1515/BC.2005.134
-
Schechter NM, Choi EJ, Wang ZM et al. (2005) Inhibition of human kallikreins 5 and 7 by the serine protease inhibitor lympho-epithelial Kazal-type inhibitor (LEKTI). Biol Chem 386:1173-84 (Pubitemid 41705372)
-
(2005)
Biological Chemistry
, vol.386
, Issue.11
, pp. 1173-1184
-
-
Schechter, N.M.1
Choi, E.-J.2
Wang, Z.-M.3
Hanakawa, Y.4
Stanley, J.R.5
Kang, Y.6
Clayman, G.L.7
Jayakumar, A.8
-
31
-
-
33644641620
-
SPINK5, the defective gene in Netherton syndrome, encodes multiple LEKTI isoforms derived from alternative pre-mRNA processing
-
DOI 10.1038/sj.jid.5700015, PII 5700015
-
Tartaglia-Polcini A, Bonnart C, Micheloni A et al. (2006) SPINK5, the defective gene in Netherton syndrome, encodes multiple LEKTI isoforms derived from alternative pre-mRNA processing. J Invest Dermatol 126:315-24 (Pubitemid 43323166)
-
(2006)
Journal of Investigative Dermatology
, vol.126
, Issue.2
, pp. 315-324
-
-
Tartaglia-Polcini, A.1
Bonnart, C.2
Micheloni, A.3
Cianfarani, F.4
Andre, A.5
Zambruno, G.6
Hovnanian, A.7
D'Alessio, M.8
-
32
-
-
0034785609
-
Gene polymorphism in Netherton and common atopic disease
-
DOI 10.1038/ng728
-
Walley AJ, Chavanas S, Moffatt MF et al. (2001) Gene polymorphism in Netherton and common atopic disease. Nat Genet 29:175-8 (Pubitemid 32952654)
-
(2001)
Nature Genetics
, vol.29
, Issue.2
, pp. 175-178
-
-
Walley, A.J.1
Chavanas, S.2
Moffatt, M.F.3
Esnouf, R.M.4
Ubhi, B.5
Lawrence, R.6
Wong, K.7
Abecasis, G.R.8
Jones, E.Y.9
Harper, J.I.10
Hovnanian, A.11
Cookson, W.O.C.M.12
-
33
-
-
4644254787
-
-/- mice
-
DOI 10.1101/gad.1232104
-
Yang T, Liang D, Koch PJ et al. (2004) Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice. Genes Dev 18:2354-8 (Pubitemid 39304682)
-
(2004)
Genes and Development
, vol.18
, Issue.19
, pp. 2354-2358
-
-
Yang, T.1
Liang, D.2
Koch, P.J.3
Hohl, D.4
Kheradmand, F.5
Overbeek, P.A.6
-
34
-
-
12344301866
-
Epidermal differentiation: The role of proteases and their inhibitors
-
Zeeuwen PL (2004) Epidermal differentiation: The role of proteases and their inhibitors. Eur J Cell Biol 83:761-3
-
(2004)
Eur J Cell Biol
, vol.83
, pp. 761-763
-
-
Zeeuwen, P.L.1
|