Essential role of mediator subunit Med1 in invariant natural killer T-cell development

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 41, 2011, Pages 17105-17110

  Yue, Xiaojing ^a,b   Izcue, Ana ^a,c   Borggrefe, Tilman ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2 RECEPTOR BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR BINDING PROTEIN;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL CYCLE REGULATION; CELL DIFFERENTIATION; CELL MATURATION; GENE EXPRESSION; INNATE IMMUNITY; INVARIANT NATURAL KILLER T CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFECT; RECEPTOR GENE; T LYMPHOCYTE; THYMOCYTE; TRANSGENE;

ANIMALS; CELL DIFFERENTIATION; CELL LINEAGE; GENE EXPRESSION; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; MEDIATOR COMPLEX SUBUNIT 1; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; NATURAL KILLER T-CELLS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTE SUBSETS;

ANIMALIA;

EID: 80054742877     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1109095108     Document Type: Article

References (41)

1. Bendelac A, Savage PB, Teyton L (2007) The biology of NKT cells. Annu Rev Immunol 25:297-336. (Pubitemid 46697911)
2. D'Cruz LM, Yang CY, Goldrath AW (2010) Transcriptional regulation of NKT cell development and homeostasis. Curr Opin Immunol 22:199-205.
3. Godfrey DI, Stankovic S, Baxter AG (2010) Raising the NKT cell family. Nat Immunol 11:197-206.
4. Das R, Sant'Angelo DB, Nichols KE (2010) Transcriptional control of invariant NKT cell development. Immunol Rev 238:195-215.
5. Matsuda JL, Mallevaey T, Scott-Browne J, Gapin L (2008) CD1d-restricted iNKT cells, the 'Swiss-Army knife' of the immune system. Curr Opin Immunol 20:358-368.
6. Egawa T, et al. (2005) Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors. Immunity 22:705-716. (Pubitemid 40814501)
7. Gapin L, Matsuda JL, Surh CD, Kronenberg M (2001) NKT cells derive from double-positive thymocytes that are positively selected by CD1d. Nat Immunol 2:971-978. (Pubitemid 32976171)
8. Bezbradica JS, Hill T, Stanic AK, Van Kaer L, Joyce S (2005) Commitment toward the natural T (iNKT) cell lineage occurs at the CD4+8+ stage of thymic ontogeny. Proc Natl Acad Sci USA 102:5114-5119.
9. Kennedy MK, et al. (2000) Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med 191:771-780.
10. Townsend MJ, et al. (2004) T-bet regulates the terminal maturation and homeostasis of NK and Valpha14i NKT cells. Immunity 20:477-494. (Pubitemid 38482125)
11. Yu S, Cantorna MT (2008) The vitamin D receptor is required for iNKT cell development. Proc Natl Acad Sci USA 105:5207-5212. (Pubitemid 351738535)
12. Matsuda JL, et al. (2002) Homeostasis of V alpha 14i NKT cells. Nat Immunol 3: 966-974. (Pubitemid 35154011)
13. Monticelli LA, et al. (2009) Transcriptional regulator Id2 controls survival of hepatic NKT cells. Proc Natl Acad Sci USA 106:19461-19466.
14. Kim PJ, et al. (2006) GATA-3 regulates the development and function of invariant NKT cells. J Immunol 177:6650-6659. (Pubitemid 44715028)
15. Belakavadi M, Fondell JD (2006) Role of the mediator complex in nuclear hormone receptor signaling. Rev Physiol Biochem Pharmacol 156:23-43.
16. Zhang X, et al. (2005) MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell 19:89-100. (Pubitemid 40884660)
17. Crawford SE, et al. (2002) Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors. J Biol Chem 277:3585-3592. (Pubitemid 34953230)
18. Ito M, Yuan CX, Okano HJ, Darnell RB, Roeder RG (2000) Involvement of the TRAP220 component of the TRAP/SMCC coactivator complex in embryonic development and thyroid hormone action. Mol Cell 5:683-693.
19. Landles C, et al. (2003) The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development. Mol Endocrinol 17:2418-2435. (Pubitemid 37542207)
20. Zhu Y, et al. (2000) Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality. J Biol Chem 275:14779-14782. (Pubitemid 30337186)
21. Stumpf M, et al. (2010) Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1. Proc Natl Acad Sci USA 107:21541-21546.
22. Liu Y, et al. (2006) A modified alpha-galactosyl ceramide for staining and stimulating natural killer T cells. J Immunol Methods 312:34-39. (Pubitemid 43795980)
23. Kronenberg M (2005) Toward an understanding of NKT cell biology: Progress and paradoxes. Annu Rev Immunol 23:877-900.
24. Benlagha K, Wei DG, Veiga J, Teyton L, Bendelac A (2005) Characterization of the early stages of thymic NKT cell development. J Exp Med 202:485-492. (Pubitemid 41186947)
25. Bendelac A (1995) Positive selection of mouse NK1+ T cells by CD1-expressing cortical thymocytes. J Exp Med 182:2091-2096.
26. McNab FW, et al. (2005) The influence of CD1d in postselection NKT cell maturation and homeostasis. J Immunol 175:3762-3768. (Pubitemid 41292036)
27. Wei DG, et al. (2005) Expansion and long-range differentiation of the NKT cell lineage in mice expressing CD1d exclusively on cortical thymocytes. J Exp Med 202:239-248. (Pubitemid 41043820)
28. Chen YH, Chiu NM, Mandal M, Wang N, Wang CR (1997) Impaired NK1+ T cell development and early IL-4 production in CD1-deficient mice. Immunity 6:459-467. (Pubitemid 27208201)
29. Mendiratta SK, et al. (1997) CD1d1 mutant mice are deficient in natural T cells that promptly produce IL-4. Immunity 6:469-477. (Pubitemid 27208202)
30. Godfrey DI, Berzins SP (2007) Control points in NKT-cell development. Nat Rev Immunol 7:505-518. (Pubitemid 46987785)
31. Benlagha K, Kyin T, Beavis A, Teyton L, Bendelac A (2002) A thymic precursor to the NK T cell lineage. Science 296:553-555. (Pubitemid 34408679)
32. Kovalovsky D, et al. (2008) The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions. Nat Immunol 9: 1055-1064.
33. Matsuda JL, et al. (2006) T-bet concomitantly controls migration, survival, and effector functions during the development of Valpha14i NKT cells. Blood 107: 2797-2805.
34. Ohteki T, Ho S, Suzuki H, Mak TW, Ohashi PS (1997) Role for IL-15/IL-15 receptor betachain in natural killer 1.1+ T cell receptor-alpha beta+ cell development. J Immunol 159:5931-5935. (Pubitemid 127471528)
35. Matsuda JL, Gapin L (2005) Developmental program of mouse Valpha14i NKT cells. Curr Opin Immunol 17:122-130. (Pubitemid 40343097)
36. Gadue P, Yin L, Jain S, Stein PL (2004) Restoration of NK T cell development in fynmutant mice by a TCR reveals a requirement for Fyn during early NK T cell ontogeny. J Immunol 172:6093-6100. (Pubitemid 38621212)
37. Chung Y, et al. (2008) A critical role of costimulation during intrathymic development of invariant NK T cells. J Immunol 180:2276-2283.
38. Felices M, Berg LJ (2008) The Tec kinases Itk and Rlk regulate NKT cell maturation, cytokine production, and survival. J Immunol 180:3007-3018.
39. Yu S, Cantorna MT (2011) Epigenetic reduction in invariant NKT cells following in utero vitamin D deficiency in mice. J Immunol 186:1384-1390.
40. Jia Y, et al. (2004) Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver. J Biol Chem 279:24427-24434. (Pubitemid 38725306)
41. Lee PP, et al. (2001) A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival. Immunity 15:763-774. (Pubitemid 34008504)